Actuate Therapeutics (Ft Worth, TX; no SBIR, founded 2015) raised $21.7 million to take its lead oncology asset deeper into the clinic. The series B round comes shortly after Actuate dosed the first patient in a phase 1/2 trial of glycogen synthase kinase‐3 beta (GSK-3β) 9-ING-41. [Nick Paul Taylor, Fierce Biotech, May 20, 19]
ArcherDX (Boulder, CO, no SBIR), a molecular technology company dedicated to developing breakthrough solutions that advance the application of personalized genomic medicine, announced the closing of an up to $60 million Series B financing round [company press release, May 15, 19]
Marrone Bio Innovations (Davis, CA) maker of biologically based pest control products, said it's partnering with Compass Minerals International (Overland Park, KS) to develop new sustainable plant nutrition products. [Mark Anderson, Sacramento Business Journal, May 16, 19]
Iovance BioThera (San Carlos, CA; no SBIR) up 36% [May 16, 19] reaction to new interim data from clinical trials evaluating its tumor-infiltrating lymphocyte (TIL) candidates. The data will be presented at ASCO in Chicago. [Douglas W. House, seekingalpha.com, May 16, 19]
Mersana Thera down 16% [May 16, 19]
Dynetics was one of eleven companies picked by NASA to produce prototypes of a human [lunar] landing platform with descent, ascent, transfer and refueling elements and shoulder at least 20 percent of the total development cost under the Next Space Technologies for Exploration Partnerships Appendix E contracts. [Jane Edwards, GovConWire, May 17, 19]
Already struggling to keep pace with Sarepta Therapeutics in the race to develop a gene therapy for Duchenne muscular dystrophy, Solid Biosciences reported another setback. A patient treated with its Duchenne muscular dystrophy gene therapy suffered a transient decline in platelet levels from the gene therapy, and a serious GI infection that wasn’t related to the treatment. The patient recovered and the trial continues, but shares nonetheless fell 40 percent. [Frank Vinluan, xconomy.com, May 17, 19]
ElevateBio unveiled $150 million in Series A funding to back its plans to invest in cell and gene therapy startups, and build a shared facility in Waltham, MA, that will manufacture their experimental treatments. [Frank Vinluan, xconomy.com, May 17, 19]
clinical-stage biopharmaceutical CinCor Pharma (Cincinnati, OH; no SBIR, founded 2018) announced the completion of a $50 million Series A round. ... the largest Series A the city has ever seen. ... also CinCor announced that Swiss multinational health care company Roche would acquire exclusive global rights to CIN-107, an aldosterone synthase inhibitor compound. Said compound will be further developed to use against treatment-resistant hypertension and primary aldosteronism. Financial terms of the deal were not disclosed. [Courtney Gabrielson, CincyInno, May 15,19 ]
Usual SBIR politics. The Senate Small Business Committee held a hearing on “Reauthorization of the SBA’s Innovation Programs,” which had a heavy emphasis on SBIR/STTR. Earlier in the day, Chairman Marco Rubio (R-Fla.) published a report on business investment, which places many shortcomings of the national economy at the feet of “sharedholder primacy” and calls for policies to incentivize investment by businesses into research and innovation. Among the topics raised during the hearing were making SBIR/STTR permanent, faster contracting, and additional support for innovative companies. [Jason Rittenberg, SSTI, May 16, 19] Usual noises that beneficiaries love SBIR for three decades, but no defensible economic evaluation. No matter, small money for beloved constituency, little harm done to government R&D.
Mirage pushing stock valuations. U.S. companies have been repurchasing their own shares at a blistering pace for more than a year, and market turbulence isn’t likely to stop them now. [Wall Street Journal, May 17, 19] little new capital investment by new cash for selling stockholders. In all, a mirage of values.
Mr. Trump’s tariffs have been fully borne by Americans, at a net cost to the country of $1.4 billion per month. ... but the tariffs are a drop in the bucket for a $21 trillion economy. [Jeff Sparshott, Wall Street Journal, May 16, 19]
Arbitrary firing law fails. Rather than defend a law that the president loves, the VA will reinstate a [civil service] hospital director whom it twice tried to fire. ... the government said it would give Hawkins his job back rather than defend the statute in court. [Isaac Arnsdorf, ProPublica, May 16, 19]
PDS Biotechnology (Berkeley Heights, NJ; no SBIR) up 41% [May 15, 19] clinical-stage immuno-oncology company pioneering the development of multifunctional immunotherapeutic products, today announced a peer-reviewed publication supporting the novel mechanisms of action of its proprietary Versamune(R) platform in cancer immunotherapy. [company press release, May 15, 19]
OncoCyte up 18% [May 15, 19]
Immunogen down 32% [May 15, 19] announced the [FDA] has recommended that the Company conduct a new Phase 3 randomized trial to evaluate the safety and efficacy of mirvetuximab soravtansine in patients with high folate receptor alpha (FR)-positive, platinum-resistant ovarian cancer as part of a Type C meeting held this week. [company press release, May 15, 19]
The U.S. Army selected Dynetics (at least 30 SBIRs) to be the prime contractor on a potential $130M contract to build and demonstrate a 100-kilowatt-class laser weapons system. Dynetics said Wednesday its partners for the High Energy Laser Tactical Vehicle Demonstrator program are Lockheed Martin, Rolls-Royce and MZA Associates. [Mary-Louise Hoffman, GovConWire, May 16, 19]
NanoGuard Technologies (Creve Coeur, MO; no SBIR, founded 2014) startup with technology that could make the world's food supplies safer, has raised $6 million [VC] ... has a plasma technology that kills bacteria, molds and other toxins in grain, nuts, meat and other foods. [David Nicklaus, St Louis Post Dispatch, May 14, 19]
More trade war. President Trump signed an executive order that would let the U.S. ban telecommunications gear from “foreign adversaries,” underscoring tensions with China even as the U.S. said it would likely resume trade talks soon in Beijing. [Wall Street Journal, May 16, 19] Do he and his Cabinet of big biz anti-regulation executives know what they are doing in international strategy?
Democratic paeans to checks and balances conceal plans for a historic power grab. [Daniel Henninger, Wall Street Journal, May 16, 19] The complainers about Congressional investigation and action could notice that the US Constitution gives the Congress ultimate power of impeachment and removal of any US government official.
Novavax up 24% [May 14, 19]
Solid Biosciences downup 29% [May 14, 19] reported financial results for the first quarter
Titan Spine (Mequon, WI; no SBIR, founded 2006) announced that Medtronic will acquire it. Terms not disclosed. .... makes interbody implants that serve as spacers inserted between the vertebrae during spinal fusion procedures. The implants help to relieve nerve pressure and hold the vertebrae in place while fusion takes place. .... has raised more than $50M in funding. [Katherine Davis, Wisconsin Inno, May 14, 19]
NASA has awarded $106M in total [SBIR Phase II] contract funds to 129 small businesses to further develop technology platforms that may help sustain human presence on the moon and Mars. ... also said it will help fund the commercialization of resulting platforms in the third phase. [Brenda Marie Rivers, GovConWire, May 15, 19]
Ten startups whose products piqued the interest of the [DOD] have completed the joint startup accelerator between Techstars and the U.S. Air Force in Boston. Among the 10, half are focused on either drones or cybersecurity. [Boston Business Journal, May 15, 19]
Vertex Pharmaceuticals is paying $70 million upfront to work with Kymera Therapeutics on the discovery of drugs that drive the elimination of disease-causing proteins. The early-stage deal features more than $1 billion in milestones tied to the success of six programs. [Nick Paul Taylor, Fierce Biotech, May 15, 19]
Counter-strike. After vowing over the weekend to "never surrender to external pressure", Beijing has defied President Trump's demands that it not resort to retaliatory tariffs and announced plans to slap new levies on $60 billion in US goods. [Tyler Durden, zerohedge.com, May 15, 19] Perhaps Trump's sacred "base" will realize that they are the chumps in the game of autocratic power.
Nammi Therapeutics (West Los Angeles,CA; no SBIR) Looks to Raise $20M BIOTECH: UCLA spinoff developing cancer treatment [Dana Bartholomew, Los Angeles Business Journal, May 10, 19] focused on optimizing cancer immunotherapy by using nanocarriers to deliver synergistic anti-tumor and immune activating agents to the tumor. [cnsi.ucla.edu, May 10, 19]
Neural Analytics (Los Angeles, CA; $3M SBIR, founded 2013) a medical robotics company developing and commercializing technologies to measure and track brain health, announced it has raised approximately $22 million Series C [company press release, May 8, 19] prior funding $51M [crunchbase.com]
Science and technology company UES (Beavercreek, OH; multi SBIRs) and the University of Dayton Research Institute have landed spots on a five-year, $99M contract to help the Air Force Research Laboratory conduct scientific studies. Both contractors will support AFRL research projects in the power, energy, thermal, integration and control areas as part of efforts to develop military weapon and emerging technology applications, the Department of Defense said. [Nichols Martin, GovConWire, May 14, 19]
G1 Thera up 21% [May 10, 19]
Catalysy Pharma up 16% [May 10, 19]
TransEnterix down 39% [May 10, 19] reported financial results
Cortxyme down 27% [May 10, 19]
Fibrogen down 20% [May 10, 19]
Twentyeight-Seven Therapeutics (Watertown, MA; no SBIR), which focuses on the modulation of RNA to treat cancer and other human diseases, raised $15M in a Series A extension, bringing the startup's total financing to more than $80M. [Boston Inno, May 10, 19]
Goldfinch Bio (Cambridge, MA; no SBIR) biotech startup seeking to develop precision medicines for people with kidney disease, will receive at least $109M in a deal with California biopharma giant Gilead Sciences. [Rowan Walrath, BostInno, May 10, 19]
Job growth at the smallest businesses has fallen to the lowest levels in nearly eight years as tiny companies struggle to attract and retain workers in the tightest U.S. job market in half a century. [Wall Street Journal, May 13, 19] Given enough time, Trump's economic game could devestate the US economy.
Trust me, I know. The president, in a series of tweets, said a prolonged trade war would be good for America even as negotiators returned to the table. [New York Times, May 11, 19] President W said much the same line in 2003 about fixing Iraq. But W at least had editors to help keep the story straight. On the Iraq question: The Iraq war was not a tragedy. It was more like a crime, compounded by the stupefying incompetence of those who embarked upon a patently illegal preventive war out of a sense of panic induced by the events of 9/11. [Andrew J. Bacevich reviewing LEAP OF FAITH Hubris, Negligence, and America’s Greatest Foreign Policy Tragedy By Michael J. Mazarr, New York Times, April 19, 19]
Be careful what you tweet for. Trump, has repeatedly badgered Europe to increase defense spending. But now that Europe is taking concrete steps to boost a pan-European defense industry, Washington is reportedly howling mad, according to Spanish daily El Pais. [Foreign Policy.com, May 13, 19]
Opportunity. U.S. Air Force plans to launch a $48M R&D program to integrate autonomous systems and sensors for potential use in U.S. military operations across cyber, air and space domains. A presolicitation notice posted [May 7] on FedBizOpps stated the Multi-Sensor Exploitation for Tactical Autonomy initiative will explore sensing autonomy platfoms in areas such as simulation and analysis, multidomain and multisensor data management, learning and computing for knowledge and understanding. The open BAA will cover basic, applied and advanced research, development, assessment, demonstration and transition of the technologies [Darwin McDaniel, GovConWire, May 10, 19] In principle, 3% of that should go to SBIR.
Cortexyme (South San Francisco, CA; no SBIR) up 93%, [May 9, 19] after $90M IPO, develops therapies for neurodegenerative diseases by targeting Porphyromonas gingivalis. The bacterial pathogen has been found in the brains of more than 90 percent of Alzheimer’s patients, according to the firm’s prospectus. ... firm has not yet generated revenue. [Elizabeth Balboa, benzinga.com, May 8, 19]
NextCure (Beltsville, MD; no SBIR) up 33% [May 9, 19] a clinical-stage biopharmaceutical company committed to discovering and developing novel, first-in-class immunomedicines to treat cancer and other immune-related diseases, announced the pricing of its [IPO] to raise $75M [company press release, May 8, 19]
Flexion Therapeutics (Burlington, MA; no SBIR) up 19% [May 9, 19] announced first-quarter 2019 operating results .. analysts plesed with progress in ramping up sales of the company's sole drug product.. [Maxx Chatsko, motleyfool.com, May 9, 19]
Dynavax Tech up 18% [May 9, 19]
Axcella Health (Cambridge, MA; no SBIR) down 31% [May 9, 19] a biotechnology company pioneering the research and development of novel multifactorial interventions to address dysregulated metabolism and support health, announced the pricing of its [IPO] to raise $71M [company press release, May 8, 19]
Infinera down 27% [May 9, 19] missed Wall Street’s revenue expectations by about 6% while reporting a narrower loss than analysts had expected. [marketwatch.com, May 9, 19]
Ionis Pharma earns $84 million, reversing loss from a year ago [San Diego Union Tribune, May 9, 10]
Cytokinetics said its drug reldesemtiv failed to improve patients’ lung function in a 485-patient Phase 2 trial, FORTITUDE-ALS. But the company will press ahead with a larger Phase 3 study because it saw positive signs outside the trial design. [Ben Fidler, xconomy.com, May 10, 19]
Moderna said that partner Merck scrapped development of an experimental vaccine for shingles, mRNA-1278. Moderna and Merck also halted development of mRNA-1777, a vaccine for respiratory syncytial virus, in favor of a potentially more potent version. [Ben Fidler, xconomy.com, May 10, 19]
Dealing with politicians: Responding on Twitter to a Texas pediatrician, a Texas state legislator has drawn national attention for calling vaccines “sorcery.” [Ben Fidler, xconomy.com, May 10, 19] Democracy does have the downside of installing into office some really awful people's representatives. Which should remind people that the best protection for government is an educated electorate.
Small biz back-blast. U.S. tariffs could inflict significant damage on China. Small, private companies are key to China’s job market and growth. They had a harrowing end to 2018 for three reasons. 1.) They are far more exposed to trade than their large state-owned peers, and suffered as exports collapsed. 2.) The crackdown on shadow banking starved them of capital. 3.) A stock-market collapse, due partly to rising trade tensions, made things worse because many business owners had pledged shares in return for loans, and were at risk of losing their equity, Nathaniel Taplin writes. The new tariffs, therefore, risk knocking out two legs of China’s private-sector-business recovery. [Jeff Sparshott, WSJ, May 10, 19] Back-blast form the tariffs could have the same effect on US small companies, which apparently are not a concern to a real-estate mogul. Congress could wake up to the threat that an unrestrained president can wreak great havoc on our economic system. The Founders knew the problem and built a government to contain power, a system that has miraculously endured since 1787.
1920s redux. The U.S. increased tariffs on $200 billion of Chinese goods to 25% Friday as President Trump ratcheted up pressure on Beijing and threatened to impose additional levies on virtually everything China exports to the U.S. [Wall Street Journal, May 10, 19] Who collects? The government. Who pays? US consumers, who don' t seem to get the memo. It's a 1920s idea that devestated the 1930s., now invoked by a president who proudly reads nothing beyond half-page with visuals.
President Trump said that the Mueller report showed “essentially no collusion.” Jimmy Fallon responded: “That’s like a waiter walking over and going, ‘Here’s your salad. There’s essentially no E. coli in it.’” [Chris Stanford and Mike Ives, New York Times, May 10, 19]
ARCA Biopharma up 20% [May 8, 19]
Catalyst Pharma down 24% [May 8, 19]
Myriad Geneticsa down 21% [May 8, 19]
Aduro Biotech down 21% [May 8, 19]
cell therapy firm Vericel (Cmbridge, MA; no SBIR) has forged a $142M deal to license a gel used to help heal burns. The gel uses enzymes to remove burned tissue, with around 93% of subjects experiencing complete removal of the damaged tissue in a Phase 3 clinical trial.
a striking decadeslong decline in American entrepreneurship: Between 1978 and 2011, “the firm entry rate—or firms less than one year old as a share of all firms—fell by nearly half.” [Edward Glaeser reviewing Grube and Johnson's Jump-Starting America, Wall Street Journal. May 8, 19] SBIR has had three decades to jump-start Amrican high tech small biz. Unfortunately Congress gave the federal R&D agencies unilateral authority to choose its innovation awardees, but with no incentive for the agencies to do other than support their own internal programs.
Catalyst Pharma down 40% [May 7, 19]
Idera Pharma down 16% [May 7, 19]
Backed by $58.5 million venture cash, new startup Verve Therapeutics (Cambridge, MA; no SBIR)’s big idea is to use gene editing to give people DNA mutations that have been found to protect the heart health of the people born with them. [Alex Lash, xconomy.com, May 7, 19]
Phoenix (formerly Phoenix Nuclear Labs, Monona, WI; no SBIR, founded 2005) said it inked a $4 million contract with the US Army to demonstrate neutron-based imaging technologies that could be used to help inspect large, complex munitions, according to a press release. The Madison-area company previously was awarded Army contracts in 2014 and 2016 worth a combined $6.6 million. [Jeff Engel, xconomy.com. May 6, 19]
Emtora Biosciences (formerly Rapamycin Holdings, San Antonio, TX; no SBIR) received FDA orphan drug designation for its novel therapeutic [San Antonio Business Journal, May 8, 19]
Cree is funneling up to $1 billion in new investments in its Durham headquarters. [Triangle Business Journal, May 7, 19]
Athenex up 28% [May 6, 19]
Imunogen up 15% [May 6, 19]
The FDA approved two oral formulations of the Pfizer drug tafamidis, approved specifically to treat the potentially deadly heart problems faced by patients with both the hereditary and “wild-type” forms of ATTR, the latter of which develops over time. ... In 2018 the FDA approved two drugs Alnylam Pharmaceuticals and Akcea Therapeutics (spinout of Ionis Pharmaceuticals, Boston, MA; no SBIR) for hereditary and wild-type ATTR. [Ben Fidler, xconomy.com, May 6 19]
Dexcom’s sales up 52 percent with strong demand in the U.S. and overseas for its glucose monitors for diabetes patients [San Diego Union Tribune, May 2, 29]
Idera Pharma up 17% [May 3, 19]
ARCA Biopharma down 14% [May 3, 19]
BioFactura (Frederick, MD; $3.2M SBIR, founded 2001) develops and manufactures high-value biosimilars, raised $6 million Series B round [crunchbase.com, Apr 29, 19]
Parhelion (Apex, NC; no SBIR) behind a laser light known as the “Firefly,” filed for bankruptcy April 30 [Lauren Ohnesorge, Triangle Business Journal, May 1, 19]
ARCA Biopharma up 23% [May 2, 19]
Auris Medical up 15% [May 2, 19]
Ultralife down 19% [May 2, 19] reported lower quarterly profits
Acadia Pharma reported a [quarterly] net loss of $85.3 million. [company press release, May 1, 19]
Exact Sciences, which makes the Cologuard take-home colon cancer test, reported revenue of $162M and test volume of about 334,000 for its first quarter of 2019. The numbers were a 79 percent increase from a year ago, according to the company’s quarterly report. [WisconsinInno, May 2. 19]
G1 Therapeutics announced plans to file for approval of cancer drug trilaciclib in small cell lung cancer. GI shares had plummeted in December when data showed more patients on placebo and chemotherapy saw their tumors shrink compared to those treated with G1’s drug and chemo. [Alex Lash, xconomy.com, May 3, 19]
Ideaya Biosciences (South San Francisco, CA; no SBIR) filed for a $70 million IPO to fund early-stage studies of lead drug IDE196 in solid tumors with particular genetic mutations. [Alex Lash, xconomy.com, May 3, 19]
Peloton Therapeutics (Dallas and San Francisco; no SBIR) is targeting $115 million in its IPO, which will fund late-stage studies testing kidney cancer drug PT2977. [Alex Lash, xconomy.com, May 3, 19]
ARCA Biopharma (Westminster, CO; no SBIR, founded 1992) up 99% [May 1, 19] announced that the paper "GENETIC-AF: Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined Heart Failure Population" was published in JACC: Heart Failure, a journal of the American College of Cardiology. ... developing genetically-targeted therapies for cardiovascular diseases through a precision medicine approach to drug development. ARCA's lead product candidate, GencaroTM bucindolol hydrochloride), is an investigational, pharmacologically unique beta-blocker and mild vasodilator being developed for the potential treatment of atrial fibrillation in heart failure patients with mid-range ejection fraction. [company press release, May 1, 19] total funding $90M [crunchbase.com]
Auris Medical down 21% [May 1, 19] Announces 1:20 Reverse Stock Split company press release, [Apr 30, 19]
SilkTech Biopharmaceuticals (Minneapolis, MN and Los Angeles, CA; at least $2.5M SBIR, founded 2013), devoted to improving eye health through the development of silk-derived protein biotherapeutics for the targeted treatment of Dry Eye Disease (DED), announced the company has received clearance of its Investigational New Drug (IND) submission with [FDA] for its SDP-4 eye drop product. [company press release, Apr 17, 19] total funding $28M [crunchbase.com]
NeoChord (St Louis Park, MN; no SBIR, founded 2007) leading the advancement of beating heart mitral valve repair in patients suffering from mitral valve regurgitation,announced that it has secure dadditional funding as anextension of its SeriesD equity financing, ... bringing the ttal for the last 12 months to $32M [comapny press release, Apr 30, 19] prior funding $67M [crunchbase.com]
HistoSonics (Ann Arbor, MI; no SBIR, founded 2009), developer of a non-invasive robotics platform and novel beam therapy, announced it has closed a $54 million Series C financing. [company press release, April 8, 2019] prior funding $32M [crunchbase.com]
G1 Therapeutics up 15% [Apr 30, 19]
Magenta Therapeutics down 15% [Apr 30, 19] announced a public offering
a spinout of Roche called Nimble Therapeutics (Madison, WI; no SBIR), which licensed the drug discovery technology from the Swiss pharma giant, said it completed a Series A venture investment [undisclosed amount] ... according to a document filed with the SEC earlier this month, Nimble closed $10 million in equity funding. ... focusing on drugs formed from peptides, which are chains of amino acids. Such drugs have appealed to pharmaceutical developers because they are thought to combine desirable properties of both small and large molecule drugs, [Jeff Engel, xconomy.com, Apr 30, 19]
Emtora Biosciences (formerly known as Rapamycin Holdings, San Antonio, TX; no SBIR, founded 2012) announced that [FDA] has granted orphan drug designation to eRapaTM for the treatment of patients with Familial Adenomatous Polyposis (FAP). ... plans to begin a Phase 2a trial in patients with FAP in late 2019. This trial will follow a Phase 1b safety and dose escalation study in early stage prostate cancer patients that will conclude this summer and will inform trial design for the FAP study. [company press release, Apr 30, 19] total funding $4M [crunchbase.com]
Codiak Biosciences (Cambridge,MA; no SBIR) filed for an $86M IPO. .... Separately, the company is expanding into West Cambridge’s Alewife Research Center along with disease monitoring company Glympse Bio. [Rowan Walrath, Boston Inno, Apr 30, 19]
Madison-based Nimble Therapeutics has closed a $10M Series A funding round led by San Francisco's Telegraph Hill Partners. Nimble, based at the University Research Park at the University of Wisconsin-Madison, is developing chemical synthesis technology for drug development. More here. [Jim Dallke, WisconsinInno, Apr 30, 19]
Beltsville, Md.-based NextCure has filed to go public three years after its founding, with a cancer-fighting drug in clinical testing and several local biotech veterans leading the charge. The company plans to trade on the Nasdaq Global Market under "NXTC," offering 5M shares to the public at $14 to $16 per share. The startup projects $66M to $77M in net proceeds from the IPO that, along with its $135M in cash on the balance sheet, will go toward pushing its products through the clinical pipeline. [DC Inno, Apr 30, 19]
Vividion Therapeutics (San Diego, CA; no SBIR, founded 2013 spun out of The Scripps Research Institute), looking to increase the number of proteins that small molecules can target, has raised $82 million series B which will bring at least one of three programs through clinical proof of concept. [Amirah Al Idrus, Fierce Biotech, Apr 30, 19] prior fnding $155M [crunchbase.com]
Salix Pharmaceuticals (Bridgewater, NJ, the largest gastroenterology-focused pharmaceutical company in the world, one NIH SBIR in 1994) has bagged the ex-Asia rights to Mitsubishi Tanabe’s late-phase autoimmune drug, amiselimod. The Bausch Health subsidiary plans to trial the S1P receptor functional antagonist in ulcerative colitis. [Nick Paul Taylor, Fierce Biotech, Apr 24, 19]
Spin-In tech. The Army is partnering with the Pentagon’s internal startup accelerator to adapt small commercial drones—think hobbyists’ quadcopters—for the battlefield. The Defense Innovation Unit announced it will begin offering its expertise to the Army’s Short Range Reconnaissance program. [Jack Corrigan,.nextgov.com, Apr 29, 19] The difficulty comes when the Army writes a doctrine and instructions for use of technology that it did not develop. Nice idea; how do we use it, buy it, supply it, carry it, and service it? The Army's backpack is already overflowing and battery demnd is skyrocketing.
Repligen up 20% [Apr 26, 19]
BioConsortia (Davis, CA; no SBIR, founded 2014), innovator of microbial solutions for natural plant trait enhancement and yield improvement, has closed a [$10M] round of equity financing for the commercial development of a number of novel microbial consortia products — focused toward corn, wheat, soy, tomatoes, and leafy veg. [company press release, Mar 29, 19] prior funding $27M [crunchbase.com]
Forge Therapeutics (San Diego CA; no SBIR) has partnered with Basilea Pharmaceutica (Swiss) to develop antibiotics. The deal gives Forge the opportunity to earn up to $167 million in milestones per drug, along with royalties. [Bradley Fikes, San Diego Union Tribune, Apr 25, 19] developing novel medicines by combining bioinorganic with medicinal chemistry to target metalloenzymes. Forge has developed a fundamentally new approach for the discovery of metalloenzymes inhibitors by focusing first on the metal in the enzyme active site. [company website] prior funding $30M [crunchbase.com]
Sirnaomics ( Gaithersburg, MD; $1.2M SBIR) has yet another $11 million in a [$47M] Series C funding round... The biopharmaceutical company kicked off the round last year with $25 million in Series C1 financing (Washington Business Journal) [DCInno, Apr 27, 19]
Dr. Peter Hart, recalled in an interview that in recruiting Dr. Nilsson, Mr. Rosen had poked his finger at Dr. Nilsson’s chest and said: “Radar? That’s like doing research on light bulbs! You have to come help us design these learning machines.” [John Markoff's obituary for Nils Nlisson, robot pioneer at Stanford University, NYTimes, Apr 27, 19]
the biggest success of the Trump Presidency has been the economy. .. the “reformacons” on the right who derided deregulation and corporate tax cuts as an out-of-date agenda should admit how wrong they were. [Wall Street Journal editorial, Apr 27, 19] The braggarts over the recent economic growth conveniently ignore the contribution of putting hundreds of billions of dollars spent by the federal government on the national credit card of deficit finance (think a $trillion a year). With enough loans, anyone can look like an economic genius, even the self-styled "king of debt".
VionX Energy (founded 2002 as Premium Power, Woburn, MA; no SBIR), flow battery company has taken in $14 million in a debt offering, according to an SEC filing. The company did not respond to a request for information about the funding. [xconomy.com, Apr 26, 19] has developed a grid-scale, long duration energy storage system delivering unmatched performance over a 20+ year life which is certified non-flammable, safe and bankable. The unique long-duration discharge of up to 10 hours at full rated power is enabled by its world leading flow battery stack technology operating at 3X higher power density than any competitor and proprietary vanadium electrolyte processing. [company website] total prior funding $114M [crunchbse.com]
The CIA-affiliated venture-capital firm In-Q-Tel has nurtured many promising technology start-ups with seed money. But getting any technological innovations to take root inside the intelligence agencies has been a challenge, thanks to embedded contractors with their own financial incentives, bespoke and aging information technology systems, and sclerotic, risk-averse acquisition policies that make it exceptionally difficult for commercial companies, especially start-ups, to work with the government. [Amy Zegart and Michael Morell, Foreign Affairs, Apr 24, 19]
Aro Biotherapeutics (Philadelphia, PA; no SBIR, founded 2018) reels in $3.5M [Philadelphia Business Journal, Apr 17, 19] focused on the development of a new protein drug platform called Centyrins, designed to achieve better efficacy and safety profiles for patients with cancer and other serious diseases. Centyrins are small, non-antibody protein scaffolds that can be expressed as multi-specifics with novel therapeutic mechanisms of action. prior funding $13M [crunchbase.com]
iRobot down 23% [Apr 24, 19] after its report of disappointing sales growth in the March quarter .... company said margins would remain pinched until this year’s December quarter. [Bill Alpert, Barron's, Apr 24, 19]
Late-stage medical device startup Intrinsic Therapeutics (no SBIR, founded Y2K) raised $38.8M in a $41.7M funding round, according to a [SEC] filing. [Srividya (Sri) Kalyanaraman, BostInno Beat, Apr 24, 19] develops therapies to treat disc herniations in the spine for discectomy patients. .. prior funding $219M [crunchbase.com]
Zeteo Tech (Sykesville, MD; $1.4M SBIR) that has developed a revolutionary new class of fieldable biological mass spectrometers, announced a contract of up to $6.5 million (including options) from the U.S. Department of Homeland Security to develop and test a new sensor technology that enables real-time detection of aerosolized biological threat agents including bacteria, viruses, and toxins [company press release, Apr 14, 19]
NeuroSigma (Los Angeles,CA; $6M SBIR, founded 2008), focused on commercializing Trigeminal Nerve Stimulation (TNS) technology for treating neurological and neuropsychiatric disorders today announced that its Monarch® eTNS® System (Monarch) received FDA clearance as a non-drug treatment for attention deficit hyperactivity disorder (ADHD). [company press release, Apr 23, 19] total funding $13M [crunchbase.com]
Atossa Genetics up 23% [Apr 23, 19]
A4 Pharmaup 22% [Apr 23, 19]
Moleculin Biotech down 47% [Apr 23, 19] announced a public offereng to raise $15M
Poseida Therapeutics (San Diego, CA; no SBIR, founded 2015), a clinical-stage biopharmaceutical company leveraging proprietary non-viral gene engineering technologies to create life-saving therapeutics, today announced closing of a Series C financing round, raising $142 million led by a $75 million equity investment from Novartis Pharma AG [company press release, Apr 22, 19] prior funding $85M [crunchbse.com]
Innovation leaders often cite Eastman-Kodak as an example of an enterprise that was too dim-witted to see the writing on the wall and so fell from its lofty perch. But Kodak’s executives weren’t ignorant. They knew technology was changing and in fact invested billions of dollars in digitization. Kodak’s fatal problem was an inflexible organization that couldn’t adapt quickly enough to forces outside of its control. [Zachery Tyson Brown's All This ‘Innovation’ Won’t Save the Pentagon, DefenseOne, Apr 23, 19] Sounds like IBM's story with the PC.
China’s Subsidized Conquest of Trade. U.S. industry fades away as state-owned companies undersell the competition. [William Galston, Wall Street Journal, Apr 23, 19] Latest US victim industries: subway cars and 5G components. In the foreign competing countries, their people are paying taxes to the state to support the state subsidies to chosen industries, something not likely to be popular in tax-cut-merica. Trump is groping with a false sense of (smartest guy in the room) self-confidence to fix the problem while desparately concealing his actual financial track record to keep the sunshine from the magic.
Trump called Congress “very partisan.” [The Hill] Imagine that!
Zynerba Pharma up 17% [Apr 22, 19]
Novus Thera (Irvine, CA; no SBIR) announced results from two OP0201 single-dose phase 1 clinical trials. The primary objective of establishing safety and tolerability was achieved in both healthy adults (study C-001) and in adults with acute otitis media (study C-004). [company press release, Apr 22, 19]
General Electric accused Cree of using a technology on Cree’s LED product which infringes the patent of GE’s TriGain LED technology. ... filed a patent infringement lawsuit against Cree on April 11, 2019. [YiningChen, ledinside.com/news, Apr 17, 19]
Faster pay, maybe. A bill introduced last week in the House of Representatives would accelerate payments to small businesses that do work for the federal government. The Accelerated Payments for Small Business Act of 2019 would direct federal agencies to disburse payments within 15 days of receiving a proper invoice if a specific payment date is not established, rather than the current 30-day standard. The bill impacts only small businesses. (Washington Business Journal) Nice thought, BUT, faster pay means more people, or more robots, to process AND VERIFY the claims.
Too free speech. We have a world where people live in cognitive bubbles of the like-minded and share one another’s biases and prejudices. According to this savvy view, our brave new world is too prone to propaganda and conspiracy-mongering to rely on Mill’s optimism about free speech [as the best disinfectant]. To do so is to risk abetting the rise of fascist and absolutist tendencies. [David Johnson, Aeon, Apr 21, 19]
Twitter: the place to go for all your drive-by crucifixion needs. [Dwight Garner, New York Times, Apr 21, 19]
Eli Lilly and Avidity Biosciences (San Diego, CA; no SBIR) signed a global licensing and research collaboration focused on the development and commercialization of new medicines in immunology and other select indications. Under the terms of the agreement, Avidity will receive an upfront payment of $20M, and an investment of $15M. Avidity is also eligible to receive up to ~$405M per target for development, regulatory and commercialization milestones, as well as tiered royalties ranging from the mid-single to low-double digits on product sales. [seekingalpha.com, Apr 19, 19] prior funding $16M [crunchbase.com]
More science, or else. It is hard to maintain leadership in any field with five decades of shrinking budgets. Science is no different—especially when your competition is devoting hundreds of billions, year after year, to beating you. ... The solution? America needs to do what it does best: compete. The U.S. has the world’s best research universities, a great scientific talent pipeline and a strong culture of innovation. Now Washington needs to invest more—much more [Alex Beam, Wall Street Journal, Apr 19, 19] Reaistically, every scientist sees a need for more knowledge but has little appetite to compete for political attention.
Not Nothing. A plausible title for the paperback editions that will soon be in bookstores might be, “We Didn’t Not Find Anything.” [Dwight Garner, reviewing the Mueller report, NYTimes, Apr 20, 19]
Talaris Therapeutics startup founded 2002 and long known as Regenerex, has secured a $100 million Series A investment ... breathes new life into an experimental cell therapy known as FCR001, a one-time treatment meant to make it possible for patients who need a kidney transplant to get one from any donor—without the need for a life-long regimen of immunosuppressive drugs afterwards to prevent rejection of the outsider’s organ. [Ben Fidler, xconomy.com, Apr 18, 19]
NASA Mimics SBIR. Invests in 18 Potentially Revolutionary Space Tech Concepts. Phase I $125K; Phase II $500K All projects are still in the early stages of development, most requiring a decade or more of concept maturation and technology development. A few awards to small biz: among new selections 3DeWitt LLC, Ancramdale, NY, no SBIR; TransAstra Corporation, Lake View Terrace, CA, no SBIR; Howe Industries LLC, Tempe, AZ, no SBIR [NASA press release, Apr 10, 19]
Qualcomm up 12% [Apr 17, 19]
Arrakis Therapeutics (Waltham, MA; no SBIR, founded 2015) pioneering the discovery of a new class of small-molecule medicines that directly target RNA, has completed a $75 million Series B financing [company press release, Apr 18, 19] prior funding #38M [crunchbase.com]
Regenerex (Louisville, KY; $7M SBIR) late clinical stage biotechnology company engaged in the development of innovative cellular therapies with the goal of providing long-term durable responses eliminating the burden of chronic immunosuppression in selected organ transplant and autoimmune conditions.gets new CEO, new funding and new name: Talaris Therapeutics [Amirah Al Idrus, Fierce Biotech, Apr 18, 19]
Nocion Therapeutics (Cambridge, MA;o SBIR), a biotech developing drugs that silence nociceptors, the neurons that send pain or itch signals when they are inflamed. The biotech is starting out with $27 million in series A funding [Amirah Al Idrus, Fierce Biotech, Apr 17, 19]
Kiadis Pharma N.V. (Netherlands), a clinical stage biopharmaceutical company, announced that it has entered a definitive agreement to acquire CytoSen Therapeutics (Dallas, TX; no SBIR, founded 2014 in Florida) [Kiadis press release, Apr 17, 19] CytoSen is on a mission to advance natural killer (NK) cell therapeutics and to make it a real cure in the fight with cancer. [company website]
Hemosonics (Charlottesville, VA; $8.5M SBIR) announced that its innovative Quantra Hemostasis Analyzer platform, and its initial QPlus cartridge have been granted de novo marketing authorization by the FDA and are now available for sale in the United States. [company press release, Mar 13, 19]
Applied Therapeutics (New York, NY; no SBIR), is aiming to raise $86 million [IPO] to bankroll a trio of assets through the clinic, advance three drugs that target aldose reductase, an enzyme that converts glucose into sorbitol, a sugar alcohol involved in multiple diseases including complications of diabetes. [Amirah Al Idrus, Fierce Biotech, Apr 15, 19]
Qualcomm up 23% [Apr 16, 19] after settling Apple dispute
Amplyx (San Diego, CA) funded by over a hundred million dollars in venture investment, plus [NIH] grants , is enrolling patients in Phase 2 trials of its lead drug candidate, APX001A ... to treat life-threatening, invasive infections caused by not only strains of Candida auris, but also Aspergillis and rare molds. [xconomy.com, Apr 16, 19]
Brussels sets out $20bn list of US goods facing tariffs. [Jim Brunsden, Financial Times, Apr 17, 19] Tit-for-tat on tariffs truned out really ugly in the 1930s, an historical fact appaprently irrelevant to the White House's American-alone campaign for American isolation.
Semantic City. “I believe the government spied on the Trump campaign,” said Mr. Barr in a town where semantic directness is simply not practiced among the political pharisees and their pilot fish in the media who seek to preserve a certain order by obfuscating true intent. [Kevin Brock, TheHill, Apr 16, 19]
A President of [just] His People? The message seems clear and so does the audience: more red meat for red-state Americans who have been the foundation of his political enterprise since his against-the-odds campaign for the White House. [Peter Baker, New York Times, Apr 16, 19]
Bio-Path Holdings up 33% [Apr 12, 19]
Fibrocell Science (Exton, PA; no SBIR), focused on transformational autologous cell-based therapies for skin and connective tissue diseases, announced the completion of a collaboration agreement with Castle Creek Pharmaceuticals (Parsippany, NJ, no SBIR) to develop and commercialize Fibrocell’s lead gene therapy candidate, FCX-007, for the treatment of recessive dystrophic epidermolysis bullosa (RDEB), a rare, life-threatening genetic disorder diagnosed at infancy with no cure or treatment approved by [FDA]. .... Castle Creek will receive an exclusive license to commercialize FCX-007 in the United States. Castle Creek Pwill be responsible for all development and manufacturing expenses up to $20 million prior to the initial Biologics License Application (BLA) filing with the FDA. .... Fibrocell will receive an upfront payment of $7.5 million, $2.5 million for the first patient enrolled in the Phase 3 clinical trial and $30 million upon BLA approval and commercial readiness. Fibrocell is also eligible to receive up to $75 million in sales milestones, consisting of $25 million when FCX-007 achieves $250 million in cumulative net sales and an additional $50 million upon attaining $750 million in cumulative net sales. In addition, Castle Creek Pharmaceuticals will pay Fibrocell a 30% share of the gross profits from FCX-007 sales. [Fibrocell press release, Apr 15, 19]
Palvella Therapeutics (Wayne, PA; no BIR) developing treatments for rare disease, raised $3.4 million in equity financing. ... about four months after Palvella entered into a $10 million development funding and royalties agreement with Ligand Pharmaceuticals. [John George, Philadelphia Business Journal, Apr 15, 19]
X4 Pharma (Cambridge, MA; no SBIR) down 17% [Apr 12, 19] priced its public offering to raise $85M [company press release, Apr 12, 19]
Evofem Biosciences (San Diego, CA; no SBIR) struck a deal to raise up to $80 million in a private placement. ... closed the first $30 million, from PDL BioPharma with the firm paying a 26.4 percent premium, ... PDL also can invest up to $30 million more. [Sarah de Crescenzo, xconomy.com, Apr 12, 19]
Cardea Bio San Diego, CA, no SBIR) which makes biosensors using graphene, raised $7.8 million from outside investors.. .... The company says its “biology-enabled transistor technology” is the first of its kind to be produced commercially. [Sarah de Crescenzo, xconomy.com, Apr 12, 19]
Being ahead of one’s time may impress posterity; it is no advantage at the polls. .... The authors blame it on voters who stress “hollow celebrity and contrived popularity” at the expense of “competence and rational judgment.” [Richard Norton Smith reviewing The Problem of Democracy By Nancy Isenberg & Andrew Burstein, Wall Street Journal, Apr 12, 19]
Don't need no outside advice neither. Pentagon officials are killing JASON in all but name.For decades, JASON studies helped DOD and other agencies get outside perspectives on scientific and technical topics. [Patrick Tucker, DefenseOne, Apr 11, 19] Just send DOD more money and cut soft stuff like food stamps, says Trump as America-alone fortress builder.
In the age of Trump, national politics is showbiz — self-righteous performance art to make the base feel good about itself. [David Brooks, NYTimes, Apr 11, 19]
PhaseBio Pharma down 11% [Apr 10, 19]
M3 Biotechnology (Seatle, WA; no SBIR) has changed its name to Athira Pharma, derived from the Arabic word meaning “a force” or “an energy,” which the company says aligns with its focus on developing regenerative therapies for Alzheimer’s, Parkinson’s and multiple sclerosis. plans to launch a phase 2 proof-of-concept study before the end of 2019 [Conor Hale, Fierce Biotech, Apr 11, 19]
Fe3 Medical (San Antionio, TX; no SBIR) announced the close of its [$11M] Series B financing for clinical trials and regulatory submissions required to obtain CE Mark and FDA approval for the transdermal patch. [company press release, Apr 10, 19] moving forward with its wearable patch that uses electrical current to deliver iron directly through the skin to treat one of the world’s most common deficiencies. [Conor Hale, Fierce Biotech, Apr 11, 19]
Inozyme Pharma (Boston, MA; no SBIR, founded 2017) developing novel medicines to treat rare, debilitating, and life-threatening mineralization disorders, announced raised $67 million in a Series A2 financing .... has to date raised $116 million in venture capital. [company press release, Apr 10, 19]
Nine months after Zogenix (Emeryville, CA; no SBIR) got a stock rally going by touting late-stage data for a new drug to prevent seizures due to Dravet syndrome, the FDA handed back their marketing application with a failing grade on inadequate and incomplete work. Officially, that’s called a refuse-to-file notice, [John Carroll, Endpoints News, Apr 11, 19
The middle class is shrinking and its economic power diminishing in the U.S. and other rich countries, a development that threatens political stability and economic growth, according to a report by the OECD. [Wall Street Journal, Apr 11, 19] Meanwhile our presidential champion of the downtrodden xenophobic white unemployed class has had two years of improving the lot of the richest, including himself, with tax "reform" and appointment of business allies to government posts to further improve the lot of established businesses, while distracting the xenophobes with loud talk about the Southern borders For this bounty, he urges us to re-elect him.
How's your self-importance? Astrophyisicists, for $50m of publicly funded ressearch, showed a picture of a massive black hole 53 milion light years from Earth. [Seth Borensten, AP, Apr 10, 19] The very idea of the "known" universe and the unknown scale of other possible universes and other possible structures of matter and energy, and the complete human ignorance of the source of any of it, reminds us the insignficance of our brief existances.
PhaseBio Pharma up 16% [Apr 9, 19]
Zosano Pharma down 27% [Apr 9, 19] announced the pricing of an underwritten [$17M] public offering of its common stock [company press release, Aug 9, 19]
PhaseBio Pharma up 17% [Apr 8, 19]
Histogenics (Waltham, MA; no SBIR), and Ocugen (Malvern, PA, no SBIR) clinical-stage biopharmaceutical focused on discovering, developing and commercializing a pipeline of innovative therapies that address rare and underserved eye diseases, jointly announced that they have entered into a definitive merger agreement under which the stockholders of Ocugen will become the majority owners of Histogenics’ outstanding common stock [joint companies press release, Apr 8, 19]
The biggest [Silicon Valley VC] decline has come in the number of angel and seed funding deals, which fell 44.2 percent between 2015 and 2018. [Cameron Schubarth, Silicon Valley Business Journal, Apr 8, 19]
When Impulse Rages. Secretary of Homeland Security Kirstjen Nielsen’s firing is the plainest example yet of the futility of trying to restrain Trump from inside—and the personal cost to those who try. [David Graham, The Atlantic, Apr 8. 19] The Founders foresaw such power grabbing and built checks and balances into the federal government structure. The federal judiciary, appointed for life, are demonstrating the check system to keep the executive within the law.
CEL-SCI up 21% [Apr 5, 19]
Aura Biosciences (Cambridge, MA; no SBIR, founded 2007) a leader in the development of novel targeted therapies in ocular oncology, today announced that it closed a $40 million Series D financing. [company press release, Apr 2, 19] prior funding $72M [crunchbase.com]
Merrimack Pharmaceuticals down 16% [Apr 5, 19] oncology company focused on biomarker-defined cancers, announced the Company is discontinuing development of MM-310, its antibody-directed nanotherapeutic for the treatment of solid tumors. This decision was the result of a comprehensive review of available safety data from its Phase 1 study. [company press release, Apr 4, 19]
Alnylam and Regeneron Pharmaceuticals are announcing a wide-ranging alliance to co-develop treatments for eye and neurological diseases using RNA interference, a method of drugmaking that has recently come of age after years of ups and downs. Regeneron will pay Alnylam $400 million in cash up front and buy $400 million in Alnylam stock—4.44 million shares at $90.01 apiece—to kickstart the deal. Alnylam could get another $200 million in downstream payments from Regeneron if the drugs in the deal progress forward and hit certain development targets. [Ben Fidler, xconomy.com, Apr 8, 19]
Up to $5 million of the $20 million allocated by ARPA-E under Design Intelligence Fostering Formidable Energy Reduction and Enabling Numerous Totally Impactful Advanced Technology Enhancements (DIFFERENTIATE) program, funding opportunity will be made available specifically for small businesses under ARPA-E’s SBIR. ...Submit trial balloon concept papers by May 20, 2019. [ARPA-E newsletter, Apr 5, 19]
Writing after the release of the Pentagon Papers, Hannah Arendt crystallized the essence of today’s obfuscatory media atmosphere: “Lies are often much more plausible, more appealing to reason, than reality, since the liar has the great advantage of knowing beforehand what the audience wishes or expects to hear.” [Alan Hirshfeld reviewing Robert Crease's The Workshop and the World, Wall Street Journal, Apr 5, 19]
Satire overwhelmed. The danger, of satire: not that it mocks and belittles respect-worthy pieties, not that it “punches down,” but that it has become impossible to separate it cleanly from the toxic disinformation that defines our era. [Justin E.H. Smith, philosophy professor, NY Times, Apr 5, 19] Free speech enables truth itself to be overwhelmed. with enough media and enough liars.
Recro Pharma up 28% [Apr 4, 19]
Ocean Power Tech down 59% [Apr 4, 19] announced the pricing of an underwritten public offering with gross proceeds of approximately $15,000,000 [company press release, Apr 4, 19]
Vaccinex down 15% [Apr 4, 19]
NGM Biopharmaceuticals (South an Francisco, CA; no SBIR, founded 2008) announced the pricing of its [IPO] to raise $107M. .... has generated a pipeline of seven experimental drugs for metabolic disorders, cancer, and eye diseases. For the past four years, NGM has been working with Merck in a partnership focused on developing drugs for diabetes, obesity, and nonalcoholic steatohepatitis (NASH), which is a type of fatty liver disease. [Frank Vinluan xconomy.com, Apr 3, 19]
Ocean Power Tech up 55% [Apr 3, 19] signed a contract with a leading oil and gas exploration and production company to complete a 12-week paid feasibility study that will examine the use of OPT's products and services in monitoring subsea wells during decommissioning activities. [company press release, Apr 3. 19]
Advaxis down 31% [Apr 3, 19]
Dyne Thrapeutics (Cambridge, MA) new biotechnology company pioneering targeted therapies for patients with serious muscle diseases, launched today with a $50 million Series A ... eveloping breakthrough medicines based on its proprietary product platform, which delivers nucleic acids and other molecules to skeletal, cardiac and smooth muscle with unprecedented precision. [company press release, Apr 2, 19]
Apexigen (San Carlos, CA; no SBIR) Apexigen revved up its pipeline with a $73 million venture round that allowed it to move its lead immuno-oncology candidate into clinical trials. Now, it’s rolling out early data from that research that are turning heads at the annual American Association for Cancer Research (AACR) meeting in Atlanta. [Arlene Weintraub, Fierce Biotech, Apr 1, 19]
SpringWorks (Baltimore, MD spinout from Pfizer, founded 2017) nets $125M to propel desmoid tumor, neurofibroma meds [Amirah Al Idrus, Fierce Biotech, Apr 1, 19]
Know Labs (formerly Visualant, Seattle, WA; no SBIR, founded 1998), developing non-invasive technology to detect and measure glucose, alcohol, and other substances in the blood, raised nearly $4 million in March. [Jeff Buchanan, xconomy.com, Apr 2, 19]
TG Therapeutics (New York, NY; no SBIR)’ PI3K delta inhibitor, umbralisib, put up encouraging phase 2b data in marginal zone lymphoma, shrinking tumors in more than half of the patients followed long enough to be evaluated. Of these patients, nearly one-fifth were in complete remission. [Amirah Al Idrus, Fierce Biotech, Apr 1, 19]
Biolinq (San Diego, CA; no SBIR) tacked on an extra $4.75 million to the total of its series A round to help fund additional clinical trials and development of its coin-sized sensor patch for monitoring blood glucose levels and other biomarkers. [Conor Hale, Fierce Biotech, Apr 1, 19]
Faraday Pharmaceuticals (Seattle, WA; no SBIR, founded 2013), developing treatments designed to reduce the risk of damage from reperfusion, the surging of blood back into tissue after an injury or medical procedure. [Jeff Buchanan, xconomy.com, Apr 2, 19] prior funding $63M [crunchbse.com]
Rodeo Therapeutics (Seattle, WA; no SBIR), founded 2017), developing small-molecule therapies aimed at promoting regeneration and repair of different types of tissue, raised more than $4.2 million in equity funding has raised more than $13.3 million in outside funding since launching. [Jeff Buchanan, xconomy.com, Apr 2, 19]
Biotech Proteon tanks after kidney disease drug fails again in phase 3 [Nick Paul Taylor, Fierce Biotech, Mar 29, 19]
Tariff, the go-to tool. The Trump administration’s demand that punitive tariffs remain to ensure Beijing enacts genuine overhauls has emerged as one of the biggest sticking points as U.S. and Chinese trade negotiators opened new talks. [Bob Davis, Wall Street Journal, Apr 3, 19] Worked to punish everyone in the 1930s.
Sangamo Thera up 29% [Apr 2, 19]
Zynerba Pharma up 29% [Apr 2, 19]
Six Madison [WI]-area tech startups are receiving grants from the SBIR Advance program, a collaboration between the Wisconsin Economic Development Corp. and the UW System Administration's Center for Technology Commercialization, to grow their businesses. Onexio Biosystems, Madison $75K, Equipment used to quickly screen potential drug compounds during the drug development process. Pyran, Madison $75K: Using wood and crop waste to make a key chemical used to manufacture paints and plastics; Stem Pharm, Fitchburg, $75K: Biomaterials for cell and tissue manufacturing; NCD Technologies, Madison $100K: Diamond and diamond-like coatings for medical devices and other industries. PhylloTech, Middleton $100K: A process to engineer plants to produce proteins that will help them resist agricultural diseases. [Judy Newman, Wisconsin State Journal, Mar 27, 19]
Phase Bio Pharma up 30% [Apr 1, 19]
Vaccinex up 23% [Apr 1, 19]
Arch Oncology (Brisbane, CA and St Louis, MO; no SBIR), a clinical-stage immuno-oncology company focused on the discovery and development of best-in-class anti-CD47 antibody therapies, today announced a successful $50 million Series B financing. The Company plans toadvance its anti-CD47 antibody AO-176’s ongoing Phase 1 clinical trial in select solid tumors, as well as its pipeline. [company press release, Mar 25, 19]
Tricida (South San Francisco, CA; no SBIR, founded 2013) up 57% [Mar 28, 19] Announces Positive Results From Long-Term Clinical Trial of TRC101 in Patients With CKD and Metabolic Acidosis [company press release, Mar 28, 19] total funding $257M [crunchbase.com]
Proteon Thera (Waltham, MA; no SBIR) down 86% [Mar 28, 19] announced results from PATENCY-2, its Phase 3 clinical trial of investigational vonapanitase in patients with chronic kidney disease (CKD) undergoing creation of a radiocephalic fistula for hemodialysis. This study did not meet its co-primary endpoints of fistula use for hemodialysis (p=0.328) and secondary patency (p=0.932). The adverse events with vonapanitase were similar to placebo and consistent with previous clinical trials. [company press release, Mar 28, 19]
Biosensor startup Biolinq (formerly Electrozyme, San Diego, CA; $2.2M SBIR, founded 2012) said it has raised $4.75 million from new investors, including the New York-based Juvenile Diabetes Research Foundation, following the results of a clinical study of its experimental biomarker monitoring device. .... seeking to commercialize a nickel-sized patch that’s designed to gauge blood-glucose level and take other measurements when the device is applied to the skin. [Sarah de Crescenzo, xconomy.com, Mar 28, 19] prior funding $10M [crunchbase.com]
Precision BioSciences (Durham, NC; no SBIR) raising $126 million [IPO]. ... proprietary technology ARCUS reprograms a gene-editing enzyme called I-Crel, which is found in algae. [Frank Vinluan, xconomy.com, Mar 28, 19]
[John] Ismay writes [New York Times] that "In June 2018, [manufacturer] Dynetics {at least 30 SBIRs) received a $470 million 'indefinite quantity' contract to supply Special Operations Command with GBU-69s." A spokeswoman told the Times USSOCOM has ordered more than 2,000 of the GBU-69s already. Read on, here . [defenseone.com, Mar 28, 19]
Advaxis executed a 1:15 reverse split. [Mar 27, 19]
Lower taxes- gut IRS. A Hollowed-Out IRS Workforce Has Led to a 91 Percent Drop in Investigations of Non-Filing Businesses, [CAO says] The agency is ignoring even tax returns with obvious discrepancies because it no longer has the resources to follow up on them. [Eric Katz, govexec.com, Mar 27, 19] Only suckers pay taxes. -- Donald Trump, Sep 27, 2016
Puritanism as a political project failed, and for a host of reasons. The Bible is too big and complex a book to inspire a single doctrine of human government. Also, the Puritans’ intense work ethic tended to generate prosperity and markets, and markets are no place for narrow orthodoxy and severe morality. [Barton Swain revieiwng Michael Winship's Hot Protstants, Wall Street Journal, Mar 27, 19] Politicians and voters could take note that evangelicals' fervor for righteousness makes a poor base for practical governance.
Phase Bio Pharma up 33% [Mar 26, 19] reported earnings
NantKwest (Culver City, CA; no SBIR, founded 2015) a leading clinical-stage, natural killer cell based therapeutics company, announced that the company’s Chairman & CEO, exercised warrants representing an aggregate cash exercise price of $39.2 million. ... a member of the NantWorks ecosystem of companies [company press release, Mar 25, 19]
Lower pay, lower quality. The White House’s top budget official argued in favor of a 2020 pay freeze for federal employees, telling lawmakers on Tuesday the plan would free up agency heads to deliver merit-based pay. [govexec.com, Mar 27, 19] Merit pay was tried in the late 1970s and soon abandoned as unworkable. There's no escaping the reality that government is not a for-profit enterprise with quantitative measures and therfore too easily politicized. Fortunately, Congress does not support such degradation of federal employment as it depends on those employees to execute the legislated programs.
Catalyst Pharma up 30% [Mar 25, 19]
Proteostasis Thera down 68% [Mar 25, 19] announced results from Phase 1 clinical studies of its proprietary cystic fibrosis transmembrane conductance regulator (CFTR) modulators [company press release, Mar 25, 19]
Recro Phrma down 34% [Mar 25, 19] "We are extremely disappointed with the receipt of a second CRL from the FDA," said [CEO] Gerri Henwood. [company press release, Mar 22, 19]
Year-old MedImmune spinoff Viela Bio (Gaithersburg, MD; no SBIR), created to focus on autoimmune disease, is raising $75M and could hit the 100-employee target by yearend, CEO Bing Yao told the WBJ. ... would add to a $282M Series A round led by three Chinese investment groups when it launched in February 2018. ... lead candidate is inebilizumab which treats NMOSD, a rare disease that affects the central nervous system. [DCInno, Mar 25, 19]
Hookipa Pharma (New York and Vienna) filed for a meaty public offering to boost toward its midstage cancer and infectious disease work. ... developing a pipeline derived from two arenavirus-based vector platforms: Vaxwave and TheraT. .... Gilead, Boehringer and Takeda have all bought into the biotech’s platforms, backing its recent funding rounds [Ben Adams, Fierce biotch, Mar 25, 19]
Shrinking government. Key Federal Agency Doesn't Have the Staff to Oversee $35B in 2017 Hurricane Recovery Money. Slow process has led to four states and territories devastated by hurricanes receiving virtually none of the funds Congress appropriated. [Eric Katz, govexec.com, Mar 25, 19]
Bio-Path Holdings up 19% [Mar 22, 19]
GRO Biosciences, a Harvard Life Lab spinoff startup co-founded by geneticist George Church raised $3.7M in a new round of equity funding, according to a Form D filing. [DCInno, Mar 22, 19]
startup TearSolutions (Charlottesville, VA; no SBIR, founded 2015) is moving ever closer to commercialization after hauling in a $6.4 million funding round. The company, which launched in 2013 as a spinout of the University of Virginia, is developing a drug called Lacripep to combat dry eye. [Kieran McQuilkin, Richmond Inno, Mar 18, 19]
Pentagon: We're Buying Boeing F-15s to Keep 2 Fighter Makers in Business. ... The acting defense secretary's ties to the company had nothing to do with the decision, a senior defense official said. [Marcus Weisgerber, Defense One, Mar 25, 9] Oh, right.
Liquidia Tech down 19% [Mar 21, 19]
Turning Point Therapeutics (San Diego CA; no SBIR, founded 2013), a clinical-stage precision oncology company designing and developing novel drugs to address treatment resistance, announced it has filed [for IPO] [company press release, Mar 21, 19] total funding $144M [crunchbase.com] plans to raise $100M [Bradley Fikes, San Diego Union Tribune, Mar 21, 19]
Sherlock Bioscienecs (Cambridge, MA; no SBIR) dedicated to making diagnostic testing better, faster and more affordable, today announced its launch and initial financing of $35 million. ... using Engineering Biology tools, including CRISPR and Synthetic Biology, to create a new generation of molecular diagnostics that can rapidly deliver accurate and inexpensive results for a vast range of needs in virtually any setting. [company press release, Mar 21, 19]
Karuna Therapeutics (formerly Karuna Pharmaceuticals, Boston, MA; no SBIR), focused on targeting muscarinic cholinergic receptors for the treatment of neuropsychiatric disorders including psychosis in schizophrenia, psychosis in Alzheimer’s disease, and pain, announced the completion of a $68 million Series B [company press release, Mar 18, 19]
Vixiar Medical (Annapolis, MD; no SBIR) dedicated to the development of non-invasive devices and systems for monitoring cardiopulmonary diseases, announced today that it closed its most recent financing of $1.5 million to complete an ongoing clinical trial and to prepare regulatory submissions. [company press rleaase, Mar 21, 19]
researchers from Memorial Sloan Kettering Cancer Center, MD Anderson Cancer Center and Dana-Farber Cancer Institute have joined forces with DNA sequencing giant Illumina and its liquid-biopsy spinoff Grail to develop a new assay. According to results published in the journal Annals of Oncology, they've come up with a method that can detect mutations in NSCLC patients’ blood with high sensitivity. [Angus Liu, Fierce Biotech, Mar 20, 19]
Flagship Pioneering (Cambridge, MA) has raised $824 million for a fund to support biotech and health companies that have come up through its Flagship Labs foundry. [Amirah Al Idrus, Fierce Biotech, Mar 20, 19]
Employees as commodities. Trump proposes to integrate the functions of the Office of Personnel Management into the General Services Administration, Defense Department and the Executive Office of the President, although much remains contingent on Congress approving legislation. [Erich Wagner, govexec.com, Mar 21, 19] Don't expect Congress to agree to remake USG into Trump Tower Inc with an arbitrary dictator.
Cytokinetics up 19% [Mar 20, 19]
Catalyst Pharma up 16% [Mar 20, 19]
Bio-Path Holdings down 15% [Mar 20, 19]
Zynerba Pharma up 15% [Mar 19, 19]
resTORbio down23% [Mar 19, 19]
Cree is selling its entire lighting division to Ideal Industries Inc. in a $310 million deal [Lauren Ohnesorge, Triangle Business Journal, Mar 15, 19]
Cubic announced the acquisition of Nuvotronics [Duham, NC and Radford,VA; $27M SBIR, founded 2008), a disruptive technology provider of microfabricated radio frequency (RF) products, for approximately $64 million in cash .... The cornerstone of Nuvotronics’ innovation platform is their patented PolyStrata® technology, which was developed under DARPA and enables the company to design and produce uniquely packaged RF devices, such as antennas, filters and combiners [Cubic press release, Mar 14, 19]
All the federal government’s initiatives and resources around [AI] can now be accessed on one dedicated website, AI.gov, which the White House launched. [Brandi Vincent, nextgov.com, Mar 19, 19]
Governor Cuomo announced companies in 43North’s portfolio have created more than 400 jobs in Western New York. 43North is the startup competition that invests $5 million annually to attract start-up companies to Western New York and cultivate their growth in the region. Since launching the competition in 2014, 43North has invested in 44 companies. [43North press release, Mar 7, 19]
Tech mafia: In Silicon Valley’s tightknit club, success typically hinges on whom you know. Employees of tech startups frequently leave the companies once they have been enriched by their firms’ [IPO]s networks of alumni from these companies — called mafias — support their peers’ new businesses with hiring, advice and money. [Erin Griffith, New York Times, Mar 17, 19]
Dermira (Menlo Park, CA; no SBIR, founded 2010) up 84% [Mar 15, 19] generated evidence that its treatment for moderate-to-severe atopic dermatitis can pose a challenge to Dupixent. [Fierce Biotech, Mar 18, 19] total funding $130M [crunchbse.com]
Phase Bio Pharma up 67% [Mar 18, 19]
Atossa Genetics up 25% [Mar 18, 19]
Aerpio Thera (one SBIR) down 71% [Mar 18, 19] announced that Administration of AKB-9778 twice daily did not meet the study's primary endpoint of the percentage of patients with an improvement of two or more steps in the study eye diabetic retinopathy severity score (DRSS) compared to placebo. [company press release, Mar 15, 19]
Synaptics down 23% [Mar 18, 19]
QR Pharma (Berwyn, PA; no SBIR, founded 2008) raised $530K [John George, Philadelphia Business Journal, Mar 18, 19] total funding $8M [crunchbase.com]
BioCold Genesys (Santa Ana, CA; no SBIR) developing novel immunotherapies used to treat cancer, has closed on $22 million in financing. [I-Chun Chen, LA Biz News, Mar 18, 19]
NantCell (Culver City, CA; no SBIR), a subsidiary of NantWorks, raised $30 million in investor funding after a similar injection late last year, according to a March 14 securities filing. [Dana Bartholomew, LA Business Journal, Mar 14, 19]
Trethera (Los Angeles, CA; no SBIR), a biotechnology firm raised up to $8 million from investors, according to a securities filing posted March 11. [Dana Bartholomew, LA Business Journal, Mar 11, 19] a preclinical-stage biopharmaceutical company developing cancer treatments for a range of cancers with unmet needs. [company website]
Include Us Out. U.S. semiconductor companies want no part of any trade deal that calls for stepped-up purchases from China. Washington has pressed Beijing to buy more than $1 trillion in U.S. goods and services as part of an agreement, and China has offered to buy $30 billion of U.S. chips over six years. But U.S. chip makers have told President Trump’s administration not to include them, Bob Davis reports. Why? Because U.S. production costs are so high, mandatory-purchase quotas would essentially force U.S. chip makers to open new factories in China and give Beijing bureaucrats more sway over the U.S. firms. [Jef Sparshott, Wall Street Journal, Mar 19, 19]
Magenta Thera up 26% [Mar 15, 19]
Catabasis Pharma up 16% [Mar 15, 19]
Atossa Genetics down 50% [Mar 15, 19]
Chinese investment in U.S. startups has remained resilient in recent months despite new legislation that some thought could severely hamper deal flow, according to a new report from research firm Rhodium Group, after a record $3.3 billion in 2018. [Rolfe Winkler, Wall Street Journal, Mar 15, 19]
Making government like a real estate biz. The Trump administration has long expressed a desire to make the federal non-salary compensation system more in line with private sector employers, who mostly have abandoned offering pensions to employees. .... “We believe it is the first step to eliminating any kind of defined benefit pension plan for federal employees,” [AFGE Senior Policy Counsel Richard] Loeb said. “Despite [the administration’s] claims to the contrary, they’re not doing this to enhance retirement benefits. They’re doing it to reduce their costs.” [Erich Wagner, govexec.com, Mar 15, 19]
Melinta Thera up 17% [Mar 14, 19]
X4 Pharmaceuticals (Cambridge, MA; no SBIR), a clinical-stage biopharmaceutical focused on the development of novel therapeutics for the treatment of rare diseases, announced the completion of its merger and the reverse stock split with Arsanis (Waltham, MA; no SBIR) . [X4 press release, Mar 13, 19]
AstraZeneca agreed to pay Seres Therapeutics (Cambridge, MA; no SBIR, founded 2010) $20 million up front to kickstart a three-year partnership focused on researching how tapping the gut microbiome could make cancer immunotherapies work better. [Frank Vinluan, xconomy.com, Mar 15, 19]
Regenerative medicine biotech Surrozen (San Francisco, CA; no SBIR) raised $50 million in Series B funding to continue developing treatments for liver diseases. Surrozen focuses on Wnt, a protein that plays a role in stem cell maintenance and tissue regeneration. [Frank Vinluan, xconomy.com, Mar 15, 19]
Zafgen ( Boston, MA; no SBIR) suspended plans to begin human testing of its experimental drug ZGN-1258 due to worrisome safety signs in preclinical tests. The disclosure marks another setback for Zafgen, which scrapped one drug due to safety problems and saw the FDA temporarily halt testing of another. [Frank Vinluan, xconomy.com, Mar 15, 19]
Via Separations (Somerville, MA; no SBIR), applying novel filtration to reduce the energy used in separation processes by 90%,announced the close of a $4.8 million Series A financing [company press release, Mar 14, 19]
President Trump is making the trade deficit bigger. "Pretty much anyone with a passing knowledge of macroeconomics could have predicted that this would be the likely result of moves by Trump and Congress to stimulate the U.S. economy with bigger federal deficits," Justin Fox writes at Bloomberg Opinion. "That Trump himself did not see this coming is another indication that, as someone recently said, the man doesn’t understand much about macroeconomics." [Jeff Sparshott, Wall Street Journal, Mar 14, 19] Or he simply has no connection to truth when spouting.
Ocean Power Tech down 23% [Mar 13, 19]
Phraxis (St Paul, MN; no SBIR, founded 2008), developing solutions, offers InterGraft, a percutaneously delivered arterio-venous shunt that provides a non-surgical approachfor patients who need vascular access to enable hemodialysis, raised $5.6M in a venture round ... prior funding $2.3M [crunchbase.com, Mar 11, 19].
QinetiQ North America has won a $152M initial contract to manufacture small unmanned ground robots for the U.S. Army’s Common Robotic System – Individual program, Defense News reported Thursday. QinteiQ NA and Endeavor Robotics separately developed robotic systems under the CRS-I program’s engineering and manufacturing development phase through a $429.1M contract awarded in April 2018. [Brenda Marie Rivers, GovConWire, Mar 14, 19] some of the robotics came from former SBIR champ, now Qinetic subsidiary, Foster-Miller.Trump warned Beijing he would not sign off on a trade deal that didn’t meet U.S. demands, Jong Un, Bob Davis, and Alex Leary report. ... a sharp departure from his recent optimism; it's not clear if they're a negotiating tactic or a sign of some underlying impasse in talks. [Jeff Sparshott, Wall Street Journal, Mar 14, 19] Unlike the US Congress Republicans, the Chinese don't worry about angering Trump's "base" who believe/hope in his omnipotence.
Mersana Thera up 17% [Mar 12, 19]
British medical device manufacturing company Smith & Nephew plc plans to acquire Osiris Therapeutics (Columbia, MD; $1M SBIR) for $660.5 million [cash]. ... Osiris is coming off a tumultuous three-year period in which four CEOs left the company and several former executives faced criminal charges for fraud. [Washington Business Journal, Mar 12, 19]
Prepare to
prepare. (NSF)
has instituted a new requirement
that is going to affect everyone who wants to submit a Phase I SBIR or
STTR proposal, starting immediately. And if you don’t react ASAP, you
may well be precluded from submitting a proposal in the current
solicitation “window” that ends June 13th—and you may even be precluded
from submitting if you react quickly but not well to the new
requirement. [Greenwood [SBIR] Consulting, Mar 12,
19] All
agencies have a problem with piles of proposals with no chance of
funding. Lots of work for the agency and lots of wasted work by the
proposers. Meanwhile, Trump keeps trying to chop the agencies' workers.
One solution is a clear agency message on what kinds of proposals have
a reasonable chance. Help them and yourself - see what they
fund,
learn what they want.
Refreshing techies. Modern Elder Academy [Resort] in El Pescadero, Mexico, considers “applications” for one-week programs [with] “tuition” of $5,000 ... aimed at workers in the digital economy — those who feel like software is speeding up while they are slowing down, no matter how old they really are. ... More workers are finding themselves in the curious position of presenting as old while still being — technically, actuarially — quite young. And Modern Elder sees a business opportunity in selling them coping workshops, salt-air yoga and access to a shaman. [Nellie Bowles, New York Times, Mar 4, 19]
Don't need no dadgum gummint. Thirty-five Congressional mandates sit unanswered, on everything from minimum seat space to secondary barriers protecting cockpits. The top job at the Federal Aviation Administration has been open for 14 months. Enforcement fines against major U.S. airlines have dropped 88% in the past two years, even as three-hour tarmac delays have more than doubled. [Scott McCartney, Wall Street Journal, Mar 12, 19]
Bio-Path Holdings up 54% [Mar 11, 19]
Aqua Bounty Tech down 26% [Mar 11, 19]
GTx (Memphis, TN; $300K SBIR) and Oncternal Therapeutics (San Diego, CA; no SBIR) biotechnology company developing potential first-in-class therapeutic candidates for cancers, jointly announced that they have entered into a definitive merger agreement under which the stockholders of Oncternal would become the majority owners of GTx’s outstanding common stock. The proposed merger will create a publicly-traded, clinical-stage oncology company, Oncternal Therapeutics. [joint companies press release, Mar 7, 19]
LKC Technologies (Gaithersburg, MD; no SBIR, founded 2014), biotech raising $635K of a maximum $1.2M round of equity according to SEC filings. ... makes devices for visual electrophysiology testing – measuring retina function to diagnose eye diseases and disorders. ... brings total funding to $3.8M. [Kieran McQuilkin, DCInno, Mar 11, 19]
Always about "me". Trump: Making daylight saving time permanent is ‘OK with me’ [AP News, Mar 11, 19]
AquaBounty Technologies (Maynard, MA; no SBIR) up 118% [Mar 8, 19] focused on enhancing productivity in the aquaculture market and a majority-owned subsidiary of Intrexon, announces the [FDA] lifting of the Import Alert, allowing the Company to start farming AquAdvantage Salmon in Indiana. ... Approximately 350,000 tons of Atlantic salmon are consumed in the United States with more than 95% of it imported. FDA's actions will allow for production and sale to begin here in the U.S., bringing opportunity for investment in rural America [company press release, Mar 8, 19]
Ra Pharma up 19% [Mar 8, 19]
Bio-Path Holdings down 46% [Mar 8, 19]
Translate Bio down 19% [Mar 8, 19]
AMAG Pharma down 18% [Mar 8, 19]
The Army is all in on innovative startups, but it will likely rely on tried and true contractors to get the tech over the finish line, Lt. Gen. Eric Wesley told SXSW. [nextgov.com, Mar 9,19] As usual, the military wants new ideas that have been thoroughly tested. Advantage: established companies. But then, the Army could be at war tomorrow in any climate, especially with a loose-cannon President.
‘The comic thing about this drama is that no one is even pretending there is a real emergency.” So says Neeraj Kaushal, 57, a professor of social policy at Columbia who has just published a bracing book on U.S. immigration policy. Her thesis: Far from presenting an emergency, as President Trump contends, America’s immigration system is the best in the world. [Tunku Varadarajan, Wall Street Journal, Mar 8, 19] Except for Trump's view as he echoes his "base." Unfortunately, Trump is classic political theatrical exploiter of convenient myths. The real Trump is playing a character called Trump who is anti immigrant because thats what the voters in middle America want. [commenter, WSJ,Mar 9, 19]
Bio-Path Holdings up 223% [Mar 7, 19]
Altimmune up 50% [Mar 7, 19]
Harpoon Thera down 18% [Mar 7, 19]
Beam Therapeutics (Cambridge, MA; SBIR, founded 2017) developing precision genetic medicines through base editing, today announced the successful completion of a $135 million Series B financing [to] to advance the company’s development of next-generation CRISPR technologies, expand its pipeline of base editing programs, and further extend its scientific and technical leadership. [company press release, Mar 7, 19] prior funding $87M [crunchbase.com]
Erasca (San Diego, CA; no SBIR, founded 2018) dedicated to advancing exceptional scientific approaches to erase cancer, has closed an extension to its Series A financing round, bringing the total raised to $64 million [to] support the company's efforts to potentially in-license new investigational compounds in development, while also accelerating the buildout of Erasca's artificial intelligence (AI) platform that will drive discovery and development of a new generation of oncology drugs designed to not just treat, but actually cure, cancer. [company press release, Mar 5, 19] prior funding $42M [crunchbase.com]
Ambrx (San Diego, CA; no SBIR), a clinical-stage biopharma focused on the development of innovative protein therapeutics and BeiGene, (China), a commercial-stage biopharmaceutical company focused on developing and commercializing innovative molecularly-targeted and immuno-oncology drugs for the treatment of cancer, announced a global research and development collaboration. ... Ambrx will receivean upfront payment of US$10 million to fund the initial discovery and research activitiesand additional upfront payments of up to US$19 million if BeiGene elects to initiate additional programs. [company press release, Mar 6, 19] prior funding $147M [crunchbase.com]
Buy American goes to China. The Sichuan provincial government has stipulated that for 15 types of medical devices, hospitals will be reimbursed only for procedures that use Chinese-manufactured devices. [ELIZABETH C. ECONOMY, Foreign Affairs, Mar 6, 19] With Trump alienating all and sundry, China will look more and more attractive to other countries despite Xi's control fetish.
Bio-Path Holdings up 160% [Mar 6, 19] announces a clinical update to the previously reported interim analysis from the Phase 2 trial of prexigebersen (BP1001) for the treatment of acute myeloid leukemia (AML) and provides its plans for the compound's clinical development moving forward toward registration. [company press release, Mar 6, 19]
Proteon Thera up 21% [Mar 6, 19]
Synthorx down 17% [Mar 6, 19]
G1 Thera down 16% [Mar 6, 19]
Ceradyne (3M subsidiary since 2012, $4.4M SBIR, founded 1967) awarded [one of three] spots on a potential $704.2M contract to supply hard armor plates to the U.S. Army. [Brenda Marie Rivers, GovConWire, Mar 7, 19]
Axial Biotherapeutics (Boston, MA; no SBIR, founded 2016 with $19M) with roots at the California Institute of Technology raised $25 million in a Series B round. .... has licensed rights to central nervous system biotherapeutics from the Mazmanian Laboratory at Caltech. [Dana Bartholomew, LA Business Journal, Feb 27, 19]
Endo International plc (Irish) announced that its subsidiaries have terminated their respective agreements to acquire Somerset Therapeutics (Somerset, NJ, no SBIR, founded 2015) and the business of its India-based affiliate Wintac Limited, which operates as Somerset Therapeutics' contract developer and manufacturer. There are no penalties or other payments associated with terminating the agreements. [Endo press release, Feb 27, 19]
Aqua Metals up 20% [Mar 5, 19]
Bionano Genomics (San Diego, CA; $4M SBIR) up 19% [Mar 5, 19], a life sciences instrumentation company that develops and markets Saphyr®, a platform for ultra-sensitive and ultra-specific structural variation detection in genome analysis, announced the publication of the largest study of human genomes on its platform to date. [company press release, Mar 5, 19]
Cerecor down 20% [Mar 5, 19] announced sale of common stock
Yield Lab, an agribusiness accelerator based in Creve Coeur [MO], has chosen six software and ingredients companies for its spring class. ... includes two firms from the St. Louis area, three from elsewhere in the United States and one from Argentina. Each gets a $100,000 investment and participates in a business development program at Yield Lab's headquarters. ... Arch Innotek (St. Louis, MO; $300K SBIR) uses a fermentation process to produce natural ingredients. ... VakSea (Baltimore, MD; no SBIR) sells immune-boosting proteins for shrimp aquaculture. [David Nicklaus, St Louis Post Dispatch, Feb 28, 19]
Anything Goes. When America, the world’s most influential democracy, has a leader without shame, who is backed by a party without spine willing to prostitute itself to Trump no matter how low he goes — and both are protected by a virtually state-run network without integrity, called Fox — it becomes a hunting license for leaders everywhere to go after their own domestic opponents and cross any human rights redline to stay in power. [Tom Friedman, New York Times, Mar 6, 19]
Luna Innovations (Roanoke VA; $180M SBIR, 200 employees) up 17% [Mar 4, 19]
Vusix up 15% [Mar 4, 19]
Precision BioSciences (Durham, NC; $500K SBIR, 130 employees) files plans for $100 million IPO. [Raleigh News & Observer, Mar 4, 19]
Mechanical Technology (Latham, NY; $200K SBIR) declared a cash dividend of $0.37 per share, .. the first dividend in the Company’s 58 year history. [company press release, Feb 26, 19]
Bio-Path Holdings (Bellaire, TX; no SBIR) up 197% [Mar 1, 19] a biotechnology company leveraging its proprietary DNAbilize(R) antisense RNAi nanoparticle technology to develop a portfolio of targeted nucleic acid cancer drugs, today announced an upcoming poster presentation at the 2019 American Association for Cancer Research (AACR) Annual Meeting [company press release, Mar 1, 19] total fundng $2.3M [crunchbase.com]
Apellis Pharma up 21% [Mar 1, 19]
XBIOTECH up 18% [Mar 1, 19] announced breakthrough results from its Phase 2 clinical trial of its antibody therapy, bermekimab [company press release, Mar 1, 19]
Editas Medicine up 15% [Mar 1, 19]
A phase 3 trial of ImmunoGen’s antibody-drug conjugate mirvetuximab soravtansine has missed its primary endpoint. The ADC failed to extend progression-free survival by more than chemotherapy. [Nick Paul Taylor, Fierce Biotech, Mar 1, 19]
Axial Biotherapeutics (Waltham, MA; no SBIR, founded 2016) dedicated to building a unique class of gut-targeted programs for neurodegenerative and neuropsychiatric diseases, today announced the completion of a $25 million series B equity financing. [company press release, Feb 27, 19] prior funding $19M [crunchbase.com]
Novavax’s RSV shot missed another phase 3 trial, causing the company’s stock price to lose about two-thirds of its remaining value premarket [Conor Hale, Fierce Biotech, Feb 28, 19]
Inovio Pharma spinout Geneos Therapeutics (Plymouth Meeting, PA; founded 2016) closed a $10.5 million first-round financing that will help launch its R&D in neoantigen-targeting cancer immunotherapies. [Phil Taylor, Fierce Biotech, Feb 22, 19]
Hunkering down. DOE has drafted new restrictions on research collaborations between the scientists it funds and certain foreign governments suspected of trying to steal sensitive technologies. DOE officials are still debating the scope of the new rules. [Jeffrey Mervis, Science, Feb 15, 19]
Like Spain in 1796, the U.S. is at the apparent apogee of its power, consciously facing a post-hegemonic future but uncertain about how to proceed. Like the Spanish monarchy then, the U.S. today is riven between hostile constituencies—radical and reactionary, Christian and secularist—with no formula for reconciling them. [Felipe Fernández-Armesto reviewing Carrie Gibson's El Norte and Robert Goodwin's America, Wall Street Journal, Mar 2, 19]
Arcadia Biosciences up 49% [Feb 28, 19] announced the company will apply its expertise to a new crop: cannabis. With the establishment of Arcadia Specialty Genomics(TM), the company is dedicating a first-of-its-kind strategic business unit to the optimization and standardization of cannabis plant content, quality, climate resiliency and yield. [company press release, Feb 28, 19]
TG Therapeutics (New York, no SBIR) up 31% [Feb 28, 19] announced that it intends to sell [common] shares in public offering. ...announced that it has entered into a debt financing agreement for up to $60.0 million ... also announced that the Marginal Zone Lymphoma (MZL) cohort of the UNITY-NHL Phase 2b pivotal trial evaluating umbralisib (TGR-1202), our novel, once daily, PI3K delta inhibitor, met the primary endpoint [company press release, Feb 28, 19]
Mersana Thera down 20% [Feb 28, 19]
Applied Optoelectronics down 17% [Feb 28, 19]
StemoniX (Maple Grove, MN; no SBIR, founde 2014), a biotech startup using stem cells to create micro-organs for drug testing and development, has raised $14.4 million in a secured $14.4 million in Series B funding .... seeks to transform conventional drug development via ready-to-assay plates containing functioning microOrgans®, including active neural circuits (microBrain®) and beating heart cells (microHeart®) [company press release, Feb 28, 19] prior funding $12 [crunchbase.com]
Ionis Pharma up 15% [Feb 27, 19]
Energous down 24% [Feb 27, 19]
Immunogen down 20% [Feb 27, 19]
Maze Therapeutics (San Francisco, CA) is launching with $191 million from investors led by Third Rock Ventures and Arch Venture Partners, both known for pouring tens of millions of dollars into new high-risk companies. Maze is looking at diseases where, in rare cases, a modifier gene is improving or even eliminating the symptoms stemming from a disease-causing gene. [Ben Fidler, xconomy.com, Feb 27, 19]
Sarepta Therapeutics has been steadily building up its gene therapy capabilities for a few years now, and it took two more steps forward on that front this morning. First, it exercised an option to buy gene therapy startup Myonexus Therapeutics (New Albany, OH; no SBIR) for $165 million. And then it disclosed early human results from the first program to come from the deal, a potential treatment for a form of Limb-Girdle Muscular Dystrophy (LGMD), a progressive, deadly genetic disease with no available treatments. [Ben Fidler, xconomy.com, Feb 27, 19]
Kaleido Biosciences (Bedford, MA; no SBIR, founded 2017), a clinical-stage healthcare company with a differentiated, chemistry-driven approach to leveraging the potential of the microbiome organ to treat disease and improve human health, announced the pricing of its [IPO]... expected to be $75 million. [company press release, Feb 27, 19]
CyTomx Thera down 19% [Feb 26, 19]
Energous down 31% [Feb 26, 19]
startup Dianomi Therapeutics (Madison, WI; no SBIR) draws a $3M investment .... says it has a new way to make prescription medications pack a bigger punch — to help not only humans but injured pets or technology combines drug candidates with mineral-coated microparticles. It is based on the concept that minerals in bones and teeth stabilize proteins and extend their staying power. [JUDY NEWMAN, madison.com, Feb 24, 19]
Motif, a startup that's a subsidiary of biotechnology major Ginkgo Bioworks, launched today with $90M Series A in its pocket to make alternative proteins. [DCInno, Feb 25, 19]
Blackstone Life Sciences, the biopharma investing arm of private equity firm Blackstone Group, has made its first strike. It has joined with Novartis to start a new biotech, Anthos Therapeutics (Cambridge, MA), backed with $250 million in cash and rights to an experimental drug originally discovered by the Swiss firm. [Ben Fidlar, xconomy.com, Feb 27, 19]
Spark Thera up 120% [Feb 25, 19]
Avrobio up 22% [Feb 25, 19]
Akcea Thera up 17% [Feb 25, 19] Novartis [said it] will pay $150 million to license a heart disease medication discovered by Ionis Pharma co-developed by Ionis with its majority-owned subsidiary Akcea Therapeutics. Ionis will get half the money, paid for with Akcea stock.[Bradley Fikes, San Diego Union Tribune, Feb 25, 19]
REGENXBIO up 16% [Feb 25, 19]
immunotherapy startup NexImmune (Gaithersburg, MD; $300K SBIR) reported raising $7.7M in new equity funding.[Kieran McQuilkin, DCInno, Feb 25, 19]
Nuvaira (Minneapolis, MN; no SBIR), developer of therapeutic medical devices for treating certain lung diseases, announced it had closed a $79 million financing round. The capital will be used to support a clinical trial for Nuvaira’s Lung Denervation System, a catheter-based treatment meant as an alternative to drug therapy. [Amanda Ostuni, MinnieInno, Feb 11, 19]
Dexcom, a maker of continuous glucose monitors for people with diabetes, said it will cut 350 full-time jobs in San Diego and Arizona as its shifts some customer support and other functions overseas. [Mike Freeman, San Diego Union Tribune, Feb 22, 19]
Universal Display up 23% [Feb 22, 19] increased its dividend by two-thirds
Liquida Tech up 22% [Feb 22, 19]
Marinus Pharma up 18% [Feb 22, 19]
Aqua Metals up 16% [Feb 22, 19]
Harpoon Thera up 16% [Feb 22, 19]
Karyopharm Thera down 43% [Feb 22, 19] FDA staff raised questions about the therapy’s efficacy and safety. [xconomy.com, Feb 22, 19]
Zosano Pharma down 24% [Feb 22, 19]
Roche (Swiss) agreed to acquire Spark Therapeutics (Philadelphia, PA, no SBIR) for about $4.8 billion. [Wall Street Journal, Feb 25, 19]
Innovation not enough. The fracking industry is struggling to attract investors after nearly a decade of losing money. [Wall Street Journal, Feb 25, 19]
Few law enforcement jobs are more coveted than the FBI’s special agent positions. But the tightest labor market in decades is forcing the bureau to aggressively recruit candidates. [Wall Street Journal, Feb 25,19] Consequences of a sleazy president attacking his own government.
Zosano Pharma (Fremont, CA; no SBIR, founded 2006, IPO 2015) up 171% [Feb 21, 19], a clinical-stage biopharmaceutical company, announced the completion of the second and final goal of the long-term safety study for [proprietary] Qtrypta, in which patients treated migraine attacks over a one year period. The long-term data generated in this trial reinforced the well-tolerated safety profile and strong efficacy results previously reported in the six-month dosing portion of this safety study and in the randomized Phase 2/3 ZOTRIP pivotal study. [company press release, Feb 20, 19] total funding $166M [crunchbase.com]
Four months after Immune Design (no SBIR) halted a late-stage study for its lead cancer vaccine and saw its stock price cut nearly in half, the immunotherapy company is now in line to join Merck’s pipeline in a deal worth approximately $300 million. Merck announced that it has agreed to acquire Immune Design [Frank Vinluan, xconomy.com, Feb 21, 19]
Small-business optimism is down for five straight months and hit a more-than-two-year low in January amid uncertainty about domestic politics and global growth. [Jeff Sparshott, Wall Street Journal, Feb 21, 19]
Everspin Tech up 18% [Feb 20, 19]
Axonics Modulation Technologies (Irving, CA; no SBIR, founded 2012, IPO Nov 2018) up 17% [Feb 20, 19], a medical technology company focused on the development and commercialization of novel implantable Sacral Neuromodulation ("SNM") devices for the treatment of urinary and bowel dysfunction, disclosed today positive top-line results from the ARTISAN-SNM pivotal study, designed to gain marketing approval from the U.S. Food & Drug Administration ("FDA") for the Axonics r-SNM(R) System(1). [company press release, Feb 19, 19] total funding $146M [crunchbase.com]
Galectin Thera up 15% [Feb 20, 19]
Blaze Bioscience (Seattle, WA; no SBIR, founded 2010) Raises $5M to Help Surgeons See Tumors From Healthy Tissue developing “tumor paint” that could help surgeons tell the difference between normal and cancerous tissue [Jeff Buchanan, xconomy.com ,Feb 20, 19] total funding $35M [crunchbase.com]
AstraZeneca retires MedImmune (Gaithersburg, MD; $3.5M SBIR, acquired 2013) brand [Washington Business Journal, Feb 20, 19]
Everspin Tech (Chandler, AZ; $600K SBIR)up 16% [Feb 19, 19] develops and manufactures magnetic RAM or magnetoresistive random-access memory, including stand-alone and embedded MRAM products as well as spin-torque MRAM. [company website]... announces that it commencedshipment of pre-productioncustomer samplesofits 28nm 1-Gigabit(Gb)Spin Torque Transfer Magnetoresistive Random Access Memory (STT-MRAM)product in December 2018.[company press release, Jan 8, 19]
Hoth Therapeutics down 17% [Feb 19, 19]
Danger words. Trump claims "absolute right to .... " declare an emergency despite the clearly framed emergency law that allows Congress to stop such a declaration.
Success. In 2017, Duchenne muscular dystrophy drug maker Sarepta signed a deal with Duke University to research potential cures for the disease using the gene-editing system CRISPR. Now the Duke lab at the center of that research pact is reporting promising results from a trial of CRISPR in mouse models of DMD. [Arlene Weintraub, Fierce Biotech, Feb 18, 19]
Passage Bio (Philadelphia, PA; no SBIR) debuted with a $115.5 million Series A financing ... to develop a portfolio of five therapeutic candidates to treat rare monogenic CNS diseases. These programs are being developed under a research, collaboration and license agreement with the University of Pennsylvania (Penn) and its Gene Therapy Program (GTP) together with the Penn Orphan Disease Center (ODC), with the support of co-founder James M. Wilson, M.D., Ph.D. [company press release, Feb 14, 19]
PureTech’s Vor Biopharma (Boston, MA; no SBIR) raised $42 million in its series A round, which will support the development of its lead asset, an engineered stem cell therapy for acute myeloid leukemia (AML). [Amirah Al Idrus, Fierce Biotech, Feb 14, 19]
Five [DARPA funded] research teams will study the behavior of marine organisms to develop sensors designed to detect and track manned underwater vehicles and drones in strategic waters. [Jane Edwardson, GovConWire, Feb 19, 19] no small biz
In the largest analysis of the issue thus far, investigators have found that the smaller the research team working on a problem, the more likely it was to generate innovative solutions. Large consortiums are still important drivers of progress, but they are best suited to confirming or consolidating novel findings, rather than generating them. The new research [is] published in the journal Nature. .... a trio of investigators led by James A. Evans, a sociologist at the University of Chicago, mined selections from three vast databases: the Web of Science, using more than 42 million articles published since 1950; the United States Patent and Trademark Office, with 5 million patents granted since 1976; and GitHub, with 16 million software projects posted since 2011. [Benedict Carey, NY Times, Feb 13, 19]
Love that
limitless credit card.
It’s no longer cool to
talk about the
federal budget
deficit. President Trump didn't talk about it during his State of the
Union. Neither did Stacey Abrams in her Democratic response. All told,
Washington’s red-ink alarms have gone dead, even though the annual
deficit
will pass the trillion-dollar mark starting in 2022. [Jeff
Sparshott, Wall Street Journal, Feb 19, 19]
The Trump Administration Can’t Get a United Front Against Iran [Defense One, Feb 19, 19] who would trust any Trumpian figure to act in the group's interest?
Hoth Therapeutics (New York, NY; no SBIR, founded 2017) up 25% [Feb 15, 19] developing topical treatments for eczema, raised $7 million from [IPO] [nasdaq.com, Feb 15, 19]
Translate Bio up 27% [Feb 15, 19]
Ablative Solutions (Kalamazoo, MI; no SBIR, founded 2011) medical device company raised a $77 million Series D [Will Flanagan, MinnieInno, Feb 5, 19] offers an alternative to surgical renal denervation for treating hypertension; total prior funding $63M [crunchbase.com]
Soliton (Houston, TX; no SBIR, founded 2012) raised $10M with its IPO; makes a medical device that quickens the tattoo-removal process. [Chris Matthews, Houston Business Journal, Feb 15, 19] prior funding $25M [company website]
Liquidia Tech up 16% [Feb 14, 19]
Caladrius Biosciences [Basking Ridge, NJ; $2M SBIR, founded 2006) down 25% [Feb 14, 19] announced top-line results from The Sanford Project: T-Rex Study, a prospective, randomized, placebo-controlled, double-blind Phase 2a clinical trial [that showed] no improvement in the primary endpoint of preservation of C-peptide levels vs. placebo at 1 year was observed at the group level [company press release, Feb 13, 19] total funding $63M [crunchbase.com]
CryoLife down 15% [Feb 14, 19]
Xeris Pharma down 13% [Feb 14, 19]
FLIR Systems raised its dividend by 6% [Feb 14, 19]
Gemini Bio-Products (West Sacramento, CA; no SBIR) and StemBioSys (San Antonio, TX; no SBIR, founded 2010, total funding $14M [crunchbase]) announce a strategic partnership that will bring StemBioSys’ [develops proprietary stem cell technologies for the regenerative medicine market] entire selection of matrices and cells into the Gemini portfolio. [joint companies press release, Feb 11, 19]
End the ending, prime the pump. Federal Reserve officials are zeroing in on a strategy to end the wind-down of their $4 trillion asset portfolio [Wall Street Journal, Feb 15, 19] national economic mirage relies on government debt boosting by posturing free-market politicians
Arcadia Biosciences up 14% [Feb 13, 19]
XOMA up 14% [Feb 13, 19]
Johnson & Johnson reached a deal to buy medical technology firm Auris Health for about $3.4 billion in cash. J&J said that Auris’s technology will help it develop a digital solution addressing different parts of patients’ lung-cancer treatment. If certain milestones are reached, Auris could also receive as much as $2.35 billion more in the deal. .... [Co-founder] Dr. Frederic Moll is also a co-founder of Intuitive Surgical that makes the da Vinci robotic-assisted surgery system as well as the Ion endoluminal system, designed for lung biopsies. [Allison Prang and Peter Loftus, Wall Street Journal, Feb 13, 19]
CTI BioPharma (Seattle, WA; $200K SBIR) announced that it has received a $10M milestone payment from Teva Pharmaceutical Industries related to the achievement of sales milestones for TRISENOX® (arsenic trioxide). TRISENOX was acquired from CTI BioPharma by Cephalon [which] was subsequently acquired by Teva. [CTI press release, Feb 11, 19]
Linnaeus Therapeutics (Haddonfield, NJ; no SBIR) raised $2.3M [Philadelphia Business Journal, Feb 11, 19] a development stage biotech company engaged in the identification and development of small molecule agents that modulate cellular differentiation for the treatment of cancer and disorders of pigmentation. [company website]
ADMA Biologics (Ramsey, NJ; no SBIR) up 21% [Feb 12, 19] biopharmaceutical and specialty immunoglobulin company that manufactures, markets and develops specialty plasma-derived biologics for the treatment of immune deficiencies and the prevention of certain infectious diseases, announces that it has entered into a senior secured term loan facility for up to $72.5 million. [company press release, Feb 12, 19]
Xeris Pharma (Chicago, IL; $8.7M SBIR, founded 2005) down 21% [Feb 12, 19] announced that it filed a registration [for] a proposed public offering of 5M shares of its common stock [company press release, Feb 11, 19] prior funding $148M [crunchbase.com]
3DEO (Gardena, CA; $1M SBIR, founded 2016), a metal 3D printing company that manufactures parts for medical and other industries, raised $14 million, according to [SEC] filing. [Dana Bartholomew, LA Business Journal, Feb 8, 19]
Neurogene (New York, NY; no SBIR, founded 2018) is breaking into gene therapy with $68.5 million in new funding to support research on experimental treatments for rare, genetic brain disorders, the first of which could start human testing next year. [Frank Vinluan, xconomy,con, Feb 12, 19]
Proteostasis Thera up 22% [Feb 11, 19]
Replimmune up 19% [Feb 11, 19]
CellDex Thera (Hampton, NJ; $600K SBIR) down 19% [Feb 11, 19] after a one-for-fifteen reverse stock split [company press release, Feb 8, 19]
FLIR Systems agreed to purchase Endeavor Robotics (spinout from iRobot, Chelmsford, MA, founded 2016) from Arlington Capital Partners for about $385M in cash to make its entry into the market for unmanned ground vehicles for military, critical infrastructure and public safety applications. ... The transaction came weeks after FLIR acquired Canada-based unmanned aerial systems manufacturer Aeryon Labs for approximately $200M. [Jane Edwards, GovConWire, Feb 11, 19]
Nuvaira (Minneapolis, MN; no SBIR, founded 2008), a developer of novel therapeutic medical devices to treat obstructive lung diseases, announced it has closed a $79 million equity financing. ... the first interventional pulmonary company to pursue and report one-year randomized, double-blinded and sham-controlled clinical evidence in COPD patients from a Phase 2b trial. [company press release, Feb 11, 19] prior funding $69M [crunchbase.com]
A soft future. CB Insights, a firm that tracks start-ups, analyzed a variety of data to create a list of 50 private companies around the world that are on a path to a $1 billion valuation. [Erin Griffith, NY Times, Feb. 10, 19] One of the fifty is doing something to create a new market - in oncology. The rest are mostly software that are almost all certain to work. The only risk is business risk - will it make a profit.
Alpine Immune down 15% [Feb 8, 19]
Gossamer Bio (San Diego, CA; no SBIR, founded 2017) a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology, announced its [IPO to raise] $276 million. [company press release, Feb 7, 19] prior funding $330M [crunchbase.com]
Cancer immunotherapy developer Harpoon Therapeutics raising approximately $76 million in [IPO] ... develops immunotherapies that direct the T cells of a patient to target and kill cancer cells. [Frank Vinluan, xconomy.com, Feb 7, 19]
biotech Sirnaomics (Gaithersburg, MD; SBIR) took in another $11 million in investments, following a $25 million raise in mid-2018 led by mainland China and Hong Kong investors. [to] support the company’s oncology and fibrosis clinical programs. [Kieran McQuilkin, DCInno, Feb 7, 19]
iRobot said it paid $8 million in higher tariffs to bring its Chinese-made robots to U.S. markets as a result of the White House’s newly installed trade policies. The company announced it would be moving some production to a manufacturer outside of China for the first time since 2002. [Brian Dowling, xconomy.com, Feb 8, 19]
Enterin (Philadelphia, PA; no SBIR, founded 2016) developing a drug that has the potential to provide a new way to treat Parkinson’s patients, raises $16.7M [John George, Philadelphia Business Journal, Feb 1, 19] prior funding $13M [crunchbase.com]
Trice Medical (Malvern, PA; no SBIR) announced that it is acquiring S.E.G-WAY™ Orthopaedics (Carlsbad, CA; no SBIR), a leader in solutions for minimally invasive orthopedic procedures. SegWAY is best known for its Endoscopic Carpal Tunnel Release (ECTR), a device that supports minimally invasive carpal tunnel surgeries. Trice Medical addresses the growing need for accurate, cost-effective orthopedic diagnostic solutions with its mi-eye™, a fully disposable arthroscopy camera. [Trice press release, Feb 7, 19]
The Army has activated an Artificial Intelligence Task Force on the Carnegie Mellon University campus in Lawrenceville, Pa., that is home to the National Robotics Engineering Center. The university has made many robotic advances, including creating flexible, soft and inflatable robots able to move over rough surfaces. What to watch: The task force is expected to spread to other institutions as the Army searches for cutting-edge advances in robotics and autonomous systems. [Association of the U.S. Army news, Feb 8, 19]
She offers clues, lingering on the nation’s narcissistic impulses, its fights over identity politics and the naivete of thinkers who believed that globalization would break down nationalism rather than intensify it. [Carlos Lozada reviewing Ratner-Rosenhagen's The Ideas That Made America, WashPo, Feb 8, 19]
In the long run, a third or so of the country cannot effectively govern the other two-thirds with an unpopular agenda and a Twitter account. [Jonathan Rauch and Peter Wehner, NYTimes, Feb 8, 19]
Solid Biosciences down 68% [Feb 7, 19] the company has revealed that its SGT-001 candidate achieved low levels of expression of microdystrophin protein at the starting dose in a phase 1/2 trial. Solid Bio says it is working toward escalating the dose used in the trial as soon as it can [Phil Taylor, Fierce Biotech, Feb 7, 19]
Sangamo Thera down 31% [Feb 7, 19] reported preliminary molecular and enzymatic evidence of editing of the human genome in vivo (inside the body). These findings are part of the interim results from the Phase 1/2 CHAMPIONS Study evaluating SB-913, a zinc finger nuclease (ZFN) in vivo genome editing product candidate for the treatment of patients with Mucopolysaccharidosis Type II (MPS II) [company press release, Feb 7, 19]
Xencor (Monrovia, CA; $900K SBIR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of autoimmune disease, asthma and allergic disease, and cancer, announced it has entered into a research and license agreement with Genentech, a member of the Roche Group, to develop and commercialize novel IL-15 cytokine therapeutics, including XmAb®24306. XmAb24306 is an IL-15/IL-15Rα cytokine complex engineered with Xencor's bispecific Fc domain and Xtend™ Fc technology and is Xencor's most advanced preclinical cytokine program. ... Genentech will pay Xencor $120 million upfront, and Xencor will be eligible to receive up to $160 million in development milestones for the XmAb24306 program and up to $180 million in development milestones for each new IL-15 drug candidate.[Xencor press release, Feb 5, 19]
Alector (South San Francisco, CA; no SBIR), taking an immunotherapy approach to Alzheimer’s disease and other brain disorders, raised $176 million in an [IPO].[Frank Vinluan, xconomy.com, Feb 6, 19]
Stealth
BioTherapeutics (Newton,
MA; no SBIR, founded 2006) plans
[IPO] to raise $81 million, to help
fund studies of its late-phase asset in multiple indications related to
mitochondria dysfunction. [Conor Hale, Fierce Biotech, Feb
7,
19]
total funding $100M [crunchbase.com]
Trump loves the new NAFTA. Congress doesn’t. and both Democrats and Republicans say it has little chance of passing without significant changes. [Jim Tankersley, New York Times, Feb 7, 19] Trump and any other aspirational leaders must face the reality that the US Constitution gives Congress the ultimate power in any disagreement. There is no binding Treaty until Congress ratifies it. And once ratified, it is the law of the land that the Executive Branch must adninister.
A. Ernest Fitzgerald, a [famous whistle-blowing] Pentagon official tasked with analyzing project expenses died at 92. At one point he noted that any high cost Pentagon system was a bundle of overpriced spare parts flying in close formation. He served in an isolated office, with secretary, from 1970 to 2006. He also cited as Fitzgerald's law that “There are only two phases of a program. The first is, ‘It’s too early to tell.’ The second: ‘It’s too late to stop.’ ” [Harrison Smith, Washington Post, Feb 7, 19]
MacroGenics up 130% [Feb 6, 19] on positive results from Sophia, its late-stage clinical study of the efficacy of margetuximab in patents with HER2-positive metastatic breast cancer. ... said its breast cancer treatment outperformed Roche's (RHHBY) blockbuster Herceptin in a late-stage test. [yahoofinance.com, Feb 6, 19]
XBiotech up 17% [Feb 6, 19]
Immunogen up 14% [Feb 6, 19]
Catabasis Pharma down 24% [Feb 6, 19]
Aeglea BioThera (Austin, TX; no SBIR) down 19% [Feb 6, 19] announced the pricing of an underwritten public offering of of its common stock at $8.00 per share [to] raise $60M [company press release, Feb 6, 19]
Bolt Biotherapeutics (Redwood City, CA; no SBIR, founded 2015) a biotechnology company focused on unleashing the power of the immune system to achieve anti-tumor immunity in patients, announced the completion of a $54M Series B financing [company press release, Feb 5, 19] founded by Ed Engleman, a professor of pathology and medicine at Stanford Medicine. The company’s drug platform is based on technology licensed from Stanford University. [Frank Vinluan, xconomy.com, Feb 5, 19] total funding $30M [crunchbase.com]
JustRight Surgical, now Bolder Surgical (Louisville, CO; no SBIR, founded in 2010), announced it has secured $27 million. ... provides surgeons right-sized surgical instruments to safely and effectively perform minimally invasive surgery in pediatric patients from neonate to teenager. [company press release, Jan 16, 19]
ArcherDX (Boulder, CO; no SBIR, founded 2013) a molecular technology company dedicated to developing breakthrough solutions that advance the application of personalized genomic medicine, is pleased to announce the acquisition of Baby Genes (Golden, CO; no SBIR) focused on empowering individuals to take charge of their health through genetic insights. [ArcherDX press release, Jan 30, 19] total funding $30M [crunchbase.com]
news and views about government programs, politics, attitudes ...1996-1997; 1998; 1999; Y2K; 2001 , 2002-2003 ; 2004-5; 2006; 2007-08 2009-2010; 2011-2012; 2013-14 ; 2015; 2016; 2017-18
BMDO/ MDA including SBIR the doings of star wars
Miscellaneous Stories 1996-1997; 1998-1999; 2000-2001; 2002-2003 ; 2004-5 ; 2006; 2007 2009-2010 ; 2011-2012; 2013-2014; 2015; 2016; 2017
IPO and Venture Markets 1996-1998 .... 1999-2005 ... 2006-present
Quotes steal them if you like
Note: in these old stories, many links are dead, obsolete, or missing
Stories about companies; 1-Al .. Am-Az .. B .. C ... D-E .. F .. G-H .. I-J .. K-L .. M ... N-O ... P ... Q-R .. S1-Se .. ... Sf-Sz .. T-U .... V-Z
10X Genomics ..... 1366
Technologies ... 1st Detect ...
21-Century Silicon ... 21st Century
Systems .... 23andMe ... 24M Technologies
... 30
Second Software ... 360fly ..... 3Bar Biologics .... 3C Semiconductor
... 3D Glass Solutions ..... 3Dnamics ..... 3D
Robotics .... 3D Systems
..... 3D Technology
Laboratories
.... 3F ... 3iNanotech .... 3PrimiR ...
3Scan ..... 3-V
Biosciences
.... 3VR ... 410 Medical Innovation .... 454 Life Sciences .... 4C
Medical Technologies .... 4D Molecular Therapeutics ..... 4s3
Bioscience ... 5D Robotics
..... 7AC
Technologies ... 89Bio ... 908Devices ... 9Mile Labs
A10 Networks ... A123Systems ... A&G
Pharmaceutical ... Aastrom
Bioscience
.. Abacus Technology ... ... Abaxis .... Abcombi Sciences
.....
Abeona Therapeutics
..... AbGenomicsInternational
... Abiomed ... Ablexis
...... ABL
Technologies .... Abpro
Therapeutics ..... AbSci .... Absorbent
Materials ... Abundant Robotics ..... AbVitro ...
Acadia Pharma ... Acambis
.. Accel Diagnostics ..... Acceleron Pharma
... Accelrys
... Accentia
BioPharmaceuticals ... Accent Therapeutics ..... Accera ....
Access Pharmaceuticals
...
Access
Scientific .... Accion Systems ..... Accumetrics
... AccuraGen ..... Accurate
Automation
.. Accuray ... Accuri Cytometers
... Acelerox ....
Acelity .... AcelRx
Pharmaceuticals ...
Acera Surgical ....
Acetylon
Pharmaceuticals ... Achaogen ... Achates
Power .....
Achillion
Pharmaceuticals ... ACIST Medical Systems .... Acorda
Therapeutics
... Acorn
Cardiovascular ... Acquia .... AcroMetrix
... AcryMed ...
ActaCell ... Actasys .... ACT Biotech ... Active
Power ...
ActivBiotics
... ActivMedia Robotics .... Acton Pharmaceuticals
...
Actuality... Acucela ... AcuFocus ....
Aculight
...
Acumentrics ... AcuraStem .... Acutus Medical .... Adamas
Pharmaceuticals ......
Adamis Pharmaceuticals
... Adapteva .... Adaptimmune Therapeutics .... Adaptive
Biotechnologies ..... Adaptive
Computing
... Adaptive
Phage Therapeutics ..... Adaptive TCR ... Adarza BioSystems
.....
Addiction
Therapeutix
...
Addrenex Pharmaceuticals ... Adelor ... Adenosine
Therapeutics
... Adesto Technologies .... Adeza Technologies ... Adherex
Technologies ... Adhesys Medical .... Adial Pharmaceuticals .... Adicet
Bio .... AdiMab
... ADispell ... Adlyfe .... Admittance
Technologies
.... Admune Therapeutics ..... Adnexus
Therapeutics ... Adrenergics .... Advanced
BioHealing ... ADS Biotechnology ... Aduro BioTech
.... Advanced Animal Diagnostics .... Advanced Biologics ..... Advanced
Bionics
... Advanced Cell Diagnostics ... Advanced Cell
Technology (now sub to Bio-Techne) ... Advanced Ceramics
.... Advanced
Circulatory .....
Advanced Countermeasures
Systems ... Advanced Diamond
Technologies .... Advanced Electron Beams ...
Advanced Fuel
Research ...Advanced Life Sciences ... Advanced Lighting
Technologies ... Advanced Liquid Logic
...
Advanced Magnetics ... Advanced Photonix ....
Advanced
Programming Concepts ... Advanced Receiver
Technologies .... Advanced Scientific Concepts ..... Advanced Targeting
Systems
.... Advanced
Technology
Materials.(ATMI) ... Advanced Uro-Solutions ..... AdvanDx ...
Advantic ..... Advaxis ..... Adventrx
... Adverum Biotechnologies ..... Advion BioSciences
...
Adynxx ...... Aegea
Medical ... Aegerion Pharmaceuticals .... Aeglea
BioTherapeutics
Holdings ..... Aerial BioPharma .... Aerie
Pharmaceuticals
... Aerin Medical ..... AerisPhotonics ...... Aerius
Photonics
... Aerodyne Research ... Aero Farms System
... Aerovel ..... AeroVironment ... Aerpio
Therapeutics .... AesRX
...
AETC ... Aethlon Medical
... Aethon .... Aevi Genomic Medicine .....
Affectiva
.... Afferent
Pharmaceuticals ..... Affigen .... Affinimark
Technologies
... Affinity BioReagents ... Affinium
Pharmaceuticals ..... Affinivax .... Affomix ....
Affymax ....Affymetrix ... aFraxis ... AgBiome ..... AgeneBio
....
Agennix ... Agenovir ..... Agenus .... Agere
Pharmaceuticals ..... Agile
Materials
... Agile
Planet ... AgileSwitch .... Agile Therapeutics ....
Agility
Robotics ..... Agilis Biotherapeutics .... Agiltron...Agilvax ....
Agilyx ....
Aagios
Pharmaceuticals... AgraQuest .... Agritope... Agrivida
... Agro Biosciences .... Aguila
Technologies.....Ahura Scientific.... Aiko Biotechnology
... Aileron Therapeutics .... Aimmune Therapeutics
(formerly
Allergen Research) ..... airtricity... Airware .... Airxpanders ....
Airway Therapeutics .... ait laboratories... Akadeum Life Sciences ....
Akamai
Physics
Akarna
Therapeutics
..... Akashi Therapeutics ..... Akcea Therapeutics ..... Akebia ....
Akero Therapeutics ... Akermin ..... Akers BioScience ..... Akita
Innovations
... Akouos ....
Akrevia Thera .... Akron
Polymer Systems ..... Akron Surface
Technologies ..... Akros Medical ....
Alabama
Cryogenics ... Alafair Biosciences .... Albany Molecular
(AMRI) ...A?
nanotech .... Alcon .... Alcresta
.... Aldagen
... Aldatu Biosciences ..... Aldea
Pharmaceuticals
... .
Alder biopharma Aldevon ..... Aldeyra Therapeutics (formerly
Aldexa Therapeutics) .... Alector .... Alexar Therapeutics .....
Alexion
... ....Alexza ....
Alfalight.... Algaeventure Systems ... Algenetix .... Algeternal
.... Algorithmia ..... Alien Technology
.... Alimera sciences.... Alios BioPharma ....Aliva
biopharmaceuticals ..... AliveGen .... Alivio Therapeutics .....
Alkermes...
Alkeus Pharmaceuticals ...
Allakos ... Allcast ....
Allegro Diagnostics ....
Allegro
microsystems ... Allena Pharmaceuticals .... Allergy Amulet
.....
Allerquest
.... Alleviant Medical .... Allied BioScience ..... Allied Minds ....
Alliqua .... Allos
Alloy Polymers .... Alloy
Surfaces .....
Allurion Technologies ... Allylix ... Alnara Pharmaceutical
...
Alnylam... Alper Biotech ... Alphabet Energy .... AlphaCore Pharma ...
Alphamed.... Alphatec
Holdings .....
Alphavax ... Alpine Biosciences .... Alpine Data
Labs .... Alpine Immune Sciences ..... Alseres ....
Algeternal
.... Alta Devices ... AltAir Fuels ... Altair
Therapeutics
... Altamira Technologies .... AltaRock
... AltheaDX .... Althea
Technologies ... Altimmune ..... Altor ...
Altra ...
Altura Medical ... Altus Pharmaceuticals ...
ALung
Technologies
... Alvine Pharmaceuticals .... Alzeca
..... AMAG
Pharmaceuticals
... Alzheon ..... Amaranth Medical .... Ambarella .....
Amberwave
... Ambiq
Micro ....
Ambit
Biosciences .... AMBP
Technology ... Ambri .... Ambrx ...
Ambry .... Ambys Medicines .... Amendia .... American Bionics .....
American
Gene Technologies International .... American Lithium Energy ....
American Medical Systems ....
American Science and Engineering
... America Stem Cell, now Targagyme .... American
Superconductor
... American XTAL .. Ames
Technology ... Amgen ... Amicus Therapeutics .... Amionx ..... Amnis
...
AMO
Pharma ..... Ampio Pharmaceuticals ..... Ampla
Pharmaceuticals ... Amplimmune .... Amplyx Pharmaceuticals
.....
Amprius .... ARMO
BioSciences
.... Amylin
Pharmaceuticals
... Amylyx ..... Amyris
Biotechnologies ... Anacor Pharmaceuticals ...
Anadys
Pharmaceuticals ... Anakim Biologics ....
Analog Computing
Solutions .... Analytical Space ..... AnaptysBio
... Anavex Life Sciences .... Anchor Therapeutics ...
Ancora Pharmaceuticals
... AnDAPT ..... Anexon .... Anew Optics ... Angeion ...
AngioDynamics
... Angiologix ... Angstrom Medica .... Angstron
Materials
... Animalgesic Labs .... ANI Pharmaceuticals ...
Animetrics .... Anivax .... Anivive Therapeutics ..... Annexon
Bioscience ..... ANP Technologies
..... Ansoft
... Ansun Biopharma (formerly NexBio) .... Antegrin
Therapeutics
..... Anthera
Pharmaceuticals ....
Antigenics ... Anue Systems ... Anulex Technologies
... Anybots ... AOBiome Therapeutics
(formerly
Nitrocell) .... AOptix Technologies
... Aortica ..... APA
Optics (Enterprises) ... Apellis Pharmaceuticals
.....
Apexigen ... Aperion
Biologics
.... Aphios
... Apic Bio .... Apieron ... Apnex Medical
... ApniCure .....
ApoCell ....
ApoGen Biotechnologies .... Apollo
Diamond
... Apollo Endosurgery ... Apollomics
(previously CBT
Pharmaceuticals) .... Apoplogic Pharmaceuticals
... Applied Biomolecular Technologies .... Applied Biosystems
.... Applied Defense Solutions ..... Applied Genetic Technology ...
Applied Nanotech ....
Applied
NanoWorks ... Applied Optimization ..... Applied
Optoelectronics ... Applied Physical Electronics ...
Applied Physical Sciences ... Applied Precision ..... Applied
Proteomics ..... Applied Quantum Technologies .... Applied Quantum
Technology
.... Applied Research Associates
... Applied
Science and Technology ... Applied Signal
Technology
... AppThwack .... Aprecia Pharmaceuticals ....
Apricus
Biosciences
... APS BioGroup .... Apse .... Aptalis Pharma .... Aptevo
Therapeutics .....
Aptima ... AptamiR
Therapeutics .... Aptinyx .... Aptose
Biosciences .... Aptus
Endosystems ... Aquaback Technologies ...
Aqua Bounty
... Aquacue .... AquaHarmonics ..... Aqua Metals .... AquaMost
...
Aquarius
Technologies ... Aquestive Therapeutics ....
AqueSys
... Aqueti .... Aquion .... Aradigm ....
AragonPharmaceuticals
...
Aratana
Therapeutics ..... Arbor Biosciences< ..... Arbor Biotechnologie
..... Arbor Pharmaceuticals
...
Arbovax
... Arbutus BioPharma (formerly OnCore) ..... Arca Biopharma ....
Arcadia Biosciences ..... Arcadia Pharma ..... Arcantatura...
Archemix
... ArcherDX ......Arch Innotek ..... Arch Therapeutics
... Arctic Sand Technologies .... Arcturus Therapeutics ....
Arcus Biosciences ..... Ardea Biosciences ...
Ardelyx .... Ardian .... Arena Pharmaceuticals
... Argentum ..... Arginetix
... Argo AI ..... ArgonST ... Argos Therapeutics ... Aria CV
...
Ariad Pharmaceuticals .. Ariosa Diagnostics ..... Arista MD
....
Arista Networks .... ARIZ Precision
Medicine .... Arkis BioSciences ....... Arkansas Power Electronics
.....
Armadillo Aerospace
... Armetheon .... ARMO BioSciences .... Armonica
Technologies .... Armorworks
... Armune BioScience ..... Aro Biotherapeutics
.... Aronora ..... Arpeggi
.... ArQule ... Arrakis Therapeutics .....
Array ... Array Information Technology ..... Arresto
Biosciences .... Arrien Pharmaceuticals ... Arrivo
BioVentures ..... Arrowhead Pharmaceuticals ..... Arrowhead
Research .... Arsanis ... Arsenal Medical
.... Arstasis ... Artel .... Arteriocyte
... Arterys
..... ArthroCare
...
Arthrosurface ... Artisan Pharma ... Artrility Medical .....
Arvegenix ..... Arvinas .... Arxan Technologies .... Aryx
Therapeutics ..... Aryx
... Arzeda
... Asana Medical (now Regentsys) .... Asante Solutions .....
Ascelegen
Therapeutics .... Ascension
Orthopedics ... Ascent
Solar Technologies ....
Ascent
Therapeutics .... AsclepiX Therapeutics .... Aseptia .... Ash
Access Technology ....
AstroWatt .... Aspen Aerogels .... AspenBio
Pharma .... Aspen Products Group ....
Aspen
Technology
... Aspyrian Therapeutics .... Assurex Health ..... Astex
Therapeutics ...
Asthmapolis
.... Astralux
... Astrobotic Technology ....
Astronautics Corp. of
America ... AstroPower... AstroTerra ..
Astrum Solar ... Astute
Medical ....
Astute Medicales ... Asuragen
... Atacama ..... Atara Biotherapeutics ..... Ataxion ....
Athenex
(formerly
Kinex) ..... Athenix
... Athens Research ..... AtheroGenics ... AtheroMed ....
Athersys .... ATI Industrial
Automation
... Atlantia ... Atmocean .....
Atmospheric Glow
Technologies ...
Atomate ... Atomic Medical Innovations .....
Atomometrics
... Atomwise ..... Atoptix .... Atossa
Genetics
... Atreaon ....
Atreon Orthopedics
..... AtriCure ... Atrium
Medical ... ATRP Solutions ... aTyr Pharma .....
Audentes
Therapeutics ..... Audience
... Augmenix
.... AUM
Cardiovascular ... Aura Biosciences ....
Auris Health .... Auris Medical .... Auris Surgical Robotics
..... Aurora
Algae ... Aurora Flight
Sciences ....
Aurora
Imaging Technology ...
Aurora Spectral Technologies
... Auspex
Pharmaceuticals ... Ausra ... Auterra
.... AuthenTec .... Autolus Therapeutics .... Automated Dynamics ...
Automated
Medical Instruments .... Autonet ... Aushon
Biosystems ... AutoGenomics .... Autonomic Materials
.... Autonomic Technologies ..... Autonomous Technologies
....
Auxilium
Pharmaceuticals ... Avalanche
Biotechnologies ....
Avanir Pharmaceuticals
... Avant Immunotherapeutics ... Avanti Metal ...
Avaxia
Biologics ... Avedro ... Avelas Biosciences ....
Aveo
Pharmaceuticals
... Avery Therapeutics ..... AveXis .... Aviation Resources
Delaware .... AVI
BioPharma ... Avici Systems ... AvidBiotics
.....Avidity
Biosciences .... Avid
Radiopharmaceuticals
... Avila Therapeutics ... Avinger ....
... Aviragen Therapeutics (formerly Biota
Pharmaceuticals)
..... Aviron ..... Avita Medical Americas ..... Avitude .... Avrobio
..... AVT Simulation .... Aware ... Axcella Health (was Pronutria)
.....
Axelo .... Axerion Therapeutics
... Axial
Biotech .... Axial Biotherapeutics ..... Axion BioSystems
.....
Axion Power
... Axis Clinicals .... Axis
Semiconductor
... Axium Nanofibers ...... Axium Pharmaceuticals .... Axogen
.... Axonia Medical ....Axonics Modulation Technologies
Axsome Therapeutics ..... Axsun Technologies ... Ayasdi
..... Azaya
Therapeutics ... Azelon Pharmaceutical ... Azimuth
.... Aziyo Biologics ..... Azure Biotech ..... AzurRx BioPharma
Baby Genes .... Bacterial Robotics .... BacterioScan .... Baebies
..... Bagaveev
.... Ballard
Power ... Bamboo Therapeutics ..... Bandgap ... Banner Life
Sciences ..... Banyan Biomarkers ... Bardy
Diagnostics .... BarioSurg ..... Baryonyx .... Barrier
Therapeutics ... Baseload Renewables .... Basis
Science
.... Bastion
Technologies
.... Batu Biologics ..... Bauhaus Software ..... Baxano ...
Baxano Surgical .... BayoTech ..... Beacon Biomedical ..... Beacon
Power ... Beam Therapeutics ..... Beat
Biotherapeutics .... Beeco
... Behavioral Recognition Systems .... Bellicum
Pharmaceuticals .... Belmont Instrument ....
Benchmark
Automation ... BeneChill
... Benefuel ... BeneVir Biopharm ....
Bennett
Aerospace .... Benson Hill
Biosystems ..... Benvenue
Medical .... Berg .... BerrieHill
Research
... BESS Technologies .... BetaBatt
...
BetaLED ....
LEDBG Medicine
... Bettergy .... Bexion Pharmaceuticals .... Bina
Technologies .... Bind
Bioscience ... Bind Therapeutics .... BinOptics ..... BiO2
Medical
... BiO2
Technologies
...
BioAmber ... BioAdvanTek ... BioAffinity
Technologies .....
Bioanalytical Systems
... BioBehavioral Diagnostics ... BioBridge
Global
..... BioCardia .....
BioCentra Molecular Innovations ..... Biocept
...
BioChemics ..... BioClin Therapeutics .... Bicycle Therapeutics .....
Bien-Etre
Labs ..... Bioconnect Systems .... BioConsortia ..... BioCritica
... BioCryst Pharmaceuticals ...
BioDelivery Sciences ... Biodesix .... BioDirection ..... BioDtech
..... BioE ...
BioFire .... BioFluidica ..... Biogenic
Reagents
.... BioGreenChoice ... BioHaven Pharmaceuticals ..... Bioheart
...
Biohelix ... Bio-Imaging Technologies
...
Bioincept .... BioKier ..... Biolex Therapeutics
... BioLife4D ..... BioLink Life
Sciences
... Biolinq (formerly Electrozyme) ,,,, Biologics
...
BioMagnetic Solutions ....
BioMarin
Pharmaceutical
... BioMarck
Pharmaceuticals .... bioMASON ..... Biomatrica ...
BioMedical
Enterprises
... Biomedical Sciences ..... Biomedical
Structures ...
BioMedix .... Biomeme .... Biometric
Signature
... BioMimetic Therapeutics
... BioMotiv .... BioNano
Genomics ... BioNanomatrix ... Bionostics
Holdings
... Bio-Path Holdings ..... Biophan Technologies
... Biophysical ... BioProcessors ...
Bioptigen
... Bioptix .... BiOptix Diagnostics ..... BioPulping
International
...
Biopure ... Biorasis ..... BioRelix ... BioResource
International
...
BioRestorative Therapies (formerly Stem Cell Assurance) ....
BioSante Pharmaceuticals ... BioScale
.... BioSense
Technologies ... BioSensics .... BioSentinel
Pharmaceuticals
... BioSig Technologies ..... Biosortia Pharmaceuticals ....
BioSphere Medical
.... Biostage (formerly Harvard Apparatus
Regenerative
Technology) ..... BioStructures .... Biosurfaces .... Biosym
Technologies later Accelrys
....
BioSystem
...
Biota Pharmaceuticals .... Bio-Techne ..... BioTechnique ....
BioTechPlex .....
Biotectix
....
Biotel
.... BioTelemetry (formerly CardioNet) ..... BioTex
....
Biothera
... BioTheranostics ... Bio Time ...
Biotix
... Biotronic NeuroNetwork ..... Biotronik ....
BioTrove
... BioVaxys .... Bioventus ..... Biovest International ....
BioVex
... BioVirtua ..... Bird Rock Bio (formerly RuiYi) .....
Birich
Technologies .... Biscayne Neurotherapeutics ..... Bitstream
... Black
Diamond Therapeutics .... Black-I Robotics
... Black Sand ... BlackThorn
..... BladeLogic
... Blasch Precision Ceramics .... Blaze
Bioscience ... Blend
Therapeutics ....
BL Healthcare ... Block Engineering ...
Bloom Energy
... Bloo Solar ..... BluDiagnostics ..... Blue Belt
Technologies
...
Bluebird
bio ...
BluDiagnostics .... Bluefin Robotics ... Bluegrass
Proteins
.... Bluegrass
Vascular
Technologies .... Blueprint
Medicines ...
BlueRock Therapeutics ..... Blue
Sky Batteries ... Bluewater Bio International ... Bolt Threads ....
Boom Supersonic ..... Boragen .... Boston Biochem
... Boston Biomedical ... Boston Dynamics
...
Boston Engineering ... Boston Micromachines ... Boston
Micromachines (formally Boston
Electrometallurgical .... Boston-Power
...
Boston
Therapeutics ... Bot Dolly .... Boundless ... BoXZY
..... Braeburn Pharmaceuticals ..... BrainCells
... BrainScope .... Brain Sentry ....
Brain Tunnelgenix
Technologies .... BrainXell ..... Branch Medical Group ..... Brayton
Energy
.... Breathe
Technologies ... Breethe .... Breonics ...
BreviTest
Technologies
..... Brewer
Science ... Bridger Photonics .... Bridgelux
... Brightsource Energy ... Bright View
...
Brimrose Corp of America ... Briteseed .... Brock Rogers Surgical
...
Bromium
.... Brooks
Automation ...
Bruker Daltonics .... Buffalo BioLabs ..... Burl
Concepts
..... Burr Oak
C12 Energy ... C2Sense .... C3Nano
... C4 Therapeutics .... C8
Sciences ....
C9 ... Cabaletta Bio .... CABG Medical ....
Cadence Pharma ....
CadheRx
Therapeutics
.....
Caisson Biotech .... Calabazas
Creek
Research .... Caladrius
Bioscience ... Cala Health ..... Calando
Pharmaceuticals
... Calbiotech .... Calera ... Caliber Biotherapeutics ....
Calibra
Medical ... Calient ... California Wave Power
Technologies ..... Calimmune ..... Caliper Life Sciences
....
CaliSolar ... Calistoga Pharmaceuticals ...
Calithera
BioSciences .... Calixa
Therapeutics ... Callidus Biopharma ... Calporta
Therapeutics
.... Calspan .... Caltech Metals ... Calysta .... Calyxt .....
Cambridge
Endoscopic Devices ... Cambridge Heart
.... Cambridge
Research & Instrumentation ... Cambrios
Technologies .... CAMX ..... Candela Laser ....
Cancer
Genetics .... Cancer Prevention
Pharmaceuticals .... CanDiag .... Canopy Biosciences ..... Capesym
... Capillary
Biomedical ..... Capio Biosciences .... Capnia
... CAPP Medical ..... Capricor Therapeutics .... Cara
Therapeutics .... Carbon .....
Carbon
Design
Systems ... Carbtex Technology
.... Carbylan Therapeutics ..... Cardeas
Pharma ....
CardiacAssist ..... Cardiac Concepts ...
Cardiac
Dimensions
... Cardiac Science ..... Cardialen ..... CardiAQ Valve
Technologies ... Cardica
... CardioDx
... CardioFocus ... CardioInsight Technologies .....
Cardiokinetix ..... CardioMag ... CardioMEMS .... Cardionomic ....
CardioNXT ..... Cardiorobotics
...
Cardiosolutions ... Cardiosolv .... CardioSpectra ... CardioTech
... Cardiovate ..... CardiOx ...
Cardioxyl
Pharmaceuticals
.... CareDx (formerly XDx) .... Caribou Biosciences
.....
Carigent Therapeutics .... Carisma Thera (formerly CARMA Therapeutics)
..... Carmot Therapeutics
..... Carnegie Robotics
.... Carnegie Speech
... .... Carnot BioSciences .... CaroGen .... Carter Aviation
Technologies
.... Carticept
Medical ... Cartiva ..... Cascade Designs ...
Cascade
Microtech
... Cascadian Therapeutics (formerly Oncothyreon) ..... Casma
Therapeutics .... Castle
Biosciences ..... Catabasis Pharmaceuticals
... Catadon
Systems ... Catalyst Biosciences ... Catalytic
Innovations ..... Catalyze ..... Catelectric
.... Cebix .... Cedarburg Pharmaceuticals .... Cedilla
Therapeutics ..... CeeTox
... Celadon ... Celator Pharmaceuticals
... CelcuityCeldara Medical ..... Celladon .... Cellara .... Cell Care
Therapeutics ..... Cellceutix
.... CellCyte
Genetics ... Cell Design Labs ..... Celldex Therapeutics
... ..... Cellectar ... Cellerant
Therapeutics
... Celleration .... Cell Genesys ... CellRight
Technologies
..... Cellular
Bioengineering
...
... Cellular Bioengineering ..... Cellular Biomedicine Group
.....
Cellular Dynamics International .... Cell>Point
.... CellSavers ..... Cellscape .... Cellscript
..... Cell
Signaling Technology ...Cell
Therapeutics (now CTI
BioPharma)
... CellTraffix ... CeloNova Biosciences
..... Cel-Sci
.... Celsion ...
Celtaxsys ..... Celula..... Celularity ..... CellzDirect ...
Cempra Pharmaceuticals.
.... CeNeRx
BioPharma ... Centocor .... Centrexion Therapeutics .....
Centrose ... Centice
...
Centritec
Seals ... Cephalon
... Cepheid
... Cephalon ... Ception Therapeutics
... Cequent
Pharmaceuticals ... Cerebras Systems ..... Ceradyne ...
Ceramitron
... Cerapedics
.... Ceramatec
... Cerevast Therapeutics .... Cerealus Holdings
... Cerecor .... Ceregene ...
Cerahelix
.. Ceres Nanosciences ..... Cerexa .... Cerion
Enterprises ...
Cermet ... Cernostics ..... Cerulean Pharma
... Cerus ... Cervel Neurotech .... Cesca
Therapeutics
....
Ceterix
Orthopaedics ... CFD Research ..
CFX Battery
.... CGI Pharmaceuticals ... ChaCha
... Chantilly BioPharma .... Chapman
Innovations ... Charles River Analytics .... Charles
River
Lab ... Charter Medical ..... Chase Therapeutics .... CHASM
.... Chatham
Therapeutics .....
Checkerspot ..... Chemat
... Chembio Diagnostic
Systems .... ChemImage ... Chemir Analytical
Services ...
ChemoCentryx
... Chemtura ....
Chesapeake Sciences
...Chesson Labs ... Chiasma .... Chimera
Bioengineering ..... Chimerix
... Chlorogen ... Choice Therapeutics
... Chondrogenics
... Chordia
Therapeutics .... Chorum Technologies
.... ChromaCode
..... ChromaDex
..... Chronix
Biomedical
... Chrysalis BioTherapeutics .... Cibus
Global
... Cidara Therapeutics .... Ciena
....Ciencia ...
Cilion .... CimaBay Thera ..... CinRx .... Ciranova
... Circle
Technologies ..... Cirius Therapeutics ..... CivaTech
Oncology
.... CiVi Biopharma ..... Civitas Therapeutics
..... Claret Medical .... Clarassance ..... Claresta
Solutions
.... Clark-MXR ...Claros
Diagnostics
.... Clean Diesel
Technologies ... Clear Catheter Systems .... ClearCount
Medical
Solutions .... ClearEdge
Power .... Clear Guide Medical .... Clearside
Biomedical ... Cleave Biosciences ... Cleveland BioLabs ...
Cleveland
Polymer Technologies ..... CleverSet ... Clinical Data
... Cloudant ... CloudMade ... Cloud
Pharmaceuticals
(formerly Teradiscoveries) .... Clovis
Oncology ... Clovis Tech ..... CMC Biologics .... C-Motive Technologies
.... CoAdna,Holdings ..... CoAxia ....
Cobalt
Biofuels
...
Cocrystal Discovery ... Codexis
... Codiak BioSciences ..... Codon
Devices ... Co-D Therapeutics .... Cofactor
Genomics ....
Cogenra .... Cogentix Medical ..... Cognex
...Cognition
Therapeutics .... Cognitive Code
... Cohera
Medical .... Coherus Biosciences .... Cohesive
Technologies ... ColdQuanta .... ColdWatt ... Collagenex
Pharmaceuticals ...
Collegium Pharmaceutical ... CoLucid Pharmaceuticals
... Columbia Labs ..... CombiMatrix ...
CombinatoRx
..... Combined Energies .... Combinent
BioMedical Systems ... Comfort Motion Technologies
...
Commonwealth Biotechnologies ... Commonwealth
Fusion Systems ..... Compact Membrane Systems ...Compass
Therapeutics .... Compellent Technologies ... Compendia
Bioscience
.....
Complete
Genomics ....
Complexa
..... Conatus
Pharmaceuticals ... Concert
Pharmaceuticals
.... Concordia Fibers ...Concurrent Technologies ...
Conductus
.. Confluence Life Sciences ..... ConforMIS ...
Cognigen
.... Conispire
.... ConjuGon .. Connecticut
Valley Bindery ... Consonus Technologies
...
Constellation
Pharmaceuticals .... Context Therapeutics ..... Contour Energy
Systems ControlRadSystems ..... Convelo
Therapeutics ....
Conventus
Orthopaedics ..... Convergen
... ConverGene .... Convio .... Convoy
Therapeutics
.... Cool-Bio
.... CoolCAD Electronics .... CoolChip Technologies
....
Cool Earth
Solar
.... Cooligy ... CoolTech .... Corbus
Pharmaceuticals
..... Corcept
Therapeutics
...
Cordex Systems .... CoreStreet ... CoreTek ...
.Corgenix
Medical
... Corindus ....Corinthian
Ophthalmic ... Corium International .... Corixa
....
CorMatrix
Cardiovascular
.... Cornami ..... Cornerstone Research
... Cornerstone BioPharma then Cornerstone
Therapeutics
..... Cornerstone Therapeutics .... Coronado
Biosciences ... CorQuest Medical ..... Correx ... Corridor
Pharmaceuticals
... Cortana ..... Cortendo AB ..... Cortexyme ....
Corvidia
Therapeutics ..... Corvus
Pharmaceuticals
..... CosmosID ..... CoStim Pharmaceuticals
.... Cougar
Biotechnology ...
Coulbourn
Instruments .... Coulter Pharmaceuticals ... Cour
Pharmaceutical
Development .... Coverity ..... Creare ...
Creative
Hybrid Solutions .... Creatv MicroTech .... Cree
Research ... Crescendo Bioscience .... Crinetics
Pharmaceuticals
....
CrispTek .... Critical Therapeutics .... CritiTech
... Crossbar .... Cross Current ..... CrossFire
... Cruise Automation .... Crux Biomedical
...
CryoCor ...
CryoLife ... Cryomedical Sciences ..... Cryptonite .....
Crystal
IS
...
Crystal Systems ... Crystallume ... CSA
Engineering ... CS-Keys ... CTD Holdings
..... CTI
BioPharma (formerly
Cell Therapeutics) .... Cubist
Pharmaceuticals
... Cue Biopharma .... Cullinan Oncology ..... Cumberland Pharma ....
CuraGen ... Current Motor
...
Curtana Pharmaceuticals .... Custom Electronics .... CVD
Equipment ..... CVRx
... CV
Therapeutics ... Cyanotech ..... Cyberdyne .... CyberKey Solutions
... Cyberkinetics Neurotechnology ... Cybernet Systems
... CyberOptics ... Cydan .... Cykloburn
Technologies ..... CymaBay
Therapeutics
.... Cymbet ... CyMedica Orthopedics ..... Cymer
...
Cynosure ... Cyntellect ... Cypher Genomics ... CyPhy Works
... Cypress Bioscience ... Cyrus Biotechnology .....
Cyteir
Therapeutics ..... Cyterix
Pharmaceuticals ...
CytImmune .... CytoBioScience ..... Cytocentrics ..... CytoCore
(formerly Molecular
Diagnostics) ..... Cytocybernetics ..... CytoDyn
.... Cytogel Pharma
.... Cytokinetics
... Cytometix ....CytomX ...
Cytonome
....
Cytori Therapeutics ... Cytophil CytoSolv
... Cytosorbents ..... Cytovas ... CytRx ..... Cytyc
...
CyVek
Dabble ..... Dairyvative Technologies ..... Daktari Diagnostics ... Dance Biopharm .... Dara BioSciences ... Daré Bioscience Operations .... Dart Therapeutics ... DaStrong .... Datafiniti .... Data Physics ... DataRobot ..... Dato (formerly GraphLab) .... Datuit .... daydream.io ..... Daylight Solutions .... DayStar ... DayZero Diagnostics ..... DBS Energy ... DCL Medical Laboratories ... Deca-Medics ... Decibel Therapeutics ..... DecImmune Therapeutics ... Deciphera Pharmaceuticals ..... Decision Biomarkers ... Deepwater Wind .. Defense Engineering .... Defense Research Associates .... Defibtech ... Dekkun .... Delcath ... Delinia ..... Deltanoid Pharmaceuticals ... Denali Medical ... Denali Therapeutics ..... Dendreon ... DeNovo Sciences .... DeNovis ... Deposition Sciences .... DermAvance Pharmaceuticals ... Dermira ... Desalitech .... Descartes Labs ..... Design Knowledge ..... DesignMedix ..... Detcon ..... DE Technologies ... Devicix ..... Dew & Ken Group ... Dewey Electronics ... Dewpoint Therapeutics .... Dexcom ... Dharmacon ..... Diagnostic Biochips .... Diagnostic Hybrids ... DiaMedica ..... Diamond Foundry ..... Dianomi Therapeutics .... Diatomix ..... Dicerna Pharmaceuticals ... Diffusion Pharma ..... DiFusion Technologies ... Digene ..... Digirad ... DigiSight Technologies ..... Digital Fusion ... Digital Lumens ... Digital Optics ... Dignify Therapeutics .... Dimien .... Dimension Therapeutics .... DioGenix .... Dipexium Pharmaceuticals ..... Directed Manufacturing .... Directed Perception .. Disarm Therapeutics .... Disc Dynamics ... Discovery Genomics ..... Discovery Labs .... Displaytech ... Distributed Energy Systems ... Divergence ... Diversified Energy ... D. Light ... DMC Biotechnologies ... DNAnexus ..... DNAPrint Genomics ... DNAtrix .... DNV GL .... Dova Pharma ..... DoX Systems ... Dracen Pharma ..... Dragon Systems .. Dragoon ITCN ..... Drilling Info ... DrillMap .... DropWise .... DR Technologies ..... DrugCendR .... DSM .... DT Solar ... DuBay Ingredients ... duPont Aerospace ... Dura Biotech .... Durata Therapeutics ... Durin Technologies .... DVS Sciences .... DxUpClose .... Dyadic International ..... Dyax ...DynaBil Industries ... Dynasil ... Dynavax Technologies ... Dynetics .... Dynogen Pharmaceuticals
E3 Clean .... Eagle
Optoelectronics ... Earl Energy .... EarLens .... Earth Networks ....
Earthrise
Nutritionals ... eASIC ..... Eboo Pharmaceuticals .... EBR
Systems ..... Ebullient
....
Echelon .... Echodyne
..... Echometrix ... EchoPixel ..... Echo Therapeutics (was
Sontra)... ECI Biotech
... ECM Technologies ..... Ecocurrent
... EcoPesticides .... EcoPro Polymers .....
Eccrine Systems ..... Ecovative
Design ... Edaptive
Computing .... Eden
Bioscience
... Edenspace
Systems ... Edge Therapeutics ..... Edico Genome .... Edison
Agrosciences ..... Editas
Medicine .... EEStor
... Effector
Therapeutics .... Egalet .... eGenesis .... Eiger BioPharmaceuticals
..... Eikos ... E-Ink
... EIS .... Ekos ... EKR Therapeutics .... Ekso
...
Elcelyx Therapeutics ... Electrical
Geodesics .....
ElectroCell
Technologies
... ElectroChemical Systems ... Electro Energy
...Electromed ... Electro Optical Sciences ...
Electro
Scientific ... Elementary Robotics ....
Elemetric Instruments
... Elevation Pharmaceuticals ... Eleven
Biotherapeutics ... Elira Therapeutics
..... Elixir Biopharm ... Elixirgen Therapeutics ..... Elixir
Pharmaceuticals ...
Ellipse Technologies ..... Elon ...
Elstar Therapeutics ..... eMagin .. Embera
NeuroTherapeutics .... Embodied ....
EmboMedics
.....
Embrex ..
EMCORE
...
Emerald BioStructures
.... Emergent BioSolutions ...
Emergent
Technologies ... EM Photonics .... Empire Genomics
.... Empire
Robotics ....
EMRes Technologies
... Emulate .... Enable
Injections ...... Enanta Pharmaceuticals ..... EnChroma ..... Encite
...
Encoded Genomics .... Encompass Bioscience ..... Encore
Vision .... Encysive
Pharmaceuticals ... Endeavor Robotics ..... Endece
...
Endgame Technologies
... EndoChoice .... Endocyte ... EndoGastric
Solutions
... Endo International ..... Endoscopic
Technologies ... Endosee ..... EndoStim
.... Endotherapeutics ..... Ener1
... EnerG2 ... Energen
... Energesis Pharmaceuticals .... Energetiq
Technology ... Energid Technologies ... Energous
..... Ener-G-Rotors
... Energy Control ... Energy Conversion
Devices .
.. Energy Focus ..... Energy Recovery ... Energy
Solutions
... Energy Storage Systems ..... EnerMat Technologies .....
EnerMed ..... Enertech
Environmental ... EnerVault ... Engineered
BioPharmaceuticals
.... Engineered Propulsion ...Engineous
Software
... Enlibrium ..... Enlight
Bioscience ... EnSync Energy Systems (formerly ZBB Energy)
.....
Ensysce Biosciences ... Entasis
Therapeutics ..... Entech
... Entegrion ... Entellus Medical .....
Entera
Biotech .... Entergem Ventures .... EnteroMedics
... Entia Biosciences ..... Entira Bio .... Entopica
Therapeutics
...
EntreMed
... Entrada Therapeutics ..... Entra Pharmaceuticals
... ENTrigue Surgical ...
Envia
Systems .. Entrotech Life Sciences ..... Entvantage
Diagnostics
..... EnviroFlight ..... Envisia Therapeutics
..... Envistacom .... EnVivo
Pharma ... Enzenia ... Enzium
... Enzo Biochem ... Enzymatics ... EnzyMed ..... Enzyvant
.....
EO2
Concepts
.... EOIR
... Eonix ....
EpiBiome ....
EpiBone .... Epicentre
Biotechnologies .... Epic Sciences .... Epic Systems ..... Epicypher
.... EpiEP ...
Epion
... Epiphany Solar Water Systems .... Epitomics
...
Epiva Biosciences ..... EpiVax ... EpiWorks .... Epix
Pharmaceuticals ... Epizyme
...
Eppin Pharma .... EqualLogic ... Equex
... Equillium .... Equipment
Concepts ...
EraGen Biosciences ... Erallo Technologies
... Erasca .... Ercole
Biotech ... ERT ..... Escalier Biosciences BV ..... Escalon
Medical
.... E-Scape
Bio ..... Escient Pharmaceuticals ..... Escoublac
....
eScription
... eSolar ... Eso-Technologies
... Esperance Pharmaceuticals ..... Esperion
Therapeutics
..... Essential Biotechnology
..... Essential Medical .... Essentient ....
Essex... Eta Devices ..... Eta-Gen .... Etegent
Technologies
... E-Tek
Dynamics ... Euclid
Labs .... Euclises Pharmaceuticals ..... Eureka
Therapeutics ..... Euthymics
Bioscience ... EVapt .... Evelo
Therapeutics ....
Evena Medical ..... Ever Cat Fuels
...
Evergen Biotechnologies ... Evergreen Solar ... Everspin
Technologies .... Evestra ....
Evident
Technologies ... Evoke Pharma .....
Evolution
Robotics ... Evolv .... Evolve BioSystems ....EWI .... Exact
Sciences .... Exagen
Diagnostics ... Excelimmune ... Excel
Technology .... Excision BioTherapeutics ..... Exelixis .....
Exelixis
Plant Sciences ... Exemplar Genetics .... Exo .....
Exogenesis
..... Exone ....
Exosome Diagnostics ..... Exovita
Biosciences .... ExploraMed
NC4 ...
Expression
Analysis .... Exquadrum .... Exsulin
....Extreme Molding ... Extremity Innovations ... EyeGate
Pharmaceuticals ... EyeNetra .... EyeTel
Fallbrook
Technologies
... Famigo ... Faraday Pharmaceuticals .... Farodox
Energy
Storage
...
FarSounder ... Far-Tech.... FastCAP Systems ...
Fate
Therapeutics
... Fathom .... Fe3 Medical .... FEI ... Femasys
.... Femta
Pharmaceuticals
.... Ferrate
Treatment Technologies ... Ferric Contrast ...... FerroKin
BioSciences ....
Fervo Energy .... Feuz Manufacturing ... FGC Plasma Solutions
..... Fiber and Sensor ....
Fiberight ...
Fiber Materials ... Fibersense ... Fiberstar ....
Bio-Ingredient
Technologies ... Fibertek .... Fibrocell Science
... FibroGen ... Filter
Sensing Technologies ...
Finally Light
Bulb ..... Finch Therapeutics Group ..... FineLine Prototyping ....
Finisar
... Fire Alarm
Specialty Design .....
Firefly
BioWorks ... Firefly Energy .... Firefly LED
...
First Solar ... Fisker Automotive ... Five Prime
Therapeutics .... Flex Biomedical
... Flexion Therapeutics ... Flex Pharma
.... Flextronics
America ....
Flexus Biosciences .... FLIR Systems
.. FloDesign
Wind Turbine ... FlowCardia
...
FlowMedica .... FlowMetric .... Flow Metrix
...
FluGen
... Fluidic Energy ... Fluidigm ... Fluid Innovation
Group
... Fluidnet ... Fluidnet
FluoroPharma
... Fog Pharma ..... Foghorn
Therapeutics .... FokusLabs .... FoldRx Pharmaceuticals
...
Follica ...
Footnote .... Foresight Biotherapeutics .... Forest Devices .... Forge
Therapeutics .....
F-Origin
... Forma
Therapeutics ...
Formlabs
.... For-Robin ..... ForSight Vision5 .... Fortis Therapeutics .....
Forty Seven ..... Forum Pharmaceuticals ..... Forus
Health ... Foster-Miller .... Foundation Medicine
... Fox Chase Chemical Diversity Center ....
Fractal
Antenna Systems ... Fractyl Labs ..... Freedom Meditech
... Free
Flow Power ... Free Form Fibers .... Freenome ..... Froedtert
Health ..... Frontier
NanoSystems ..... Frontier Technology ..... Front Range Biosciences
.... FTL Solar
...
FuelCell Energy
... Fuel Tech
.. Fulcrum Therapeutics ..... Fulgent Therapeutics ..... Full
Spectrum Genetics .... Furiex
.... Fused
Innocation.
...
Fusion
Coolant Systems ... Future Technologies
G1 Therapeutics ..... G3 .... Gadusol Laboratories (aka
Seaceuticals) ..... Galderma .... Galectin Thera ..... Galenea ...
Galena
Biopharma
.... Galera
Therapeutics ..... Galil Medical ..... Galleon
Pharmaceuticals ... GAM Enterprises .... GameSalad
... Gamma Medica Ideas ... Garland
Technology .....
Garwood Medical Devices ..... GATR Technologies ..... G-Con .... Gecko
Biomedical .... Gecko Robotics .... Gel Combs .... Gelesis ...
Geltech ...
Gema Diagnostics .... GEMFIRE .. Gemin X Pharmaceuticals
... Gemmus
Pharma ... Gemneo Bioscience ..... Gemphire Therapeutics
......
Gemstone
Biotherapeutics
..... Gen9 ...
Genaera ...
Genalyte
... Genapsys .... GenAudio .... Gene by Gene .... GeneCentric
Diagnostics
... Genelabs Technologies ... Gene
Logic ... Geneoscopy ..... General Compression
...
General
Pneumatics
..... Generation Bio ..... Generex
Biotechnology ... Gene Security Network .... GeneSegues
Therapeutics ..... GenesisLabs ....
GeneSystems ... Genetesis .... Genetic Networks ..... Genetix
Pharmaceuticals
... GeneTx Biotherapeutics ..... Geneu .... Genia
Technologies
.... GenMark Diagnostics
.... Genoa Pharmaceuticals ..... Genocea
Biosciences
... Genomatica
... Genome Profiling ... GenomeQuest ... Genomic Health
...
Genomind ....
Genoptix
Medical
Laboratory ... Genor ... Genprex .... Gen-Probe
...
GenSpera
.... GenTel BioSciences ... Gentris ... GenturaDx
...nbsp; GenVec ... GenWay Biotech ..... Genzyme .... Geocent
.... Geocove ..... Geomagic
... GeoMed
Analytical ... GeoVax Labs ...
Geospiza
... Germfalcon ..... Geron ...
Gevo
..... GI Dynamics
...
GigOptix
... Gilead Sciences .... Giner . ..
Ginkgo BioWorks
.... Glauconix ..... Glaukos
.... GlideLine
Systems ... Gliknik ... Global Blood
Therapeutics
...... Global Cancer Diagnostics ..... Global Positions ...
Global Blood Therapeutics ....
GlobeImmune ....
Gloucester Pharmaceuticals ... Glowforge ..... GlucaGo ...
GlycoFi
... GlycoMimetics .... GlyGenix ... Glympse Bio
.... Glyscend .....
GlySens
... GMZ
Energy
... GnuBio
.... Goddard Labs .... Goldfinch Bio ..... Good Start Genetics
.... Gore
Photonics ... Gossamer Bio ..... Gotham Biotech .... Gotham
Therapeutics ..... GPC-Rx
... gRadiant Research ... Gradiant ....
GraftWorx
..... Grail ..... Graphene
Energy
... Graphenix Development .... Graphic
Surgery ... GraphLab (now Dato) .... Grassroots Biotechnology
...
Greatbatch
... GrayBug ..... Graybug Vision ..... Great Basin Scientific .....
GreatGrow Maryland ....
GreatPoint Energy
... Green & Grow .... GreenFuel
Technologies .... Greenlight Biosciences .... GreenMark Biomedical
..... Green Mountain Radio
Research .... GreenSight Agronomics ..... Green Sulfcrete
.....
GreenTech America
... Greenwich Geriatrics .... GridBridge .... Grid
Therapeutics
..... Gritstone
Oncology
..... GRO Biosciences ..... Group14 Technologies ..... Grove
Instruments
... Grow Home Organics
.... GSI Technology ... GT Advanced
Technologies ...
GTC Biotherapeutics ... G-Tech Medical .... GT
Equipment .... GTI
Diagnostics
... GT Medical
Technologies ..... GTx .... Guardant Health .... Guided Surgery
Solutions
....
Guided
Therapeutics
.... .... Guided Therapy Systems ..... Gynesonics .....
G-Zero
Therapeutics
2 Energy Now ...... H2O Score ..... H2Pump ...
H2Sonics
.... H3
Biomedicine ... HNC Software ... Halozyme ...
Hana
Biosciences .... Hansen Energy and Environmental
....
Hansen Medical ... Haplogen Genomics ..... Harbor
Technologies .. Hardcore Computer ... HarkerBio .... Harmony
Enterprises ....
Harpoon Medical .... Harpoon Therapeutics .... Harvard Apparatus
Regenerative Technology .... Harrisvaccines .... Harvard Bioscience
... Harvest Automation .... Harvest Power ...
Harvest Technologies .... Healionics .. Health Diagnostics
Laboratories .... HealthMyne ....
Healthtronics
.... Hearforward
... Heartland Robotics .... HeartWare International
... Heat
Biologics .... ... HeatGenie ... Helicos
BioSciences
... Helion Energy .... Heliovolt ...
Helius Medical
Technologies ..... Helix
Therapeutics
... Helomics (formerly Precision Therapeutics)
.....
Hemadvance ..... HemaQuest Pharmaceuticals ... Hemarrest ... Hemera
Biosciences .... Hemispherx Biopharma .... HemoGenyx .... Hemoshear
Therapeutics ..... HemoSonics..... Hemostasis
... Hennepin Life Sciences .... Hepregen ... Heraeus Medical
Components .... Herley Industries
... Hermes Biosciences ... HexaTech
.... Hexfuel .... Hibernaid .... Highbury Defense
Group .... High Impact
Environmental
.... High Performance
Technologies ... High Point Pharmaceuticals .....
Histogen
.... HighRes Biosolutions .... Histogenics
... HistoRx
... HistoSonics .... HJM
Precision .....
HocusLocus ..... Hoku
Scientific
... Holaira .... Hollingsworth & Vose .... Hollis-Eden
Pharmaceuticals ... Holomni .... Homology Medicine
.....
Honeycomb Batteries .... Hontek
... Hoopers Island Oyster Aquaculture ...
Hoppe Tool
.... Hoth Therapeutics ..... Hsiri Therapeutics ..... HTG
Molecular ..... HTSS
...
Humacyte
...
Humanetics ..... Human
Genome
Sciences ...
Human
Metabolome Technologies .... HuTerra .... Huya Bioscience International
.... Hybritech ..... Hybrivet .... HYCOR
Biomedical ...
Hydra Biosciences ...
HydroCision ... Hydrogen
Safety ... HydroLogic Industries .... Hygeia
Therapeutics
... HyperBranch Medical
Technologies ... Hyperion Therapeutics ... HyperMed
... HYPRES .. Hy-SyEnce
... HyTrust
IAP ... IBC Advanced .... iBiquity Digital ..... Ibis
....
Iblogix
.... IBT
Laboratories
... Icagen .... Icardiac.... Ichor Medical Systems .... Iconic
Therapeutics ..... Icos.... ICX....
Idaho.... Ideal
Converters ... Ideapaint.... Ideaya Biosciences ..... Idera
Pharmaceuticals ..... ID Genomics ....
Idevices
... IDx ..... iFirst Medical Technologies ...... IFM
Therapeutics
..... Igenica
Biotherapeutics .... Ignyta.... Ii-IV
.... Ikaria... Ikonisys... Illinois Superconductor.... Illumigen....
Illumina.... Illuminating Diagnostics ..... Illuminoss....
Illumitex.... Imagen Energy .... Imagevision.... Imaging
Biometrics... Imagineoptix ... Imago Instruments... Imanis
Life...
Imbed Biosciences... Imetalx... Immco... Immersion... Immtech...
Immucell .... Immucor ....
Immune... ... Immune... Immune Pharma .... Immunetics...
Immunex...
Immunexcite...
Immuneworks... Immunexpress ..... Immunicon... ImmunoCellular Thera
.... ImmunoChemistry
Technologies ..... Immunocore...
Immunogen... Immunome ..... Immunomedics..... Immunomic Therapeutics
.....
Immunophotonics ... Immurx... .... Immusant...
Immusoft ..... Impact Biomedicines .... Impact Proteomics
.... Impact Science...
Impel
Neuropharma... Imperium Renewables... Impinj... Implant
Sciences... Impossible Foods .... Imprimis Pharmaceuticals .... Imprint
Energy .... Impulse
Monitoring ... Imricor Medical Systems ..... Imris .....
Imthera...
I-nalysis ... Inari Agriculture .... InCarda Therapeutics ....
INCELL .... Incelldx
..... Incitor (now XF
Technologies) .... Incodema3D ..... Incontrol
Research... InCube Labs ..... Incyte ....Incytu... Indalo
Therapeutics ..... Indiana
Nanotech... Indi Molecular ... Industrial Heat ..... Industrial
Perception...
Inentec ... InfaCare Pharmaceutical .... Infarct Reduction
Technologies .... Infinera...
... Infinia... Infinity... Infinium
.... Inform
Genomics... Infoscitex... Inframat... Infraredx... Infrascan... Inf
Robotics ... Infusion Medical ... Ingeneus... Ingeneron .....
Inhibitex... Inhibkase
Therapeutics .... INI
Power... Inland Labs ..... Inmobly .... InnAVasc Medical ....
Inneroptic...
Innerpulse... Innocrin Pharmaceuticals ..... Innography...
... Innopad... Innotec ..... Innovalight...
Innovari Energy Design Microplate Scientific...
pulmonary solutions.... silicon... Innovate Biopharmaceuticals .....
Innovative Spinal...
Innovative... Innoventiontech ... Innovention (now
Ccardiorobotics) ... Innovative Trauma or...
Innovolt ...
Innowave... ... ... Innoviva ...
Innov-x... Inocucor ..... Inorganic Specialists... Inotek...
Ino
.... Inova
Labs
Biomedical... Inovio... Inovise Medical ..... Inozyme Pharmaceuticals
..... Inphase...
... Inphi... Inpria ..... Inscripta ..... Insert MRI...
Insight...
..Insite Vision...... Insitu... InSitu
Biologics ..... Insmed... Inspired Solar Systems ...
Inspire...
Insulet
Labs
... Intact Vascular... Intaglio... Intalio ... Intarcia
Therapeutics ...
Integenx... Integra Group Diagnostics... Integral Molecular .....
Integrated BioTherapeutics
.... Integrated
Diagnostics .... Integrated
Diagnostics InDi .... Integrated DNA Technologies ..... Integrated
Fuel...
... Integration Associates... Intelect
Medical
Intelleflex ... Intellia Therapeutics .....
Intellicyt
Automation Bio-systems ...
Intelligent Devices .... Intelligent Epitaxy Technology .....
Intellimedix ..... Intelliphage.... Intellirad
Control...
.Intellisense .... Intelomed ....Inter-4... Interactive Supercomputing
... Interdigital
Interlace ....
Intermagnetics General ...Intermolecular ... Intermune....
International Stem Cell ... Interrad Medical ..... IntersectENT ....
Intersense...
Intersystems ...
Intervalve....
Intevac.... Intra-Cellular Therapies .....
Intralase ...... Intralytix .... Intrexon ..... Intrinsity....
Introgen....
... Intuitive Biosciences .... Intuitive Genomics ..... Intuitive
Surgical.... Invenra ....
Invensense .... Inventev ..... Inverness
Innovations.... Invirsa ..... Invertix.... Invictus.... Inview
Technology....
Inviragen.... Invisage Technologies ....
....InvisionHeart .... Invision Medical ....
Invitae....
Invitrogen.... ...Invivosciences.... Invivo Therapeutics=
Holdings .... Invuity....
Inx Medical.... IoGyn .... Iomai.... ... Iomed....
IOmet
Pharma ..... Ion America Optics..... Ionic Materials ..... Ion
Torrent.... Iovance Biotherapeutics ..... Iovation.... Iowa Thin
Film....
Ipierian.... IPG Photonics.... ... Iquum
...Irhythm...
iRobot... Iroko...Ironbridge.... ... Ironwood....
... .... Irvine Sensors... .... biopolymer
. .... Ischemia Care.... iSee ..... iSIGHT
Partners
.....
Isis.... Island Ddata....
Isogenis.... Isomark.... IsoPlexis .... Isoray....
Isothermal....
Isthmus Biosciences ..... IstoTechnologies....
itaconix....
I-Therapeutix..... Itherxm Pharmaceuticals.... Itraumacare... .. Itseez
..... Itzbig ..... Iwalk
Jade Therapeutics ..... J&Y ... Janssen Biotech .... Janus Biotherapuetics ... Javelin Pharmaceuticals ... Javelin Semiconductor ... JDP Therapeutics ..... Jennerex ... Jnana Therapeutics ..... Joule Biotechnologies .... Jounce Therapeutics .... Joyent .... Joylux .... Juno Therapeutics ..... Just Biotherapeutics
K2M .... K2 Therapeutics .... KAER
Biotherapeutics .... Kala
Pharmaceuticals ... Kallyope ..... KaloBios
Pharmaceuticals
..... >Kalocyte .... Kalon
Biotherapeutics ..... KalVista Pharmaceuticals .... Karius .....
Karyopharm Therapeutics ... Kateeva
..... Kayo
Technology ..... KaZaK
... KC BioMediX ... KCI .... KDH Defense Systems
... Kebotix .... Keithley Instrument ...
Kelyniam ...
Kenall
Manufacturing
..... Kensey-Nash
... Kent Displays ... Kentucky
BioProcessing ....
KeraNetics .... Keros Therapeutics ..... Kezar Life Sciences ..... KeyW
.... Kilawatt
Technologies ... Kindara .... KinDex ... KindHeart ..... KineMed ....
Kinestral Technologies ..... Kineta ...
Kinetic
Concepts .... Kinex
Pharmaceuticals .... Kingbright .... Kior .....
Kips Bay
Medical ... Kite Pharma ..... Kitware ...
Kiva Systems ... KLD
Energy Technologies .... Klotho Therapeutics .... KMel
Robotics .... Knightscope
.....
Knome ...
Knopp
Neurosciences .... KNOW Bio ..... KnuEdge .... Koam
Engineering Systems .... Kodiak Sciences
.... Kolltan
Pharmaceuticals
...
Komoku ... Kona Medical .... Konarka ... Koning ...
Kopin
.. KOR
Electronics ...
Koronis Pharmaceuticals ... Kosan Biosciences ... Kosmetikos
....
Kovio ... KPI
Therapeutics (from Kineta)... Kraig Biocraft ..... Kratos Defense
& Security
Solutions
.... Kronos Advanced
Technologies ... Krystal Biotech .... KSE
... KSQ Therapeutics ..... Kultevat ..... Kura Oncology ....
Kumu Networks .... KVH
.. Kylin
Therapeutics
...
Kyma ....Kymera Therapeutics ..... Kymeta
... Kyn Therapeutics .... Kyocera
Solar .... Kypha ..... Kyras Therapeutics ..... Kyron Clinical Imaging
.... Kytopen
LAAMScience ... LaBelle
Associates .....
LabNow
...Laborie Medical Technologies ... Labrys Biologics ... Lacerta
Therapeutics ..... Lactic
Solutions ..... Laguna
Pharmaceuticals (formerly ChanRx) ..... La Jolla
Pharmaceutical
... Lake Shore Cryotronics .... Landec
.... Landos Biopharma .... Lantern
Pharma ..... Lantheus
...
Lantos
Technologies ... Lariat Biosciences .... Laser
Design .... Lasergen ..... LaserMax ..... LaserMotive
... Laser Tissue
Welding .... Lattice Biologics ..... Lattice
Biotech ....
Lawrie ... Lazarus Effect ..... LDR
Holding
..... Lead
Therapeutics
... LeafBio .... LeCroy ... LED Lighting
Fixtures
... Lehigh
Technologies .... Leica Microsystems
.....
LetoSolutions .... Lexicon
Genetics
... Lexicon Pharmaceuticals ... Leyden Energy ... Libra
BioSciences .... LifeCell ... LifeGen
Technologies ...
Life Image ... LifeMine Therapeutics .... LifeSprout ....
Life Technologies
....
Ligand
Pharmaceuticals ....Ligon Discovery ... Lightpointe
... Light Sciences Oncology ... LightWorks Optics
....
Lilliputian Systems
.... Lily Robotics ..... Linares Management
Associates
.. Lingotek
... LinQuest .... Lionano .... Lion Biotechnologies ..... Lipocine ....
LipoScience
...
Liquid Biotech ..... Liquidia
Technologies ...
Liquid Light ...
Liquid Metal
Battery ...
LiquidPiston ... Liquid Robotics ... Liquid X Printed Metals
....
LiQuifix ...
Lithium Technology
... LiveData ... . LiveLeaf
Bioscience .... Locus Biosciences .... Lodo Therapeutics .... Logical
Therapeutics
... LogicBio Therapeutics ..... Logos
Tech
... Lohocla Research
.....
Lombard Medical ..... Longeveron ..... LonoCloud .....
Lookingglass ..... Loon Medical
..... Lotus Tissue
Repair
...
Loxo Oncology ... LPath Thera .... Lq3 Pharmaceuticals ....
LS9
...
Luca
Technologies .... Lucerno Dynamics .... Lucidux ...
Lucigen
.... LumaSense Technologies .... Lumena
Pharmaceuticals .... Lumen Bioscience .... Lumencor
... Lumense .... Lumera ... Lumicell Diagnostics
...
Luminary
Micro ...
Luminex .... Luminus Devices ... Lumisyn
..... Lumitex
... LumiThera .... Lumos Pharma .... Luna Innovations
... Luna
Technologies
... Lung Therapeutics .... Lutonix
...
Luxtera
... Lycera ... LyGenesis ..... Lyncean .....
Lynntech ... Lynx Biosciences ... Lyra Therapeutics ..... Lysosomal
Therapeutics ....
Lytro Therapeutics
M3 Biotechnology .... MabVax .... MacAulay-Brown
..... Macrochem ...
MacroFab ..... Macrogenics
... Macrolide Pharma ..... Macrophage Therapeutics ....
Madison
Vaccines .... Madrigal Pharmaceuticals ..... MagBioSense ..... Magenta
Therapeutics ..... Magic Leap
..... MagneMotion ...
Magnesium Development ..... Magnetek ... Magnolia
Medical
Technologies .... Magnolia Optical
Technologies
... Magnolia Solar ... Mainstay Medical International ......
Mainstream Engineering ... Major
Pharmaceuticals .... Mako Surgical
... Manhattan Scientifics ..... Mantra Bio .....
>Manufcturing Techniques ..... MapInfo
...MAP
Pharmaceuticals
... Mapp
Biopharmaceuticals .... Marathon Pharmaceuticals ..... Marcadia
Biotech
... Marina Biotech ... Marinus
Pharmaceuticals
... Maritime Applied Physics .... Marrone Bio Innovations
....
Martek Biosciences ...
Mascoma ... Mashery
... Mason Box ... Masten Space Systems
... Masterson Industries .... Mast Therapeutics
(formerly
ADVENTRX) .... Material Sciences ... Material
Technologies ... MathStar ... Mati
Therapeutics .... Matouk
Textiles ... Matritech ... Matrix Product Development
.....Matrix
Research ....
Matrix Sensors ... Maverick Therapeutics .... MAX
BioPharma
...
MaxCyte ...... Maxdem
... Maxpower ... Maxygen ....
MBio Diagnostics
.... MC10 .... MCube .... M
Cubed Technologies .... MD Biosciences ..... MDSolarSciences
... Mebias Discovery ..... Mechanical
Technology
...
Mechanology ... Medafor ...
Medarex ...
MediBeacon .... Medicago USA .... Medical21 ..... Medical Cyberworlds
.... Medical
Device Logistics ...
MedicaMetrix... Medgenics ..... MediciNova .....
Medicool
Technologies .... MedImmune ..
Medina Medical .... Mediomics .... Medior Therapeutics .... Medis
... MEDITE Group .... Medivation ... Mednology Solutions ....
Medrobotics ...
MedShape .... MedSocket (formerly 1CDS) ...... Medsphere Systems .....
MedTel ..... MEI Pharma
..... Meka .... MELA
Sciences .... Melinta Therapeutics .... Melior Discovery .... Memjet
...Memry ...
Memsic ... MEMS Optical...Menlo Therapeutics ..... MER
...
Mercator Therapeutics ... Mercury Computer
Systems .... Merganser Biotech ....
Merge
Technologies ... MeriaGTx ..... Meridian Bioscience
... Meritage Pharma ..... Merkatum ... Merrimack
Pharmaceuticals
... Meryx .... Mersana Therapeutics ... Mesa
Photonics ... Mesocopic
Devices ... Metabasis ... Metabiota .... Metabolic Solutions
Development .... Metabolex .... Metabolix
... MetaCarta ... Metacrine .... Metactive Medical
.....
Metal Oxygen
Separation Technologies ... Metamark Genetics ...
MetaModix
... Metavention ..... Metompkin Seafood .... MetroLaser ...
MGC
Diagnostics
...
MIACH Orthopaedics ..... Misaole .... Micell
Technologies
... Michelman ... Micracor .... Micrel ... MicroCoating ...
Micracor ....
Microbe Detectives
... Microbia ... Microbot Medical ... Microfluidics International
(Microbia)
... MicroGreen
Polymers .... MicroIslet ...
Microlin Bio ....
MicroMask ...
Micronics ... MicroOptical (New
Mexico)... MicroOptical
(Massachusetts) ... MicroOptx ..... MicroPower Technologies
...
MICROrganic Technologies .... MicrowSat
Systems .... Microscopy Innovations ..... Microstaq
... MicroTransponder ..... Microvision ... MicuRx
Pharmaceuticals
.... Midori Renewables
..... Mid Valley
Industries
... Millendo Therapeutics (born as
Attercor) ..... Million Concepts ..... Miltec .... MiMedx Group ....
MimiVax ....
Minerva
Biotechnologies
... Minerva Neurosciences .... Minerva Surgical
.... Minimally Invasive Devices .... Minnesota
Thermal Science ..... Minnetronix ... MIOX ..... Mirador Biomedical
... Mira Dx ... MiRagen
Therapeutics .....
Miramar Labs .... Mirati Therapeutics ..... miRecule .... Mirimus ...
Mirina ... Mirna
Therapeutics.... Miromatrix Medical ...
Mirus Bio ....Mirum Pharmaceuticals ..... Mission Bio ..... Mission
Research ...
Mississippi Polymer ... Mithridion ...
Mitochon Pharmaceuticals ..... Mnemosyne
Pharmaceuticals ...
Mobile Robots ... Mobius Therapeutics ..... Moderna Therapeutics ....
Modern Meadow .... Modern Technology Solutions
.... Moduline Systems .... Modumetal ..... MOgene Green Chemicals ....
Molecular
Biometrics
... Mohawk
Innovative Technology ..... Molecular
Detection ... Molecular Diagnostics .... Molecular Imprints
... Molecular
Insight
Pharmaceuticals ... MolecularMD ... Molecular
Sensing ...
Molecular
Templates
.... Moleculin Biotech ..... Molten
Metal .. MoMelan Technologies ... Momenta
Pharmaceuticals ... Monebo ... Monogram Biosciences
.... Monteris Medical ..... Morphic Therapeutics
.....
Morphormics
... Morphotek
...
Morris
Innovative Research ... Mortara Instrument ...
MortaSecurity .... Motricity
... Motus Therapeutics .... Mound Laser
& Photonics Center ..... Movia Robotics ..... Moximed .... MPP
Group ... MPSP ...
MSNW ....
Mudawar Thermal
Systems
.....
Munksjo Paper ... Muons ... Muse bio .... Myco
Technology
....
Myocor
... MyoKardia
...
Myomo
... Myonexus Therapeutic ..... Myovant Sciences
.....
Myriad Genetics
...
Myriant
Technologies
... Mystic Pharmaceuticals
N12 Technologies
... (N30 Pharmaceuticals) now Nivalis Thera .... NABsys
... Nalas
Engineering ....
NanOasis Technologies ... NanoBio
...
Nanobiosym ... Nano-C ... NanoCellect (formerly NanoSort)
.....
Nanocomp Technologies ...
NanoCoolers ... Nanocopoeia ... NanoCor Therapeutics
...Nanodynamics (Buffalo) ... Nano DX ..... Nanodynamics
(NYC)...
NanoeXa
.... Nanofiber Solutions ... Nanogen ... NanoGraf (formery SiNode)
..... NanoGram .... nanoGriptech
..... NanoH2O ... Nanohmics ... NanoLab
... NanoLite Systems ... NanoLogix ...
NanoLumens
..... Nanomaterials
Research
... NanoMatrix ... NanoMedex ... NanoMedicalSystems
...
NanoMedical Systems .. Nanomix ... nanoMR ..... Nanophase
Technologies
... NanoPhotonica ... Nanopore Diagnostics ..... Nanoptek
... Nanoramic
Laboratories (formerly FastCap Systems) ..... nanoRETE .... Nanoscale
Components ...
Nanoscale
Materials
... Nanosolar ...
Nanosonic ... Nanospectra Biosciences .... Nanosphere ... NanoSteel
...
Nanostim .... NanoString
Technologies .... Nanosys ...
NanoSystems ... Nano Tailor ... Nanotek Instruments
.....
Nano-Terra ... Nanotherapeutics ..... NanoTune Technologies
... Nanova
....
Nanovation
Technologies ... NanoVault Medical .... NanoViricides
... NanoVision Diagnostics .... NantCell
..... Nantero
... Napo
Pharmaceuticals ... NantKwest ..... Narus
Biotechnologies ..... Nascentric
... Nastech
Pharmaceutical ... Natera .... National Technical Systems
..... Natural Molecular Testing ..... NaturalNano ...
Nature's
First .....
Natus Medical ... Naverus ... Navidea
Biopharmaceuticals ... Navini Networks
... Navire Pharmaceuticals .... Navitor Pharmaceuticals ....
Navmar Applied Sciences
... NBD Nanotechnologies ....NCD Technologies
.... nContact
Surgical ...
Neah Power ... Near Infinity .... Neato Robotics ... Nektar
Therapeutics ... Nekton
Research
.... NemaMetrix .... NeoChord ... Neogen
.... NeoGenomics ..... Neograft
..... NeoLight ..... Neon Therapeutics ....
NeoPhotonics ... Neoprobe
...
Neos Therapeutics ..... NeoSync ..... Neothetics .... Neotron
...
NephroGenex .... Nereus
Pharmaceuticals ... Nest .... Netcentric .... Netezza ...
NetLogics
Microsystems... Netspeed Systems ...... Net Watch
Solutions
..... NetworkFab
...
NeurAccel
Biosciences ...
Neurala .... Neural Analytics .... Neuralstem .... Neuraly
..... Neuraptive
Therapeutics .....
Neuro
Amp .... Neurobiological
Technologies
...
NeuroChaos Solutions .... Neurocrine Biosciences
...
NeuroDx Development ... NeuroEM .... Neurodyne Medical ...
Neurofluidics ....Neurogastrx .... Neurogen
... NeurogesX ...
Neurognostics .. NeuroHabilitation .... NeuroLogica
.... NeuroLutions ..... NeuroMap
... Neuro Kinetics ....
NeuroMetrix... Neurona Therapeutics .... Neuronetics .
Neuronex .. NeuroOne ..... NeuroPace
...
NeuroPhage
Pharmaceuticals
... Neuron Systems ... NeuroPointDX
..... Neuroptix
... Neuroscience .... NeuroTek .... Neurotrack ....
NeuroTronik .... Neurotrope ..... Neurovance
... NeuroVigil ...
Neurovascular
Diagnostics ..... NeuroVision Imaging .... NeuroVista ....
NeuroVive
.... NeuWave
Medical ...Nevro ... New Dominion Enterprises ..... NewLeaf
Symbiotics .... NewLink Genetics
.... Newlink genetics england ... biolabs ...
new
era technology ... New Haven Pharmaceuticals ... Nexant
...Nexbio
... NexImmune .... NexPlanar .... NextCODE Health ....
NextCure ..... Nextio ....
NEXTracker
....Nextreme Thermal Solutions ... NextStep Robotics .....
Nexus
Biosystems ..... NG1 Technologies .... NGM Biopharmaceuticals .... Nico
..... Night Vision ...
Nimblegen Systems ... Nimble Storage ....
Nimbus Discovery ... Nimbus Therapeutic
.....
Ninepoint
...Niowave ... NIRvana Sciences .... Nitero....
Nitric Biotherapeutics
....Nitricgen ... Nitride Solutions .... Nitrogenics .....
Nitromed ...Nitronex
... Nivalis Therapeutics formerly N30 Thera ..... NKT
Therapeutics ...
Nlight ... NMT Medical .... Noah
Technologies ....
Noble Fiber
... Nohla Therapeutics .... Noivatone .... Nok Nok
Labs
....
Nomadics .... NONA Composites .... Noninvasix ....
Nonvolatile
Electronics .... Nora Therapeutics .... Norian ... NorMedix
.....
Normoxys
.... Norse .... Northeast Photosciences
... Northstar Medical
Radioisotopes .... Northstar Photonics...
Northwest Biotherapeutics .. Norwich Technologies ....
Nostopharma .... Notice
Ttechnologies ... .Novacea
... Novalar Pharmaceuticals ... Novalux
... Novan
Therapeutics .... NovaScan
... Nova Synthetix .... Novatek ... NovaTorque
... NovaTract
Surgical
... Novavax .... Novazyme Pharmaceuticals ..... Novecon
Technologies ... Novella
Clinical
.... Novelos
Pharmaceuticals
... Novelos Therapeutics ... Noveome Biotherapeutic
.....
Novian Health .... Novira
Therapeutics ...
Novocell ... Novogy
... Novomer ...
Novophage ... Novo Sol-u-tions MD .... Novosource ...
Novozymes .... Novus Biologicals ....
Noxilizer
... Nox Technologies ... NP Photonics ...
NPS Pharma ..... NRGindependence ..... NSS Labs
..... Nucelis
.... Nuclea
Bioechnologies ... Nufern .... NuGEN Technologies ..... NuMat
Technologies ..... NuMedii
.... NumereX .... NUMiX Materials ..... NuPathe .... Nurel
(now PeriphaGen) ....
Nuron
Biotech ... Nutrabiotix
... Nutrient Recovery and Upcycling .... NuVant
... NuVascular Technologies .... Nuve ..... Nuventix ...
Nuvera Biosciences ... Nuvera Fuel Cells.. . Nuvotronics
.....
Nuvox
Pharma ..... Nu Waves ..... NxThera ... Nvision
Biomedical
Technologies ..... NZ
Applied Technologies
Oak-Mitsui .... Oasys ...
ObjectVideo
... Obsidian Therapeutics ..... OBS
Medical ... Ocarina Networks ... Ocata Thera ...
Occipital
....
Ocean Power
Technologies
... Ocean Renewable Power .... Ocera Thera .... OCI ...
Ocugen ..... Ocular
Therapeutix
....
Oculeve
... Oculogica ..... Oculus ... Oddpost
... Odyssey Systems
Consulting Group ... Oil Chem
Technologies ... OLEDWorks .... Omeros
... OmniGene Bioproducts ... OmniGuide ...
OmniLytics
... Omniox ..... OmniSonics Medical Technologies
... Omnis
PharmaRebiotix .... Omni
Water Solutions ... Onboard Dynamics .... ONCE Innovations
.....
OnChip
Power .... Oncobiologics ..... OncoCyte
.... Oncogenex
... Oncolmmune ..... Oncolinx .... Oncolix ..... Oncolytics
Biotech
...
OncoMed
Pharmaceuticals .... OncoNano Medicine .... Onconova
Therapeutics
...Oncoscope
...
OnCore Biopharma ..... OncoResponse ..... Oncorus .....
OncoSec
Medical
.... OncoTartis ...... Oncothyreon
... Oncovista Innovative Therapies ..... Onduo ..... One
Resonance Sensors .... Onko
Solutions .... ONL
Therapeutics ....
On-Q-ity .... Onspira Therapeutics .... On Target
Laboratories
.... Ontela ..... On-X
Life
Technologies ....
Onyx
Pharmaceuticals ... Oorja
Protonics .... Open Algae ... Open Monoclonal Technology
.....
Open Silicon
... OpenWater
Power .... Opertech Bio ..... Opexa
Therapeutics
... OpGen ... OPNET Technologies
... Opsonix .... OptTek
Systems ... Optelecom ...Optelecom-NKF ... Optherion ...
Optical
Concepts .. Optigain .. Optimal Technologies ... Optimus
Technologies .... OptiNose .... Optivision
...
Optofluidics ... OptoLum ..... Optonicus .... Opto Technology
...
Optomec
....
OPX
Biotech
... Oragenics .... OraMerix
... Orasi Medical ... OraSure
Technologies ....
Orbital
Technologies
... Orbotix .... Orchard Therapeutics ..... Orchid
Cellmark
... Oregon Iron
Works .... Orexigen
Therapeutics
... Organic Research .... Organogenesis ...
Organovo
..
ORIC Pharmaceuticals ..... Oricula Therapeutics .... Origin
Medsystems ..... OriginOil
... Orion Energy Systems ... Orion Genomics ...
Ormet
Circuits ... Orologic... OrphoMed ..... Ortel ...
OrthoAccel
Technologies ... Ortho Kinematics
.... Oryx Technology ...Oscient Pharamceuticals ...Oscilla
Power
.... Osiris
Therapeutics ... OSI Pharmaceuticals ... Oso Biopharmaceuticals
Manufacturing .... Osprey Medical ....
Ossianix
... OSSIO ..... Ostendo Technologies ...
Osteotech ... Osterhout Design Group .... OtoNexus Medical
Technologies .... Otonomy .... OtoSense
.... Ottomatika .... Outset Medical .... OvaScience ...
>Ovid Therapeutics ..... Oxalo Therapeutics .... Oxford
Performance Materials ... Oxis International .... Oxygen
Biotherapeutics
P3I ... Pace Packaging .... Pacific Biosciences
.... Padlock Therapeutics .... Pain Therapeutics ...
PaizaBio .... Palantir Technologies .... Palleon Pharmaceuticals ....
Palmaz Scientific ..... Palmer
Labs
...
Paloma Pharmaceuticals ... Panacea Solutions ....
Panacos
... Pandion ..... Pandromics ..... Pan Genome Systems .... Panomics
..... PanTheryx .... Paper
Battery ....
PapGene .... Parabricks .... Paradigm Diagnostics
.... Paradigm
Sensors
... Paradromics ..... ParaGen Technologies ..... Paragon
Bioservices ..... Paragon Dynamics
...
Paragonix Technologies .... Parasol Therapeutics
... Paratek
Pharmaceuticals .... Parexel International .... Parion Sciences
... ParkerVision .... Partner Therapeutics ..... Partpic ....
Passport
Systems ... Pasteuria Bioscience ... Pathfinder ...
PathoGenetix
... PathoVax ..... Pathway Genomics .... PatientStream ...
PatientWise ...
Patton Medical Devices ... Patton Surgical .... Pavilion
Technologies ... Pax Streamline ... PaxVax ...
PDI Therapeutics ..... PDL
BioPharma ... PDS Biotechnology ..... Pearl
Therapeutics
... Pear Therapeutics ..... PECA Labs
.... Pediatric Bioscience .... Peerless Technologies .... Pegasus
Sustainability Solutions ....
Pelican
Products ..... PellePharm .... Pellion
Tech ... Peloton Therapeutics ..... Peninsula
Pharmaceuticals ..... PennAlt Organics ..... Penumbra .....
PeproMene Bio .... Peptimed
... Peptilogics .... Peptimmune
... Perceptive Navigation ..... Perceptive Sciences
... Perceptron ....
PercipEnz
Technologies
... Peregrine Semiconductor .... PeriphaGen .... Permeon
Biologics
...
Perosphere .... Perscitus Biosciences ... Perseon .....
Persimmon
Technologies ....
PersonalBee ... Personalis ...... Personal Genome
Diagnostics
.... Pervasis Therapeutics
... Pervasive
.... Petra Pharma ..... Pfenex ...
Pharmacyclics
.... PharmaJet .... PharmAkea Therapeutics ....
Pharmasset
... PharmAthene
... PharmatrophiX .... PhaseBio
Pharmaceuticals .... Phase Bioscience ... PhaseRx ....
Phigenix
..... Phoenix Biotechnology .... Phoenix
Nuclear Labs ...
Phoenix Science .. Phononic
Devices
... Photobit ... Photolitec .....
PhotoMedex
... Photonics
Innovations ... Photon-X ....
PhotoSonix Medical .... PhotoThera
...
Photronics ... Phoundry Pharmaceuticals .... Phrixus
Pharmaceuticals ..... Phurnace
Software ...
Phylonix
.... Phylos Bioscience ..... Physcient .... Physical
Optics... Physical
Sciences
... PhysioGenix
... PhysioSonics ... PhytoTech ... Picolight ....
Picometrix
... Piedmont Biofuels .... Pieris Pharmaceuticals ..... Pika
Energy ... Pilus
Energy ....
Pinger
...
Pinnacle Technology ... Pioneer Surgical
Technology .... Pionyr Immunotherapeutics ..... Pivot
Bio ..... Pixelligent .... Pixel
Optics .. Pixim ... Pixtronix ... Plakous Therapeutics .....
Planar Energy
...
Planar Systems ... Planet Labs .... Plano Microwave ..... Plasan ...
PlasmaTech Biopharmaceuticals .... Platelet
BioGenesis .... Platypus
... Play-i
.... PLC
Medical Systems
... Plextronics ... Plexxikon
... Pliant Therapeutics .... Plug
Power ... Pluromed ... PLx Pharma ..... PLX Technology ....
PMT
.... PMV Pharmaceuticals .... PneumRx .....
Point Source .... Polarean ..... Polatis
.... Polychromix
...
Polyera ... PolyMedica ... PolyMedix ... Polymer
Technology
Systems ... Polynoma ..... PolyNova .... PolyPlus ... PolyRemedy ...
Polysciences ... Polystor ... Portola
Pharmaceuticals ... Poseida Therapeutics .... Possis
Medical ... Pothole Pros ... PowerGenix ...
Powerlight
... Power
Precise Solutions ... PowerVision ... Pozen ... PQ
Bypass .... Prairie
Technologies ..... Pranalytica ... Praxis Biotechnology .....
Precision Biopsy
...
Precision BioSciences
.... Precision for Medicine .... Precision Genome
Engineering .... Precision Ocular Metrology ..... Precision Optics
...
Precision
Therapeutics (now Helomics) .... Precision Virologics .... Predictive
Biosciences
... Pregmama ..... Presage Biosciences
... Presidio
Pharmaceuticals
.... Pressure BioSciences
... PreTalen ..... Prevail Therapeutics ..... Preventice .....
Prevention
Pharmaceuticals ....
Prieto Battery ..... Primary Data ..... Primera
Biosciences ... Primordial .... Primorigen Biosciences
... Primus Power .... Princeton Satellite
Systems ..... Principia Biopharma ....
Prism
Solar Technologies .... Procept BioRobotics ..... ProCertus
BioPharm
... Processa Pharmaceuticals .....
Proclara
Biosciences (formerly
NeuroPhage
Pharmaceuticals) .... Procyrion .... Profectus BioSciences .
.. Progenics
Pharmaceuticals
... Progenity .... Progeny Systems ..... Prologic
...
Promedior
...
Promega .....
Promentis
.... Pronutria ..... Propagenix ..... Propeller
Health ....
Propulsive Wing
.... ProstaGene ....
Protagonist
Therapeutics .... Protein Foundry ..... Protein Sciences
... ProteinSimple (formerly Cell
Biosciences) .... Proteon Therapeutics
...
Proteostasis
Therapeutics
... Proteotech ... Proteus
Biomedical
... Proteus Digital Health .... Protez Pharmaceuticals
.... Prothena .... ProThera Biologics ...
Proto Labs ... Proton Energy Systems ...Protonex ..
Prototype
Productions .Provagen ... Provenance Biopharmaceuticals
... Provention Bio .... Proventys
... Provista Diagnostics .... Pryor Medical Devices .....
PsiKick
..... pSivida
... PTC Therapeutics
.... Pulmatrix ... Pulmonx .... Pulmotect ..... Pulse
Electronics ....
PulseTherapeutics .... Puma Biotechnology ..... PUR
Biologics ..... Pure Bioscience .... Purfresh
... Purillume ..... Pursuit Vascular ... PurThread
.... PvP
Biologics
Qcept Technologies .... Qcue .... QD Vision
...
QED ... qFuzion ..... Qioptiq
... QM Power
... Qpex .... QPixel ... QR
Pharma
... QSpex .... Qteros
... QuaDPharma .... Quadra-Aerrow International ...
Quadraspec
...
Quad Technologies .... Qualcomm ... QualityMetric
...
Qualtech Systems ....
Qualtré ... Quanterix
... QuantRx Biomedical
.... Quanttus .... QuantTera .... Quantum Circuits ..... Quantum
Epitaxial
Designs ... Quantum Fuel Systems... Quantum Logic
Devices
... Quantum Materials .... QuantumSphere
.... Quantum Xchange .... Quark
Biotech ... Quark
Pharmaceuticals ... Qubitekk ..... Quentis Therapeutics .....
Quick–Med
Technologies .... Quid ..... Quidel
... Quincy
Bioscience
... Quintessence Biosciences ... Quorum
Systems
Radant Technologies ... Radiabeam Technologies
... Radiance Technologies .... Radiant Photonics...Radiation
Monitoring Devices
... RadioMedix ... Radius
Health ....
Rafagen ... Rainbow Organic Farms ... RainDance
Technologies
...
RainStorm ...
Rain Water Solutions ... Rallybio ..... Raland Therapeutics .... RaNA
Therapeutic ...
RAN Biotechnologies .... Range Fuels
... Rapamycin Holdings ..... RaPharmaceuticals
... Rapid Diagnostek ... Rapid
Micro Biosystems
... Rapiscan ... RareCyte ..... Raser Technologies
.... Raydiance ... Raydiant Oximetry .... Raymond
.... Raze
Therapeutics
.... RE2
.... Ready Robotics ..... Reata Pharmaceuticals .... Rebellion
Photonics .... Rebion ..... Rebiotix ....
Receptor Logic ...
Receptos
..... Recodagen ...
Recombinetics
... ReconRobotics
.. Recovery Engineering ..... Recro Pharma ....
Recursion
.... Redox Power
Systems .... Red
Rock
Biofuels .... RedShift BioAnalytics .... Redwood Robotics .... RedZone
Robotics .... RefleXion
Medical .... Refuge Biotechnologies .... Regado
Biosciences
... ReGear Life Sciences ..... ReGen
Biologics ... Regenerative
Medical Solutions ..... Regenerative Sciences ... Regentys
(formerly Asana Medical) .... Regenxbio
....
Regulus Therapeutics ... Rehabtics .... Relay Therapeutics
..... ReliantHeart ....
ReliefBand Technologies ..... Relievant Medsystems
..... Relypsa .... Remedy Plan Therapeutics .... Remedium
Technologies ... RemoteReality .... Rempex
Pharmaceuticals .... Renaissance Services ..... Renegade
Materials .... Reneo
Pharmaceuticals ..... Renerva ..... ReNeuroGen .... Renewable
Alternatives
... Renewable Energy Group .... Renmatix .....
RenovoDerm ..... Renovia .... Renovion .... Renovis ...
Rentech ... Replidyne
...
Repligen .. Replimune Group .... Research Frontiers
.. Research Innovations ..... Resolve
Therapeutics
... Resolvyx
Pharmaceuticals ... Resonetics ..... Respicardia
... Respira
Therapeutics .... Response Genetics
...
Restoration Robotics ..... resTORbio ..... Restore Medical ... Retectix
..... Retek
...Rethink
Robotics ... Retia Medical .... Retriever
Technology
.... RetroSense Therapeutics ..... Reva Medical
... Revance Therapeutics Pharmaceutical ....
Revegen
... ReVision Optics ....
ReVision
Therapeutics .... Revitope Oncology ..... ReVivo Medical
....
RevMedx .... ReVolt Tech
... Revolution
Medicines .... ReWalk
Robotics (Israel) .... Rexahn
Pharmaceuticals
... Rex Computing ..... RF Code ...
RFMicron
.. RFS Pharma ..... RF Surgical.
.... Rgenix .... Rhenium
Alloys .. Rheos Medicines ..... Rheostat
Therapeutics ..... Rheumco .... Rhevision
... Rho ... Rhythm Pharmaceuticals ... Rhythmia
Medical
... Ribometrix ....
RiboNova .... Ribon Therapeutics ..... Rib-X
Pharmaceuticals ... Rice Technology ..... Ridgetop
Group ... Rigel Pharmaceuticals .... RightEye ..... RightHand
Robotics .... Rinat
Pharmaceuticals
.... Rinovum Women’s Health ..... Rio Grande Neurosciences .....
RipCode ... Rite
Solutions .... Ritter
Pharmaceuticals ..... River Vision Development ..... Rive Technology
... RJA Dispersions ... R.L. Phillips ...
RMH
Sciences ...
Robb Surgical Devices .... Robopsy ...
Robotic FX ... Robotics VISION
Technologies ..... Robotic Technology
... Rocket Pharmaceuticals .... Rockwell Medical
..... Rocky Research .... Rodin Therapeutics ... Roka
Bioscience
.....
RoosterBio .... RootPath .... Rosina Food Products ....
Ross Valve ..... Rotational
Medical .... RotoMetrics ..... RoverMed Biosciences ..... Rowbot
Systems .... Royole ..... RQx
Pharmaceuticals .... RRE
Solar ....
Rubicon Tech ...
Rubigo Therapeutics .... Rubitection ..... Rubius Therapeutics ....
RubrYc Therapeutics ..... Rules-Based
Medicine
... Rushford Hypersonic ... Ruud Lighting ..... RxFunction
...
RXi Pharmaceuticals
...
RxMedic .... Rypos
S2 ... Sadasis .... SafeShot .... Saffron
Technology
.... Sage
Electrochromics ... SADAR 3D .... Sage Science ... Sage
Therapeutics ...Sakti3 ... Salarius
Pharmaceuticals .....
Salient Surgical
Technologies
... Salix
Pharmaceuticals ... Salutaris Medical Devices ..... SAM Medical ....
Sancilio
Pharmaceuticals .... Sand 9 .
.. Sandia Biotech .... Sangamo
Biosciences
... Sangart
... Santalis Pharmaceuticals ..... Santarus .... Sanuwave
Health
.... Sapheon .... Sapphire
Energy ....
SARbarcode .... Sarda
Technologies ...
Sarepta Therapeutics .... SatCon
Technology ...
Satori Pharmaceuticals
.... Savara Pharmaceuticals .... Savi ...
SBH
Sciences ...
Scanadu ..... Scholar Rock .... Sciaderm ..... SciClone
Pharmaceuticals
... Sciencescape ..... Scientific
Conservation .... Scientific Research ...
Scientific
Solutions ... Scientific Systems ... SciFluor Life Sciences ... Scilex
Pharmaceuticals .... Scinovia ..... Scioderm .... SciQuest ...
Scopic Software
... Scout Bio .... Scynexis ...
SD Catalyst
Group ... SDL .. SeaChange ...
Seacoast Science
... Seahawk Biosystems ... Seahorse
Bioscience
... Seaside Therapeutics .... Seattle BioMed .....
Seattle
Genetics
...
Seattle Medical Tech .... Sebacia .... Second Genome ....
Second
Sight Medical
Products ... Securboration ..... Secure
Computing ... Sedia Biosciences ..... Seeo
....Segetis ... Seldon
Labs ... Selecta Biosciences
... SELLAS Life Sciences Group .... SeLux
Diagnostics .... Sema4
Natalis
..... Semiconductor
Laser ... SemiProbe ... Semler
Scientific
.... Semma Therapeutics .... Semnur
Pharmaceuticals .... Semprius ... Semprus
BioSciences .... Sencera International ...
SenesTech .....
SenGenix ....
Senior Scientific ..... Seno Medical
Instruments .... Senomyx
... SensAble Technologies ... Sense .... Sense
Diagnostics
....
Senseonics ..... Sensintel .... Sensiotec ...
Sensors
Unlimited
... SensorTran ... Sentelligence
... Senti Biosciences ..... Sentient
Technologies ..... SentreHEART ..... Sepracor
... SeprOx .... SeQual Technologies ... Sequella ...
Sequel
Pharmaceuticals .... Sequenom ... Sequenta ...
Sequent
Medical
.... SeraCare Life Sciences ... Seragon
Pharmaceuticals .... Seraxis ..... Seres Health .... Serenex
... Sermonix
Pharmaceuticals .... Servergy .....
SetPoint Medical .... Seurat Therapeutics ..... Seventh Sense
Biosystems ...
SGB
Biofuels ..... SGX
Pharmaceuticals ...
Shamrock Energy ... Shape Pharmaceuticals ..... Shape Security ....
Shapeways .... Sharklet
Technologies ..... Sharp Edge Labs ..... Shift Labs ..... Shift
Pharmaceuticals ..... Shiloh
Labs ....Shine
Medical Technologies
... Shore
Thing Shellfish .... Shuttle
Pharmaceuticals ..... Si-Bone .... Sicel Technologies ...
SiCortex
... Sideris Pharmaceuticals ..... SI
Diamond Technology .... Sienna Biopharmaceuticals ..... Sierra Energy
..... Sierra Monolithics
... Sierra Nevada ...
Siga Technologies ...
SiGe Semiconductor ... Sigilon Therapeutics ....
Sigma Labs
(NM) .... Sigma
Technologies .... SignalFX (formerly Signal Fuse) ..... Signal Genetics
.... Signature
Genomic Laboratories
... Sila Nanotechnologies .... Silarus Therapeutics
.... Silatronix ..
Silent
Power ... Silicon Biosystems Menarini ..... SiliconBlue
....
Silicon Laboratories ...
Silicon
Mountain
Design .. Silicon Space Technology .... Silk .... Silk Tech ....
Siluria ...
Silverbrook
... Silverback ..... Silvergate Pharmaceuticals .... Silver
Spring Networks
... Simbol Materials ... Simply Incredible Foods ... SiMPore
...
Simulation
Technology and Applied Research ... Simulution
... Singlera Genomics ..... Singulex ... Sinmat
... SiNode Systems .....
Sintact Medical Systems
..... Sion
Power
... SiOnyx ... Sioux Manufacturing ...
Sirga Advanced
Biopharma .... Sirion Therapeutics ...
Sirnaomics ..... Sirna
Therapeutics ... Sirtris Pharmaceuticals ... Sisu Global
Health
..... Sitari Pharma .....
Skybox Imaging .... Skyhawk Therapeutics ..... Skyline Medical
....
Skyonic
... SLI .. SLIPS Technologies .....
SmartCells
... Smart Modular
Technologies ... SmartSpark Energy Systems ...
Smart
Structures .... Smart Wires ..... SmartZyme BioPharma ....
Smisson-Cartledge Biomedical ...
Smooth-Stone
...
SNP Bio ..... Socrates Health Solutions .... Soft Machines
....
Soft Robotics ..... SoftSwitching
Technologies
... Soft Tissue
Regeneration ... Soladigm (now View) ..... SolAero
Technologies ..... Solaicx ....
Solais Lighting
....
Solana Surgical ..... SolaranRx ..... SolarBridge
Technologies ... Solar Connection ....
Solarea .....
Solaria ...
Solarmer
Energy ...
Solar Power Technologies ... SolarWinds
... Solazyme
... Solexant ... Solexel ... SolFocus ... Soliant
... Solid Biosciences .... Solid Concepts ..... SolidEnergy
....
Solidus Biosciences
..... SolidWorks
... Soliris .... Soliton ..... Solixia
... Solix
Biofuels
... SolMap
Pharmaceuticals ... SoloHealth ... Solomon
Technologies
... Solo Power .... Solstice Biologics .... Soluble Therapeutics ....
Solx ....
Solyndra ... Soma .... SomaLogic .... Somatic Labs
..... Somaxon
Pharmaceuticals ....Somna Therapeutics ...
Sonalysts ...
Soneter .... Sonex Aircraft ... Sonitus Medical
... Sonivate ..... SonoSite
... Sonovex .... Sontra Medical ... Sonus
Pharmaceuticals
...
Sophiris
Bio .... Sophono ..... Soraa .... Sorrento Therapeutics ....
Soteira
... Sostena .... Sotera Wireless ... Sound Pharmaceuticals
.....
Sourcefire
... Source MDx
... Southwall Technologies ... Southwest Windpower
...
Space Dev ...
Spaltudaq ... Spansion .... Sparkbuy ..... SparkCharge .... Spark
Therapeutics ....
Sparo Labs .....
Spatial Photonics
...
SPEC ..... Spectra254 .... Spectragenetics .... Spectral Energies .....
Spectral
Systems .....
Spectranetics ...
SpectraWatt ... Spectro Coating ... SpectrumS4 ....
Speech
Tails ... Speer Medical .... Spero Therapeutics ..... Spinal
Modulation ..... Spinal
Restoration
... Spinal Simplicity ..... Spinal
Stabilization Technologies ..... SpineEX .... SpineGuard ...
Spineology
... Spine Wave .. Spintech .... Spin
Transfer
Technologies ....
SpiralGenetics .... Spiral Therapeutics .... Spiration
... Spire
... Spirox (formerly Nasoform) ..... Spoonflower .... Spotfire ... Spot
On Sciences ...
Spredfast
... Spring Bank Pharmaceuticals ... SpringLeaf Therapeutics
... SpringWorks Therapeutics .... SPR Therapeutics
.... Spyrix ....SQZ
Biotech ..... SRL ... Staktek Holdings ... Standard
Bariatrics .... STAR Cryoelectronics
... Starfire ... Startech Environmental
... Startup Circle Pharma .... StarVision
Technologies .... Stasys Medical ..... SteadyMed Therapeutics
..... Stealth
Therapeutics ... Steel City Optronics ....
Stellaray
.... Stellar Biotech .... Stellar Science ....
Stellent .... Stemagen ... StemBioSys .... Stem Cell Assurance (Now
BioRestorative Therapies) .... StemCells
... Stemcentrx ..... StemCo
Biomedical ... Stemgent ...
StemImmune ....
Stemina Biomarker
Discovery ... Stemonix ..... Stem Pharm .... Stereotaxis ...
Sterilmed ...... Sterling
Semiconductor ..... StimMed ..... Stirling Energy .... Stoke
Therapeutics ..... Stottler
Henke ... Straight Flight .... Stratagene ... Strata Oncology
..... Stratasys
... Stratatech
... Strategic Response Initiatives .... Stratos
Genomics
... Strella Biotechnology ..... Stromedix ....
Strongbridge
Biopharma .....
Sucampo Pharmaceuticals ..... Summit
Technology
.... Sun BioPharma ..... Sun Catalytix
.... Sunesis
Pharmaceuticals
.... SunHealth Solutions ... Suniva ....
Sunovion
Pharmaceuticals
... SunPower ... Sun Power Biodiesel ...
Sunrise
Ridge Algae ....Sunshine Heart .... Suntech ...
Suono ..... Superconductive
Components ... Superconductor Technologies ... SuperDimension ...
SuperFlex ..... Superior
Organoid Technologies ..... Supernus
Pharmaceuticals .... SuperPower ... Superprotonic
.... SupraSensor .....
Surefire
Medical
.... Surface
Logix
... Surface Oncology ..... Surgient ...
SurgiQuest
.... Surmet
... SurModics ... Suro Biopharma .....
Suros Surgical Systems
..... Surrozen .... SURVICE Engineering ..... Sustainable
Bioproducts .... Sustainable Oils ....
SustainX ... Sutro Biopharma ..... Sutron .....
SutroVax ..... SuturePro
Technologies (now Ceterix) .... SuviCA .... SuVolta ... Suzlon Rotor
... SVS
... SPEC ... Swallow Solutions .... SweetSpot Diabetes Care
... Swift Biosciences .... Syagen Technology
... Symbiomix Therapeutics ..... Symbiont Web
...
Symbotic ...
Symetrix .... Symic Biomedical ..... Symyx
Technologies
... Synack .... Synageva BioPharma ... SynAm Vaccine
....
SynapDx
....
Synaptics ... SynCardia Systems ..,.. Synchroneuron ....
SynchroPET .... Syndax
Pharmaceuticals
... Syndexa Pharmaceuticals .... Synedgen ....
Synergy
Biomedical
....
Synergy Pharma ..... SynGen .... Synlogic ..... Synopsys .... SynSonix
.... Synta
Pharmaceuticals ... Syntax-Brillian ... SyntheMed
... Synthetic Biologics ..... Synthetic Genomics
.... SyntheZyme .....
Synthorx ....
Syntimmune ..... Syntrix
Biosystems .... Syntronics .... Synvitrobio ..... Syros
Pharmaceuticals .... Sysgain .... Syslogic .... Systagenix Wound
Management .....
Systems and Processes Engineering
SPEC ... Systima Technologies ..... Sytera
T2
Biosystems ... T3D Therapeutics ..... Tabula ... Taconic
BioSciences ..... Tactical Engineering and Analysis ..... Tactile
Systems
Technology .... Tactiva Therapeutics ..... TAI Diagnostics .....
Talecris Biotherapeutics
... Talee Bio ..... Taligen Therapeutics
...
Talima Therapeutics ... Tal Medical ... Talon Therapeutics
... Tandem Diabetes Care ...
Tangen Biosciences
..... Tango
Therapeutics ..... Tanox ..Tantaline
.... TapImmune .... Tarari ...
.Targacept ...
TargeGen
... Targ-Anox ... Targanta
... Targazyme (formerly)America Stem Cell....
Targeson
... Targeted Genetics ... Targeted Growth
... Taris Biomedical .... Tarveda Therapeutics
..... Tascent .... Tauriga
Sciences
.... Taxa Biotechnologies ..... Taxon
Biosciences .... Taxus
Cardium (formerly Cardium Therapeutics) ... Taylor
Devices ..... TCR² Therapeutics ..... TDA
Research .... Tealium ..... TearScience
...
Tech-X .... Techniscan Medical Systems
... Technology
and Devices Int'l ... TechTol Imaging ... TELA Bio .....
Telecardia ...
TeleContinuity ... Telefactor ..... Telemedicine
Up Close operates as DxUpClose ...... Telik ... Tempest
Therapeutics ..... Templex
Technology... Tempus ..... Tenax Therapeutics .... Tenaya
Therapeutics ..... Tendril
...
Tendyne
Holdings ..... Tensha Therapeutics ...
Tepha
... TeraDiode .... TeraDiscoveries (now Cloud
Pharma) ....
Terapio ... TeraStor ...
Terrabon ...
Terrajoule ... TerraMetrics ... Terumo BCT .... Terus
Technologies .... TESARO ....
TeselaGen
Biotechnology .... Tessera
Technologies ... Tethys BioScience .... Tetra
Discovery
Partners .... Tetragenetics
... TetraLogic Pharmaceuticals ...
Tetraphase
Pharmaceuticals ... TetraVue ... Tezzaron
Semiconductor .... TFF Pharmaceuticals .... TGS Knee Innovations
... TG Therapeutics .... Thar Pharma .... Thalchemy ..... The
ExOne .... The Medicines ..... Therabron Therapeutics ..... Theraclone
Sciences
...
Theragenics
.... Therametric Technologies ... Theranos
....
Therion
Biologics ... Thermacore ... Thermage
...
Thermal Gradiant .... Thermal Spray Technologies
....
ThermalTherapeutic Systems
... Thermedical ...
ThermoAura ....
ThermoCeramiX .... ThermoGenesis .... Thermon ... TherOx ....
Thesan
Pharmaceuticals .... Theseus...
Thetis Pharmaceuticals ...
ThingMagic... Third Wave Technologies .. Thoratech
Tech
... Thorley Industries .... ThreeRivers 3D ..... Threshold
Pharmaceuticals ...
ThromboVision .... Thyritope Biosciences
.... Tiax
...
Tibbetts Industries
... Tibion ..... Tiburio
Therapeutics ..... Tilera ...
Tillges
Technologies ... Tioma Therapeutics ..... TissueGene ..... TissueLink
... Tissue Regeneration Systems .... Titan
Pharmaceuticals .... Titan Spine ..... TJ Technologies .... TLC
Precision Wafer
... Tmunity Therapeutics .... Tobira Therapeutics ....
Tocagen
...
Tokai Pharmaceuticals .... Tolerx .... TomoTherapy
... Tone Tree ..... Topia Technology .... TopicalRemedy ....
Topokine Therapeutics
.... Torax
Medical ... Torque Therapeutics ..... Total Immersion
...
TotipotentRx .... Totus Solutions .... TP Therapeutics ..... Trace
Genomics ..... Tracon
Pharmaceuticals
... TranS1
.... Transatomic Power .... Transcend Medical ...Transcept
Pharmaceuticals
.... TransCorp
..... Transcriptic ..... TransEnterix ... Transgenomic
...
Translattice
.....
TransMedics
... Transmeta ... TransMolecular
... Transphorm .....
TransTech
.... TransTech Pharma (now vTv Therapeutics) ... Transzyme
Transzyme Pharma ... Traverse
Biosciences ... Traycer
Diagnostic Systems ..... Trellis
Bioscience
... Trellis Earth Products ...
Trevena
... Trevi Therapeutics ..... Trex Enterprises ... Triad
Semiconductor .... Tri Alpha
Energy ..... Triangle
BioSystems .... Tribogenics
....
Tribologix
.... Trice
Orthopedics .... Tricida ..... Trident Systems ... Trilumina ....
Trimble Navigation
.... Trimeris
... Triquint
Semiconductor ...
Triton Systems ... Trius Therapeutics ...
TriVascular
Technologies .... Trovagene ..... Trubion
Pharmaceuticals ... Tru-D SmartUVC ..... True Diagnostics
....
True Health Diagnostics
.... True North Therapeutics .... Truestone ..... TruTouch Technologies
..... Try Eco ..... Tryton
Medical
... Tularik .... Turtle Mountain
Communications .... TVA Medical
... Tvardi Therapeutics .... Twelve .... Twentyeight-Seven
Therapeutics ...... Twin Star Medical ... Twist
Bioscience
..... TwoXAR ..... Tyme Technologies .... TypeZero Technologies ....
Tyrosine
Pharmaceuticals
....
Tyrx
uBiome .... UCAN ... UES
... Ulthera .... UltraCell ... Ultragenyx
....
Ultralife Batteries
...
Ultramet... Ultradian
Diagnostics ..... Ultraviolet Sciences ... Unbounded Robotics
.... Unchained Labs .... UNIAX
... Unica
... Unidym ... UniEnergy Technologies ..... Unified
Nexsys
.... Unilife ..... Uni-Pixel .... Uniqure
.... United
Devices ... United
Therapeutics
... United Therapies ..... Unity Biotechnology .... Universal
Cells ...... Universal
Display ... Universal
Robots ..... Universal
Technical Resources .... Universal
Technology .... Unleash Immuno
Oncolytics ..... Unum Therapeutics .... Unwired
Nation ... Uptake Medical
... UQM Technologies ... Urbix Resources ....
Urigen
Pharmaceuticals
.... UroGene Pharma ..... US
Nanocorp ... Uroplasty ..... US Bioscience ..... US
Silicones ... UTC Power .... Utilidata ... Utron
.....
UVision360
Vaccinex ..... Vaccinogen .... Vader Systems .....
Vala
Sciences
....Valencell ... Valence Technology .... Validity
Sensors
... Valmont Industries .... Vanda Pharmaceuticals
... Vanguard Space Technologies ..... Vapogenix ..... Variant
Pharmaceuticals ..... Vascudyne ..... Vascular
Biogenics (also VBL Therapeutics) .....
Vascular
Designs ... Vascular Genesis ..... Vascular Pathways
...
Vascular Pharmaceuticals ....
Vascular Solutions .....
Vasculox .... VasoGenix
Pharmaceuticals ... Vasoptic Medical ..... Vast Therapeutics
.... Vativ
Technologies ... Vaxart ... Vaxess
Technologies ....
VaxGen
...
VaxInnate ... vCalc .... Vecna Tech ...
Vectorlogics
....
Vedanta
Biosciences
.... Veeva Systems .... Veezyon
... VeinAid ... Velano Vascular .... Velicept
Therapeutic
..... Velocimed ...
Velomedix
... VelosBio ..... VenatoRx Pharmaceuticals ..... Venaxis
..... Vendormate
....
Veniti ... Vensun
Pharmaceuticals ....
VentiRx
...
Ventria Bioscience
... Ventrix ..... Ventrus
Biosciences ... Veracode
... Veracyte
... Veran Medical Technologies ..... Verastem
... VeraSun Energy
... VerAvanti .... Verax
Biomedical ... Verdezyne ... Vergent Bioscience .....
VerinataHealth ...
Verenium ... Vericel (formerly Aastrom Bio) .... Verifica-BG
... Veritas Genetics .....
Vermillion .... Vermont
Composites ...Veros Systems ... Verrica Pharmaceuticals .... Versar
.... Versartis ...
Vestagen
Technical
Textiles .... Vestaron .... VerteCore ..... VerteraSpine ..... Vertex
Pharmaceuticals ... VeruTEK Technologies ... Vesper
Medical
..... Vextec
... VGBioCogCubed .... V-Glass .... VGo
Communications ... VGX Pharmaceuticals ..... ViaCell
... ViaCyte
.... Viacor
.... Viamet Pharmaceuticals
... ViaSat
... Via Separations .... Vical . .. Vicarious .... Vicus Technologies
.... Vidacare
... View ..... Viking
Therapeutics .... Vion
Pharmaceuticals
... ViraCor Laboratories ... Viracta Therapeutics ..... Viral
Genetics ....
Virdante Pharmaceuticals ...
Virdia
.... Virent Energy Systems ... Viresco Energy
... Virobay .... ViroPharma . .. ViroXis ...
Virtify .
VirtualScopics
.... Virtusa
... Viscardia ..... VisEn Medical ... VisiGen
Biotechnologies
... VisionGate ..... VisionQuest ..... Vision-Sciences
... Vistagen
Therapeutics ... Vistec
Lithography ... Visterra ...
Visualase .... Vitae Pharmaceuticals ..... VitalMedix
... Vital Therapies ...... Vital Vio .... VitaPath Genetics
... Vitriflex .... Vium ..... Vivex Biomedical
.... Vividion Therapeutics ..... Vivisimo .... Vixar
... Vixel ... Vixiar Medical ..... Vizzario .... Vlingo
... VLST ..... VMware ... Voci Technologies .... Volcano ....
VoltServer ... VORAGO Technologies (previously Silicon
Space Technology) ..... Vorbeck Materials
... Vor BioPharma ..... Vortex Biosciences ..... Vortex
Medical
... Voxel
.. voxeljet ..... Voyager Therapeutics
.... Vtesse ....
VT
Silicon
.... vTv Therapeutics (formerly TransTech Pharma) ..... VUV Analytics
.... Vuzix .... Vyriad .... Vyrx
Pharmaceuticals ..... VytronUS
WaferGen
Biosystems ...
Wakonda Technologies ... Walker Magnetics Group ...
Waste2Watergy
.... Waveband
..... Wave Computing ..... Waveguide ..... WaveRx ... Weinberg Medical
Physics .... WellStat
Therapeutics .... Whole Biome ..... Whole
Trees
.....
WiBotic .... Wicab ..... WildcatDiscovery .... Wiliot .....
Willow Garage
...
Wilocity
.... Wilson
Greatbatch
.. Wilson Tool International .... Wilson Wolf Manufacturing
...
WiMax.com ...
Windlift ... Windtree
Therapeutics ..... WinSanTor .... Wintegra ... WISErg .... Wizbe
Innovations ...
WMR
Biomedical (now Arsenal Medical) ... Wolf Technical
Services ... WoundZoom .... Woven Orthopedic Technologies
....
Wright Materials Research
... Wright Therapy Products ..... W Solar
Group
X4 Pharmaceuticals ..... Xanofi ... Xanthus
Pharmaceuticals
... XBiotech USA ..... X-Body Biosciences
... Xcede Technologies ..... XCELL BIOLOGIX .....
Xcell Biosciences
....
Xcellerex ... XChanger
Companies .... Xencor .... X-energy ..... Xenetic Biosciences ....
Xenex
Disinfection Services .... Xenex
Healthcare Services ... XenoGen Biosystems .... Xenomics
... Xenoport ... Xeris
Pharmaceuticals ... Xetrios Therapeutics .... XF
Technologies .... xG Technology .... Xidex ... Xitronix
... XL
Hybrids ... Xlumena .... Xoc Pharmaceuticals ..... Xollai ...
Xolve
(formerly
Graphene Solutions)
... Xoma
... XProSciences (now Icagen) ..... X-Ray Optical .... X-Spine
.... XSunX
...
Xtalic .. Xtant Medical
Holdings ..... Xtent ...Xtreme Power
... XTuit Pharmaceuticals ....
Xunlight .... XyloCor Therapeutics .... Xynomic
Pharma
Yan Engines ... Yardney Technical Products .... Y-Carbon ... Yulex .... Yumanity Therapeutics .... Yurie
Z ... Zacharon Pharmaceuticals .... ZafGen .... Zavante Therapeutics ..... ZBB Energy ... ZeaChem ... ZeaKal .... Zebra Imaging .... Zebra Medical Vision (Israel) ..... Ze-gen ... ZenBio ... Zenomics .... Zenverge ..... Zeo .... Zephyr Technology ... ZeptoMetrix .... ZeroFOX .... Zero Locus .... Zero Mass Water .... ZetaRx Biosciences .... Zilker Labs ... Zinc Matrix Power ... Zintera ..... Ziopharm Oncology ... Ziptronix .... Zogenix ... Zosano Pharma ... ZPower ... ZS Genetics ..... zSpace ..... ZS Pharma ... ZSX Medical .... Zumobi ... Zunum Aero ..... Zurex Pharma ... Zwitter Technology .... Zyga Technology .... Zygo ... Zymergen ..... ZymoGenetics ... Zynerba Pharmaceuticals .....Zymeworks ..... Zyomyx ... Zystor Therapeutics ... Zyvex Technologies