News

Tetraphase Pharmaceuticals (Watertown, MA; no SBIR, founded 2006) won a $67m contract [in February] from America’s Biomedical Advanced Research and Development Authority (BARDA) for an antibiotic that might treat both anthrax outbreaks and serious infections in hospitals. GSK also has a contract with BARDA to test an antibiotic for Gram-negative bacteria. However, the company recently suspended enrolments to its trial because of complications in some patients. Seeking new ways to kill these vicious bugs is likely to be one of the main aims of the European Commission’s new partnership. [The Economist, May 12, 12]

Hewlett-Packard plans to cut its workforce by 25,000 to 30,000 employees, a record number for the venerable tech giant as it grapples with declining revenue and profits. [Wall Street Journal, May 18] Trouble in techno-land as R&D giant shrinks. It's no longer the visionary company that H&P invented and ran.

American Science & Engineering down 24% [May 15, 12] as revenue, earnings, and margins shrank

Solutions [to USG finance dilemma] are easy to come by “when you’re sitting at the Council on Foreign Relations in New York,” said Rubin, the council’s co-chairman. “It’s a lot harder to do it when you’re sitting in Washington and it’s one minute of midnight.” [Lori Montgomery, Washington Post, May 15]

Arena Pharma up 74% [May 11, 12] FDA advisory committee recommended the agency approve a drug [by Arena Pharmaceuticals] to treat obesity, the second time this year agency advisors have backed a fat-fighting medication. [Wall Street Journal, May 11, 12]

Onconova Therapeutics (Newtown, PA; $2M SBIR) raised $7.05 million in a private equity financing, according to [SEC] documents ... seeking to raise a total of $30 million. ... developing new therapies to treat cancer and related disorders. [John George, Philadelphia Business Journal, May 11, 12]

PolyMedix (Radnor, PA; $8M SBIR) said it has stopped enrollment in two clinical trials for its new drug candidate PMX-60056 because of observations of reductions in blood pressure in some study patients. [John George, Philadelphia Business Journal, May 10, 12]

Cell Therapeutics. (Seattle WA; 0ne SBIR) has received permission from the European Commission to market its cancer drug Pixuvri (pixantrone) in the European Union as well as in Iceland, Liechtenstein and Norway. [Jennifer Sokolowski, Puget Sound Business Journal, May 10, 12]

MicroVision said private investors have invested $5 million in the company [Puget Sound Business Journal, May 10, 12]

A123 Systems supported by grants from the Obama administration, reported a significant loss and drop in revenue as a result of quality problems and slower-than-expected demand for electric cars.The company also said it plans to raise $50 million through a private offering of convertible notes [Wall Street Journal, May 14, 12]

In a New York minute. New York has the nation's fastest-growing tech sector and has surpassed Boston as the No. 2 hub, behind Silicon Valley, for Internet and mobile technologies, according to a report released Wednesday by the Center for an Urban Future. .... in part because much of the innovation happening now is connected to industries that are centered in New York: advertising, fashion, financial services and media. ... The 10 New York tech start-ups that received more than $50 million in funding between 2007 and 2011 include Gilt Groupe, an online designer fashion sales company; ZocDoc, a platform for finding and booking appointments with doctors; Tumblr; and Foursquare. [Jennifer Maloney, Wall Street Journal, May 11] Despite sky-high taxes and space rental, it pays to sleep near the clients. Look for more wailing by the fly-over states on share of government contracts, including SBIR, even though it is unlikely that many of the start-ups in Silicon Alley will be looking for government handouts. One company with 16 DOD and NASA Phase 2s, not in the aforementioned NY industries, in the last decade is Honeybee Robotics in mid-town Manhattan.

The intrepid entrepreneurs at Thumbtack have today released a fantastically detailed and informative survey of small businesses across the United States. The full results are here, and for each state, the survey provides a detailed regional breakdown as well as specific comments from business owners. Outstanding stuff. [Dane Stangler, growthology.org]

Entrepreneurs, at their best, solve problems. Some problems (trying to figure out a cheaper and more powerful source of energy) are more important than others (an improved search engine algorithm), or may seem so at first blush. Ex post, we may realize that solving one problem gave rise to a host of new challenges, but we probably wouldn't return to the prior state of affairs. This is the nature of economic progress. Actually, it's the nature of all human history: two steps forward, one step backward. [Dane Stangler, growthology.org]

Religion wins in the Bible Belt. Last weekend, former President Bill Clinton took to North Carolina phone lines with a recorded message warning of the perils of a constitutional amendment banning same-sex marriage and civil unions. “What it will change is North Carolina’s ability to keep good businesses, attract new jobs, and attract and keep talented entrepreneurs,” Mr. Clinton asserted. “If it passes, your ability to keep those businesses, get those jobs and get those talented entrepreneurs will be weakened.” That argument landed with a thud, as North Carolina voters resoundingly supported the amendment by a margin of 20 percentage points. [James Stewart, New York Times, May 12] If you're looking for a state for high-tech biz, notice that the religious impulse extends basically from the Virginia coast in a broad belt through the Confederacy all the way to the California border. Does warmer weather suppress the intellect? Why does tech biz gravitate to Massachusetts and California?

Dynavax down 23% [May 9, 12] priced a stock offering at a 17% discount to Tuesday's closing price [Marketwatch.com]

Motion-sensing chip maker InvenSense (Sunnyvale, CA; no SBIR). stock dropped by as much as 25 percent on Friday after it lowered first quarter sales guidance. .... went public in November at $7.50 a share and rose to as high as $23.35 in late March but traded as low as $12.51 on Friday. [Cromwell Schubarth, Silicon Valley / San Jose Business Journal, May 4, 12]

A deal's a deal .. until. Ryan (R-WI) introduced a bill that would replace the budget sequester established by the Budget Control Act of 2011, in order to protect defense discretionary spending from automatic cuts. .... would replace cuts to defense spending, [AAAS, May 9] Horrors! Our friends would have to actually pay the price of the deal.

Politics misuses economics. [An economist] argues that every dollar taken from the private sector and channeled to the public-sector for government spending produces a GDP multiplier of less than one. Thus, the economy has gotten worse under Obama's big-government policies. He would have been better off leaving the money in private hands. The multiplier might be true, but was never tested because the money for the stimulus was never taken from private hands. It was borrowed - hear the Republicans wail - which put even more money into the economy and in no way restricted private spending or investment at risibly low interest rates. Oh, never mind, if you don't like a president, you'll invent convenient interpretations to justify your view. Post hoc, ergo propter hoc still lives in politics. Eventually millions of Americans will vote for president but not on the basis of real economics, only on some overall view of the candidates. The adults with some knowledge of economics know they have heard all the promises before. You can vote secretly but when you go to explain why, you need some sensible arguments to be credible. And take note that the stock market has doubled in Obama-time.

Never give up -- Winston Churchill. After two anti-evolution bills died in [Oklahoma legislature] committee, the same language appeared as an amendment to another bill which would have extended a deadline for local school districts to meet standards for media, equipment and textbooks. [AAAS, May 9] Not only can they not stop evolution, they will not stop trying. Old news from the Bible Belt.

Eleven Biotherapeutics (Cambridge, MA; no SBIR, founded 2010) said it has secured $20 million dollars in Series A equity financing, .... to advance Eleven’s first drug candidate, known as EBI-005, into clinical development later this year. The drug is designed to treat dry-eye syndrome. [Chris Reidy, Boston Globe, May 9, 12]

dandv writes with a story from VentureBeat about another entry in the race to escape national jurisdiction by offshoring work — literally offshoring, that is : "Blueseed is a Silicon Valley company that plans on launching a cruise ship 30 minutes from the coast of California, housing startup entrepreneurs from around the world. These startuppers won't need to bother with U.S. visas, because the ship will be in international waters. They'll have to pay tax to whatever country they're incorporated in, though. So far, 146 startups said they'd like to come to the ship." [slashdot.org, May 8]

Trolling for techno-votes President Obama said he wants to replicate Albany [NY] NanoTech's business model around the country, using the venue to urge Congress to approve his economic agenda. .... The NanoTech complex employs 2,700 people who focus on semiconductors .... the newest NanoTech building, being built by Watervliet-based M+W U.S. Inc., (Plano, TX; a full service engineering, architecture, and construction management firm) that will house joint research by the world's largest computer-chip companies. In total, it is a $4.8 billion investment, mostly private funding with government aid mixed in. [Adam Sichko, The Business Review (Albany), May 8]

Pork is a handout to someone else. Sen Schumer said Thursday that fuel-cell funding that would benefit Plug Power (Latham, NY) cleared a hurdle and was headed to the full Senate. .... Plug CEO said the funding was also critical “to accelerate the use of fuel cells in early market applications.” [The Business Review (Albany), May 8] Where is the market failure that needs government intervention?

Don't want no innovation. North Carolina voters approved a constitutional amendment defining marriage as strictly between a man and a woman. [Wall Street Journal, May 9] The political system sends mixed messages about inviting innovation and science into a den of religion,especially for biotech companies dabbling in stem cells and reproductive science, and parents with school age children. Perhaps the eventual solution is suggested in Tom Toles's cartoon where a marriage officiator says If anyone here objects to the marriage of these two men, speak up now because opponents are aging and dying off and soon won't matter anymore. [Washington Post, May 9]

Rib-X Pharma going IPO tomorrow to raise about $70M with Deutsche Bank as lead. will be highly speculative and any reward will be years in the making. ... has also received a letter from its independent financial auditing firm expressing doubts about whether Rib-X will be financially able to continue its business. Additionally, in its S1, Rib-X states that the cash from the IPO is still not enough to complete a phase 3 trial of Delafloxacin. [seekingalpha.com, May 7]

Vertex Pharma up 55% [May 7, 12] new cystic fibrosis drug Kalydeco, when combined with its experimental treatment for the disease, led to significantly improved breathing ability in a mid-stage study, .... The data suggested Vertex could have a multibillion-dollar franchise in cystic fibrosis, a life threatening genetic disorder that affects about 70,000 people worldwide. [Reuters, May 7] Vertex had $1M SBIR in the early 1990s and its market cap is now $12B..

Optics systems maker Boston Micromachines (Cambridge, MA; six Phase II SBIRs in ten years) has landed a NASA Phase 2 SBIR to support NASA’s Exoplanet Exploration program. .... will construct a 2048 actutor that can handle the harsh environments and correct what space telescope optics cannot. [Patricia Resende, Mass High Tech, May 7, 12]

GE Lighting is touting what it calls a breakthrough in light-emitting diode bulbs, thanks to a development accomplished with the help of Nuventix (Austin, TX; no SBIR). .... will use just 27 watts of power and will be able to replace 100-watt incandescent bulbs .... It makes an oscillating membrane called a synthetic jet that fits within the bulb and provides cooling [without making it bigger]. [Austin American Statesman, May 7, 12] The company website says that much of the development was supported by DARPA, the U.S. Navy, and NSF.

SWIM for water. [Today] a host of water startups and established companies will hold an all-day symposium to try and answer the question of how Massachusetts could become the global innovation leader of the $500 billion water industry. ... dubbed the Symposium on Water Innovation in Massachusetts (SWIM) [Don Seiffert, Mass High Tech, May 7, 12]

The [right wing] Heritage [Foundation] plan reforms and funds those government programs that matter most to people who need the government’s help, and it frees the private sector to create the millions of jobs that will dramatically reduce the growth of dependence on government. http://www.heritage.org/research/reports/2012/02/2012-index-of-dependence-on-government Bah!. The private sector was always free to create millions of jobs; it didn't do because there was too little profit to be made from employees getting a decent wage. BTW, uutold numbers of SBIR awardees are also on the dole because their stuff can't cut it in the private sector. The exact number will remain untold because the politicians don't want it revealed that they are handing out corporate welfare.

Connecticut Innovations said it invested an an additional $445,683 in CyVek (Wallingford, CT; no SBIR) biotech firm. CI invested $802,500 in cyvek in 2010. The latest funding is part of a $3 million round of financing.CyVek is developing a technology for "measuring multiple markers simultaneously in patient blood samples," CI said — a tool that can be used in drug discovery as well as diagnosis in doctors' offices. [Hartford Courant, May 3, 12]

for $3.7 billion in cash ... Hologic of Bedford, Mass., said it is buying Gen-Probe (San Diego, CA; three 1989 Phase I SBIRs), a 29-year-old company known worldwide for its diagnostic tests and equipment. Gen-Probe recently won FDA approval for Progensa, a test that determines if men who have prostate cancer need a biopsy. .... only a week after Ardea Biosciences (San Diego; no SBIR) was purchased by British drug maker AstraZeneca for $1.2 billion. AstraZeneca is moving to replenish its drug pipeline and wanted a diabetes therapy that Ardea developed. [Gary Robbins, utsandiego.com, Apr 30, 12]

Burns any fuel. The U.S. Army will test four of INI Power (Morrisville, NC; $800K SBIR in Illinois)’s fuel omnivores this year... little dynamo can burn: gasoline, ethanol, diesel, kerosene, jet fuel, methanol, grain alcohol, rum, paint thinner, hydrogen. Any liquor that’s 151-proof and stronger will do in a pinch. .... a decade-long struggle for a breakthrough. The company has burned through $20 million in private investment and federal grants, Markoski said. For the past three years, the 10-employee business has been “self-funded” [John Murawski, Raleigh News & Observer, May 6, 12]

Department of Energy's loan program is in shambles. Its reputation destroyed by the failure of Solyndra ... a near-perfect case study. It spent too much money too fast. In addition to the $535 million from the DOE, the company raised over $1.2 billion from private investors, including some of venture capital's most prominent firms. What Solyndra lacked, though, was market savvy and manufacturing flexibility. [David Rotman, Technology Review, M/J12] .... [renewable energy] all seemed intoxicating and revolutionary: a way to boost jobs, temper fossil-fuel prices, and curb global warming, while minting new fortunes in the process. Much of that enthusiasm has now fizzled. Natural gas prices have plummeted in the United States, the result of technology that has unlocked vast supplies of a fuel that is cleaner than coal. .... the government has schizophrenically ramped up and down support for renewable power, confusing investors and inhibiting the technologies' development; it has also structured its subsidies in inefficient ways. [Jeffrey Bell, Foreign Affairs, M/J12] Since government "investment" responds more to press release opportunities than profit opportiunities, no one should be surprised at some individual failures that supply even more press release opportunities. VCs in contrast quietly bury their failures and focus on exploiting the successes for total return onthe total investments.

The success of many biotech companies over the last two decades suggests how such collaborations can work. Like clean-energy companies, biotech startups face a lengthy and expensive commercialization process for their products. But many have avoided that process by making themselves attractive targets for large pharmaceutical companies. The acquisition of startups by drug companies desperate to gain innovative new technologies has fueled much of the biotech industry's growth. These deals by large pharmaceutical firms, which recognized that their own research was inadequate and their drug pipelines were collapsing, gave venture capitalists a highly profitable way to cash out of their investments in biotech startups long before the fledgling companies had to deal with the expense and difficulty of scaling up or commercializing their technologies. In turn, these lucrative "exits" for venture investors provided strong incentives to invest in the next round of early-stage companies. "It is a virtuous cycle," Nanda says. [David Rotman, Technology Review, M/J12]

"The [energy startups] that are breaking out are the ones able to craft meaningful partnerships with larger companies," says Jim Matheson, a general partner at Flagship Ventures. Matheson is a director of Mascoma (Waltham, MA; no SBIR), a company that struggled for years to find the funding for a commercial-scale plant that would make cellulosic biofuels based on its novel process for turning biomass into ethanol. Late last year it signed an agreement with Valero Energy; the large oil refiner and ethanol producer will provide the majority of the financing for a $232 million cellulosic-ethanol facility in Kinross, Michigan, and will help operate the plant. [David Rotman, Technology Review, M/J12]

Who's really recovering? The stock market has doubled since March 2009, while corporate profits and exports have surged to records. [Daniel Gross, author of coming book Better, Stronger, Faster] Which political party best represents those winners but cannot even whisper the success in its restless search for things to complain about?

Forget about Seattle's grand plans for a city-sponsored, superfast broadband network. Seattle has quietly given up, ending nearly a decade of blue-ribbon commissions, reams of studies and public outreach. ..... Over the past decade, cities across the country tried offering free Wi-Fi through public-private partnerships that largely failed. Now phone and cable companies are trying to seal the coffin. [Brier Dudley, Seattle Times, May 6] Where there's a competitive private market, public structures cannot and need not keep up. We don't need free bread for everyone. Nor do we need free bread for uncompetitive, life-style small tech biz.

As Twain said: "Get your facts first, then you can distort them as you please." You can be forgiven for a cockamamiee self-serving economic theory, but not for having no facts that fit it. In economics, though, there are so many facts that almost any two can be connected with such a theory, especially among the true believers.

Sleep tracking device maker Zeo (Newton, MA; no SBIR) raised $2 million in a debt round of funding, according to an amendment filed with the SEC. ... recently secured a partnership with training, physical therapy and nutrition company Athletes’ Performance to provide wannabe-pro football players with its sleep tracking technology, Sleep Manager Bedside and the mobile version of the technology to track and measure their sleep. [Patricia Resende, Mass High Tech, May 3, 12]

Kensey Nash up 32% [May 3, 12] said it will be acquired for about $360 million by Royal DSM, a Dutch manufacturer with operations in the pharmaceutical, food and automotive sectors [AP]..... but a law firm is investigating the Board of Directors of Kensey Nash Corporation for possible breaches of fiduciary duty and other violations of state law in connection with the sale of the Company to Royal DSM [Business Wire]

the White House released a comprehensive national strategy to guide federal investments and collaborations with the private sector in the life sciences. The National Bioeconomy Blueprint identifies five strategic objectives that will inform administration efforts to boost the bioeconomy. Key among these objectives is the expansion of foundational, cross-disciplinary research, which will require improved funding mechanisms that are flexible enough to support many kinds of collaborations and that encourage high-risk/high-reward research [SSTI, May 3] The gap between bloviating and results is likely to be as cloudy as all earlier attempts to perfect government R&D investment. As the Army exhorts its leaders: Do something even if it's wrong.

Slithering underway. OMB says that the Department of Veterans Affairs (VA) would be exempt from the across-the-board cuts of between 8 and 10 percent scheduled to take effect in January 2013. [AAAS Policy Alert, May 3] Soon every other program will claim equal holiness and the budget will be re-opened for political re-jiggering. .... once again, we are more likely to witness dithering and bickering in Washington, accompanied by political posturing packaged in competing election-driven narratives [Mohammed El-Erian, WashPo, May 4] As an example of political dodging, European leaders are talking growth, even as Germany remains adamant that it doesn't want the fiscal framework it has established over the past two years going up in smoke as soon as the going gets tough. [Wall Street Journal, May 4] Talk growth on the campaign trails, even though the political system has no credible means of producing it without adding even more debt. Such dithering will go on in all democratic countries until the electorate stops accepting irredeemable promises.

Speech Tails (Elm Grove,WI; no SBIR) that offers online speech learning for children said Wednesday it has raised $300,000 of funding from angel investors. ... helps parents with early detection of speech issues through a free website assessment parents can take with their children. Then it helps parents, educators and professionals deliver a set of services to manage and correct issues. [Kathleen Gallagher, Milwaukee Journal Sentinel, May 2, 12]

Naval Ravikant, chief executive of AngelList, told attendees at the NVCA annual meeting that he expects the number of successful starts to grow, The Wall Street Journal reports. The early-stage investor and matchmaker said there's been a huge jump in fundings from VCs and newcomers for seed-stage companies. Ravikant attributed low-cost Internet resources as one reason the number of startups is increasing. [Austin Business Journal, Apr 30]

Success has a thousand fathers. [experts] pointed to the Google search engine, iPod technology, and the Human Genome Project as examples of how federal funding has aided transformational innovation and economic growth. ..... The investment in knowledge represented by the federally funded Human Genome Project had a $796.3 billion economic impact from 1998 to 2010, according to a 2011 study by Battelle Memorial Institute. [Earl Lane and Becky Ham, Science, Apr 27] Unfortunately, no one can assign definite value to any piece of research before it starts, and the budget mavens are not proposing to zero out government science. It's just standard pleading to oppose any proposed cuts to programs that employ smart scientists, and the steady accumulation of PhDs make the problem more acute every year. Stand by for much wailing as a lot of people are going to give up something to get government finance back on track.

We're looking for bold innovative strategies to pretty much maintain the status quo. -- Wall Street Journal cartoon caption. That's a variation in the old idea that we want a brand new idea that's been thoroughly tested. The dilemma is that the great and proved idea will be very expensive by then and in the hands of your competitors. But then life is full of uncertainty.

Semprius (Durham, NC; $500K SBIR) startup that claims to have developed the world’s most efficient solar panel made a prestigious roster of the most important emerging technologies in the world.- the annual list compiled by [MIT] Technology Review, [on] criterion for emerging technologies: their potential to change the world .... has raised $44 million from venture capitalists and Siemens [John Murawski, Raleigh News & Observer, May 2, 12] The other nine technologies are: egg stem cells by OvaScience (Boston, MA; no SBIR) ; A camera that lets images be adjusted after the shot by Lytro (Mountain View, CA; no SBIR); solar powered micro-grids by Mera Gao Power (Reusa, India); 3-D transistors by Intel; a faster Fourier transform by MIT; nanopore DNA sequencing by Oxford Nanopore
(Oxford, England); crowd-funding by Kickstarter (New York Cit); high speed materials discovery by Wildcat Discovery Technologies (San Diego, CA; no SBIR); and Timeline interface by Facebook.

Pursuit Vascular (Maple Grove, MN; no SBIR) raised $750,000 in bridge financing during the first quarter and will soon kick off another round of fundraising, the company announced. ... has developed a catheter technology that it says could reduce the risk of infection in hemodialysis patients. In addition to the bridge financing, the company now wants to raise $2 million, which it will put toward prepping for clinical trials and intellectual-property costs. [Katherine Grayson, Minneapolis / St Paul Business Journal, Apr 30, 12]

Cleveland BioLabs and its subsidiary, Incuron LLC, have plans to test a new cancer drug in Russia. [Tracey Drury, Buffalo Business First, Apr 29, 12]

Having trouble sifting through all that DNA data gathered in a gene sequencing test? There’s an app for that. Illumina, a maker of machines that map genes, said that it’s setting up a software marketplace around its BaseSpace gene sequencing service. Called BaseSpace Apps, the marketplace is a genomics version of Apple’s Apps Store, and it aims to break a bottleneck around software for analyzing genetic information. [utsandiego.com, Apr 27, 12]

Bloom Energy (Sunnyvale, CA; no SBIR, founded 2001) a fuel cell technology company, started building a factory in Newark, DE ... plans to hire “hundreds” of people to work in the factory on a 272-acre site owned by the Univ of Delaware [that] used to be a Chrysler assembly plant. [Stephen EF Brown, San Francisco Business Times, Apr 30, 12]

Transcept Pharmaceuticals (Richmond, CA; no SBIR) would use some of the $37.6 million it hopes to net from a public stock offering to sell its FDA-approved middle-of-the-night sleep drug and to move forward with a drug for obsessive compulsive disorder. [Ron Leuty, San Francisco Business Times, Apr 26, 12]

austerity policies are failing to spark confidence in the region's economies ahead of a week of expected anti-austerity protests and a string of important national elections..... both French and Greek elections this weekend are expected to castigate incumbents. [David Roman and Stephen Fidler, Wall Street Journal, May 1] The very nerve of those politicians to give us the free lunch we clamored for despite economic reality that deficit finance must eventually end. US Republicans take note - voters don't like austerity.

DOD has released another SBIR solicitation with a June 24 deadline. It provides the names of the topic authors and their phone numbers and e-mail addresses for questions until May 23. You can ask them anything but they have some restrictions on what they can tell you. They are looking for the best technology in their area and they will (should) tell you if what you plan to propose interests them. Remember though that if you are not the best in the country at what you propose, you have little chance of winning an award. Fortunately for first-timers, DOD is not finicky about minor details if you have just what they want. And if you have a really hot idea, they have the option of picking up the phone and telling you to start work. DOD always has money for what they must have. http://www.acq.osd.mil/osbp/sbir/solicitations/sbir20122/index.shtml

Aware up 64% [Apr 27, 12] will sell some patents related to WiFi and 4G LTE to Intel Corp for about $75 million [Reuters, Apr 27]

A123 Systems rose the most in three weeks after the US Army introduced a prototype vehicle that uses its products. [Bloomberg News, Apr 27, 12]

Voters shy from hard choices. Lexington’s bet is that Americans will never give the Republicans a clean mandate to drown the sort of state they have now. Like voters everywhere, they want many impossible things before breakfast, including low taxes and all the things that high taxes pay for. They will expect their leaders to muddle through. And muddle through they probably will [The Economist, Apr 27]

Repligen down 40% [Apr 26, 12] said it expects U.S. health regulators to reject its imaging agent to detect structural abnormalities in the pancreas [Reuters]

Targacept (one SBIR a decade ago) announced that it will lay off 65 people, or about 46 percent of its workforce, following the failure of an antidepressant drug candidate in Phase 3 clinical trials.[Triangle Business Journal, Apr 26, 12]

medical device company Corinthian Ophthalmic Raleigh, NC; no SBIR) raised $625,000 in equity, according to securities filings. But the company still has a long way to go to reach its goal of raising $4 million by the end of May. ... for a new device that Ballou hopes could replace the eyedropper [Lauren Ohnesorge, Triangle Business Journal, Apr 26, 12]

The most widely held theory of politics is also the simplest: the powerful get what they want. Financial regulation is driven by the interests of banks, health policy by the interests of insurance companies, and tax policy by the interests of the rich. Those who can influence government the most ... eventually get their way. [Dani Rodrik]

Illumina, the market-leading maker of DNA sequencing instruments, said it is creating an open platform for genomic software developers to make apps for scientific customers who want to slice and dice through DNA data. This new initiative is called Basespace Apps, and will enable researchers to store their data on cloud computing infrastructure provided by Amazon Web Services, and then make it possible to download various genomic software “apps” to analyze and interpret the data. [Luke Timmerman, xconomy.com, Apr 25, 12]

Cymer (San Diego, CA; $400K SBIR twenty years ago) is developing the next generation of laser systems that will allow semiconductor manufacturers to produce even smaller, more powerful chips. Cymer recently showed off its technology, called Extreme Ultra Violet, in demonstrations .... expects to spend $58 million in research and development in the second quarter [Mike Freeman, utsandiego.com, Apr 25, 12]

Shares of TriQuint Semiconductor plunged in extended trading on Wednesday as investors balked at the semiconductor specialist's weak guidance. [James Rogers, San Jose Mercury News, Apr 25, 12]

"What do you call a credit bubble built on a commodity bull market built on a much bigger Chinese credit bubble?" asks Société Générale strategist Dylan Grice in his latest research note. Sadly, the answer isn't funny for some living in the southern hemisphere. "Leveraged leverage? A CDO squared? No, it's Australia." [Wall Street Journal, Apr 26]

SeraCare Life Sciences (Milford, MA; one SBIR in CA) said that it has completed its previously announced merger with affiliates of Linden Capital Partners following a vote by SeraCare shareholders [Chris Reidy, Boston Globe, Apr 24, 12]

in an aggressive, noisy campaign, the public may not fully understand the candidates' positions. After all, precision and clarity have never been the hallmarks of presidential campaign advertising. ..... The American people deserve a full debate and discussion on our fiscal problems. With four $1 trillion deficits in row and a debt ratio over 70%, the Washington response of both political parties has been to "kick the can down the road." [Bill Frenzel, realclearmarkets.com, Apr 24] But the people don't want to hear the truth; they want someone else to pay, and they will accept a vague political promise that they won't have to suffer. It's been going on for fifty years. LBJ wouldn't pay for Vietnam and Bush-Cheney wouldn't pay for Iraq, etc.

Achillion Pharma down 19% [Apr 23, 12] following an analyst downgrade and an update on a key experimental drug..... while Achillion's phase 2 clinical data showed strong efficacy (you can't do better than 100%), it took 24 weeks for ACH-1625 to reach its endpoint. Time could be an issue here as Gilead's drug is proving effective in a much shorter time. [Motley Fool]

NeuroMetrix said that that it will support a clinical study of 50 obese patients with diabetes at the Joslin Diabetes Center. The patients will participate in a weight and lifestyle management program as the study seeks to determine whether weight loss and improved diabetes management can impact the progression of diabetic peripheral neuropathy, or DPN. DPN affects more than 50 percent of people with diabetes and causes significant morbidity including pain and increased risk of falling. [Chris Reidy, Boston Globe, Apr 23, 12]

Argos Therapeutics (Durham, NC; no SBIR), which last month withdrew its plans to raise money with an initial public offering of stock in the wake of a lackluster market, has rebounded by raising $25 million in venture capital funding. [David Ranii, Raleigh News & Observer, Apr 24, 12]

American Superconductor raised $25 million of a $56 million offering, according to [SEC report] [Mass High Tech, Apr 20, 12]

Amag Pharmaceuticals said that its iron deficiency treatment has gotten a positive review from a panel of European regulators, raising the possibility that the drug could go on the market in Europe later this year. [Boston Globe, Apr 20]

Two companies founded by Ms [Angela] Belcher are already making things with viruses. Cambrios Technologies (Cambridge, MA; one SBIR) is producing transparent coatings for touch screens and Siluria Technologies (no SBIR) (Ms Belcher likes to name her companies after geological time spans) is using viruses to develop catalysts for turning natural gas into oil and plastics. There are also potential applications in solar cells, medical diagnostics and cancer treatment. And all that from an idea inspired by a sea shell. [The Economist, Apr 21, 12] The Economist ran a compelling piece on the third industrial revolution (the fruit of digitization) that has the potential to lure back manufacturing from distant cheap-labor Asia to smart-labor America where the customers shop with flexible ideas. Government funding sources serious about the economic future would do well to heed the implications of future manufacturing, although not because it would create that many unskilled jobs.

Alder BioPharmaceuticals (Bothell, WA; one SBIR) said it's raised $38 million in Series D financing, which it said will support the development of the company’s clinical stage pipeline.[Ben Miller, Puget Sound Business Journal, Apr 20, 12]

Cytokinetics (South San Francisco, CA; $500K SBIR) experimental drug to treat patients with amyotrophic lateral sclerosis, or Lou Gehrig’s disease, won fast-track designation [San Francisco Business Times, Apr 20, 12]

Hyperion Therapeutics (South San Francisco,CA; no SBIR) biotech company developing drugs against metabolic disorders, will seek $57.5 million in an [IPO]. [San Francisco Business Times, Apr 17, 12]

In its fourth round of venture funding, Neato Robotics (no SBIR) raised $12.2 million. [San Francisco Business Times, Apr 19, 12]

Religion in science class. Tennessee Gov. Bill Haslam (R) allowed HB 368 [into] law ... encourages teachers to present the "scientific strengths and scientific weaknesses" of topics that include evolution and climate science. [SSTI, Apr 19] Maybe a teacher or two will introduce books like Dava Sobel's Gallileo's Daughter as extra-credit reading on how unrestrained religious authority denies science. Surely, other Dixie states will form a phalanx for the dumbing down of science as they retreat to the intellectual safety of the Middle Ages.

Cell Therapeutics (Seattle, WA; one SBIR a dozen years ago) said it has agreed to pay $30 million in cash and stock for worldwide rights to a drug candidate that has completed a phase-two clinical trial for myelofibrosis, a bone marrow disease. [Seattle Times, Apr 19]

3M subsidiary 3M New Ventures said it has invested in Zephyr Technology (Annapolis, MD; no SBIR), a developer of real-time devices that monitor human performance through smart-fabric sensor technology. The amount was not released. [Ed Stych, Minneapolis / St Paul Business Journal, Apr 16, 12] founded 2003 In addition to the US, Zephyr™ has distributors and representatives in key markets such as the UK, Germany and Singapore. [company website]

The money is flowing again: Venture capital investing in Austin companies soared in this year's first quarter, thanks to a boost from six deals that topped $10 million. .... a 204 percent jump over the $90.2 million that companies received in the first quarter a year ago. It's also the most money raised since the fourth quarter of 2007 when the U.S. recession officially began. [Lori Hawkins, Austin American Statesman, Apr 20] In contrast, Just a few Triangle companies succeeded in raising venture capital funding in the first quarter, and collectively they didn’t raise very much. The $11.8 million in venture capital attracted by four up-and-coming companies was the Triangle’s worst quarterly showing in more than a dozen years. [David Ranii, Raleigh News & Observer, Apr 20]

Unemployment in global competition. U.S.-based multinational companies increased their work forces at home by 0.1% in 2010 while expanding overseas employment by 1.5%, the Commerce Department said. The modest expansion of the global companies' employment in the U.S. came in a year when the private sector as a whole shed 0.6% of its U.S. workers. .... Since 1999, U.S.-based multinationals have cut U.S. employment by about 1 million, or roughly 4%, and added 3.1 million workers overseas, a 39% increase [David Wessel, Wall Street Journal, Apr 19] Don't be surprised if the partisan political battle for president never draws an accurate picture of the forces driving US employment.

Swiss drugmaker Roche said it would not extend a $6.8 billion hostile offer for genetic specialist Illumina as the U.S. group's shareholders blocked its move to appoint new directors. [Reuters, Apr 18, 12] Having had $8M SBIR by 2006, the company now disdains $6.8B. If it remains independent, we shall see how well it swims the shark filled waters of open global competition.

Metabolix announced the opening of its first office in Europe. [Boston Globe, Apr 18, 12]

Mechanical Technology turned its first annual profit in at least 15 years in 2011 [The Business Review (Albany)]

Six investment funds received $25 million Tuesday, money aimed at backing up to 100 seed-stage companies around New York. The total investment in small businesses will wind up being at least $75 million, because each winning fund must supply at least $2 of private investment to pair with every dollar coming from the state. [Adam Sichko, The Business Review (Albany), Apr 17] Seed-stage is actually a true market-failure situation for government intervention, but government support is unstable because it is so driven by politicians with short time horizons. New York politicians, like every other state politicians, want the publicity of market intervention, provided it carries some other name. This New York fund with 2-for-1 private matching has the chance to pick future winning technology because the private investors won't go for kind of scientific blobs that science agencies typically fund. Good luck, NY.

Subsidies come and go. A report to be released Wednesday by scholars at the Brookings Institution and Oakland's Breakthrough Institute warns that federal spending on clean technologies is drying up, with little sign of additional help coming from Congress. As a result, more cleantech companies are likely to go bankrupt or be consolidated, ..... "We're falling off the cliff," Mark Muro, a senior fellow at the Brookings Institution, said [San Jose Mercury News, Apr 18]

Attitude checks. [NSF SBIR] Phase I project will develop multi-dimensional neurodynamic models of the cognitive organizations of teams that span zero history to proven entrepreneurial teams (ET), with the purpose of developing a neurophysiologic instrument to rate a team's entrepreneurial aptitude. ..... Neurodynamic models will be generated using EEG technologies and protocols previously developed for high fidelity military training activities. These models dynamically follow the engagement and workload of each member of the team as well as the entire team and will be customized for studying entrepreneurial teams. [NASA SBIR abstract] Using a developed tool to study another specimen could be an endlessly profitable job for the research team, BUT where's the downstream economic impact? The proprietary neurodynamic assessment system will be marketed to corporate training / coaching programs, financial backers who wish to decrease uncertainty in ventures, and entrepreneurial organizations who wish to optimize their performance. The scientific and technical merit people in government will believe almost any commercialization story to justify SBIR for their favorite research.

Austerity hits science. the long-delayed 2012 [Spanish] national budget would slash the funding for science by more than 25% surpassed their worst predictions.[Science, Apr 13] On this side of the pond, we are still pretending that we can afford all our famous debt-financed public science.

Merck entered into an agreement with Endocyte (West Lafayette, IN; $3.6M SBIR) to develop and commercialize Endocyte’s experimental cancer therapy in a deal potentially worth $1 billion. [John George, Philadelphia Business JounraL Apr 16, 12]

First Solar up 10% plans to close its Frankfurt [Germany] manufacturing operations and idle four production lines at its plant in Malaysia, as it looks to reduce costs amid a deteriorating solar market in Europe.[Wall Street Journal, Apr 17, 12]

Albany Molecular Research said it has been selected by Melbourne, Australia-based Biota Holdings Limited to further develop and manufacture Biota’s influenza antiviral drug laninamivir. AMRI said it would provide these services to support a New Drug Application to the U.S. Food and Drug Administration. Biota is seeking to have the drug manufactured in the United States and approved in clinical trials for adults and children. AMRI said it potentially could be chosen to manufacture the drug for commercial use. [Eric Anderson, Albany Times-Union, Apr 17, 12]

InView Technology (Austin, TX; no SBIR) a two-year-old startup that develops advanced cameras and imaging technology, said that it has received $2 million in funding as part of a second investment round. .... investors included In-Q-Tel, which led the company's $4 million first investment round, and the state's Emerging Technology Fund. .... continue to develop its "compressive sensing," which uses advanced mathematics to take sharp photographic images in low light conditions and can detect images hidden by smoke and fog. [Kirk Ladendorf, Austin American Statesman, Apr 17, 12]

Molecular Detection (Wayne, PA; no SBIR) has raised $3.5 million in a private stock sale, according to [SEC] documents .... founded in 2007, develops molecular diagnostic tests used to detect infectious diseases. [John George, Philadelphia Business JounraL Apr 13, 12]

BioDelivery Sciences (Raleigh, NC; $1.7M SBIR in New Jersey a decade ago) stock rose 12 percent after the company announced it had extended [for seven years] the patent protection for its experimental treatment for chronic pain and received a $15 million milestone payment from partner Endo Pharmaceuticals. [David Bracken, Raleigh News & Observer, Apr 18, 12]

Cree fell as much as 10 percent in after-hours trading Tuesday in the wake of underwhelming quarterly results. [Raleigh News & Observer, Apr 18, 12]

Alcresta (Newton, MA; no SBIR) start-up looking to commercialize enzyme-based nutritional products such as infant formulas, emerged from the stealth mode by announcing a $10 million Series A venture capital financing. [Boston Globe, Apr 17, 12]

Enduring myths. this intense focus on small businesses may overstate the economic case. Big businesses actually employ far more people than small ones and, according to government data, the overwhelming majority of small businesses don't employ anyone at all. .... [Kelly Edmiston, a senior economist at the Federal Reserve Bank of Kansas City] says small-business jobs are far less stable than jobs at big businesses, in part because small businesses are created and also fail at such a high rate. .... tend to offer lower pay and fewer benefits. ... he actually concludes that in terms of economic development, it makes far more sense for states and cities to promote small business than to spend tons of money to try to lure a large factory into town. [Tamara Keith, npr.org, Apr 18] Not to worry: politicians will continue to tell people the enduring myths they want to hear.

Can't/won't escape continuous connection. In a bid to capitalize on the growing market for fast Internet access on planes, Honeywell has signed a deal with satellite-operator Inmarsat to provide gear for airborne broadband connections. [Wall Street Journal, Apr 18]

The UC Board of Regents is expected to vote next month to approve the Center for Innovative Therapeutics, or CIT, a $110 million research complex that would house UCSD scientists and researchers from biotech companies. Regents are hoping to get companies to more quickly develop products and treatments invented by university scientists, a branch of research known as “bench-to-bedside.” [Gary Robbins, utsandiego.com, Apr 17]

Y biz luvs guv. In a libertarian world where politicians all just say no to subsidizing businesses, then businesses would end up reasonably evenly distributed across the country (due to labor markets, distribution requirements, etc.) and taxpayers would not be paying any subsidies. However, because politicians fear that their community will lose if they don’t play the subsidy game like everyone else (the equivalent of staying silent while your partner is ratting you out in prison) what we end up with is still having businesses reasonably evenly distributed across the country, but with massive subsidies in place. [coyoteblog.com, Apr 16] Interstate competition is natural where politicians have to convince voters to re-elect them. Unfortunately the result if the subsidies is a large diversion of tax revenue to private business.

CoolChip Technologies (Somerville, MA; no SBIR) has raised $500,000 in debt funding out of $1.5 million sought, according to federal filings. The money is the first filing for the company, which works on low-cost, high-performance electronics cooling systems, specifically a central processing unit cooler. [Don Seiffert, Mass High Tech, Apr 13, 12]

Imbed Biosciences (Madison, WI; no SBIR) has received a $326,000 [SBIR] to continue developing biologic dressings that could be used to prevent wound infections and promote cell growth and healing. {Kathleen Gallagher, Milwaukee Journal Sentinel, Apr 13, 12]

Five Connecticut companies have qualified for more than $1 million in grants and loans through the Small Business Express Program. ... a bi-partisan effort created last year to help small businesses with 50 or fewer workers boost their payrolls and fund capital investments. Innovation companies: Nature's First (Orange, CT; no SBIR); Nalas Engineering (Essex, CT; one SBIR); [Janice Podsada, Hartford Courant, Apr 13, 12]

A new report from the Office of Science and Technology Policy (OSTP) examines the use of prizes to achieve ambitious national goals over the past few years, and presents a number of ways this approach could be improved. Read the report... [SSTI, Apr 12]

A new report by the Pew Center on the States found that half of the states with tax incentive programs do not take the basic steps needed to know whether or not they are effective. The study identified 13 states with good assessments, 12 with mixed results, and 26 not meeting any criteria for scope or quality of evaluation. A major problem seems to be that states conducting rigorous evaluations of some incentives tend to ignore others and many states evaluate infrequently or not thoroughly enough. The authors focused the study on four criteria for effective evaluation and assessed the states' practices as to how well they: inform policy choices, include all major tax incentives, measure economic impact, and draw clear conclusions. Leading examples are found in Connecticut, Oregon, Louisiana, and Washington. Evidence Counts: Evaluating State Tax Incentives for Jobs and Growth is available at: http://www.pewcenteronthestates.org/uploadedFiles/015_12_RI%20Tax%20Incentives%20Report_web.pdf. [SSTI, Apr 12] Evidence has an uphill fight for recognition where politics wants to hand out gifts.

The Ohio State University and Ohio University announced a new $35 million venture capital fund to address the lack of critical, early stage funding for innovative technology ventures in the state. Ohio State will contribute $20 million and Ohio University will provide the remaining $15 million. The universities also committed to leveraging their resources and assets to support entrepreneurial activity and venture creation in Ohio. Read the press release... [SSTI, Apr 12]

Even when a state has the most favorable tax policies for a particular type of business, the policy does little to influence where people start companies. .... most would-be entrepreneurs can’t choose between states in which to start their companies without relocating. And few people switch states to start businesses. [Scott Shane, Bloomberg Businerss Week, Apr 10]

Thanks to a cold call placed by the Saratoga [NY] Economic Development Corporation in 2005, pitching the area as an ideal site for a factory, GlobalFoundries (no SBIR), a semiconductor manufacturer, is building a $4.6 billion, 2m-square-foot campus in a Saratoga forest ..... the area has returned to its roots. GE Global Research, founded 112 years ago, traces its origins to a carriage barn in nearby Schenectady. After shrinking its manufacturing arm in the 1990s, it is bringing it back to New York, making high-energy-density batteries and digital x-ray-detectors..... Sematech, a chip consortium, has moved to Albany from the high-tech magnet of Austin ... the area has the lowest per-capita county taxes in New York state. [The Economist, April 14] The Capital District has a long industrial history, frigid winters, a first class technical university, and no urge to suppress science in the name of religion.

Unlike with some rural economic development programs in his office, [Texas Agriculture Commissioner Todd] Staples decided last fall to outsource investment decisions to two private [VC] firms,. "I didn't want to be involved in the selection process," Staples said. "I wanted to have that removed from this office and that to be based on economic criteria and investment criteria, so it would be based on clear market circumstances." [Laylan Copelin, Austin American Statesman, Apr 15] What a novel idea: use private investors to decicde where to invest in private companies for economic return. A better idea is to get government out of investing in private entities where an ROI is easily calculated. Limit government investment in true market-failure situations.

SiOnyx (Beverly, MA; three SBIRs) which makes a special semiconductor material called Black Silicon, has raised $6.9 million in equity financing, according to federal documents ... founded in 2006 by Professor Eric Mazur and James Carey of Harvard University, is commercializing a patented semiconductor process that enhances the infrared sensitivity of silicon-based photonics. [Don Seiffert, Mass High Tech, Apr 11, 12]

ViaSat has been awarded a $31.5 million contract to provide the government with high-tech communications hardware, the Defense Department announced [Nathan Max, utsandiego.com, Apr 11, 12]

Food scraps and trashed Christmas trees could one day be a source of a billion-dollar business, according to Harvest Power (Waltham, MA; no SBIR), a start-up that just raised $110 million to help convert organic waste to energy and fertilizer. .... hoping to replicate in North America what countries such as Germany and Spain have been doing for years. [Yulika Chernova, Wall Street Journal, Apr 12] Since we were rich, we didn't see much need to recycle or conserve which leaders like VP Cheney denigrated as personal virtue but irrelevant. Making a profit frlom such conversion seems to be much harder than idealized. In the extreme, Harrisburg, PA went bust trying.

Defense Conversion, 1992 Redux. with the war in Iraq over and the conflict in Afghanistan winding down, robot makers are facing a reboot. .... At the same time, the administration's new defense strategy pledges a "strong commitment" to emerging technologies and singles out robotics as an area of promise [Nathan Hodge, Wall Street Journal, Apr 12] Defense conversion was all the rage in the 1992 campaign, with almost every involved Congressional committee suggesting more SBIR as a big contributor. The new Clinton administration got busy trying to make civilian technology out of military R&D. As usual, it failed for price and the inability of the federal agencies to adapt to private market disciplines. Soon enough the fanfare subsided and defense business as usual regained its hold.

Vijay Govindarajan and Chris Trimble's "Reverse Innovation," a book that offers provocative insights into the quickly changing dynamics of the global economy. As the subtitle has it, the authors advise companies to "create far from home" and "win everywhere." .... Cisco CEO John Chambers told me that he expects developing countries to account for 70% of his company's business a decade from now, up from 30% today. Chief executives at other multinationals make similar forecasts.... Govindarajan and Trimble make a persuasive case for a different model. They say that, increasingly, business success is coming from companies that use their knowledge and resources to create innovative new products for developing countries and then adapt those products to satisfy demands in the developed world. The traditional flow of innovation—from rich to poor nations—is moving in reverse. [Alan Murray, Wall Street Journal, Apr 12] More global competition for American myths of innate and permanent superiority in R&D and innovation.

[Harvard Econ students said] "Today, we are walking out of your class, Economics 10, in order to express our discontent with the bias inherent in this introductory economics course. We are deeply concerned about the way that this bias affects students, the University [sic], and our greater society." .... Today's economics is dominated by ideas, like the efficient market hypothesis, making such sweeping generalizations that they render human beings practically unrecognizable. Do people ever have "perfect information" or a complete understanding of their best interests? .... where economics finds itself today, stuck between failed methodologies and whispered realities. It can continue to produce elegant theorems that work only by ignoring obvious real-world situations and conditions. [Eric Weiner, Institute for New Economic Thinking in New York, LA Times, Apr 11] Conventional thinking in both R&D and Economics under question.

Making transportation spending about the construction jobs instead of the infrastructure is like making investment decisions based on how attractive the broker is rather than the expected return of the investment. [Adrian Moore, Real Clear Markets, Apr 12] Never mind, if it has jobs anywhere in the content, the politicians are for it in front of a public that tells pollsters that jobs will drive their voting preferences. How and why they actually vote is much more complex. We get the government we deserve.

Viro Pharma down 22% [Apr 10, 12] said that three companies are now selling low-cost generic versions of its drug Vancocin, an antibiotic that brings in half of ViroPharma's revenue.[AP, Apr 10]

A new Army laboratory [in Warren, MI] will develop technology such as fuel cells and hybrid systems for combat vehicles as the Pentagon steps up its push for cleaner and more reliable energy, federal officials said ... The military uses 90 percent of the energy consumed by the federal government, which accounts for about 2 percent of all U.S. energy consumption. [John Flesher, AP, Apr 11]

Cree says it has halved the cost of its light-emitting-diode streetlights and hopes the new lower prices will sway local governments to adopt the new technology. .... the new bulbs will be comparable in cost to traditional high-pressure sodium vacuum technology when maintenance and energy costs are included. That would clear what has been seen as a key obstacle to greater adoption. .... "LED roadway lighting is pretty much a price war at this point," said Michael Barber, a former street-light official in Anchorage, Alaska .... Cree attributes the changes to improvements in its proprietary silicon carbide technology. [Kate Linebaugh, Wall Street Journal, Apr 10, 12] SBIR boosted the SiC development in Cree's nursery years soon after which Cree spread its wings and flew in private markets.

The [Chinese] government desperately wants its economy to move up the value chain, to become a source of innovation rather than just a producer of cheap goods. To make that happen, it has employed the traditional instruments of science and technology policy, but it has also relied on industrial espionage directed at foreign high-tech companies. Hackers have reportedly targeted the negotiation strategies, business plans, and financial information of foreign energy and banking companies, too. ..... With a growing population of 500 million Internet users, it is easy to see why the Chinese believe that the future of cyberspace belongs to them. [Adam Segal, Foreign Affairs, M/A 12]

HemaQuest Pharmaceuticals (San Diego, CA; no SBIR) said it raised $13 million in an extension of its Series B funding round to support a mid-stage trial of its experimental drug for patients with sickle cell disease. [Bruce Bigelow, xconomy.com, Mar 16, 12]

In “Globalization of S&T: Key Challenges Facing DOD,” Timothy Coffey and Steven Ramburg argue that the demographic and industrial strengths that shaped the highly successful U.S. S&T strategy over the past 50 years is not likely to be sustainable in the 21st century. ... as emerging countries enter a phase of rapid economic growth and accordingly ramp up investments in R&D. .... the DoD should shift from inventing and discovering new things at home to forecasting the invention and discovery of new things abroad. [William Pentland, Forbes, Apr 6]

Beware of freeware. Techdirt reports that the latest versions of Wikipedia's mobile apps have switched to OpenStreetMap from Google Maps. Says Techdirt's commentary: "One wonders how Google didn't see this coming — or if they did, what exactly their strategy is here. OpenStreetMap is gaining a lot of momentum, and in some areas even features much better data. The real lesson here is that there's never an incumbent that isn't at risk of being unseated, no matter how widespread the adoption of their product or service—especially if they make an anti-customer decision like Google when it put a price tag on Maps. The situation also points to the long-term strength of open solutions: while a crowdsourced system like OpenStreetMap never could have put together a global mapping product as quickly as Google did, over time it has become a serious competitor in terms of both quality and convenience." [slashdot.org, Apr 8]

Start the pump-and-dump machine. The signing of the new JOBS law opens crowdsourcing for startup companies which invites scamsters to pump trash concepts as the technology of the future for unsophisticated investors. Human gullibility being what it is, and the SEC chasing bigger scamsters with a declining federal budget, wanna buy warrants on a bridge?

AMSC (a.k.a American Superconductor) raised about $25 million in gross proceeds through the sale of convertible notes and warrants. [Chris Reidy, Boston Globe, Apr 4, 12]

OvaScience (Cambridge, MA; no SBIR) specializing in fertility treatments, announced that it has completed a $37 million Series B financing. [Chris Reidy, Boston Globe, Apr 4, 12]

Connecticut Innovations has invested $269,160 antibiotics developer BioRelix (New Haven, CT; no SBIR)., its second investment in the firm after a $500,000 infusion in December. ... developing antibiotics using "riboswitches," which are "short stretches of messenger ribonucleic acid (mRNA) that bind small molecules and control genes that are essential for the survival of many human pathogens," first identified in the laboratory of Yale professor Ron Breaker. The firm is developing a treatment for a hospital-acquired infection. [Hartford Courant, Apr 3, 12]

VirtualScopics (Linden Oaks, NY; one SBIR) said it has completed the first closing in a sale of a new series of preferred stock to the Merck Global Health Innovation Fund for $3 million. [Smriti Jacob, Rochester Business Jounral, Apr 4, 12]

ReconRobotics (Edina, MN; no SBIR) said it has acquired Xollai, (St. Paul, MN; no SBIR) that develops systems to help military drones land. ReconRobotics makes throwable microrobots for the military, ... a spokesman for ReconRobotics, said Xollai's St. Paul office will remain open and all nine of its employees will stay with the company. ReconRobotics now has 54 employees, Klobucar said. [Ed Stych, Minneapolis / St Paul Business Journal, Apr 4, 12]

U.S. lawmakers, banks and the SBA recently have expanded the scope of what they commonly consider small. ... The SBA has made similar upward revisions over the last year in 130 industries, adding at least 27,400 new companies to its definition of a small business. Many of the definitions hadn't been adjusted since the 1980s despite inflation over that time.[Angus Loten, Wall Street Journal, Apr 4]

"The challenges facing the American economy today are not primarily about the vibrancy or efficiency of the business community. They are about the barriers to economic opportunity and economic security for many Americans....These challenges can only be addressed by government action." [SECTREAS Timothy Geithner, Apr 4] The Republican view says cut taxes and spending to fix what ails the American economy, which by implication will liberate business to invigorate the economy [and help further concentrate the wealth at the top of the heap]. Not to worry much because there are not enough rich voters and gullible middle class voters to let it happen.

Angel investors shelled out $22.5 billion in investment dollars during 2011, up about 12 percent from the previous year’s total, according to the 2011 Angel Market Analysis released by the Center for Venture Research at the University of New Hampshire.[Boston Globe, Apr 2]

A new program launched in Massachusetts will help companies commercialize technologies developed under [SBIR] by picking up where Phase II of the program leaves off, providing financial support, coaching and introductions to potential investors. The Massachusetts Technology Development Corporation will initiate the program with $6 million over the next three years. [SSTI, Mar 28] Nice theory but usually too late since the agency thought first of its own needs and then leaves the commercializing for afterwards. The problem is far too many market-dead companies getting SBIR to do nice government R&D on just criteria of scientific and technical merit. If you want good stew, start with good ingredients. Not to worry though, with an election coming up, the politicians will see the merits of amny such investments with glitzy announcements.

AbVitro (Boston, MA, no SBIR,founded in 2010) received $745,000 in equity out of a $3 million offering ... working on a next-generation antibody discovery platform [Don Seiffert, Mass High Tech, Apr 2, 12]

The Texas Emerging Technology Fund has attracted almost $1.3 billion of outside investment in technology companies and university research, the fund's director testified Friday, but he urged the Legislature to prod Texas colleges to do more in converting research into businesses. .... He said that the state has invested $192 million in 133 companies since the fund's inception in 2005 but that most of the money was disbursed in 2009 and 2010. [Laylin Copelin, Austin American Statesman, Mar 30] Theories abound on state investments in high tech companies, including those politically connected to the governor or other politicians, with little economic evaluation of the results except the easily counted jobs paid for with the investment. The same theories abound in federal investments like SBIR. The proponents are the politicians who can announce a handout and the beneficiaries who like free money. But then, government have only ever been good at measuring money spent.

Illumitex (Austin, TX; no SBIR, founded in 2005) received $2 million in debt securities, according to a securities filing. The company develops and sells high brightness LEDs for the general lighting market, including residential, commercial and industrial uses. .... has raised a total of about $41 million. [Lori Hawkins, Austin American Statesman, Mar 29, 12]

Nearly every CEO and business leader I speak with says virtually the same thing: They are hesitant to make major investment decisions until they know how Washington intends to grapple with its huge deficits. That uncertainty is a major drag on job creation because the price of uncertainty for business is paralysis. Companies with healthy balance sheets that could be creating jobs are sitting on the sidelines, waiting to see if the federal government will begin increasing market stability by reducing long-term deficits.[Michael Bloomberg, Wall Street Journal, Mar 29] If you're waiting for the magic pain-free (for you) solution to the national debt hole, there is no such solution. When the smoke clears, everyone will be paying something in lost benefits and higher taxes.

A123 fell 12%; said it will recall defective battery packs developed for auto makers that were made at its Livonia, Mich., plant. [Wall Street Journal, Mar 26, 12]

The U.S. Supreme Court ordered an appeals court to take a new look at a lawsuit challenging Myriad Genetics's (Salt Lake City, UT; one 2000 SBIR) patents on human genes. [Wall Street Journal, Mar 26, 12]

FRX Polymers (Chelmsford, MA; no SBIR) has signed a long-term lease with Bayer Material Science to operate its first commercial plant in Antwerp, Belgium.... Founded in 2007, FRX has 20 granted patents and 58 patent applications .. The company says it’s producing at capacity in the current plants. [Don Seiffert, Mass High Tech, Mar 24, 12]

It’s hard to find a better example of how technology is revolutionizing patient care than the tiny edible sensor Proteus Biomedical (Redwood City, CA; no SBIR) plans to begin selling this fall in the UK. When the grain-of-sand-sized sensor is integrated into a drug tablet or capsule and activated by stomach fluid, it signals when the medicine was taken to a patch on the patient’s body. Then the patch relays the information along with the person’s heart rate and other medical details to a caregiver’s phone – all without a visit to the doctor. [Steve Johnson, San Jose Mercury News, Mar 26, 12]

Nuventix (Austin, TX; two 2003 SBIRs as Innovative Fluidics, Atlanta, GA) said that it has raised an additional $10 million in investment funds to accelerate the company's global marketing program and to support development of a new generation of its SynJet cooling systems for LED lighting and electronics. .... total investment capital raised to $52 million since it was founded in 2004 [Kirk Ladendorf, Austin American Statesman, Mar 23, 12]

a closer look at China's supercomputers reveals a program that is far less of a threat to U.S. technological dominance than commonly believed. Chinese researchers say decisions about how supercomputers are used are often made by local politicians more interested in local development projects than breakthrough technology. China's bureaucrats meanwhile haven't figured out how to mount software development projects that come close to U.S. or European standards. Chinese scientists also lack the funding, and freedom, to explore technologies that haven't already been endorsed by the government, which can keep them well behind the cutting edge. [Bob Davis, Wall Street Journal, Mar 24] Imagine that: politicians favor local benefits in deciding how government will "invest". Just like Mississippi Senators deciding the Navy has to have ships built in Mississippi despite the Navy saying it doesn't need them. Should we doubt that Mississippi Senators are not the least schooled in national maritime strategy?

Azelon Pharmaceutical (West Conshohocken, PA, no SBIR) which formerly operated as Zelos Therapeutics, has raised $2.4 million in a private stock sale. .... plans to use the proceeds to support its development of a nasal spray formulation of teriparatide for the treatment of osteoporosis. [John George, Philadelphia Business Journal, Mar 22, 12]

Icagen is operating under a new name: Neusentis. The Durham biotechnology company became a wholly owned subsidiary of pharmaceutical giant Pfizer when it was acquired for $56 million at the end of October [David Ranii, Raleigh News & Observer, Mar 21]

Tariff wall helps some, hurts others. . The threat of U.S. tariffs on imported Chinese solar panels could slow down North Carolina’s red-hot solar industry, according to those who benefit from the plummeting costs of solar power.U.S. trade officials on Tuesday imposed tariffs on Chinese panels in response to complaints by American solar panel manufacturers. The modest tariffs are between 2.9 percent and 4.73 percent, about three times lower than had been feared by some. [John Murawski, Raleigh News & Observer, Mar 21]

Investors bailed out (down 45%) on Tranzyme Pharma (Durham, NC; no SBIR) after the drug-development company said new test results demonstrated that its most advanced drug candidate performed no better than a placebo. [David Ranii, Raleigh News & Observer, Mar 12, 12] Went public in 2011 to raise $50M.

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Stories about companies; 1-A B-E F-J K-O P-R S T-Z

1366 Technologies ... 1st Detect ... 21st Century Systems .... 23andMe ... 24M Technologies ... 30 Second Software ... 3C Semiconductor ... 3D Technology Laboratories .... 3F ... 3PrimiR ... 3VR .,. 4s3 Bioscience ... . 7AC Technologies ... A123Systems ...Aastrom Bioscience ..... Abaxis ... Abiomed ... Ablexis ...... Absorbent Materials ... Acadia Pharma ... Acambis .. Acceleron Pharma ... Accelrys ... Accentia BioPharmaceuticals ... Access Pharmaceuticals ... Access Scientific .... Accumetrics ... Accurate Automation .. Accuray ... Accuri Cytometers ... AcelRx Pharmaceuticals ... Acetylon Pharmaceuticals ... Achaogen ... Achillion Pharmaceuticals ... Acorda Therapeutics ... Acorn Cardiovascular ... AcroMetrix ... AcryMed ... ActaCell ... ACT Biotech ... Active Power ... ActivBiotics ... ActivMedia Robotics .... Acton Pharmaceuticals ... Actuality... Acucela ... Aculight ... Acumentrics ... Adamis Pharmaceuticals ... Adaptive Computing ... Adaptive TCR ... Addiction Therapeutix ... Addrenex Pharmaceuticals ... Adelor ... Adenosine Therapeutics ... Adeza Technologies ... Adherex Technologies ...AdiMab ... ADispell ... Adnexus Therapeutics ... Advanced BioHealing ... ADS Biotechnology ... Advanced Bionics ... Advanced Cell Diagnostics ... Advanced Cell Technology ... Advanced Ceramics .... Advanced Diamond Technologies .... Advanced Electron Beams ... Advanced Fuel Research ...Advanced Life Sciences ... Advanced Liquid Logic ... Advanced Magnetics ... Advanced Photonix .... Advanced Programming Concepts ... Advanced Targeting Systems .... Adventrx ... Advanced Technology Materials.(ATMI) ... AdvanDx ... Advion BioSciences ... .Aegea Medical ... Aerie Pharmaceuticals ... Aerius Photonics ... Aero Farms System ... AeroVironment ... AesRX ... AETC ... Aethlon Medical ... Affectiva .... Affinimark Technologies ... Affinity BioReagents ... Affomix .... Affymax ....Affymetrix ... aFraxis ... AgeneBio .... Agennix ... Agenus .... Agile Materials ... Agile Planet ... Agiltron .... Agilyx ... Agios Pharmaceuticals ... Agritope ... Agrivida ... .Aguila Technologies ... Ahura Scientific ... Aiko Biotechnology ... Aileron Therapeutics ... AirXpanders ... Airtricity ... AIT Laboratories ... Akebia Therapeutics ... Akermin ... Alabama Cryogenics ... Albany Molecular ... Albany NanoTech ... Aldagen ... Aldevon ... Alexion Pharmaceuticals ....Alexza Pharmaceuticals ... Alfalight ... AlgEternal Technologies .... Alien Technology ... Alimera Sciences ... Aliva Biopharmaceuticals ... Alkermes ... Allegro Diagnostics ... Allegro MicroSystems ... Allena Pharmaceuticals ... AllerQuest ...Allos Therapeutics .... Alloy Polymers .... Alloy Surfaces ... Allurion Technologies .... Allylix ... Alnara Pharmaceutical ... Alnylam Pharmaceuticals ... AlphaMed ... AlphaVax ... Alseres Pharmaceuticals .... Alta Devices ... AltAir Fuels ... Altair Therapeutics ... AltaRock ... Althea Technologies ... Altor ... Altra ...Altus Pharmaceuticals ... ALung Technologies ... AMAG Pharmaceuticals ... Amberwave . ..Ambrx ... American Science and Engineering ... American Superconductor ... American XTAL .. AMBP Technology .. . Ames Technology ... Amgen ... Amnis ... Ampla Pharmaceuticals ... Amylin Pharmaceuticals ... Amyris Biotechnologies ... Anacor Pharmaceuticals ... Anadys Pharmaceuticals ... AnaptysBio ... Anchor Therapeutics ... Ancora Pharmaceuticals ... Anexon .... Anew Optics ... AngioDynamics ... Angiologix ... Angstrom Medica .... Angstron Materials ... Ansoft ... Anthera Pharmaceuticals .... Antigenics ... Anue Systems ... Anulex Technologies ... Anybots ... AOptix Technologies ... APA Optics (Enterprises) ... Apexigen ... Aphios ... Apieron ... Apnex Medical ... Apollo Diamond ... Apollo Endosurgery ... Apoplogic Pharmaceuticals ... Applied Nanotech .... Applied NanoWorks ... Applied Optoelectronics ... Applied Physical Electronics ... Applied Physical Sciences ... Applied Quantum Technology .... Applied Research Associates ... Applied Science and Technology ... Applied Signal Technology ... Apricus Biosciences ... Aptima ... Aptus Endosystems ... Aquaback Technologies ... Aqua Bounty ... AquaMost ... Aquarius Technologies ... AqueSys ... AragonPharmaceuticals ... Arbor Pharmaceuticals ... Arbovax ... Arcantatura ... Archemix ... Arch Therapeutics ... Arena Pharmaceuticals ... Arginetix ... ArgonST ... Argos Therapeutics ... Aria CV ... Ariad Pharmaceuticals .. Armadillo Aerospace ... Armorworks ... ArQule ... Array ... Arresto Biosciences .... Arrien Pharmaceuticals ... Arrowhead Research .... Arsanis ... Arsenal Medical .... Arstasis ... Arteriocyte ... ArthroCare ... Arthrosurface ... Artisan Pharma ... Aryx ... Arzeda ... Ascension Orthopedics ... Ascent Solar Technologies .... Ascent Therapeutics .... Ash Access Technology .... AstroWatt .... Aspen Aerogels .... AspenBio Pharma .... Aspen Technology ... Astex Therapeutics ... Astralux ... Astrobotic Technology .... Astronautics Corp. of America ... AstroPower... AstroTerra .. Astute Medicales ... Asuragen ... Athenix ... AtheroGenics ...ATI Industrial Automation ... Atlantia ... Atmospheric Glow Technologies ... Atomate ... Atomometrics ... Atossa Genetics ... Atreaon .... AtriCure ... Atrium Medical ... Audience ... Augmenix .... AUM Cardiovascular ... Aura Biosciences .... Aurora Algae ... Aurora Flight Sciences .... Aurora Spectral Technologies ... Auspex Pharmaceuticals ... Ausra ... Autonet ... Aushon Biosystems ... Autonomic Materials .... Autonomous Technologies .... Auxilium Pharmaceuticals ... Avanir Pharmaceuticals ... Avant Immunotherapeutics ... Avanti Metal ... Avaxia Biologics ... Avedro ... Aveo Pharmaceuticals ... AVI BioPharma ... Avici Systems ... Avid Radiopharmaceuticals ... Avila Therapeutics ... Aware ... Axelo .... Axerion Therapeutics ... Axial Biotech .... Axion Power ... Axis Semiconductor ... Axonia Medical ... Axsun Technologies ... Azaya Therapeutics ... Ballard Power ... Bandgap ... Barrier Therapeutics ... Bastion Technologies .... Baxano ... Beacon Power ... Beeco ... Bellicum Pharmaceuticals .... Belmont Instrument .... BeneChill ... Benefuel .. BetaBatt ... BG Medicine ... Bind Bioscience ... BiO2 Medical ... BiO2 Technologies ... BioAmber ... BioAdvanTek ... Bioanalytical Systems ... BioBehavioral Diagnostics ... Biocept ... BioCritica ... BioCryst Pharmaceuticals ... BioDelivery Sciences ...BioE ... Bioheart ... Biohelix ... Bio-Imaging Technologies ... Biolex Therapeutics ... BioLink Life Sciences ... Biologics ... BioMarin Pharmaceutical ... BioMarck Pharmaceuticals .... Biomatrica ... BioMedical Enterprises ... Biomedical Structures ... Biometric Signature ... BioMimetic Therapeutics ... BioNano Genomics ... BioNanomatrix ... Biophan Technologies ... BioProcessors ... BioPulping International ... Biopure ... BioRelix ... BioResource International ... BioSante Pharmaceuticals ... BioScale .... BioSense Technologies ... BioSentinel Pharmaceuticals ... BioSphere Medical .... BioSystem ... Biotectix .... Biotel .... Biothera ... Bio Time ... Biotix ... BioTrove ... BioVex ... Bitstream ... Black-I Robotics ... Black Sand ... BladeLogic ... Blend Therapeutics .... BL Healthcare ... Block Engineering ... Bloom Energy ... Blue Belt Technologies ... Bluebird bio ... Bluefin Robotics ... Blueprint Medicines ... Blue Sky Batteries ... Bluewater Bio International ... Boston Biochem ... Boston Biomedical ... Boston Dynamics ... Boston Engineering ... Boston Micromachines ... Boston-Power ... Boston Therapeutics ... Boundless ... BrainCells ... Brain Tunnelgenix Technologies .... Breathe Technologies ... Breonics ... Brewer Science ... Bridgelux ... Brightsource Energy ... Bright View ... Brimrose Corp of America ... Brock Rogers Surgical ... Brooks Automation ... Bruker Daltonics ... C12 Energy ... C3Nano ... C8 Sciences .... C9 ... Calando Pharmaceuticals ... Calera ... Calibra Medical ... Calient ... Caliper Life Sciences .... CaliSolar ... Calistoga Pharmaceuticals ... Caltech Metals ... Cambridge Endoscopic Devices ... Cambridge Heart .... Cambridge Research & Instrumentation ... Candela Laser .... Capnia ... Cara Therapeutics .... Carbon Design Systems ...Cardeas Pharma .... Cardiac Concepts ... Cardiac Dimensions ... CardiAQ Valve Technologies ... Cardica ... CardioDx ... CardioFocus ... CardioMag ... Cardiorobotics ... Cardiosolutions ... CardioSpectra ... CardioTech ... CardiOx ... Cardioxyl Pharmaceuticals .... Carigent Therapeutics ... Carnegie Speech ... Carticept Medical ... Cascade Designs ... Cascade Microtech ... Catabasis Pharmaceuticals ... Catadon Systems ... Catalyst Biosciences ... Catelectric .... Celadon ... Celator Pharmaceuticals ... CellCyte Genetics ... Celldex Therapeutics ... Cellectar ... Cellerant Therapeutics ... Cellular Bioengineering ... Cellular Dynamics International ... Cell Genesys ... Cell>Point .... Cell Signaling Technology ...Cell Therapeutics ... CellTraffix ... Celsion ... Celula... CellzDirect ... Cempra Pharmaceuticals. .... CeNeRx BioPharma ... Centrose ... Centice ... Centritec Seals ... Cephalon ... Cepheid ... Cephalon ... Ception Therapeutics ... Cequent Pharmaceuticals ... Ceradyne ... Ceramitron ... Ceramatec ... Cerealus Holdings ... Ceregene ... Cerahelix ... Cerion Enterprises ... Cermet ... Cerulean Pharma ... Cerus ... CFD Research .. CFX Battery .... CGI Pharmaceuticals ... ChaCha ... Chapman Innovations ... Charles River Lab ... Chemat ... ChemImage ... Chemir Analytical Services ... ChemoCentryx ... Chemtura .... Chesapeake Sciences ...Chesson Labs ... Chiasma .... Chimerix ... Chlorogen ... Choice Therapeutics ... Chondrogenics ... Chorum Technologies .. Chronix Biomedical ... Cibus Global ... Ciena ....Ciencia ... Cilion .... Ciranova ... Civitas Therapeutics ..... Clark-MXR ... Claros Diagnostics .... Clean Diesel Technologies ... ClearCount Medical Solutions .... ClearEdge Power .... Clearside Biomedical ... Cleveland BioLabs... CleverSet ... Clinical Data ... CloudMade ... Cobalt Biofuels ... Cocrystal Discovery ... Codexis ... Codon Devices ... Cognex ...Cognitive Code ... Cohesive Technologies ... ColdWatt ... Collagenex Pharmaceuticals ... Collegium Pharmaceutical ... CoLucid Pharmaceuticals ... CombiMatrix ... CombinatoRx ..... Combinent BioMedical Systems ... Comfort Motion Technologies ... Commonwealth Biotechnologies ... Compact Membrane Systems ... Compellent Technologies ... Complete Genomics .... Conatus Pharmaceuticals ... Concert Pharmaceuticals .... Concordia Fibers ...Concurrent Technologies ... Conductus .. ConforMIS ... ConjuGon ... Consonus Technologies ... Constellation Pharmaceuticals .... Convergen ... Convio .... Cool Earth Solar .... Cooligy ... Corcept Therapeutics ... CoreStreet ... CoreTek ... .Corgenix Medical ... Corindus .... Corixa .... Cornerstone Research ... Cornerstone Therapeutics .... Coronado Biosciences ... Correx ... Corridor Pharmaceuticals ... Cougar Biotechnology ... Coulbourn Instruments .... Creare ... Creative Hybrid Solutions .... Cree Research ... Crinetics Pharmaceuticals .... CritiTech ... CryoCor ... CryoLife ... Crystal IS ... Crystal Systems ... Crystallume ... CSA Engineering ... CS-Keys ... Cubist Pharmaceuticals ... CuraGen ... Current Motor ... CVRx ... CV Therapeutics ... CyberKey Solutions ... Cyberkinetics Neurotechnology ... Cybernet Systems ... CyberOptics ... Cymbet ...Cynosure ... Cyntellect ... CyPhy Works ... Cypress Bioscience ... Cyterix Pharmaceuticals ... CytImmune .... Cytogel Pharma .... Cytokinetics ... Cytometix ....CytomX ... Cytonome .... Cytori Therapeutics ... Cytophil CytoSolv ... Cytyc ... CyVek ... Daktari Diagnostics ... Dara BioSciences ... Dart Therapeutics ... DayStar ... DBS Energy ... DCL Medical Laboratories ... Deca-Medics ... Decision Biomarkers ... Deepwater Wind .. ... Dekkun .... Delcath ... Deltanoid Pharmaceuticals ... Dendreon ... DeNovo Sciences .... DeNovis ... DermAvance Pharmaceuticals ... Dermira ... DE Technologies ... Dew & Ken Group ... Dewey Electronics ... Dexcom ... Diagnostic Hybrids ... Dicerna Pharmaceuticals ... DiFusion Technologies ... Digirad ... Digital Fusion ... Digital Optics ... Directed Perception .. Disc Dynamics ... Discovery Labs .... Displaytech ... Distributed Energy Systems ... Divergence ... Diversified Energy ... D. Light ... DNAPrint Genomics ... DNAtrix .... DoX Systems ... Dragon Systems .. Drilling Info ... DR Technologies ..... DT Solar ... DuBay Ingredients ... duPont Aerospace ... Dyax ...DynaBil Industries ... Dynasil ... Dynavax Technologies ... Dynogen Pharmaceuticals... Eagle Optoelectronics ... Earthrise Nutritionals ... Echelon ... Echometrix ... Echo Therapeutics (was Sontra)... ECI Biotech ... Ecocurrent ... Eden Bioscience ... Edenspace Systems ... EEStor ... Eikos ... E Ink ... Ekos ... Elcelyx Therapeutics ... ElectroCell Technologies ... ElectroChemical Systems ... Electro Energy ...Electromed ... Electro Optical Sciences ... Electro Scientific ... Elemetric Instruments ... Elevation Pharmaceuticals ... Eleven Biotherapeutics ... Elixir Pharmaceuticals ... Elixir Biopharm ... Elon ... eMagin .. Embera NeuroTherapeutics .... Embrex .. EMCORE ... Emerald BioStructures .... Emergent BioSolutions ... Emergent Technologies ... Encite ... Encysive Pharmaceuticals ... Endece ... Endgame Technologies ... Endocyte ... EndoGastric Solutions ... Endoscopic Technologies ... EndoStim .... Ener1 ... EnerG2 ... Energen ... Energetiq Technology ... Energid Technologies ... Ener-G-Rotors ... Energy Control ... Energy Conversion Devices . .. Energy Recovery ... Energy Solutions ... Enertech Environmental ... Engineered BioPharmaceuticals .... Engineous Software ... Enlight Bioscience ... Ensysce Biosciences ... Entech ... Entegrion ... Entergem Ventures .... EnteroMedics ... Entopica Therapeutics ... EntreMed ... Entra Pharmaceuticals ... Envia Systems .. EnVivo Pharma ... Enzenia ... Enzo Biochem ...EOIR ... Epicentre Biotechnologies ....EpiEP ... Epion ... Epitomics ... EpiVax ... Epix Pharmaceuticals ... Epizyme ... EqualLogic ... Equex ... Equipment Concepts ... EraGen Biosciences ... Erallo Technologies ... Ercole Biotech ... Escalon Medical .... Escoublac .... eScription ... eSolar ... Eso-Technologies ... Essex... E-Tek Dynamics ... Euthymics Bioscience ... EVapt .... Ever Cat Fuels ... Evergen Biotechnologies ... Evergreen Solar ... Evident Technologies ... Exact Sciences .... Exagen Diagnostics ... Excelimmune ... Excel Technology .... Exelixis Plant Sciences ... Exogenesis ..... ExploraMed NC4 ... Extremity Innovations ... EyeGate Pharmaceuticals ... EyeTel ... Fallbrook Technologies ... Famigo ... Farodox Energy Storage ... FarSounder ... FastCAP Systems ... Fate Therapeutics ... FEI ... Femta Pharmaceuticals .... Ferrate Treatment Technologies ... Feuz Manufacturing ... Fiber Materials ... Fiber and Sensor .... Fibersense ... Fibrocell Science ... FibroGen ... Filter Sensing Technologies ... Finisar ... Firefly BioWorks ... Firefly Energy .... Firefly LED ... First Solar ... Fisker Automotive ... Flex Biomedical ... Flexion Therapeutics ... FLIR Systems .. FloDesign Wind Turbine ... FlowCardia ... FlowMedica .... Flow Metrix ... FluGen ... Fluidic Energy ... Fluidigm ... Fluid Innovation Group ... Fluidnet ... Fluidnet FluoroPharma ... FoldRx Pharmaceuticals ... Follica ... Footnote .... F-Origin ... Forma Therapeutics ... Forus Health ... Foster-Miller .... Foundation Medicine ... Fractal Antenna Systems ... Free Flow Power ... FTL Solar ... FuelCell Energy ... Fuel Tech ... Fusion Coolant Systems ... Galenea .... Galleon Pharmaceuticals ... GameSalad ... Gamma Medica Ideas ... Gelesis ... Geltech ... GEMFIRE .. Gemin X Pharmaceuticals ... Gemmus Pharma ... Gen9 ... Genaera ... Genelabs Technologies ... Gene Logic ... General Compression ... Generex Biotechnology ... GenesisLabs .... Genetix Pharmaceuticals ... Genocea Biosciences ... Genomatica ... Genomic Health ... GenomeQuest ... Genoptix Medical Laboratory ... Genor ... Gen-Probe ... GenSpera .... GenTel BioSciences ... GenVec ... Geomagic ... GeoMed Analytical ... GeoVax Labs ... Geospiza ... Geron ... GI Dynamics ... GigOptix ... Giner . .. Ginkgo BioWorks .... GlideLine Systems ... Gliknik ... Global Positions ... Gloucester Pharmaceuticals ... GlucaGo ... GlycoFi ... GlyGenix ... GlySens ... GMZ Energy ... GnuBio .... Good Start Genetics .... Gore Photonics ... GPC-Rx ... gRadiant Research ... Graphene Energy ... Graphic Surgery ... Greatbatch ... GreatPoint Energy ... GreenFuel Technologies .... GreenTech America ... Grove Instruments ... GSI Technology ... GT Advanced Technologies ... GTC Biotherapeutics ...GT Equipment .. GTI Diagnostics ... Guided Therapeutics .... G-Zero Therapeutics ... H2Pump ... H3 Biomedicine ... HNC Software ... Halozyme ... Hana Biosciences .... Hansen Medical ... Harbor Technologies .. Hardcore Computer ... Harvard Bioscience ... Harvest Automation .... Harvest Power ... Healionics .. Healthtronics .... Hearforward ... Heartland Robotics .... HeartWare International ... HeatGenie ... Helicos BioSciences ... Heliovolt ... Helix Therapeutics ... HemaQuest Pharmaceuticals ... Hepregen ... Herley Industries ... Hermes Biosciences ... Hibernaid .... High Performance Technologies ... Histogenics ... HistoRx ... Hoku Scientific ... Hollis-Eden Pharmaceuticals ... Hontek ... Hoppe Tool .... HTSS ... Humacyte ... Human Genome Sciences ... Hybrivet .... HYCOR Biomedical ... Hydra Biosciences ... HydroCision ... Hydrogen Safety ... Hygeia Therapeutics ... HyperBranch Medical Technologies ... Hyperion Therapeutics ... HyperMed ... HYPRES .. Hy-SyEnce ... IAP Research ... IBC Advanced Technologies ... Ibis Technology ... iBLogix ... IBT Laboratories ... Icagen ... iCardiac Technologies ... ICx Technologies ... Idaho Technology .. Ideal Power Converters ... IdeaPaint .... II-VI .. Ikaria .... Ikonisys ... Illinois Superconductor ... Illumigen Biosciences ... Illumina ... IlluminOss Medical ... Illumitex ... Imaging Biometrics ... Imago Scientific Instruments ... Immersion ... Immtech ... Immune Control ... Immune Design ... Immunetics ... Immunex .... ImmuneXcite ... ImmuneWorks ... .Immunicon ...ImmunoGen ... Immunomedics ... ImmuRx .... ImmusanT ... Impact Science & Technology ... Imperium Renewables ... Impinj .... Implant Sciences ... Impulse Monitoring ... ImThera Medical ... i-Nalysis ... INC Research ... Incyte ....InCytu ... Incelldx ... Indiana Nanotech ...Infinera ... Infinia ... Infinity Pharmaceuticals ... Inform Genomics ... Infoscitex .... Inframat ... InfraReDx ... InfraScan ... Inhibitex ... INI Power ... InnerOptic Technology ... InnerPulse ... Innography ... InnoPad ... Innovalight .. Innovari Energy ... Innov-X .... Innovative Microplate ... Innovative Silicon ...Innovative Spinal Technologies .... Innovative Technologies ... InnoventionTech ... Innovention Technologies (now Cardiorobotics) ... InnoWave ... Inorganic Specialists ... Inotek Pharmaceuticals ... Inovio Biomedical ... InPhase ... Inphi ... Insight ..InSite Vision... . Insitu ... Inspire Medical Systems .... Inspire Pharmaceuticals ... Insulet ... IntAct Labs .... Intaglio ... Intalio ... IntegenX ... Integra Group ... Integrated Diagnostics ... Integrated Fuel Cell Technologies ... Integration Associates ... Intelect Medical .... Intelleflex ... Intelligent Automation .. Intelligent Bio-Systems ... Intelligent Medical Devices ... Intelliphage ... .Intellisense ... Interactive Supercomputing ... Interdigital ... Interlace Medical ... Intermagnetics General ...Intermolecular ... InterMune ... International Stem Cell ... Intersense ... Intersystems ... Intevac ... IntraLase.... Intrinsity ... Introgen Therapeutics ...Intuitive Surgical ... Invensense ... Inverness Medical Innovations ... InView Technology ... Inviragen .... InVisage Technologies .... Invitrogen ...Invivosciences ... InVivo Therapeutics Holdings ..... Iomai ... Iomed ... Ion America ... Ion Optics .. Ion Torrent ... Iovation ... Iowa Thin Film Technologies ...IPG Photonics ... IQuum ... iRobot ... Ironbridge Technologies ... Ironwood Pharmaceuticals ... Irvine Sensors... Isis Biopolymer .... Isis Pharmaceuticals ... Island Data ... Isogenis ... IsoRay ... Isothermal ... Itaconix ... I-Therapeutix .... Itherx Pharmaceuticals .... Itzbig ..... iWalk ... J&Y ... Janssen Biotech .... Janus Biotherapuetics ... Javelin Pharmaceuticals ... Javelin Semiconductor ... Jennerex ... Joule Biotechnologies .... Joyent ... Kala Pharmaceuticals ... Karyopharm Therapeutics ... KaZaK ... KC BioMediX ... KDH Defense Systems ... Keithley Instrument ...Kensey-Nash ... Kent Displays ... Kilawatt Technologies ... Kineta ... Kitware ... Kiva Systems ... KLD Energy Technologies .... Knome ... Knopp Neurosciences .... Kolltan Pharmaceuticals ... Komoku ... Konarka ... Koning ... Kopin .. KOR Electronics ... Koronis Pharmaceuticals ... Kosan Biosciences ... Kovio ... Kratos Defense & Security Solutions .... Kronos Advanced Technologies ... KSE ... KVH .. Kylin Therapeutics ... Kyma .... Kyron Clinical Imaging ... LAAMScience ... LabNow ...Laborie Medical Technologies ...La Jolla Pharmaceutical ... Landec .... Lantos Technologies ... LaserMotive ... Laser Tissue Welding .... Lawrie ... Lead Therapeutics ... LeCroy ... LED Lighting Fixtures ... Lexicon Genetics ... Lexicon Pharmaceuticals ... Leyden Energy ... Libra BioSciences .... LifeCell ... LifeGen Technologies ... Life Image ... Life Technologies .... Ligand Pharmaceuticals ....Ligon Discovery ... Lightpointe ... Light Sciences Oncology ... Lilliputian Systems .... Linares Management Associates .. Lingotek ... LipoScience ... Liquidia Technologies ...Liquid Metal Battery ... LiquidPiston ... LiQuifix ... Lithium Technology ... LiveData ... .Logical Therapeutics ... Logos Tech ... Lotus Tissue Repair ... LS9 ... Luca Technologies .... Lucigen .... Lumencor ... Lumera ... Lumicell Diagnostics ... Luminary Micro ... Luminex .... Luminus Devices ... Lumitex ... Luna Innovations ... Luna Technologies ... Luxtera ... Lycera ... Lynntech ... MabVax Therapeutics ... Macrochem ... Macrogenics ... MagneMotion ... Magnetek ... Magnolia Optical Technologies ... Magnolia Solar ... Mainstream Engineering ... Mako Surgical ... MapInfo ...MAP Pharmaceuticals ... Marcadia Biotech ... Marina Biotech ... Marinus Pharmaceuticals ... Martek Biosciences ... Mascoma ... Mashery ... Mason Box ... Masten Space Systems ... Material Sciences ... Material Technologies ... MathStar .. Matouk Textiles ... Matritech ... Matrix Sensors ... Maxdem ... Maxpower ... Maxygen .... MC10 .... MDSolarSciences ... Mechanical Technology ... Mechanology ... Medafor ... Medarex ... Medical Device Logistics ... MedicaMetrix... MedImmune .. Medis ... Medivation ... Medrobotics ... MELA Sciences .... Memjet ...Memry ... Memsic ... MEMS Optical...MER ... Mercator Therapeutics ... Mercury Computer Systems .... Merge Technologies ... Meridian Bioscience ... Merkatum ... Merrimack Pharmaceuticals ... Mersana Therapeutics ... Mesocopic Devices ... Metabasis ... Metabolic Solutions Development .... Metabolix ... MetaCarta ... Metal Oxygen Separation Technologies ... Metamark Genetics ... MetroLaser ... Micell Technologies ... Micrel ... MicroCoating ... Micracor ....Microbia ... Microfluidics International (Microbia) ... MicroGreen Polymers .... MicroIslet ... MicroMask ... Micronics ... MicroOptical (New Mexico)...MicroOptical (Massachusetts) ... MicroPower Technologies ... Microstaq ... Microvision ...Mid Valley Industries ... Minerva Biotechnologies ... Mirador Biomedical ... Mira Dx ... Mirina ... Mirna Therapeutics.... Miromatrix Medical ... Mirus Bio ... Mission Research ... Mississippi Polymer ... Mithridion ... Mnemosyne Pharmaceuticals ... Mobile Robots ... Molecular Biometrics ... Molecular Detection ... Molecular Imprints ... Molecular Insight Pharmaceuticals ... Molecular Templates .... Molten Metal .. MoMelan Technologies ... Momenta Pharmaceuticals ... Monebo ... Monogram Biosciences .... Morphormics ... Morphotek ... Morris Innovative Research ... Mortara Instrument ... Motricity ... MPP Group ... Mudawar Thermal Systems ..... Munksjo Paper ... Mx Orthopedics .... Myocor ... Myomo ... Myriad Genetics ... Myriant Technologies ... Mystic Pharmaceuticals ... N12 Technologies ... NABsys ... NanOasis Technologies ... NanoBio ... Nanobiosym ... Nano-C ... Nanocomp Technologies ... NanoCoolers ... Nanocopoeia ... NanoCor Therapeutics ...Nanodynamics (Buffalo) ... Nanodynamics (NYC)... NanoH2O ... Nanohmics ... Nanogen ... NanoGram ... NanoLab ... NanoLite Systems ... NanoLogix ... Nanomaterials Research ... NanoMatrix ... NanoMedex ... NanoMedicalSystems ... NanoMedical Systems .. Nanomix ... Nanophase Technologies ...Nanoptek ... Nanoscale Materials ... Nanosolar ... Nanosonic ... Nanosphere ... NanoSteel ... Nanosys ... NanoSystems ... Nano-Terra ... NanoTune Technologies ... Nanovation Technologies ...NanoViricides ... Nantero ... Napo Pharmaceuticals ... Nascentric ... Nastech Pharmaceutical ... NaturalNano ... Natus Medical ... Naverus ... Navidea Biopharmaceuticals ... Navini Networks ... Navmar Applied Sciences ... NCD Technologies .... nContact Surgical ... Neah Power ... Nektar Therapeutics ... Nekton Research .... NeoChord ... Neogen .... Neograft ..... NeoPhotonics ... Neoprobe ... Neotron ... Nereus Pharmaceuticals ... Netezza ... NetLogics Microsystems... NetworkFab ... NeurAccel Biosciences ... Neuralstem .... Neuro Amp .... Neurobiological Technologies ... Neurocrine Biosciences ... NeuroDx Development ... Neurodyne Medical ... Neurogen ... Neuroges ... Neurognostics .. NeuroLogica .... NeuroMap ... NeuroMetrix... Neuronetics .. Neuronex .. NeuroPhage Pharmaceuticals ... Neuron Systems ... Neuroptix ...NeuroVigil ... NeuroVista ....NeuWave Medical ... Nevro ... New England BioLabs ... New Era Technology ... Nexant ... NexBio ... NextIO ... Nextreme Thermal Solutions ... Nexus Biosystems ... Night Vision ... NimbleGen Systems . .. Nimbus Discovery .. NinePoint Medical ... Nitero .... Nitric BioTherapeutics .... NitroMed ... Nitronex ... NKT Therapeutics ... nLight ... NMT Medical ... Noble Fiber ... Nomadics ... Nonvolatile Electronics ... Norian ... NormOxys .... Northeast Photosciences .. Northstar Battery ... Northstar Neuroscience ... Northstar Photonics .. Northwest Biotherapeutics ..Notice Technologies ... .Novacea ... Novalar Pharmaceuticals ... Novalux ... NovaScan ... Novatek ... NovaTorque ... NovaTract Surgical ... Novecon Technologies ... Novelos Pharmaceuticals ... Novelos Therapeutics ... Novira Therapeutics ... Novocell ... Novogy ... Novomer ... N ovophage ... Noxilizer ... NP Photonics ... Nuclea Bioechnologies ... NuPathe .... Nutrabiotix ... NuVant ... Nuventix ... Nuvera Biosciences ... Nuvera Fuel Cells.. . NxThera ... NZ Applied Technologies ...Oasys ... ObjectVideo ... OBS Medical ... Ocarina Networks ... Ocean Power Technologies ... OCI ... Ocular Therapeutix .... Oculeve ... Oculus ... Oddpost ...Oil Chem Technologies ... Omeros ... OmniGene Bioproducts ... OmniGuide ... OmniLytics ... OmniSonics Medical Technologies ... Omni Water Solutions ... OnChip Power .... Oncogenex ... Oncolytics Biotech ... OncoMed Pharmaceuticals .... Oncoscope ... OncoSec Medical .... Oncothyreon ... On-Q-ity .... Onyx Pharmaceuticals ... Oorja Protonics .... Open Algae ... Open Silicon ... Opexa Therapeutics ... OpGen ... OPNET Technologies ... OptTek Systems ... Optelecom ...Optelecom-NKF ... Optherion ... Optical Concepts .. Optigain .. Optimal Technologies ... Optivision ... Opto Technology ... OPX Biotech ... OraMerix ... Orasi Medical ... Orbital Technologies ... Orchid Cellmark ... Orexigen Therapeutics ... Organogenesis ... Organovo .. OriginOil ... Orion Energy Systems ... Orion Genomics ... Ormet Circuits ... Orologic... Ortel ... Ortho Kinematics .... Oryx Technology ...Oscient Pharamceuticals ...Osiris Therapeutics ... OSI Pharmaceuticals ... Osteotech ... Otonomy .... OvaScience ... Oxford Performance Materials ... Oxygen Biotherapeutics .... Pacific Biosciences .... Pain Therapeutics ... Palmer Labs ... Paloma Pharmaceuticals ... Panacos ... Panomics ...Paper Battery .... Paradigm Sensors ... Paragon Dynamics ... Paragonix Technologies .... Parasol Therapeutics ... Paratek Pharmaceuticals .... Parion Sciences ... Pasteuria Bioscience ... Pathfinder ... PathoGenetix ... Patton Medical Devices ... Patton Surgical .... Pavilion Technologies ... Pax Streamline ... PaxVax ... PDL BioPharma ... Pearl Therapeutics ... Pellion Tech ... Peptimmune ... Perceptive Sciences ... PercipEnz Technologies ... Permeon Biologics ... Perscitus Biosciences ... PersonalBee ... Pervasis Therapeutics ... Pervasive .... Pfenex ... Pharmacyclics ... Pharmacyclics .... Pharmasset ... PhaseBio Pharmaceuticals .... Phase Bioscience ... Phoenix Science .. Phononic Devices ... Photobit ... PhotoMedex ... Photonics Innovations ... PhotoThera ... Photronics ... Phurnace Software ... Phylonix .... Physical Optics... Physical Sciences ... PhysioGenix ... PhysioSonics ... PhytoTech ... Picolight .... Picometrix ... Piedmont Biofuels ....Pika Energy ... Pinger ... Pinnacle Technology ... Pixel Optics .. Pixim ... Pixtronix ... Planar Energy ... Planar Systems ... Plasan ... Platypus ... PLC Medical Systems ... Plextronics ... Plexxikon ... Plug Power ... Pluromed ... Polatis .... Polychromix ... Polyera ... PolyMedica ... PolyMedix ... Polymer Technology Systems ... PolyPlus ... PolyRemedy ... Polysciences ... Polystor ... Portola Pharmaceuticals ... Possis Medical ... PowerGenix ... Powerlight ... Power Precise Solutions ... PowerVision ... Pozen ... Pranalytica ... Precision Biopsy ... Precision BioSciences .... Precision Optics ... Predictive Biosciences ... Presage Biosciences ... Pressure BioSciences ... Prevention Pharmaceuticals .... Primera Biosciences ... Primorigen Biosciences ... Prism Solar Technologies .... ProCertus BioPharm ... Profectus BioSciences . .. Progenics Pharmaceuticals ... Prologic ... Promedior ... Promentis .... Propulsive Wing ... Protein Sciences ... Proteon Therapeutics ... Proteostasis Therapeutics ... Proteotech ... Proteus Biomedical ... Protez Pharmaceuticals .... ProThera Biologics ... Proto Labs ... Proton Energy Systems ...Protonex .. Prototype Productions .Provagen ... Provenance Biopharmaceuticals ... Proventys ... pSivida ... PTC Therapeutics .... Pulmatrix ... Purfresh ...Qcue .... QD Vision ... Qioptiq ... QM Power ... QPixel ... QR Pharma ... Qteros ... Quadra-Aerrow International ... Quadraspec ... QualityMetric ... Qualtré ... Quanterix ... Quantum Epitaxial Designs ... Quantum Fuel Systems... Quantum Logic Devices ... QuantumSphere .... Quark Biotech ... Quark Pharmaceuticals ... Quick–Med Technologies .... Quidel ... Quincy Bioscience ... Quintessence Biosciences ... Quorum Systems ... Radant Technologies ... Radiant Photonics...Radiation Monitoring Devices ... RadioMedix ... Radius Health .... Rainbow Organic Farms ... RainDance Technologies ... RainStorm ... Rain Water Solutions ... RaNA Therapeutic ... Range Fuels ... RaPharmaceuticals ... Rapid Diagnostek ... Rapid Micro Biosystems ... Rapiscan ... Raser Technologies .... Raydiance ... Receptor Logic ... Receptos ..... Recodagen ... Recombinetics ... ReconRobotics .. Regado Biosciences ... ReGen Biologics ... Regulus Therapeutics ... RemoteReality .... Rempex Pharmaceuticals .... Renewable Alternatives ... Renovis ... Rentech ... Replidyne ... Repligen .. Research Frontiers .. Resolvyx Pharmaceuticals ... Response Genetics ... Restoration Robotics .....Restore Medical ... Retriever Technology .... Reva Medical ... Revegen ... ReVision Therapeutics .... ReVolt Tech ... Rexahn Pharmaceuticals ... RF Code ... RFMicron .. RF Surgical. .... Rhenium Alloys .. Rhevision ... Rho ... Rhythm Pharmaceuticals ... Rhythmia Medical ... Rib-X Pharmaceuticals ... RipCode ... Rive Technology ... RJA Dispersions ... R.L. Phillips ... Robopsy ... Robotic FX ... Robotic Technology ... Rocky Research .... RRE Solar .... .Rules-Based Medicine ... Rushford Hypersonic ... RXi Pharmaceuticals ... RxMedic .... Rypos ... S2 ... Sage Electrochromics ... Sage Science ... Sage Therapeutics ... Sakti3 ... Salient Surgical Technologies ... Salix Pharmaceuticals ... .. Sangamo Biosciences ... Sangart ... Sapphire Energy .... Sarda Technologies ... SatCon Technology ... Satori Pharmaceuticals .... Savara Pharmaceuticals .... Savi ... SciClone Pharmaceuticals ... Scientific Conservation .... Scientific Research ... Scientific Solutions ... Scientific Systems ... SciFluor Life Sciences ... SciQuest ... Scopic Software ... Scynexis ... SD Catalyst Group ... SDL .. SeaChange ... Seacoast Science ... Seahawk Biosystems ... Seahorse Bioscience ... Seaside Therapeutics .... Seattle Genetics ... Seattle Medical Tech .... Secure Computing ... Seeo ....Seldon Labs ... Selecta Biosciences ... Semiconductor Laser ... SemiProbe ... Semprius ... Semprus BioSciences .... Sencera International ... Senomyx ... SensAble Technologies ... Sensors Unlimited ... SensorTran ... Sentelligence ... Sepracor ...SeQual Technologies ... Sequella ... Sequel Pharmaceuticals .... Sequenom ... Sequent Medical .... SeraCare Life Sciences ... Serenex ... Seventh Sense Biosystems ... SGX Pharmaceuticals ... Shiloh Labs ....Shine Medical Technologies ... Si-Bone .... Sicel Technologies ... SiCortex ... SI Diamond Technology ..Sierra Monolithics ... Siga Technologies ... SiGe Semiconductor ... Signature Genomic Laboratories ... Silatronix ...SiliconBlue .... Silicon Laboratories ... Silicon Mountain Design .. Siluria ... Silverbrook ... Silver Spring Networks ... SiMPore ... Simulation Technology and Applied Research ... Simulution ... Singulex ... Sinmat ... Sion Power ... SiOnyx ... Sioux Manufacturing ... Sirga Advanced Biopharma .... Sirion Therapeutics ... Sirna Therapeutics ... Sirtris Pharmaceuticals ... Skyonic ... SLI .. SmartCells ... Smart Modular Technologies ... SmartSpark Energy Systems ... Smooth-Stone ... Solaicx .... SoftSwitching Technologies ... Soft Tissue Regeneration ... Solais Lighting .... SolarBridge Technologies ... Solaria ... Solarmer Energy ... Solar Power Technologies ... SolarWinds ... Solazyme ... Solexant ... SolFocus ... Soliant ... SolidWorks ... Solixia ... Solix Biofuels ... SolMap Pharmaceuticals ... Solomon Technologies ... Solo Power .... Solx .... Solyndra ... Somaxon Pharmaceuticals .... Sonalysts ... Sonex Aircraft ... Sonitus Medical ... SonoSite ... Sontra Medical ... Sonus Pharmaceuticals ... Soraa .... Soteira ... Sourcefire ... Source MDx ... Southwall Technologies ... Southwest Windpower ... 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Wintegra ... Wizbe Innovations ... WMR Biomedical (now Arsenal Medical) ... Wolf Technical Services ... Wright Materials Research ... W Solar Group ... Xanthus Pharmaceuticals ... X-Body Biosciences ... Xcellerex ... Xenex Healthcare Services ... Xenomics ... Xenoport ... Xeris Pharmaceuticals ... Xidex ... Xitronix ... XL Hybrids ... Xolve ... Xoma ... XSunX ... Xtalic .. Xtent ...Xtreme Power ... Xunlight ... Yardney Technical Products ... Y-Carbon ... Yurie ... Z ... Zacharon Pharmaceuticals .... ZafGen .... ZBB Energy ... ZeaChem ... Ze-gen ... ZenBio ... Zilker Labs ... Zinc Matrix Power ... Ziopharm Oncology ... Zogenix ... Zosano Pharma ... ZPower ... Zumobi ... Zurex Pharma ... Zygo ... ZymoGenetics ... Zystor Therapeutics

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Prepared by Carl Nelson Consulting Inc, carl@carl-nelson.com; http://www.carl-nelson.com