Company Stories P

Stories that earlier appeared in Nelson's News 
Note 1: Carl Nelson Consulting, Inc is not an investment adviser and may hold a financial interest or client relationship in companies discussed.
(Note 2: Carl Nelson Consulting does not endorse these companies or organizations or their activities.) 
Looking for other older stories? Visit the archives

  

helping small high-tech companies get from idea to market


P3I ... Pace Packaging .... Pacific Biosciences ... Padlock Therapeutics ... Pain Therapeutics ... PaizaBio ..... Palantir Technologies .... Palmaz Scientific ..... Palmer Labs ... Paloma Pharmaceuticals ... Panacea Solutions .... Panacos Pharmaceuticals .... Pandromics ..... Pan Genome Systems ... Panomics ... PanTheryx ..... Paper Battery ... PapGene ..... Paradigm Diagnostics .... Paradigm Sensors ... Paradromics ..... Paragon Dynamics ... Paragonix Technologies ... Parasol Therapeutics ... Paratek Pharmaceuticals ... Parexel International .... Parion Sciences ... ParkerVision .... Partpic .... Passport Systems .. Pasteuria Bioscience ... PathoGenetix ... PathoVax ..... Pathway Genomics .... PatientStream .... PatientWise ... Patton Medical Devices ... Patton Surgical ... Pavilion Technologies ... Pax Streamline ... PaxVax ... PDL BioPharma ... Pearl Therapeutics ... PDI Therapeutics ..... Pear Therapeutics ..... PECA Labs ... Pediatric Bioscience .... Peerless Technologies ... Pegasus Sustainability ..... Pelican Therapeutics .... Pelican Products ... Pellion Tech ... Peloton Therapeutics ..... Peninsula Pharmaceuticals ... PennAlt Organics ..... Penumbra .... Peptilogics ..... Peptimed ... Peptimmune ... PercipEnz Technologies ... PersonalBee ... Perceptive Navigation ..... Perceptive Sciences ... Perceptron ... Peregrine Semiconductor .... PeriphaGen .... Permeon Biologics ... Perosphere ... Perscitus Biosciences ... Perseon .... Persimmon Technologies ... Personalis .... Personal Genome Diagnostics .... Pervasis Therapeutics ... Pervasive ... Petra Pharma ..... Pfenex ... Pharmacyclics ... PharmaJet ... PharmAkea Therapeutics .... Pharmasphere .... Pharmasset ... PharmAthene ... PharmatrophiX ... PhaseBio Pharmaceuticals ...Phase Bioscience ... PhaseRx ... Phurnace Software ...Phigenix ..... Phoenix Biotechnology ..... Phoenix Nuclear Labs ... Phoenix Science ... Phononic Devices ... .. Photobit ... Photolitec .... PhotoMedex ... Photonics Innovations ... Photon-X .... PhotoSonix Medical .... PhotoThera .. Photronics ... Phoundry Pharmaceuticals .... Phylonix ... Physcient .... Physical Sciences ... Physical Optics ... PhysioGenix  ... PhysioSonics ... .... Phylos Bioscience .... PhytoTech ... Picolight ... Picometrix ... Piedmont Biofuels ... Pika Energy ... Pilus Energy .... Pinger ... Pinnacle Technology ... Pioneer Surgical Technology .... Pixelligent .... Pixel Optics ... Pixim ... Pixtronix ...Planar Energy ... Planar Systems ... Planet Labs .... Plano Microwave .... Plasan ... PlasmaTech Biopharmaceuticals ..... Platelet BioGenesis .... Platypus ... Play-i .... PLC Medical Systems ... Plextronics ... Plexxikon ... Pliant Therapeutics ..... Plug Power ... Pluromed ... PLx Pharma .....PLX Technology .... PMT .... PMV Pharmaceuticals .... PneumRx ..... Point Source .... Polarean .... Polatis ... Polychromix ... Polyera ... PolyMedica ... PolyMedix ... Polymer Technology Systems ... Polynoma .... PolyNova ... PolyPlus ... PolyRemedy ... Polysciences ... Polystor ... Possis Medical ... Pothole Pros ... PowerGenix ... Portola Pharmaceuticals ... Powerlight ...Power Precise Solutions ... PowerVision .... Prairie Technologies ... Pozen ... Pranalytica .... Precision Biopsy ... Precision BioSciences ... Precision for Medicine .... Precision Genome Engineering ... ..... Precision Optics ... Precision Therapeutics ... Precision Virologics ..... Predictive Biosciences ... Pregmama .... Presidio Pharmaceuticals .... Presage Biosciences... Pressure BioSciences ... Prevencio ...... Preventice .... Prevention Pharmaceuticals ... Prieto Battery .... Primera Biosystems ... Primordial ... Primorigen Biosciences ... Primus Power .... Princeton Satellite Systems ...... Principia Biopharma .... Prism Solar Technologies ... Procept BioRobotics ..... ProCertus BioPharm ... Proclara Biosciences (formerly NeuroPhage Pharmaceuticals) ..... Procyrion...... Profectus BioSciences ... Progenics Pharmaceuticals ... Progenity ..... Prologic ... Promedior ... Promega .... Promentis .... Pronutria .... Propagenix ..... Propeller Health ..... Pro-Pharmaceuticals ... Protagonist Therapeutics ... Propulsive Wing ... ProstaGene ..... Protein Foundry ..... Protein Sciences ... ProteinSimple (formerly Cell Biosciences) .... Proteon Therapeutics ... Proteostasis Therapeutics ... Proteotech ... Proteus Biomedical ... Proteus Digital Health ... Protez Pharmaceuticals ... Prothena ..... ProThera Biologics ... Proto Labs ... Proton Energy Systems ... Protonex ... Prototype Productions ... Provagen ... Provenance Biopharmaceuticals ... Proventys ... Provista Diagnostics .... Pryor Medical Devices .... PsiKick ..... pSivida ... PTC Therapeutics ... Pulmatrix ... Pulmotect ..... Pulse Electronics ... PulseTherapeutics ..... Puma Biotechnology ..... PUR Biologics .... Pure Bioscience .... Purfresh ... Purillume ..... Pursuit Vascular ..... PurThread ..... PvP Biologics

....

P3I (Hopkinton, MA

A massive U.S. Air Force contract has been awarded to a group of five small businesses that will share in the $851 million worth of work, according to Washington Technology ...  sharing the contract: Abacus Technology (Chevy Chase, MD); EIS (Vienna, VA); Odyssey Systems Consulting Group(Wakefield, MA); P3I (Hopkinton, MA); and SpectrumS4 (Burlington, MA). [Dayton Business Journal, Nov 1, 12]  No SBIR to any.

Pace Packaging (Fairfield, NJ)

Fast-growing  packaging manufacturer Pro Mach (Cincinnati, OH; no SBIR) is continuing its acquisition streak, purchasing two companies ...  Benchmark Automation (Athens, GA; no SBIR, 30 employees) and Pace Packaging (Fairfield, NJ; no SBIR, 52 employees) mark Pro Mach’s 12th and 13th acquisitions, respectively, in the last three years.  [Andy Brownfield, Cincinnati Business Courier, Sep 12, 14]  Pro Mach [in turn] announced that affiliates of AEA Investors LP are acquiring the packaging machinery leader from The Jordan Company. [company press release, Sep 16, 14]

Pacific Biosciences of California

Pacific Biosciences, (Menlo Park, CA; no SBIR) developing disruptive technology to detect biological events at single molecule resolution, said it received grants totaling more than $1.9 million from the National Institutes of Health.  [Silicon Valley/San Jose Business Journal, Oct 8, 09]

Pacific Biosciences(Menlo Park, CA; no SBIR) makes novel use of fluorescent labels that allows it to read long stretches of DNA fragments, base by base, quickly and efficiently. Stephen Turner, the firm’s founder and chief technology officer, is confident that his firm will soon be able to sequence a complete human genome in under 15 minutes. He expects its first commercial product within two years.  [The Economist, Apr 18, 09]

Pacific Biosciences (Menlo Park, CA; no SBIR) is a company that startup people are willing to leave hefty jobs for because it sits on so much potential. ... building a next generation gene-sequencing machine. The goal of the three-and-a-half-year-old company is to bring gene sequencing to the masses ... Over the summer, PacBio raised $100 million in funding in its fifth round of financing.  [Michael Copeland, Fortune, Sep 29, 08]

[The Who's Who of ]Investors are pumping $100 million into a start-up developing technology to propel DNA sequencing into mainstream medicine. The infusion is expected to enable Pacific Biosciences of California (no SBIR) to introduce in 2010 its high-speed system for reading the chemical "letters" of DNA. The technology is designed to expand the use of sequencing to develop treatments tailored to patients' genetic makeup. [Wall Street Journal, Jul 14]

Padlock Therapeutics (Cambridge, MA)

Bristol Myers Squibb has agreed to acquire Padlock Therapeutics (Cambridge, MA; no SBIR, founded 2014) in a deal that could be worth up to $600 million if everything breaks right. Specifically, Bristol will pay up to $225 million in “upfront and near term” milestone payments   ...  raised just about $18 million since its inception   ....  zeroed in on what are known as protein-arginine deiminases, or PAD enzymes, and targeted them to make new drugs for autoimmune diseases. PAD enzymes can transform normal proteins into slightly modified forms attract the immune system’s attention, spurring it to attack otherwise healthy tissue.   [Ben Fidler, xconomy.com, Mar 22, 16]

Johnson & Johnson Innovation said it has formed alliances with six Massachusetts-based life science and research companies to further innovation in pharmaceuticals, medical devices and diagnostic and consumer healthcare. .... • Minerva Neurosciences (Cambridge, MA; no SBIR)– Partnering with Janssen Pharmaceutica N.V., Johnson & Johnson Innovation and the Janssen neuroscience therapeutic area, Minerva has begun a program that will focus on the treatment of patients with primary and secondary insomnia and potentially treating other related neuropsychiatric disorders.Rodin Therapeutics (Cambridge, MA; no SBIR)- With initial investment from Johnson & Johnson Development Corporation, Rodin’s will work in collaboration with Johnson & Johnson Innovation in studying the inheritable changes in gene activity for the treatment of cognitive disorders, including Alzheimer’s disease.Energesis Pharmaceuticals (Cambridge, MA; no SBIR) - Janssen Pharmaceuticals Inc. and Johnson & Johnson Innovation have established a collaboration with biotechnology company Energesis to identify biological compounds that stimulate the formation of brown fat for use in treating metabolic diseases. The company’s approach is a novel strategy, leveraging recent scientific insights in BAT biology to increase the body’s ability to burn stored fat and lower insulin resistance.Navitor Pharmaceuticals (Cambridge, MA; no SBIR) - Johnson & Johnson Development Corporation has made an equity investment in Navitor, which will work in collaboration with Johnson & Johnson Innovation to develop highly-specific modulators to regulate a cell’s response to nutrient availability, including cell growth and function.Ascelegen Therapeutics (Cambridge, MA; no SBIR)– With an equity investment from Johnson & Johnson Development Corporation, and in collaboration with Johnson & Johnson Innovation, Ascelegen is working on developing novel therapies for cardiovascular diseases, including heart failure. Ascelegen’s work builds on research conducted at the Harvard Stem Cell Institute and Brigham and Women's Hospital. Padlock Therapeutics (Cambridge, MA; no SBIR) – With an investment from Johnson & Johnson Development Corporation, and in collaboration with Johnson & Johnson Innovation, Padlock is developing new therapies targeting a protein that mediates how protein conversions lead to rheumatoid arthritis and how it drives inflammation and immune complex formation in active autoimmune disease.  [Boston Business Journal, Jun 19, 14]

Pain Therapeutics

Pain Therapeutics (Austin, TX; $200K SBIR, founded 1998) announced today it has been awarded an approximately $1.8 million [NIH] research grant.  This grant will support innovative technology developed by the Company to diagnose Alzheimer's disease with a simple blood test. [company press release, Sep 18, 17]  also  announced that it has been awarded a research and development grant from the National Institute on Drug Abuse (NIDA).  The grant of approximately $2.2 million provides Pain Therapeutics with a path forward to develop FENROCK™, a drug candidate for severe pain.  FENROCK is a transdermal patch that contains the prescription drug fentanyl to manage pain and incorporates novel abuse-deterrent technology. [company press release, Sep 18, 17]

Pain Thera up 11% [Sep 14,17]

Pain Thera down 53% [Oct 27, 14]  believes it will regain full development and commercial rights to REMOXY from Pfizer, ...Pfizer  intention to terminate development of REMOXY. Actual termination will become effective six months from today, [company press release, Oct 24, 14]

 Pain Therapeutics has stepped up its research on Fenrock, a new early-stage drug candidate that will administer the pain reliever fentanyl using a transdermal patch. The expected market for fentanyl patches in the U.S. is estimated to be as much as $900 million because the use of a patch prevents users from abusing the drug, which can have intense euphoric effects.   ....  not yet been submitted to [FDA] ... The company’s main drug, Remoxy, is going through a prolonged journey to the market in its partnership with Pfizer Inc. and the development of additional drugs is part of its strategy to widen its drug pipeline and become less dependent on the success of that one drug.   [Chad Swiatecki, Austin Business Journal, Sep 26, 14]

Pain Thera down 10% [Jun 27, 14]

Pain Thera up 21% [Feb 5, 14]

Pain Thera down 14% [Jan 15, 14]

Pain Thera up 11% [Nov 25, 13]

Pain Thera up 10% [Nov 8, 13]

Pain Thera up 16% [Oct 22, 13]

Pain Thera  up 36% [Aug 16, 13]

Pain Thera  down 50% [May 10, 13]   Pfizer said it could not decide whether to pursue regulatory approval for Pain Therapeutics painkiller Remoxy, for which the [FDA] sought additional studies  [Reuters, May 10, 13]

Pain Thera up 15% [May 7, 13]

Pain Therapeutics (2 SBIRs) up 26% [Apr 30, 13] following Pfizer's conference call and what Gabelli's Kevin Kedra told Dow Jones are "positive" comments about Remoxy, a long-acting oxycodone capsule the pair have been developing.  [Wall Street Journal, Apr 30]

Pain Therapeutics (two SBIRs) declared a special dividend.

[Nov 2012]

Pain Therapeutics  down 37% [Oct 31, 12]  Pfizer Says to make "go or no go" decision by March 2013 on whether to renew marketing application for Remoxy pain medicine * Says its decision on drug, partnered with Pain Therapeutics , will hinge on new trial results  [Reuters, Nov 1, 12]

Pain Theraup 10%  [Aug 6, 12]

Pain Therapeutics up 11% [Oct 10, 11]

Pain Thera up 15% [Aug 9, 11]

Pain Thera down 26% [Jun 27, 11]

Pain Thera down 43% [Jun 24, 11]  delayed in gaining U.S. approval for a second time of a new type of painkiller designed to curb drug abuse [Bloomberg, Jun 24, 11]

Pain Therapeutics up 13% [Mar 30, 11]

Pain Therapeutics up 10% [Feb 11, 11]

Pain Therapeutics  down 17% [Jul 7, 09] after its partner for painkiller Remoxy -- King Pharmaceuticals -- said it plans to resubmit a new drug application later than investors had expected. [Wall Street Journal, Jul 8]

Pain Thera down 10% [Mar 5, 09]

Pain Thera up 20% [Mar 3, 09]

Pain Thera down 26% [Mar 2, 09]

Pain Therapeutics down 21% [Dec 11, 08]

An FDA panel on Thursday gave Pain Therapeutics’s tamper-free pain pill mixed reviews. At least 10 members of the Food and Drug Administration panel said Remoxy, the drug developed by Pain Therapeutics and licensed by King Therapeutics Inc., was less likely to be abused than painkillers currently on the market, according to the news agency Reuters.  But eight members said Pain Therapeutics didn’t show that the long-acting, tamper-proof version of the $2 billion painkiller oxycodone would prevent abuse.  [San Francisco Business Times, Nov 13, 08]

Pain Thera  up 11% [Oct 16, 08]

Pain Therapeutics up 12% [Sep 18, 08]

PaizaBio (Albuquerque, NM)

PaizaBio (Albuquerque, NM; no SBIR) announced an agreement with Taiwan-based JHL Biotech to provide fill-finish services for multiple projects, specifically, turning compounds into injectables for clinical trials in both oncology and immunology therapy.  ... because the China Food and Drug Administration, the country’s counterpart to the United States Food and Drug Administration, is finally moving to implement reform in manufacturing standards.  “There are over 5,000 pharmaceutical manufacturing companies in China, and 3,000 of them aren’t going to meet quality standards,” said [founder and CEO Stuart] Rose.  [Joe Cardillo, Albuquerque Business First, May 18, 16]

Palantir Technologies (Palo Alto, CA)

Palantir Technologies (Palo Alto, CA; spooks don't do SBIR) disclosed that it has raised $50 million more in a funding round that now totals about $444 million.  ....  backers include the CIA's In-Q-Tel venture fund and Thiel's Founders Fund. Its customers include government intelligence agencies such as the National Security Agency.  [Cromwell Schubarth, Valley Business Journal, Sep 15, 14]

Palmer Labs (Durham, NC)

A giant nonprofit and a technology startup in the Triangle each snagged a slice of a $78 million federal stimulus grant to promote biofuels research. Both grant recipients are hiring engineers, project managers and other scientists for the research efforts. ... Palmer Labs (Durham, NC; no SBIR), 18-month-old, nearly $1.5million .. RTI International $750,000 to study new ways of cooking wood waste [John Murawski, Raleigh News & Observer, Jan 15, 10] Love stimulus? Remember that somebody has to pay for it, and the government has no money of its own.

Paloma Pharmaceuticals (Jamaica Plain,MA)

Paloma Pharmaceuticals  (Jamaica Plain, MA; no SBIR) has pulled in $500,000 in a first tranche of a planned $2 million securities offering, according to a regulatory filing. [Mass High Tech, Sep 4, 09]

Palmaz Scientific (San Antonio, TX)

Palmaz Scientific (San Antonio, TX; no SBIR). is selling $32.2 million in a private-placement [Series C financing] offering from shareholders as a way to keep the company afloat, the San Antonio Express News reported [Nov 19]. The company, headed by heart stent developer Dr. Julio Palmaz, is a research and development company that is working to commercialize a pipeline of metallurgical and nanotechnology processes that can aid in cardiovascular procedures. However, ever since its founding in 2008, Palmaz Scientific has not been able to launch any of its technology to market, according to the newspaper.  [James Aldridge, San Antonio Business Journal, Nov 19, 15]

Panacea Solutions (Research Triangle Park, NC)

NC IDEA has awarded more than $200,000 in grants to five North Carolina startups.  Three of them are: FokusLabs (Wake Forest, NC; no SBIR) has developed an intervention tool designed to remind individuals with autism and ADHD to get back on task when their attention wanders.  NIRvana Sciences (Durham, NC; no SBIR) is focused on novel fluorescent dyes developed at N.C. State University for use with medical diagnostic and imaging tests.   Panacea Solutions (Research Triangle Park, NC; no SBIR)  is using robotic technology to create low-cost, 30-day supply nutritional packets that are personalized for an individual’s needs.   [David Ranii, Raleigh News & Observer, Dec 10, 13]

Panacos Pharmaceuticals

Panacos Pharmaceuticals (Gaithersburg, MA; $3M SBIR) has announced a number of restructuring efforts, including layoffs of seven employees, the closing of the company’s Gaithersburg, Md., facility and the retainment of a financial advisor for the purpose of exploring a possible sale of the company or of its HIV development efforts.  [Mass High Tech, Feb 24, 09]

Panacos Pharmaceuticals said it has sold the rights and assets of bevirimat, a potential HIV drug, for $7 million.  The buyer is another biotech firm, Myriad Pharmaceuticals  of Salt Lake City, Panacos said. [Boston Globe, Jan 21, 09]

Panacos Pharmaceuticals (Watertown, MA; $4.5M SBIR) has laid off 18 employees, about 55 percent of its staff, and has announced that the company’s strategic considerations include financing, partnering or selling the company or its assets, Panacos officials said.  In September, Panacos reported a quarterly loss of $8.2 million on total quarterly revenue of $20,000[Mass High Tech, Dec 12, 08]

Panacos Pharmaceuticals (Gaithersburg, MD; $4M SBIR) reports it has completed negotiations to sever ties with its former partner Hercules Technology Growth Capital Inc. VC firm Hercules had on Nov. 19 accused Panacos of defaulting on a loan agreement signed in June 2007.  [Mass High Tech, Nov 24, 08]

Panacos Pharmaceuticals (Watertown, MA; $5+M SBIR) has been warned by NASDAQ for being below the buck. [Mass High Tech, Feb 1, 08]

Pandromics (San Jose, CA)

startup Pandromics (San Jose, CA; n SBIR) won an $18 million contract [from DARPA’s $65 million brain-machine interface program], vaulting it into the top ranks of Silicon Valley companies surging into the field of brain-machine interfaces. ...  It wants to squeeze a device the size of a mobile phone into a chip small enough to insert into a human brain, where it would “read” nerve signals and replace senses and abilities lost due to injury or diseases.  [CEO Matt] Angle said a model of his device for animal research should be available next year, but it might be a decade before it’s ready to be sold to people.  [Charles Piller, statnews.com, Aug 17, 17]

Pan Genome Systems (Madison, WI)

Seven [Wisconsin] companies each will receive a $75,000 grant under a new program aimed at helping them commercialize their products. The first-ever grants are being distributed by a program called SBIR Advance. ... with $1 million from the Wisconsin Economic Development Corp. and administered by the UW-Extension Center for Technology Commercialization.   All of the companies have already received [SBIR or STTR]. But they aren't able to use those funds for activities like patent work and customer development and validation. receiving the grants are: C-Motive Technologies (Madison, WI; one SBIR)  Isthmus Biosciences (Madison, WI; one SBIR); Nutrient Recovery and Upcycling LLC (Madison, WI; one SBIR);  Pan Genome Systems (Madison, WI; one SBIR);  V-Glass LLC  (Milwaukee, WI; one SBIR); Fiberstar Bio-Ingredient Technologies (Eau Claire,WI; one SBIR);  Medical Cyberworlds (Verona, WI; $600K SBIR).  [Kathleen Gallagher, Milwaukee Journal Sentinel. Sep 25, 14]

Panomics (Fremont, CA)

Affymetrix agreed to buy Panomics (Fremont, CA; $2.3M SBIR) for $73 million in cash. -... Panomics makes products for genetic, protein and cellular analysis. [San Francisco Business Times, Nov 11, 08]

PanTheryx ((Boulder,CO)

Aiming to maximize the potential of bovine colostrum to benefit global health, PanTheryx (Boulder, CO; no SBIR, founded 2007) is announcing two major acquisitions that make it the world’s premiere manufacturer of nutrient rich colostrum. In separate purchases, PanTheryx has acquired the two leading producers of colostrum and related nutritional products, APS BioGroup (Phoenix,AZ; no SBIR) and La Belle Associates (Bellingham, WA; no SBIR). In March of 2016, PanTheryx announced that it entered into a $53 million financing with Pegasus Capital Advisors. ... The terms of the acquisitions were not released. [company press release, Feb 14, 17]

Paper Battery (Troy, NY)

Paper Battery (Troy, NY; no SBIR), developer of an innovative supercapacitor­based energy storage and battery enhancement technology, announced the completion of UL certification for its PowerResponder® product line. PowerResponder is a line of new hybrid supercapacitors with technology enhancements that aim to replace traditional lithium ion batteries in select applications. PowerResponder has also been certified as RoHS compliant, giving it added environmental and safety benefits. The product line will be available in a range of sizes from 90F to 9000F with initial products available to OEM customers by the end of the year.  [company press release, Dec 14, 15]

[CEO] says Paper Battery (Troy, NY; no SBIR)  remains on track to generate revenue in 2015. ...  says the battery technology startup continues to test its ultrathin supercapacitor products in up to four verticals.  [Megan Rogers, Albany Business Review, Mar 23, 15]

Two Albany area startups in the battery and energy storage industry have been awarded $250,000 in New York state funding for product development. Eonix (Colonie, NY; no SBIR) [startup developing technology to expand the capacity of ultracapacitors] and Combined Energies (Latham, NY;  SBIR) [developing distributed generation systems to extend the life of electrochemical batteries] were among the nine companies that received funding from the New York State Energy Research and Development Authority.  ... also gave $250,000 to Hollingsworth & Vose  (East Walpole, MA; no SBIR) an advanced materials manufacturing company with filtration, battery separator and industrial applications.   [Megan Rogers, Albany Business Review, Oct 27, 14]  Since 2012, the state agency has funded Paper Battery Co., BESS Technologies, Rensselaer Polytechnic Institute, and many other state entities. 

A new $3 million investment will help take Paper Battery (Troy, NY; no SBIR, founded 2009) from the lab to the market. "It will go towards developing the rest of the pilot line and scaling it up," said Shreefal Mehta, president and CEO of Paper Battery.  ...  has developed an ultrathin ultracapacitor technology that seeks to re-define the way cell phones, bluetooth headsets and wireless speakers operate and perform. The paper-thin device helps lithium batteries last longer and charge quicker. The now five-year-old company has partnered with TWS Industrial, a major battery supplier in China.  [Keshia Clukey, Albany Business Review, Jun 12, 14]

Paper Battery (Troy, NY; no SBIR) startup developing a paper-thin energy technology, has been named to a Silicon Valley list for the 50 hottest early-stage tech companies. ....   expects to generate its first revenue from products this year as the company makes the transition from development to commercialization.  [The Business Review (Albany), May 23, 13]

Paper Battery (Troy, NY; no SBIR) , a nanotechnology/energy startup, developing a battery as thin as a piece of paper received a $1 million grant to take the next step in the production process. ... trying to break into the $500 million ultra capacitor market   [Michael DeMasi, Business Review (Albany), Sep 26, 11]

PapGene (Baltimore, MD)

PapGene (Baltimore, MD; no prior SBIR) announced that it was recently awarded a highly competitive Fast-Track NIH SBIR [Phase I plus contingent Phase II] to commercialize a test to detect ovarian and endometrial cancers. ... The PapGene test couples massively parallel sequencing (MPS) with a proprietary error-reducing technology developed in the Ludwig Center at the Johns Hopkins Kimmel Cancer Center. [company press release, Feb 4, 16]

Paradigm Diagnostics (Phoenix, AZ)

Paradigm Diagnostics (Phoenix, AZ; no SBIR) announced the near completion of their $7M Series B financing, adding an additional $3M  ...  towards further accelerating commercial adoption of the flagship Paradigm Cancer Diagnostic Test, PCDx, a comprehensive genomic profiling test and expanding the Paradigm cancer registry. ....  PCDx is a comprehensive clinical-grade NGS-based test that is designed to provide physicians and patients with a more targeted, personalized approach to cancer treatment by identifying the underlying genomic and proteomic alterations of a tumors DNA, RNA & protein.   [company press release, Feb 16, 17]

Paradigm Sensors (Milwaukee,WI

Paradigm Sensors (Milwaukee, WI; no SBIR) will begin production of biodiesel testing devices this year from a new home inside a business incubator ... start-up firm hopes to hire more than 25 people in the coming year as it starts manufacturing handheld devices that analyze biodiesel to ensure product quality ...  will soon close its first round of venture-capital funding after a $200,000 investment announced Tuesday by the Wisconsin Housing and Economic Development Authority.  [Thomas Content, Milwaukee Journal-Sentinel, Apr 3, 08]

Paradromics (San Jose, CA)

More fruits of miniaturization.  DARPA selected [Matt] Angle’s small company, Paradromics (San Jose, CA;  no SBIR), to lead one of six consortia it is backing with $65 million to develop technologies able to record from one million individual neurons inside a human brain simultaneously.   Matt Angle for years insisted that the key to solving one of neuroscience’s most intractable challenges lay in a 1960s-era technology invented in the tiny nation of Moldova.   [Adam Piore, Technology Review,  July 10, 17]  recently been awarded an $18.3M [DARPA] contract to build a high bandwidth cortical implant. The Neural Input–Output Bus, or NIOB, will be capable of reading and stimulating brain activity from 1 million neurons with an effective data rate of > 1 Gbps. [company press release, Jul 10, 17]  DARPA has awarded contracts to five research organizations and one company that will support the Neural Engineering System Design (NESD) program: Brown University; Columbia University; Fondation Voir et Entendre (The Seeing and Hearing Foundation); John B. Pierce Laboratory; Paradromics(San Jose, CA; no SBIR), Inc.; and the University of California, Berkeley. [DARPA press release, Jul 10, 17]

Paragon Dynamics (Aurora,CO)

Mercury Computer Systems  (Chelmsford, MA; no SBIR, market cap $400M) will pay $70 million to acquire a pair of companies that make electronic warfare and intelligence-gathering systems. Mercury is buying KOR Electronics (Cypress, CA; $6.8M SBIR mostly USAF) which makes digital radio and radar test gear, as well as Paragon Dynamics (Aurora, CO; no SBIR), which provides intelligence analysis and exploitation services.  [Hiawatha Bray, Boston Globe, Dec 23, 11]

Paragonix Technologies (Cambridge, MA)

Paragonix Technologies (Braintree, MA; no SBIR) cleared another major hurdle [FDA premarket clearance] toward commercializing the company's Sherpa Pak Transport Systems products, which are based on organ transplant transportation technology developed by researchers in San Antonio.   [James Aldridge, San Antonio Business Journal, Dec 2, 14]

Some Bay State largesse.  The Massachusetts Life Sciences Center, a quasi-public agency tasked with implementing the state’s ten-year, $1 billion Life Sciences Initiative, today announced the awarding of $2.2 million in loans [$750K each] to three early-stage life sciences companies. Intelligent Bio-Systems, (Waltham, MA; $6.3m SBIR)  DNA sequencing company with a patented, higher performance, lower cost, DNA sequencing instrument and consumable system; Allurion Technologies,(Wellesley, MA; no SBIR) company that is developing a novel medical device designed to induce significant weight loss by displacing volume in the stomach. The device can be delivered without surgery and it can be eliminated via an orally available, non-toxic dissolution agent; and Paragonix Technologies,(Cambridge, MA; no SBIR) company that is commercializing first-in-class, single-use and highly portable organ preservation and transport devices called ‘Sherpas.’ Paragonix has begun with a Sherpa for kidney transport, but is planning to expand their ‘Sherpa’ product line for other organs.  [DC Dennison, Boston Globe, Dec 28, 11]

Parasol Therapeutics (Cambridge,MA)

biotech startup Visterra, formerly known as Parasol Therapeutics, (Cambridge, MA; no SBIR) has landed $6 million in its first round of funding ... develops technology to “interrogate how pathogens interact with human cells,” which is used to develop diagnostics, vaccines and therapeutics   [Mass High Tech, Jul 12, 10]

Paratek Pharmaceuticals (Boston, MA)

Paratek Pharma up 27% [Aug 23, 17] announced that [FDA] informed the Company that the FDA (i) has completed its review of the Company's responses to requests from the FDA for additional information relating to certain findings observed in nonclinical toxicology studies of lumateperone in an animal species and (ii) agrees that the Company has presented adequate data to support its position that the metabolic pathway in the animal species is distinctive from humans, which indicates that the toxicity observed in the animal species is not relevant to humans. [company press release, Aug 23, 17]  Bloomberg said the company, gearing up to file a new antibiotic, is considering a sale.  [Phil Taylor, Fierce Biotech, Aug 23, 17]

Paratek Pharma down 11% [Aug 9, 17]

Paratek Pharma (Boston, MA; $3.8M SBIR) up 11% [Aug 7, 17]

Paratek Pharma (Boston, MA; $3.8M SBIR) up 15% [May 4, 17]  Reported positive top-line efficacy and safety data in the OPTIC study, a Phase 3 registration study of omadacycline in CABP [company press release, May 3, 17]

Paratek Pharmaceuticals (Boston, MA; $3.8M  SBIR) up 23% [Apr 4, 17] reports that its antibiotic, omadacycline, has hit all its main and secondary goals in a study of 774 patients with hospital-acquired pneumonia. It is the second of two trials; last year, Paratek’s antibiotic succeeded in a study of 645 patients with certain types of bacterial skin infections.  Omadacycline is being developed both as an IV treatment and once-a-day pill, which would allow patients to continue taking the drug once discharged from the hospital.  [Ben Fidler, xconomy.com, Apr 4, 17]

Paratek Pharma down 20% [Jun 21, 16]

Paratek Pharmaceuticals (Boston, MA; $3.8M SBIR) surged more than 20 percent after its antibiotic, omadacycline, succeeded in the first of two Phase 3 trials. [Alex Lash, xconomy,com, Jun 17, 16]

Paratek Pharma (Boston, MA; $3.8M SBIR) down 18%  [Nov 12, 15] after reporting quarterly results

Paratek Pharma down 10% [Jan 2, 15]

Paratek Pharma up 17% [Dec 17, 14]

Paratek Pharma  up 20% [Dec 10, 14]

Paratek Pharma  up 13% [Dec 9, 14]

Paratek Pharma ($3.8M SBIR) up 14% [Dec 8, 14] 

Paratek Pharma  up 10% [Nov 3, 14]

Paratek Pharmaceuticals (Boston, MA; $3.7M SBIR in two Phase 2s) said that it has filed a registration statement on Form S-1 with the Securities and Exchange Commission relating to a proposed initial public offering of shares of its common stock. According to its website, engaged in the discovery and commercialization of new therapeutics that treat life threatening infectious and other serious diseases.  [Boston Globe, Sep 28, 12]

Paratek Pharmaceuticals (Boston, MA; $3.8M SBIR)  signed a worldwide license and commercialization agreement with Novartis, in which Paratek stands to receive up to $485 million in milestone and upfront payments. The agreement centers around Paratek’s antibiotic PTK 0796, currently in Phase 3 clinical trials.  [Mass High Tech, Oct 8, 09]

Paratek Pharmaceuticals (Boston, MA; $3.8M SBIR) closed the $22M first tranche of a $40M private financing to be used to push development of its broad-spectrum antibiotics.  [Mass High Tech, Oct 25]

Parexel International

Parexel International, a clinical research organization that helps biotechs to bring their drugs to market, said it has unveiled a new brand promise: “Your Journey. Our Mission.” That promise is part of an effort to convince biotechnology firms that Waltham-based Parexel is the ideal partner for simplifying and accelerating all aspects of drug product development, the company said in a Wednesday press release. [Boston Globe, Feb 13]

Parion Sciences (Durham, NC)

Shire plc (Lexington, MA) and Parion Sciences (Durham, NC; $2.4M SBIR, emerged from [UNC] in 1999) announced they have entered into an agreement granting Shire exclusive worldwide rights to develop and commercialize P-321. Shire will lead development of P-321, an investigational epithelial sodium channel (ENaC) inhibitor for the potential treatment of dry eye disease in adults, with the opportunity for Parion to co-fund. [joint companies press release, May 1, 17]

Parion Sciences (Durham, NC; $2.6M SBIR, 14 employees) start-up with no products on the market, has signed the biggest deal in its 16-year history: a licensing agreement worth up to $1.17 billion with Vertex Pharmaceuticals.  ...  will collaborate to develop an inhaler that stimulates hydration and clears out the sticky mucus clogging the lungs of cystic fibrosis patients. Under the deal, privately-owned Parion will receive an up-front payment of $80 million and nearly $1.1 billion in milestone payments for development of the drug for cystic fibrosis and other pulmonary conditions.  [John Murawski, Raleigh News & Observer, Jun 5, 15]

drug developer Parion Sciences (Durham, NC; $2.8M SBIR) received $3 million from Cystic Fibrosis Foundation Therapeutics (CFFT) to continue work on its investigational treatment for cystic fibrosis (CF).  ... will speed up the timeline for a Phase 2 trial in which Parion will test its experimental drug, called P-1037, in patents with CF. [Jason deBruyn, Triangle Business Journal, Sep 16, 14] 

Parion Sciences (Durham, NC; $1.8M SBIR), working on treatments for pulmonary diseases, received a biodefense grant from the National Institutes of Health worth about $850,000. ... to continue testing of its most advanced experimental medicine to prevent radiation-induced lung injuries after a nuclear incident.  .... founded in 2001 and employs about 10. Its research into diseases that result from a failure of the body's mucosal defenses is based on technology developed at UNC-Chapel Hill.   [Sabine Vollmer, Raleigh News & Observer, Dec 17, 08]

Parion Sciences (Durham, NC; $1.8M SBIR)  has signed a $25 million deal with a Korean company to test an experimental medicine. [Raleigh News & Observer, Oct 29, 08]

ParkerVision (Jacksonville, FL)

The U.S. Supreme Court declined to hear ParkerVision (Jacksonville, FL; no SBIR)’s patent infringement lawsuit against Qualcomm, putting an end to an intellectual property dispute dating back to 2011. ... the federal judge overseeing the [2013] case voided the jury verdict in 2014, saying the technical evidence didn’t support the jury’s findings.  ....  ParkerVision launched a 10-to-1 reverse split  [Mike Freeman, San Diego Union Tribune, Mar 29, 31]

A U.S. appeals court upheld a lower court's decision to clear Qualcomm in a patent lawsuit by ParkerVision (no SBIR), allowing it to escape a $173 million verdict for infringement.  [Reuters, Jul 31, 15] ParkerVision has accused Qualcomm of being the chief impediment to the adoption of its wireless designs by the telecommunications industry.  [Susan Decker, Bloomberg News]

The Florida jury ordered Qualcomm to pay $173 million in damages to Jacksonville-based ParkerVision for infringing on patents related to semiconductors used in smartphones. [Mike Freeman, utsandiego.com, Oct 24, 13]

A Florida jury found that Qualcomm infringed on four patents from ParkerVision (Jacksonville, FL; no SBIR) for semiconductor chips used in smartphones.  [Mke Freeman, utsandiego.com, Oct 18, 13]

Partpic (Atlanta, GA)

Partpic (Atlanta, GA; no SBIR)  which has developed visual recognition software technology, has raised $1.5 million from angel investors. ... The startup sells to manufacturers, distributors and retailers who use the technology to identify product parts, co-founder Jason Crain said.   [Urvaksh Karkaria, Atlanta Business Chronicle, Jun 16, 15]

Passport Systems (N Billerica, MA)

In its first federal filing in five years, cargo container scanning company Passport Systems (N Billerica, MA; $1.4M SBIR) reports that it’s secured $3.8 million in debt financing out of a $4.5 million offering. .... founded in 2002 to fill the post-Sept. 11, 2001 demand for better ability to tell what’s inside shipping containers in a fraction of the time required by other systems. The company’s website says it has completed preliminary designs for a full-scale NRF scanner with more than $35 million in government and private funding.  In 2009, the company won an $8.6 million contract with its partner American Science and Engineering for development of a system for X-ray analysis of cargo, and later that year, reported that it won a $9.8 million contract for a nuclear detection system with the U.S. Navy.  [Don Seiffert, Mass High Tech, Jun 12, 12]

Pasteuria Bioscience (Alachua; FL)

Pasteuria Bioscience, (Alachua; FL; one SBIR) a venture-backed biopesticide company focusing on the development and commercialization of a platform of natural products for the control of nematodes in agriculture, received the Ag Innovation Showcase “2010 High Yield Business Award.”  [LARTA Vox, Jul 13, 10]

Pathfinder (Cambridge, MA)

Pathfinder (Cambridge, MA; no SBIR) cell-based therapeutics firm, and New Jersey biomaterials firm SyntheMed (no SBIR) have merged, the two companies announced   [Mass High Tech, Dec 23, 10]

PathoGenetix (Woburn, MA)

PathoGenetix (Woburn, MA; no SBIR), which raised $4 million in August, has added $7.5 million to round out its Series B financing, the company announced.   ... first knwon as  U.S. Genomics said it plans to apply the $11.5 million total investment toward development and commercialization of its Genome Sequence Scanning (GSS) technology, aimed at identifying thousands of bacteria strains in one test in three hours.  [Michelle Lang, Mass High Tech, Nov 1, 11]

PathoVax (Baltimore, MD)

startup PathoVax (Baltimore, MD; no SBIR, founded 2014) won $500,000 as a finalist company at the 43North [of Start-Up New York] pitch   [Morgan Eichensehr, Baltimore Business Journal,Oct 31, 16] committed to addressing the devastating economic burden, social stigma, and poor compliance rates resulting from the incomplete protection of current HPV vaccines.   [company website]

Pathway Genomics (San Diego, CA)

FDA has a clear message for Pathway Genomics  (San Diego CA; no SBIR), the company that just unveiled a blood test that it claims can detect various cancer types: “[Y]ou are offering a high risk test that has not received adequate clinical validation and may harm the public health,” the agency wrote in a letter to Pathway’s founder and CEO Jim Plante. The FDA has given Plante two weeks to respond and set up a time to meet with the agency. ... And this isn’t the first warning that Plante has fielded from the FDA. In 2010, the agency sent him a similar warning letter regarding Pathway’s Genetic Health Report, a home-use saliva test that reportedly screened individuals’ genomes for a slew of disease risks.   [Bob Grant, the-scientist.com, September 25, 2015]

Pathway Genomics  (San Diego, CA; no SBIR, founded 2008), known for pushing the boundaries of direct-to-consumer genetic testing, will launch a cancer screening test designed to detect bits of cancer DNA in the blood of otherwise healthy people.  ...  a first in the rapidly developing field of "liquid biopsies," which use gene sequencing technology to screen blood samples for trace amounts of DNA associated with different cancers. ... The cost to consumers begins at $299 to periodically check for DNA in their blood ... Guardant Health and Personal Genome Diagnostics Inc already offer blood tests for cancer patients. Roche-backed Foundation Medicine Inc, Genomic Health Inc, Illumina Inc and Sequenom Inc say they have similar tests in the works. [Julie Steenhuysen, Reuters, Sep 9, 15]

PatientStream

Univ of Washington will announce that seventeen startups were started last fiscal year to exploit technology developed at the school. Among the ventures it called out is GraphLab, Professor Carlos Guestrin’s analytics venture, which draws on his research into machine learning. Also noted was PatientStream, an electronic information system developed at Harborview Medical Center that replaces traditional whiteboards in hospitals.  [Brier Dudley, Seattle Times, Jul 17, 13] The UW Center for Commercialization& says UW students, faculty or technology are behind more than 250 companies. 

PatientWise (Middleton, WI)

Six young Wisconsin bioscience companies have been chosen by the state's biotech trade organization as emerging companies with good growth potential.  The companies have all transitioned successfully out of research and development and are developing commercial products, said Bryan Renk, executive director of BioForward .... : Fused Innocation  (Neenah; WI) VibeTech (Sheboygan, WI); Somna Therapeutics (Germantown, WI); PatientWise  (Middleton, WI); NanoOncology, a subsidiary of Peptimed (Madison, WI); PharmaSeek Financial Services (Middleton, WI).  [Kathleen Gallagher, Milwaukee Journal Sentinel, Aug 30, 12]  None had SBIR.

Patton Medical Devices (Austin TX)

Patton Medical Devices (Austin TX; no SBIR) raised $15M to step up the national launch of its first product, a "port" through which diabetics inject insulin. ... the company's first [money]  from institutional investors ... has raised about $12M from other investors since its founding in 2004 [Austin American-Statesman, Oct 18]

Patton Surgical (Austin TX)

Patton Surgical (Austin, TX; no SBIR) has received $3 million from the Texas Emerging Technology Fund to commercialize its devices, which are used in minimally invasive surgery. Founded in 2002, Patton has developed several devices, including a trocar with a shielded cutting tip. The trocar is used to insert medical instruments into a patient's abdominal cavity during what's known as laparoscopic surgery. [Austin American-Statesman, Oct 23, 09]

Pavilion Technologies (Austin TX)

Pavilion Technologies (Austin   TX; $1.5M SBIR), independent software development, has agreed to be acquired by Rockwell Automation  [Austin American-Statesman, Oct 31]  SBIR advocates often plead that SBIR should help companies remain independent. Nonsense, that is just using taxpayer funds to support companies in the life-style to which they would like to be accustomed.

Pax Streamline (San Rafael, CA)

ARPA-E winners in San Francisco Bay area: Envia Systems (Hayward); NanOasis Technologies (Richmond); Pax Streamline, (San Rafael); and Stanford University. None had SBIR. official list of winners

PaxVax (San Diego, CA)

The FDA approved a cholera vaccine, Vaxchora, giving  PaxVax (Redwood City, CA; $300K SBIR)  its second commercial product.  [Alex Lash, xconomy,com, Jun 17, 16]

Biotech company PaxVax (Redwood City, CA; 4300K SBIR, founded 2007) raised $105 million in funding to develop vaccines for diseases such as typhoid and cholera.  Cerberus Capital Management led the funding and has acquired a majority economic interest in the company. ...  manufactures and markets Vivotif, a typhoid vaccine which is currently licensed in 27 countries  [Gina Hall, San Francisco Business Times, Dec 8, 15]

Vaccine maker PaxVax (Redwood City, CA; $300K SBIR), said it raised up to $50 million in debt financing and sold $12 million of its Series B stock. ...  At the same time the firm said it acquired from Crucell an oral typhoid vaccine called Vivotif, which has been on the market for more than 20 years, as well as infrastructure and Crucell employees involved in the Vivotif business. PaxVax has a cholera vaccine in Phase 3 trials and aims to grow in the market aimed at travelers.  [Alex Lash, xconomy.com, Jul 31, 14]

A single-dose experimental cholera vaccine from PaxVax (Redwood City, CA;  $300K SBIR) passed a key test toward becoming the only vaccine for U.S. residents traveling abroad. ....  was effective 10 days and 90 days after vaccination when compared against patients given a placebo in a late-stage trial.  ...   in December lined up $22 million in Series B financing and converted $35 million in debt to move forward with its clinical trials.  [Ron Leuty, San Francisco Business Times, Jul 3, 14]

PaxVax, (San Diego, CA; no SBIR) startup backed by Seattle’s Ignition Capital, has raised $2 million of a planned $6 million investment round, according to a document filed with the [SEC]. ... founded in early 2007 to develop new oral vaccine technology based on a common cold virus called the adenovirus.  [signonSanDiego, Nov 9, 09]

PDI Therapeutics (San Diego, CA)

Avalon Ventures and UK-based drug giant GSK said they have formed another San Diego biotech startup. ... PDI Therapeutics (named for the enzyme protein disulfide isomerase, La Jolla, CA) , will develop immunotherapies for cancer. Like all other companies formed under the three-year-old partnership, PDI will be housed at Avalon's COI Pharmaceuticals, an incubator that provides shared facilities and management.  Meanwhile, Avalon said the first two companies created under the collaboration, Sitari Pharmaceuticals and Silarus Therapetics, have identified a clear path to potential drugs, thus meeting their first milestones, said Jay Lichter, an Avalon managing director and also COI's president and CEO. Sitari and Silarus are respectively developing drugs for celiac disease and iron overload disorders. ...  GSK and Avalon established their partnership in April 2013, with up to $465 million from GSK and up to $30 million from Avalon to form up to 10 companies in San Diego. Up to $10 million in Series A funding is to be invested in each company to get it off the ground. ... The five other companies founded by the Avalon/GSK collaboration are Thyritope Biosciences, Adrenergics, CadheRx Therapeutics, Calporta Therapeutics, and Iron Horse Therapeutics.    [Bradley Fikes, San Diego Union Tribune, May 20, 16]

PDL BioPharma PDLI

PDL Biopharma down 15% [Nov 23, 16]

PDL Biopharma down 18% [Nov 16, 16]

PDL BioPharma down 12% [Sep 17, 14] 

PDL BioPharma (no SBIR) fell 32% [Mar 5, 08]. The biotechnology company abandoned plans to sell itself and said it will cut an additional 250 jobs in an effort to reduce costs. [Wall Street Journal, Mar 6]

Pearl Therapeutics (Redwood City, CA)

Clarus Ventures, which has backed some big Bay Area biotech M&A winners over the past year, is raising $375 million for a third fund, part of a $2 billion or more surge in life sciences VC funds over the past year.   ....  It invested in the East Bay's FerroKin BioSciences ($100K SBIR) which Shire bought in 2012 for up to $325 million, Redwood City  respiratory disease drug developer Pearl Therapeutics  (Redwood City, no SBIR), which AstraZeneca bought in June for $1 billion, and eye drug maker SARcode Bioscience (no SBIR) purchased a year ago by Shire for at least $160 million. It also has put money into up-and-comers like cancer drug developer Cleave Biosciences (Burlingame, no SBIR).  [Ron Leuty, San Francisco Business Times, Feb 7, 14] 

Respiratory disease business Pearl Therapeutics (Redwood City, CA; no SBIR) raised $15 million in loans that will be converted to equity in its next round of venture funding. [SEF Brown, San Francisco Business Times, Feb 2, 10]

[VC] firm Clarus Venures has invested in $18 M dollar financing of Pearl Therapeutics (no SBIR), a California-based biopharmaceutical company developing products for major respiratory diseases. ..... Pearl, founded in 2006, has raised $36 M of VC and other funding to date.  Nektar Therapeutics (no SBIR) has licensed advanced particle technology to Pearl, and the company it is using to develop technology that will give patients and their health care providers a choice of formulations and dosage strengths of respiratory treatments.  [Mass High Tech, Jul 7, 08]

Pear Therapeutics (Boston, MA)

Pear Therapeutics (Boston, MA; no SBIR)  with offices in San Francisco, has received $20 million in series A funding ... for an an app could make subsrnce abuse therapy more effective.   [Jessica Bartlett, Boston Business Journal, Feb 4, 16]

PECA Labs (Pittsburgh, PA)

The latest round of investments from the Open Field Entrepreneurs Fund is headed to six startup companies, all with Carnegie Mellon University ties.  Includes PECA Labs (Pittsburgh, PA; no SBIR) developing a heart specifically designed for pediatric patients. Called the Masa Valve and going through FDA approval process.   [Malia Spencer, Pittsburgh Business Times, Jan 7, 13] 

Pediatric Bioscience (San Diego, CA)

Pediatric Bioscience (San Diego, CA; no SBIR, founded 2006) In a potentially major advance in diagnosing autism spectrum disorder, San Diego's Pediatric Bioscience is preparing to sell a blood test later this year that would detect risk of one of its most common forms.   The company's test detects antibodies in a woman’s blood that can cause what it calls “maternal autoantibody-related” autism, which the company says, based on clinical studies, represents 23 percent of all autism cases.  [Bradley Fikes, utsandiego.com, Jan 15, 15]    is a specialty clinical diagnostic company that was formed  by a group of researchers and experienced business leaders to identify and develop promising new discoveries in the field of autism [company website]

Peerless Technologies (Fairborn, OH)

Peerless Technologies [Fairborn, OH; $3M SBIR) will get as much as $53.7 million during the next four years to support Air Force Research Laboratory.  [Joe Cogliano, Dayton Business Journal, Dec 25, 15]  Is that a win for SBIR?  The SBIR advocates will certainly claim so, but a real economist would look askance at such claims and ask how much political pressure was involved for a favored class.  If they won the deal in open competition with no consideration of their sheltered class, OK. But it's not a new market and no new jobs, only shifting the supplier of what the government would buy anyway.

Peerless Technologies (Fairborn, OH; $2.5M SBIR) will get as much as $68 million during the next five years to support the F-22 program office at Wright-Patterson. ...  will provide management and professional support services; engineering and technical services; and studies, analyses and evaluations to help the F-22 division to sustain and modernize the Air Force fleet.   [Joe Cogliano, Dayton Business Journal, Jan 16, 15]  Presumed innovation SBIRs lead to government support contracts, no new markets, nor new jobs, nor economic growth, just substutting for another company to perform the service. Not a market-failure.

Peerless Technologies (Fairborn, OH;  $2.6M SBIR) has been selected for a $110 million deal with NASA, marking the biggest single contract the company's 14-year history.  ....  for the PACE IV, a five-year effort for professional, administrative, computational and engineering support, according to a statement on the General Service Administration's contractor Web site at FBO.gov.   [Joe Cogliano, Dayton Business Journal, Feb 11, 14]

Pegasus Sustainability Solutions (Fitchburg, WI)

[Wisconsin]EDC certified four other companies to receive the tax credits They were: MPSP LLC, Milwaukee; HuTerra LLC, De Pere; and HealthMyne, Madison. Pegasus Sustainability Solutions, Fitchburg, was approved to receive the certification and a $125,000 loan.  WEDC also said Tuesday that it has approved low-interest loans for two other emerging companies. Xolve , Middleton, will receive a $330,000 loan; and Shamrock Energy, Neenah, will get a $150,000 loan.[Kathleen Gallagher, Milwaukee Journal Sentinel, Jul 2, 13]  None had SBIR. 

Pelican Products (Torrance, CA)

Minnesota Thermal Science  (Plymouth, MN; no SBIR; founded 2004), which once won the U.S. Army's Greatest Inventions Award for its gear that keeps blood fresh and usable, has been bought by storage-products company Pelican Products (Torrance, CA; no SBIR) ....  Datamonitor Financial Deals Tracker valued the deal at $26 million.  [Mark Reilly, Minneapolis / St Paul Business Journal, Jan 9, 13]

Pelican Therapeutics (Austin,TX

Pelican Therapeutics (Austin, TX; no SBIR, two employees) announced that it won a $15M from the Cancer Prevention and Research Institute of Texas (CPRIT). ... to develop agonists directed at TNFRSF25, a recently discovered T cell costimulator for immuno-oncology indications. TNFRSF25 antibodies have a distinct mechanism for preferential activation of the tumor cell-killing (CD8+) arm of the immune system, making TNFRSF25 a potential best-in-class target among peer programs targeting OX40, 4-1BB, GITR, CD40 & ICOS.  [company press  release, May 19, 16]

Pellion Tech

using the computational tools developed by his materials genome project,Pellion, a startup (Cambridge, MA; no SBIR), that he cofounded in 2009, has identified new cathodes for a magnesium-based battery. If it works, Ceder says, the batteries could have double or triple the energy density of today's lithium-ion batteries.  [David Rotman, Technology Review, J/F12]

ARPA-E Awards. The administration announced $106M in ARPA-E stimulus awards. Small biz winners:  Ginkgo BioWorks (Boston, MA; one SBIR) $6M primary;  OPX Biotech (no SBIR) $6M primary; Logos Tech (Arlington, VA; $2M SBIR) secondary; Sion Power (Tucson, AZ; $250K SBIR) $5M primary; ReVolt Tech (no SBIR) $5M primary; PolyPlus Battery (Berkeley, CA; one SBIR) $5M; Pellion Tech (no SBIR) $3.2M primary; A123 Systems  secondary, twice;  Planar Energy Devices (no SBIR) $4M;Maxpower (Harleysville, PA; $9M SBIR) secondary; NanoLab (Newton, MA; $5M SBIR) secondary; Codexis (no SBIR) $4.6M; Nexant (no SBIR) secondary.

Peloton Therapeutics (Dallas TX)

Peloton Therapeutics (Dallas TX; no SBIR), a drug discovery and development company focused on advancing first-in-class, small molecule cancer therapies, announced the completion of a $52.4 million Series D financing round ... “The company’s lead program targeting hypoxia-inducible factor-2α (HIF-2α) has generated exciting responses in patients with renal cell carcinoma, with potential applications in von Hippel-Lindau disease, glioblastoma multiforme and other diseases with high unmet medical need.” [company press release, Sep 15, 16]

Peninsula Pharmaceuticals

Adynxx (San Francisco, CA;  no SBIR) has kept a low profile since its founding five years ago, but is discussing its work publicly today, announcing it has completed enrollment in its initial clinical trial of 30 healthy volunteers. ... supported by a Series A venture financing of $18 million from Domain Associates from 2010, is composed of people who worked together on a series of Domain-backed companies that were acquired, including Peninsula Pharmaceuticals (no SBIR), Cerexa  (no SBIR), and Calixa Therapeutics (no SBIR).  [Luke Timmerman, xconomy,com, Aug 7, 12]

PennAlt Organics (Pittsburgh, PA)

A newly formed life sciences company PennAlt Organics (Pittsburgh, PA; no SBIR) raised $6 million Series A financing round [Patty Tascarella, Pittsburgh Business Times, Oct 14] focuses on neurological disorders

Penumbra (Alameda, CA)

Penumbra (Alameda, CA;  SBIR, founded 2004 ) up 38% [Sep 18, 15]  past its [$120 million] IPO marks, with its stock jumping by nearly 38 percent on first day trading. [Cromwell Schubarth, Silicon Valley Business Journal, Sep 18, 15]      designs and develops medical technology aimed at helping people who have suffered strokes and other neurovascular conditions. Among the company's products is the Penumbra System, which acts like a minimally invasive 'vacuum' inside the artery to quickly remove a blood clot from the brain.  [San Jose Mercury News, Sep 18, 15]

Penumbra (Alameda, CA; no SBIR) medical device company has disclosed its IPO pricing to raise up to $122.4 million ....  markets surgical access devices for neuro and peripheral vascular conditions and diseases.  [Riley McDermid, Silicon Valley Business Journal, Sep 8, 15]

Penumbra (Alameda, CA; no SBIR, founded 2004) medical device developer wants to use a $115 million initial public offering to boost its product offerings, research and sales force....  its steady stream of revenue from catheters and coils that treat strokes, aneurysms and other vascular conditions make it a rarity. Most drug developers have longer timelines for bringing drugs to market, but medical device development can move much more quickly. [Ron Leuty, San Francisco Business Times, Aug 20, 15]

Peptilogics (Pittsburgh, PA)

Peptilogics (Pittsburgh, PA; no SBIR, founded 2013), plans clinical trials in two years for a new class of antibiotics that attack bacteria in a different way when compared to conventional drugs, with the promise of fewer side effects and a longer-lasting solution. ...   to commercialize novel ways of killing bacteria, especially kinds already resistant to antibiotics...  University of Pittsburgh spinout ... Pharmaceutical industry veteran Rick Oleson is Peptilogics’ chief development officer. Oleson worked for 18 years at Cubist Pharmaceuticals Inc. where he was vice president of nonclinical development. Merck acquired Cubist in 2014 for $8.4 billion. [Matt Lepri, ideafoundry.org, Sep 28, 15]

Peptimed (Madison, WI)

PeptiMed (Jefferson, WI; no SBIR) raised $200,000 in equity funding from a single investor, according to [SEC] document. [Jeff Buchanan,  xconomy.com, Jun 27, 16] ... one of the drugs it’s invented is aimed at treating various cancers—breast, prostate, lung, colon, ovarian, and skin—using ribonucleic acid interference (RNAi). [company website ]

Six young Wisconsin bioscience companies have been chosen by the state's biotech trade organization as emerging companies with good growth potential.  The companies have all transitioned successfully out of research and development and are developing commercial products, said Bryan Renk, executive director of Fused Innocation  (Neenah; WI) VibeTech (Sheboygan, WI); Somna Therapeutics (Germantown, WI); PatientWise  (Middleton, WI); NanoOncology, a subsidiary of Peptimed (Madison, WI); PharmaSeek Financial Services (Middleton, WI).  [Kathleen Gallagher, Milwaukee Journal Sentinel, Aug 30, 12]  None had SBIR.

Peptimmune (Cambridge, MA)

Peptimmune (Cambridge, MA; one SBIR) announced today that it has granted drug maker Novartis an exclusive option to obtain exclusive worldwide rights to develop and commercialize Peptimmune's multiple sclerosis drug candidate.  [Chris Reidy, Boston Globe, Jan 15] ... could net Peptimmune a half billion dollars and more. [MHT, Jan 16, 09] 

Biotechnology companies in the United States are raising less cash than they have in a decade, in part because of the global economic crisis. The reductions have led to bankruptcies and threaten development of drugs based on biomedical breakthroughs. ... Twenty-five percent of the 370 public U.S. biotechnology companies have less than six months of cash, according to data compiled by the Biotechnology Industry Organization, a trade group in Washington. .... Among others,Peptimmune (Cambridge, MA; one SBIR), a 6-year-old firm, said it is struggling to pay for clinical trials of its multiple sclerosis drug. ... cut its staff more than half, to 22 people; moved to smaller offices to conserve the $6.5 million it has on hand; and is delaying research on drugs for Alzheimer's disease and Parkinson's disease, chief executive Thomas Mathers said. ....  On Nov. 10, MicroIslet (San Diego, CA;  $1.8M SBIR) developer of diabetes treatments, and Accentia BioPharmaceuticals (Tampa, FL; no SBIR) sought bankruptcy protection to reorganize, each citing an inability to raise money.   [David Olmos and Rob Waters, Bloomberg News, Dec 1, 08]

Peptimmune (Cambridge, MA; one SBIR) reports it has landed $8.9 million in a second close of a Series D preferred stock offering.  [Mass High Tech, Jul 17, 08]

Peptimmune (Cambridge, MA; one SBIR a decade ago) closed on an $8.2 M first tranche of a Series D funding ... to advance clinical development of Peptimmune's multiple sclerosis treatment, PI-2301 [Mass High Tech, Jan 17]

Perceptive Navigation (Baltimore, MD)

medical device startup Perceptive Navigation (Baltimore, MD; no SBIR) raised $500,000 toward securing federal regulatory approval for its ultrasound device. ...  developing an invasive ultrasound device with imaging technology on its tip.  [Sarah Gantz, Baltimore Business Journal, Aug 26, 15]

Perceptive Sciences (Austin, TX)

They're trained to know when you're fooling yourself, and by identifying that in their subjects they can help clients get better feedback to develop better products..... Perceptive Sciences (Austin, TX; one SBIR)  with an academic approach to product testing, market research and user experience. ... About a third of Perceptive's work focuses on Web sites, a third on software and a third on gadgets. [Dan Zehr, Austin American Statesman, Mar 3]

Perceptron (Plymouth, MI)

Perceptron (Plymouth, MI; one SBIR) up 11% [Feb 10, 14]

Perceptron down 10% [Jan 24, 14]

Perceptron up 23% [Jan 10, 14] announced that, starting in March 2014, it expects to begin shipping 45 inline gauging systems to a premium German automotive manufacturer.  [Market Wired, Jan 9]

Perceptron (Plymouth, MI; one SBIR, 229 employees) down 10% [Feb 13, 13]

Perceptron  (Plymouth, MI; one SBIR) up 10% [Jan 9, 13]

PercipEnz Technologies (Madison WI)

Three [Wisconsin] angel investment groups have banded together to put more than $1 M into a Madison software company [PercipEnz Technologies; $1.6M SBIR]  aiming to dramatically expand its clinical data management business. This is the first time several of the groups involved did their due diligence and negotiated terms together, "and that bodes well for bigger deals in Wisconsin," said Charles Goff, general partner of Appleton-based NEW Capital Fund.  [Kathleen Gallagher, Milwaukee Journal-Sentinel, Aug 22]

Peregrine Semiconductor (San Diego, CA)

Perigrine Semiconductor (San Diego, CA; $3.7M SBIR) down 16% [Feb 4, 14]

Peregrine Semiconductor (San Diego, CA; $3.7M SBIR) down 11% [Sep 20, 13]

PeriphaGen (Pittsburgh, PA)

PeriphaGen (Pittsburgh, PA; no SBIR) a life sciences company has closed on $6.5 million [capital raise]  ...  for product development and hiring ... originally Nurel, a University of Pittsburgh spinout that was acquired by a Stockholm-based medical company, Diamyd Medical AB, in 2006. In October 2012, a management group bought the business from Diamyd. [Patty Tascarella, Pittsburgh Business Times, Apr 1, 14]

Permeon Biologics (Cambridge, MA)

Biotech startup Permeon Biologics (Cambridge, MA; no SBIR) has taken in $2.5 million in an equity and debt financing round ....  looking to develop therapies based on the discovery of a class of proteins that will allow protein-based therapies otherwise too complex to finally get inside a cell wall. The company was founded by Harvard University professor and Howard Hughes Medical Institute investigator David R. Liu, also the founder of Ensemble Therapeutics (no SBIR).  [Rodney Brown, Mass High Tech, Dec 30, 11]

Perosphere (Danbury, CT)

Perosphere  (Danbury, CT; no SBIR), a small pharmaceutical company, borrowed $1.5 million from Connecticut Innovations  [from CI's Bio-Facilities Fund, established in 1998. [which] has spent more than $40 million] .... looking to improve the drug delivery methods for drugs already on the market, but also is working on new indications for already approved drugs, such as seeing if an anticonvulsant can be administered in such a way that it could reduce brain cell damage after a heart attack, stroke, or traumatic brain injury . It also is working on developing fast-acting rescue drugs.  The company's lead drug candidate, a reversal agent for anticoagulants, is in Phase II clinical trials.  [Mara Lee, Hartford Courant, Jul 7, 14]

Perscitus Biosciences (Madison WI)

The Wisconsin Department of Commerce has qualified two biotech companies to receive investor tax credits, the agency said Thursday. Perscitus Biosciences LLC, Madison, is developing a molecule that has shown an ability to protect healthy human cells against the harmful effects of chemotherapy and radiation. HTSS LLC, Milwaukee, is developing a technology that analyzes muscle activity to help reduce injuries during exercise regimens. Certain investors in both companies are now eligible to claim tax credits under legislation known as Act 255. [Milwaukee Journal-Sentinel, Jun 27]  No SBIR.

Perseon (Salt Lake City, UT)

Galil Medical (St Paul, MN; no SBIR, founded in Israel, under 100 employees) said it's reached a deal to buy Perseon (Salt Lake City, UT; no SBIR) for $10.6 million in a deal that will take the publicly traded Perseon private. ...   Galil, which makes needles that deliver super-chilled gas to freeze and destroy cancer tumors, said in its announcement that the acquisition of Perseon is contingent on Galil raising $26 million in new debt and equity.   ...  Perseon also specializes in cancer-destroying tech, but it uses microwave heat therapy.   [Mark Reilly, Minneapolis / St. Paul Business Journal,  Oct 27, 15]

Persimmon Technologies (Wakefield, MA)

Persimmon Technologies (Wakefield, MA; no SBIR, founded 2010) has added $1.5 million to a round of investment first announced more than a year ago .... provides vacuum robotics for the semiconductor, flat-panel display and solar markets  [Don Seiffert, Boston Business Journal, Mar 4. 14]

The CEO of Persimmon Technologies (Wakefield, MA; no SBIR) says that a $5.8 million round of Series B funding will go toward development of its hybrid-field motor technology as well as expansion of its manufacturing facility for vacuum robotics.[Don Seiffert, , Boston Business Journal, Jan 14, 13] 

Persimmon Technologies (Wakefield, MA; no SBIR, founded 2010) which provides motor technology and robotics for the semiconductor, solar, LED and flat-panel display equipment markets, received a $500,000 Phase II NSF SBIR to develop soft magnetic material for use in electric motors. ... In March, received $2 million in equity financing,   [Don Seiffert, Mass High Tech, Nov 30, 12]

Persimmon Technologies (Wakefield, MA; no SBIR, founded 2010) which provides direct drive vacuum robotics, has received $2 million in equity financing, according the federal documents. ...  [company's] website says it is the developer, manufacturer, and distributor of atmospheric and vacuum robotics, vacuum modules, and automation systems for a range of industries, including semiconductor, data storage, LED, OLED, solar and flat panel display equipment markets. Its goal is to be the largest vacuum robotics company serving the semiconductor, LED and solar markets by 2020.  [Don Seiffert, Mass High Tech, Mar 21, 12]

PersonalBee

Technorati agreed to acquire fledgling startup Personal Bee [which] developed a service for people to collect and publish news, information, and entertainment. [RedHerring.com, Apr 13]

Personalis (Menlo Park, CA)

Personalis  (Menlo Park, CA; no SBIR), a startup that provides exome and genome sequencing and interpretation, has completed a $33 million Series C financing round. ...   will use the funding to scale up operations. [Gina Hall, Silicon Valley Business Journal, Jan 13, 15]

Personalis  (Menlo Park, CA; no SBIR) , a startup that provides exome and genome sequencing and interpretation, raised $22 million in Series B funding.  ....  brings the total raised to more than $42 million.  ....  to expand its commercial team further, including in Asia.  .... The company said that since its first customer purchase 13 months ago it has received more than $14 million in orders to sequence and analyse more than 7,000 human samples.    [Cromwell Schubarth, Silicon Valley Business Journal, Oct 6, 13] 

Personal Genome Diagnostics (Baltimore, MD)

Personal Genome Diagnostics (Baltimore, MD; no SBIR, 21 employees) raised $4.32 million [Series A] ... Using gene research from Johns Hopkins University, Personal Genome Diagnostics analyzes the DNA of tumors to better diagnose cancer. The company in May released its newest test, ImmunoSelect-R, which will be used to develop cancer therapies that stimulate and strengthen the patient’s immune system to fight cancer.  [Sarah Gantz, Baltimore Business Journal, Jun 5, 15]

Personal Genome Diagnostics (Baltimore, MD; no SBIR, launched in 2010 and has 19 employees) closed a $2.8 million fundraising round to help propel the firms research into tumor DNA.  ... is commercializing Johns Hopkins gene research to use as tests that can help evaluate tumors during cancer treatment.  .... recently launched its first commercially available test, METDetectTM, which is a less invasive alternative to a tumor biopsy.  [Sarah Gantz, Baltimore Business Journal, Apr 3, 14]

Pervasis Therapeutics (Cambridge, MA)

Pervasis Therapeutics (Cambridge, MA; no SBIR) raised $10 million out of a $17 million third round of financing. ... focuses on creating cell-based compounds and devices. It is also exploring technology in non-vascular applications, such as bone and joint repair, wound healing and inflammation.  [Julie Donnelly, Mass High Tech, Sep 16, 09]

Pervasis Therapeutics (Cambridge, MA; no SBIR) secured $9.75M in additional financing. ...focuses on regenerative cell-based therapies and devices [Boston Globe, Jan 16]

Pervasis Therapeutics (Cambridge, MA; no SBIR), developer of cell-based therapies and devices, reports it has nabbed a $9.8M tranche of Series B financing ... founded 2004 [Mass High Tech, Jan 15]

Pervasive (San Diego, CA)

a new semiconductor startup, courtesy of venture funding from the Bay Area.  Pervasive, (San Diego, CA; no SBIR) a fabless semiconductor design company that is focused on smart grid applications, raised $6 million from investors, according to a recent filing with securities regulators.  [Bruce Bigelow, signonsandiego.com, Jun 17, 10]

Petra Pharma (NYC,NY)

Seattle’s Accelerator Corp. made its long-awaited splash in New York last week with its first Manhattan biotech startup, Petra Pharma (NYC, NY; no SBIR). Now here comes Lodo Therapeutics  (NYC, NY; no SBIR), Accelerator’s second startup, right in Petra’s wake [with $17M].    Lodo didn’t get the big $48 million round that Petra did last week. But the startup, built around the work of Rockefeller University researcher Sean Brady, got a respectable $17 million Series A round and, what’s more, some of that money comes from The Bill & Melinda Gates Foundation—which has over the past few years increasingly sought to back biotech startups that align with its mission of improving global health.  [Ben Fidler, xconomy.com, Jan 10, 16]

Pfenex (San Diego, CA)

Pfenex  (San Diego, CA; no SBIR), an early-stage biotech specializing in biosimilars, aims to price its stock at $12 to $14 a share in an IPO that could arrive next week, according to a regulatory filing. Pfenex was spun out of Dow Chemical, currently its largest shareholder, to advance technology that uses a fluorescing microbe in a fermentation process to make a variety of protein biotherapeutics, including drugs, vaccines, and diagnostic reagents. [Alex Lash, xconomy.com, Jul 10, 14]

Pfenex  (San Diego, CA; no SBIR, founded 2009), a Dow Chemical spinoff developing a drug for retinal diseases, filed with the SEC Thursday to raise $74.8 million in  [IPO]  ....  Pfenex's technology was originally developed at Mycogen (San Diego, CA; no SBIR), biotech later purchased by Dow.  [Bradley Fikes, utsandiego.com, Jun 5, 14]

Elevation Pharmaceuticals (San Diego, CA; no SBIR, founded 2008) startup developing aerosol-based treatments for respiratory diseases, said it has raised a tranched $30 million in Series A venture funding. It’s a sizable round for the [San Diego] life sciences community, but other recent fundings have come close. Last month, VentiRx (no SBIR) raised $25 million, Pfenex (no SBIR) got $24 million, and Zogenix (no SBIR)  got $20 million.  [Bruce Bigelow, signonsandiego.com, Mar 8, 10]

Pharmacyclics (Sunnyvale, CA)

Pharmacyclics up 17% [Feb 25, 15]

Pharmacyclics (Sunnyvale, CA; one SBIR, market cap $9.3B) up 16% [Jan 13, 15]

Pharmacyclics (one SBIR) up 15% [Jul 29, 14]

More capitalism competition - for new ideas.  How J&J and Dr. Lebowitz homed in on the California prospect and recruited its maker, Pharmacyclics (Sunnyvale, CA; one SBIR in 1995, market cap $10B) reflects a shift in how big drug companies find new medicines. .... the scouting kicked into higher gear. J&J scientists would get to know counterparts at companies on their Bullseye charts, building relationships at medical meetings and other venues. Sometimes, a J&J scientist might talk with a prospect for months—even years—before raising the issue of a deal.  .... its drug hunters flew to Europe to woo the drug [daratumumab]'s [Danish maker. .... in 2013, it bought Aragon Pharmaceuticals (no SBIR), which has a potential prostate-cancer treatment that is in clinical trials.  [Jonathan Rockoff, Wall Street Journal, Mar 9, 14]

A step toward European approval of the blood cancer drug Imbruvica will net Pharmacyclics (one SBIR in the 1990s) a $50 million payment from partner Johnson & Johnson.  ....  on top of $60 million that Pharmacyclics, led by CEO Robert Duggan, earned from Janssen Biotech Inc. when the Food and Drug Administration last week approved Imbruvica for mantle cell lymphoma patients previously treated with other drugs.  The company received another $75 million from Janssen Biotech in September, when the FDA accepted Imbruvica's application.  [Ron Leuty, San Francisco Business Times, Nov 20, 13] 

Pharmacyclics up 12% [Jun 10, 13]

With a promising drug that could be an alternative to chemotherapy, Pharmacyclics (Sunnyvale, CA; one SBIR in 1995) has seen a meteoric rise.  [Diana Samuels, Silicon Valley / San Jose Business Journal, Nov 23, 12]

Pharmacyclics (Sunnyvale, CA; one SBIR two decades ago) has seen its stock quadruple from the beginning of this year. The company has boomed on growing evidence that supports its new drug for blood cancers, ibrutinib, which is designed to selectively block a molecular target called Bruton’s tyrosine kinase (Btk).  [Luke Timmerman, xconomy.com, Jul 9 ,12]

Pharmacyclics up 17% [Feb 13, 21]

Pharmacyclics  up 17% [Feb 10, 12]

Pharmacyclics  up 13% [Feb 9, 12]

Pharmacyclics  down 15% [Dec 9, 11]

Pharmacyclics down 12% [Aug 4, 11]

Pharmacyclics up 11% [Jun 10, 10]

Pharmacyclics up 12% [May 10, 10]

Pharmacyclics down 14% [May 7, 10]

Pharmacyclics up 14% after announcing data from two preclinical studies. [Apr 18, 07]

Hope for FDA reconsideration of Pharmacyclics case had a bad day as the stock dropped 11%.[Apr 10, 07]

Pharmacyclics up 15% after asking the FDA  that its new drug application for a cancer treatment be filed over protest. [Apr 5, 07]

Pharmacyclics dropped 37% after announcing that the FDA rejected a marketing application for the company's drug to treat lung cancer that has spread to the brain. [Feb 21, 07]

PharmaJet (Golden, CO)

[FDA] OK'd the use of PharmaJet (Golden, CO; no SBIR) needle-free injectors for flu shots, giving the  company its best chance to break into the domestic market for vaccine delivery. ...  the first FDA approval for a needle-free injection for a flu virus vaccine, freeing PharmaJet to create a market among the 150 million people who get flu vaccinations annually in the U.S.  [Greg Avery, Denver Business Journal, Aug 19, 14]

PharmAkea Therapeutics (San Diego, CA)

PharmAkea Therapeutics  (San Diego, CA; no SBIR) raised $45 million from venture capital and biotech investors. .....  to develop drugs for cancer and fibrotic diseases.  ...... Celgene is contributing $35 million of the total [Bradley Fikes, utsandiego.com, Oct 18, 13]

Pharmasphere (Boston, MA)

[Massachusetts] has rescinded $360,000 in tax credits to a fledgling biotechnology company PharmaSphere (Boston, MA; no SBIR) that misled officials about the size of its workforce, the first time such an award has been revoked. ...  has been struggling to raise the $6.5 million in private financing it needs for the project, has yet to receive any of the promised public money. ... claimed on the application that it had 11 to 50 employees. The company later acknowledged it never had those workers. [Todd Wallack, Boston Globe, Dec 25, 10]

Pharmasset

OnCore Biopharma (Doylestown, PA; no SBIR) biopharmaceutical company seeking to develop a cure for hepatitis B, is merging with Tekmira Pharmaceuticals (Canada) ....  founded in 2012 by the group at Pharmasset (led by Mike Sofia) that developed Sovaldi, a drug now used as part of a combination therapy to cure hepatitis C. Pharmasset was acquired by Gilead Sciences (NASDAQ: GILD) for $11.5 billion in early 2012. ...  will focus on developing a "curative regimen" for hepatitis B patients by combining multiple therapeutic approaches.   [John George, Philadelphia Business Journal, Jan 12, 15]

Later this year [FDA] is expected to approve a new pill that can cure hepatitis C—a chronic infection that afflicts about 170 million people worldwide and annually kills 350,000 people, including 15,000 in the U.S.—faster and with fewer side effects than current remedies [for $84000 per case].  ...  Pharmasset (Princeton, NJ; $2M SBIR in Georgia 2000-2003, founded 1998) had been looking at a group of drugs known as nucleotide analogues, which met some of these criteria, since the mid-2000s. ...  Researchers then ran into a few big biochemical problems. ... Michael Sofia, then at Pharmasset, solved the problems by adding two compounds known as esters to the analogue.  ...  The new formulation was named sofosbuvir in Sofia's honor; the company was purchased, in 2011, by Gilead for $11 billion. [Jessica Wapner, Scientific American, Aug 19, 14]

Gilead announced a roughly $10.4 billion deal to buy Pharmasset  (Princeton, NJ; $2M SBIR 2000-2003 in Georgia),[up 85%] a company that doesn’t yet have meaningful revenue but is developing treatments for hepatitis C.[Shira Ovida, Wall Street Journal, Nov 21. 11]  HHS has another big econonmic SBIR story.  Would that the other agenices could be so smart in picking techologies and companies with a future.

Pharmasset  down 12% [Nov 4, 11]

Pharmasset up 15% [Aug 9, 11]

Pharmasset up 10% [Jun 8, 11]  on encouraging clinical data, it plans to test its hepatitis C treatment PSI-197 as a stand-alone therapy. Pharmasset is currently testing PSI-197 in combination with peginterferon and ribavirin, two standard treatments for the chronic liver disease. [MarketWatch, Jun 8]

Pharmasset  up 12% [Apr 5, 11]

Pharmasset up 10% [Mar 31, 11]

Pharmasset up 24% [Mar 7, 11]

Pharmasset  up 10% [Mar 16, 10]

Pharmasset  down 10% [Apr 30, 09]

Pharmasset  up 11% [Apr 29, 09]

Pharmasset  down 10% [Apr 20, 09]  stopped development of Clevudine for hepatitis B in the wake of side effects in long-term users in South Korea, where it already is sold. [Wall Street Journal, Apr 21]

Pharmasset  up 10% [Apr 8, 09]

Pharmasset  up 11% [Mar 26, 09]

Pharmasset up 12% [Mar 17, 09]

Pharmasset  up 14% [Mar 23, 09]

Pharmasset up 12% [Mar 12, 09]

Pharmasset up 15% [Mar 3, 09]

Pharmasset down 19% [Feb 25, 09]

Pharmasset up 15% [Oct 16, 08]

Pharmasset up 15% [Oct 14, 08]

Pharmasset up 26% [Oct 13, 08]

Pharmasset down 12% [Oct 10, 08]

Pharmasset up 10% [Mar 13, 08]

Pharmasset  up 17% [Jan 16, 08]

Pharmasset up 12%. [Jan 15, 08]

Pharmasset up 33% [Jan 8, 08] after the company announced positive data from a short-term early stage study on its hepatitis C candidate, R7128

Pharmasset rose 14% after saying it will receive a $7.5M payment from Roche for a collaboration on hepatitis C treatment research

Pharmasset which IPO'd Apr 27,07 is holding its price. 14 HHS SBIR Phase 1s over $100K.

PharmAthene (Annapolis, MD)

PharmAthene (Annapolis, MD; no SBIR) a clinical-stage bio-defense company, announced  it has scrapped a planned merger with Theraclone Sciences  (Seattle, WA; no  SBIR)  .... days after Theraclone disclosed that the Biomedical Advanced Research and Development Authority (BARDA) had declined to fund clinical trials for one of its product candidates  [Bill Flook, Baltimore Business Journal, Dec 2, 13]

Theraclone Sciences (Seattle, WA; no SBIR, 34 employees) plans to combine with a publicly traded biotech PharmAthene (Annapolis, MD; no SBIR, 50 employees)  in a merger of equals ... Theraclone is developing disease-specific antibodies to fight cancer and serious infectious diseases, while PharmAthene is a biodefense company focused on anthrax and chemical nerve agents. [Seattle Times, Aug 1, 13]

Biodefense company PharmAthene (Annapolis, MD; no SBIR) could get $100 million in damages following a decision by the Delaware Supreme Court that Siga Technologies acted in bad faith by backing out of a proposed licensing agreement for its smallpox treatment medication to be used in response to a biochemical attack, the Daily Record reported.  [Baltimore Business Journal, May 30, 13]

PharmatrophiX (Chapel Hill,NC)

PharmatrophiX  (Chapel Hill,NC; no SBIR, founded 2005), a small drug developer working toward therapies for Alzheimer’s disease, recently raised more than $5 million of a $9.5 million round.[Jason deBruyn, Triangle Business Journal, Jul 18, 14]

PhaseBio Pharmaceuticals (Morrisville, NC)

PhaseBio Pharmaceuticals (Malvern, PA; no SBIR)  entered into a deal giving the exclusive rights to its drug-delivery technology for use in treating cancer to Duke University.   PhaseBio retained development and commercialization rights to all other applications of its elastin-like polypetide [ELP] technology platform.   [John George, Philadelphia Business Journal, Mar 25, 16]

PhaseBio Pharmaceuticals (Morrisville, NC; no SBIR)  has raised about $8 million to date in two rounds of financing  [Triangle Business Journal, Nov 13, 09]

Phase Bioscience (Durham NC)

PhaseBio Pharmaceuticals (Malvern, PA; no SBIR) biopharmaceutical company working on a once-weekly insulin treatment for diabetics, raised $40 million [series C financing... led by AstraZeneca] in a private stock sale. ... to conduct mid-stage clinical testing of its once-weekly insulin treatment, PE0139, in patients with type-2 diabetes.   [John George, Philadelphia Business Journal, Mar 12, 15]

PhaseBio Pharmaceuticals (Durham, NC; no SBIR) raised $25 million in a series B round of financing, the company announced ...  developing therapies based on its proprietary technology with proteins that can be used to enhance the delivery of therapeutic drugs. [Triangle Business Journal, Jan 7, 10]

Phase Bioscience (Durham NC: $200K SBIR)raised $6.6M in its most recent round of financing. [Raleigh News&Observer, Oct 25]

PhaseRx (Seattle, WA)

PhaseRx up 14% [May 26, 16]

PhaseRx (Seattle, WA; no SBIR) filed for IPO [Seattle Times, Apr 18, 16]  biotechnology company focused on developing mRNA therapeutics to treat orphan liver diseases [company website]

PhaseRx (Seattle, WA; no SBIR) got a $1.5M venture round   ....developing therapies via sIRNA technologies. [xconomy.com,Dec 26, 12]

Phigenix (Atlanta, GA)

Phigenix (Atlanta, GA; no SBIR) biotech plans to raise $10.5 million, according to [SEC] filing ... uses molecular therapeutics that target the immune system to prevent and fight prostate cancer. The company is developing diagnostic tests which may detect prostate abnormalities at the pre-malignant state years before the onset of cancer, according to its website [Urvaksh Karkaria, Atlanta Business Chronicle, Aug 19, 15]

Phoenix Biotechnology (San Antonio, TX)

Phoenix Biotechnology  (San Antonio, TX; no SBIR) which has been developing a plant-based drug to treat Alzheimer’s for more than a decade, is looking for help in promoting its therapy because it is running out of time and money. The biotech company published findings in 2016 that showed that its drug may be able to produce an antioxidant response in the brain and may stimulate a protein related to memory and learning. [Angela Shah, xconomy.com, May 1, 17]

Phoenix Nuclear Labs (Monona, WI)

Phoenix Nuclear Labs  (Monona, WI; $1.2M SBIR) announced it has been awarded multiple contracts by the U.S. Army totaling $3.6 million [to] build an advanced neutron radiography system to detect defective munitions and demonstrate the ability to use their neutron generators to detect and identify concealed explosive threats.  [company press release, Aug 2, 16]  Phoenix grew out of technology that medical physicist Paul DeLuca created in the 1970s and 1980s at the University of Wisconsin-Madison, but has developed its own intellectual property, he said. ... Now the company has potential to develop into a "highly viable, $100 million a year in sales company," he said.   [Kathleen Gallagher, Milwaukee Journal Sentinel, Aug 2, 16]

Phoenix Nuclear Labs (Madison, WI, $1M SBIR) raised $790K ... makes particle acceleration and neutron generation systems. Its customers include companies in the neutron radiography and materials processing industries. [Milwaukee Journal Sentinel, Jan 7, 16]

Phoenix Nuclear Labs (Monona, WI; $900K SBIR) maker of neutron generator technology, said it has converted $3.2 million of debt financing from 10 investors into equity. That financing includes $2 million the company raised in November  [Kathleen Gallagher, Milwaukee Journal Sentinel, Mar 12, 15]

Phoenix Nuclear Labs (Monona, WI; $900K SBIR, founded 2005) maker of neutron generator technology, said it has raised $2 million from outside investors.  ... In February, the company signed what it said was its first large-scale commercial contract, which has it supplying a thermal neutron generation system to Ultra Electronics Holdings, a British maker of control systems.  Phoenix spun out Shine Medical Technologies (no SBIR) in 2010.   [Kathleen Gallagher, Milwaukee Journal Sentinel, Nov 24, 14]

Phoenix Nuclear Labs (Monona, WI; $900K SBIR) announced today that it has been awarded a one-year, $3 million contract by the U.S. Army to build an advanced neutron radiography unit. The neutron imaging system will be used for the nondestructive inspection of munitions, pyrotechnics and other critical defense components. ...  an upgraded, second-generation version of a similar system that it delivered to Picatinny Arsenal [NJ] in 2013. ...  The PNL neutron radiography platform is the first system capable of bringing neutron radiography out of an R&D environment and into a production setting, similar to industrial X-ray systems.     [company press release, Oct 6, 14]

Phoenix Nuclear Labs (Monona, WI; no SBIR) said it has completed a $590,500 round of equity fundraising to continue developing its particle accelerator technology.  ... is collaborating with Shine Medical Technologies and the Morgridge Institute for Research to develop a new process for producing molybdenum-99, a medical isotope used in medical imaging procedures. [Milwaukee Journal Sentinel, May 21]

Phoenix Science (Chelmsford, MA)

Phoenix Science & Technology (Chelmsford MA) got a $15M Phase III Navy SBIR for more development of pulsed light and acoustic devices for for ultraviolet water treatment and for paint stripping of naval vessels. [Mass High Tech, Aug 26]  Navy mainline takes advantage of sole-source rules for SBIR awardees to ease its contract administration. It means juicy contracts for the good (Navy likes them) companies. The one downside to that policy is that Navy will favor companies ready for large contracts for Phase 1 and 2.  Phoenix has at at least $3.5M of Navy SBIR since 1995

Phononic Devices (Raleigh, NC)

Phononic (RTP, NC; no SBIR, founded 2009) has patented new solid-state cooling and refrigeration technology that will replace older refrigeration systems. This new Phononics solid-state semiconductor technology has enabled Phononics to enter a broad new range of consumer and business products. The company has received almost $90 million in outside funding to date.  [Raleigh News & Observer, Mar 3, 16]

Phononic Devices (Durham, NC; no SBIR) raised $5.5 million in its second equity round.  ....  develops advanced thermoelectric devices designed to efficiently manage and monetize heat, including coolers and generators, and has received $3 million in government seed funding. [Lauren Ohnesorge, Triangle Business Journal, Dec 20, 12]

The White House held up a small [17 employees] company as an example of the success of its policy. Phononic Devices (Raleigh, NC; no SBIR) scored $3 million from the U.S. Department of Energy two years ago and earlier this year netted $12 million in private investment. ... develops semiconductor devices that capture and recover waste heat and could tap a rich source of energy.  [John Murawski, Raleigh News & Observer, Aug 31, 11]

Phononic Devices  (Raleigh, NC; no SBIR) startup that makes miniature electronic heat pumps has scored $10 million in venture capital to create prototypes of its product for demonstration to potential customers. ... with 10 employees at its Centennial Campus office, plans to hire up to 20 scientists and engineers in the next 18 months as it ramps up production of its thermodynamic devices, CEO Anthony Atti said.  The 2-year-old company is developing a product designed at Oklahoma University to replace conventional equipment that removes heat from computer and refrigeration components. In the past two years, Phononic won a prestigious $3 million grant from the U.S. Department of Energy and $2 million in venture capital. The first $5 million went into research, development and design. The latest round of venture financing will pay for further testing and assembly of prototypes. [John Murawski, Raleigh News & Observer, Feb 24, 11]

Photobit (Pasadena, CA)

Photobit Acquired. Photobit (Pasadena, CA) was quietly acquired by Micron Technology in Micron's run at the emerging CMOS image sensor market. No price reported. eNews says at least 20 chipmakers are believed to be producing or developing CMOS image sensors, though no single supplier is considered entrenched.. Photobit, a JPL spinoff acquired key patents to the JPL technology and some government contracts, especially SBIR from (then) BMDO , Then it needed deep pockets volume manufacturing capacity, and the know-how to optimize a process technology for cost and performance. Enter Micron, which claims that combining Photobit's IP with its process expertise will enable high resolution in a small pixel size to significantly reduce chip size, cost, and power consumption, Frost & Sullivan estimated the 2001 image sensor market, including CCDs, at about $1 billion.

Photolitec (Buffalo, NY)

Photolitec LLC  (Buffalo, NY; no SBIR), a spin-off from Roswell Park Cancer Institute, finalized a new $2 million investment from an Indian pharmaceutical company AMI Organics should be the final boost needed ... to begin clinical trials and commercialize its specialized photosensitive compounds, which kill cancer cells when exposed to light through photodynamic therapy (PDT).  ...  Additional private funding for Photolitec's work included a $5 million investment from Zhejiang Hisun Pharmaceutical Co. Ltd., a Chinese pharmaceutical group, which made its final payment last year. 
Zhejiang Hisun retains licensing rights for China, Taiwan, Hong Kong and Singapore; while AMI will control licensing for the U.S., Canada, Europe and India. 
   [Tracey Drury, Buffalo Business First, Mar 3, 15] 

PhotoMedex (Montgomeryville, PA)

medical-device developer MELA Sciences (Irvington, NY; $3M SBIR as Electro-optical Sciences) that recently acquired a local company’s laser skin care technology is planning to relocate its headquarters to Montgomery County [PA].  The move is a result of an agreement to purchase PhotoMedex (Horsham, PA; no SBIR)’s Xtrac and Vtrac laser devices used to treat psoriasis and other skin disorders, for $42.5 million. [John George, Philadelphia Business Journal, Jul 15, 15]  PhotoMedex is a global skin health company providing aesthetic solutions to dermatologists, professional aestheticians and consumers. [company website]

PhotoMedex  (Montgomeryville, PA; no SBIR) has raised $2.7 million in a private stock placement. ... develops proprietary excimer laser and fiber optic systems for the treatment of skin disorders [John George, Philadelphia Business Journal, Oct 23, 09]

Photonics Innovations (Birmingham, AL)

Laser systems maker IPG Photonics(Oxford, MA, founded 1990; no SBIR) has acquired Photonics Innovations (Birmingham, AL; one SBIR) a maker of active and passive laser materials and tunable lasers.[Mass High Tech, Jan 26, 10]

Photon-X (Huntsville, AL)

Lucidux LLC  (Providence, RI; no SBIR), a startup that makes 3-D imaging technology for surgery and other medical applications, has received $250,000 in funding from the Slater Technology Fund, a non-profit corporation that works like a venture capital firm ... founded in 2011, is developing its technology with corporate partner, Photon-X (Huntsville, AL; $6M SBIR)  The real-time, three-dimensional imaging of internal organs and tissues uses software-enhanced presentation and can be used by surgeons during procedures such as laparoscopy and arthroscopy. The company says it can highlight diseased tissue, allowing surgeons to remove it without damaging healthy tissue nearby.  [Don Seiffert, Mass High Tech, Jul 30, 12]

PhotoSonix Medical (Ambler, PA)

PhotoSonix Medical  (Ambler, PA; founded 2014)  is developing a treatment for dermal diseases generated by bacterial biofilm, such as acne. Biofilms, which make treatment extremely difficult, shield bacteria from attack by both drugs and the immune system, often inducing a chronic inflammatory response. Photosonix's product, CLENS, will cut through biofilm by combining both ultrasound and violet light to kill underlying biofilm bacteria.  [Lauren Hertzler, Philadelphia Business Journal, Jan 16, 15]  investors Ben Franklin Technology Partners

PhotoThera (Carlsbad, CA)

Dr. Jackson Streeter once held the ultimate cool job. In the mid-1990s he was the first medical doctor to be a pilot in the elite U.S. Navy Fighter Weapons School, more commonly known as TOPGUN ... he gave it all up in May, 1997, to start a company, PhotoThera (Carlsbad CA; no SBIR), built around an unlikely laser therapy he learned about from an obscure Hungarian medical journal.  ... His device, called NeuroThera, is still in clinical trials, but it is gaining respect from stroke specialists and once-skeptical venture capitalists. ...managed to drum up $750,000 in financing from Hamilton BioVentures and California Technology Ventures in 2001, in part by crashing a Goldman Sachs investment meeting in San Diego. Positive data in animals helped him raise an additional $4.35 M, then $19 M more, and finally in 2006, $30.5 M. [Catherine Arnst, Business Week, Nov 19]

Photronics (Brookfield, CT)

Photronics (Brookfield, CT; no SBIR)  reports it plans to raise more than $85 million in a public stock offering ... to repay some of its outstanding bank loans ...   imaging technology company  [Mass High Tech, Sep 11, 09]

Phoundry Pharmaceuticals (Research Triangle Park, NC)

"that GSK was downsizing really helped accelerate our company,” says Paul Feldman, the CEO of newly formed Phoundry Pharmaceuticals (Research Triangle Park, NC) a drug developer ...  this group of six made up one-fifth of GSK’s Enteroendocrine Discovery Performance Unit, which was caught up as part of the downsizing GSK announced late last year.  ...  the group took their six years of work with them, including huge amounts of data, more than five semitrailers in equipment, two top assets that could one day treat metabolic diseases and the institutional knowledge to create intellectual property. In return, they agreed to give GSK a royalty of 2 percent on net sales if those two assets become marketable drugs.  ...  raised $500,000 and plans a second tranche of another $500,000 in the coming months  [Jason deBruyn, Triangle Business Journal, Aug 18, 15]

Phurnace Software

Phurnace Software (Austin, TX; no SBIR),18-month-old company, which sells software that accelerates the deployment of Java applications, completed its $5 million first round of venture backing. [Austin American-Statesman, Jul 21]

Two Austin startups,30 Second Software Inc. and Phurnace Software Inc., have received venture capital infusions. 30 Second Software, founded by Austin entrepreneur Dave Sikora, has raised $2.9 million from two corporate investors, to develop mobile commerce technology and services. Phurnace, which won the 2006 University of Texas MOOT Corp business-plan competition, received $1.3 million [from] a Texas-based venture fund affiliated with Draper Fisher Jurvetson.  [Austin American-Statesman, Sep 3]

Phylonix

A Fish for All Seasons. Phylonix Pharmaceuticals (Cambridge, MA; $8M HHS zebrafish SBIR) got a two-year EPA contract for up to $4.3M to explore the use of zebrafish as a screening tool.

Doing Its Thing.  NSF handed Phylonix a $500K Phase 2 SBIR  to assess possible toxic effects of chemicals on the development of human organs and tissues using tests performed in zebrafish. The company calls itself a Contract Research Organization providing in vivo zebrafish assays.

Phylos Bioscience (Portland, OR)

Phylos Bioscience, (Portland, OR; no SBIR) which is mapping the cannabis genome, has raised $250,000 in equity, according to [SEC] filing with the U.S. Securities and Exchange Commission.  ... could raise another $1.75 million, according to their filing.   .... collaborating with a half-dozen research universities to uncover the plant's biology.    [Elizabeth Hayes, Portland Business Journal, Feb 3, 15]  Not exactly a market-failure situation, and therefore no need for government subsidy.

Physcient (Durham, NC)

Physcient (Durham, NC; $700K SBIR) is gearing up to re-invent the way doctors perform surgery. Co-founder and CEO Hugh Crenshaw and team are tackling blunt dissection, a surgical standard that has been largely unchanged for decades. [Amanda Jones Hoyle, Triangle Business Journal, Sep 6, 13]

Physical Optics (Torrance, CA)

Ceradyne got $436M in government contracts in  2006, says fedspending.org's database. Physical Optics $21M.

Loving Experience.   Scientific Systems (Woburn,MA; $50M+ SBIR) won a NASA JPL Phase 2 SBIR for Distributed Formation State Estimation Algorithms Under Resource and Multi-Tasking Constraints. Creare (Hanover NH; $120M SBIR) won four NASA JPL Phase 2 SBIRs. Intelligent Automation (Rockville MD; $100M SBIR) won three NASA JPL Phase 2 SBIRs. Physical Optics (Torrance, CA; $200M SBIR) won one NASA JPL Phase 2 SBIR. Radiation Monitoring Devices (Watertown, MA; $90M SBIR) won one NASA JPL Phase 2 SBIR. Etc, etc, etc. A zillion start-ups all over America got letters saying there was not enough money to nurture their ideas.

Physical Optics (Torrance, CA), still a private firm after 15 years of SBIR and 322 Phase 1s through 1998 (if the SBA database is current) spun off its fourth subsidiary to focus on commercial products" But SBIR cheerleaders should ask why POC hasn't had a BMDO Phase 2 since 1994 alongside its tons of military service awards. It did have three Phase 2s from DOE last year.

POC's website claims POC’s rapid growth has been achieved through a successful commercialization strategy based on in-house manufacturing, corporate alliances, licensing and joint ventures. POC also has a long and successful history of converting technologies developed under Federal SBIR programs into commercial products. This conversion has been accomplished using multimillion dollar venture capital investments, and strong banking relationships and allows us to capitalize on both commercial & government growth opportunities. With our unique expertise, $10 million in assets, and a strong growth record, POC is well positioned to become a major player in the rapidly growing optoelectronic markets.  You may notice that the website has little useful data (it's a private corporation) by which anyone could evaluate whether SBIR was getting its money's worth. POC has managed over the years of SBIR to never go public despite being in a hot industry.

Physical Sciences (Andover, MA)

Physical Sciences, a huge consumer of SBIR, bought Q-Peak  to get Q-Peak's solid-state laser systems which would complement and support PSI's activities in laser applications.

Lucent signs cascade-laser sales deal. US-based technology-development company Physical Sciences Inc. (PSI) has signed a deal with Lucent Technologies to develop and sell gas sensors that are based on quantum cascade lasers (QCL). PSI says that, with prototype sensors already under development, the devices will be available for delivery by the middle of the year. The QCL sources operate between 5 and 12 µm, which corresponds to the fingerprint molecular-absorption region of many common and pollutant gases. PSI has also licensed patents and technologies from Gemfire, based in California, which has developed periodically poled lithium niobate crystals to convert laser emissions in the visible and near-infrared into the 2 to 4.5 µm region. Gas sensors for water-vapour and hydrocarbon detection that are based on these sources are also under development at PSI.Together with the QCL-based sensors, PSI will be able to cover the spectral range from the visible through to the far-infrared.

Alan Gelb of Physical Sciences Inc  (Andover, MA) got a BMDO Phase 2 for a versatile, charge-free atom beam tool for semiconductor processing. The tool uses PSI's proprietary microwave-driven plasma beam technology..... In the Phase II program, the oxygen beam will be developed into a processing tool capable of meeting the uniformity and cleanliness requirements for the 300 mm wafer fab. Addtionally, chlorine atom and CF4/02 beams will be generated, characterized and demonstrated for metal and chamber cleaning applications. The proposed program will be carried out in collaboration with a major equipment manufacturer to assure the development of a commercial tool. . How nice an oxygen beam! Alan Gelb and PSI got the first SDIO Phase 2 in 1986 for ... an oxygen beam. Wonder what PSI has done in the intervening decade about commercializing its beam technology? Ask CEO Bob Weiss why he wants more and biger SBIR with all the present management schemes (without co-investment) that he so often taps. What is PSI's ROI for all that government investment? Maybe holding his feet to a co-investment fire was the only way to force realistic proposals.

PhysioGenix (Wauwatosa, WI)

start-ups in the drug field within the Milwaukee 7 economic development region suggests another strategic direction for the regional economy. Those new ventures come as Concordia University of Wisconsin mounts an impressive campaign to build a new pharmacy school in southeastern Wisconsin, possibly in downtown Milwaukee. ... New ventures  in the emerging drug-making concentration:  MPP Group  (no SBIR)a venture headed by serial entrepreneur Frank Langley that is building drugs aimed at alcoholism. James Cook, a University of Wisconsin-Milwaukee researcher, developed the compounds.  Neuro Amp (no SBIR),a spin-off from PhysioGenix (Wauwatosa, WI; $3M SBIR) that is aiming at diseases of the central nervous system and Alzheimer's.  Promentis (no SBIR), a collaboration between Marquette University's David Baker and UWM researchers and former Schwarz Pharma managers who are targeting schizophrenia and central nervous system disorders.  Cytometix (no SBIR), a 2004 start-up headed by Lane Brostrom that is developing drugs for the treatment of pain and asthma. Endece  (no SBIR), a 2006 Mequon start-up headed by James Yarger that is developing compounds for treating cancer, sepsis, learning and memory. [John Torinus, Milwaukee Journal Sentinel, Jan 31, 09]

PhysioGenix (Wauwatosa, WI; $3.5M SBIR) which sells pre-clinical services to drug companies, said it plans to spin off a subsidiary that will attempt to create drugs out of compounds developed at the University of Wisconsin-Milwaukee  [Kathleen Gallagher, Milwaukee Journal Sentinel, Jan 18, 09]

PhysioSonics (Seattle, WA)

PhysioSonics, (Seattle, WA; no SBIR) a University of Washington spinout company that's developing an ultrasound device to monitor blood flow in the brain, has raised $2 million in funding to move toward commercialization of its first product. [Puget Sound Business Journal, Jun 24, 09]

PhytoTech (Monmouth Junction, NJ)

A Real Industrial Plant  PhytoTech (Monmouth Junction, NJ) is on the verge of parlaying one SBIR into an industry. Whereas most companies bleat that environmental technology is too much potential and too little immediate earnings prospects (and therefore needful of government succor), last week it filed for an IPO to raise $11M for the "bio-technology" of using metal-loving plants to capture metals from the soil. PhytoTech has one 1997 Army SBIR to absorb uranium from Army-contaminated ranges. The same hyper-uptake principle would work also for hydroponic culture to remove metals from flowing water. One warning: don't eat the leaves. In late 1994, the company raised more than $3 million US in private placement venture capital. Of this, $1.1M was committed to Rutgers for research to be conducted. Field trials have been conducted in Chernobyl, Ukraine, in Sheffield, England, and in Trenton, NJ.  PhytoTech's market success is likely to depend on three things: the bureaucracy of getting government to buy such a product, the economics of finding better uses (like concentrating trace metals for pharmaceutical supplements), and the general market attitude to biotech companies. Michael Gianturco (financial pundit) [Bloomberg Personal, May 98] says biotech is where digital was in the 1970s. That is, stocks are unpredictable and therefore dangerous, a situation where the best thing about this sector is also the worst  That alone scares conservative investors and bureaucrats. Gianturco also notes more optimistically that Molecular biology is to the second half of the 20th century what physics was to the first half: a springboard for a torrent of widely used commercial applications.The SBIR deciders MAY note the potential or they may just simply use the technology for cleanup as a pure service contract. Their imaginations can be put to the test.

Picolight (Boulder, CO)

Picolight (Boulder, CO) did a cross-licensing deal with Honeywell for its “oxide confined” VCSELs.  Picolight started life in 1996 with an BMDO SBIR, got seven Phase 2 SBIRs 1997-2000 and now employs 100 people. Companies like Picolight, with entrepreneurs like Jack Jewell, and products like the next generation VCSELs make the perfect SBIR start-up situation.

Picolight's 100 employees testify that the company has made exemplar use of a little SBIR money and a wad of venture capital sine starting up in 1995. Its latest news is that it made the first 1310nm transceivers out of its signature product - VCSELs. Six Phase 2 SBIRs in the late nineties was all the government R&D help he needed. It is actually founder Jack Jewell's second such rise to success, having pulled the same trick after starting Vixel in 1991.If there was ever a poster child for SBIR, Jack makes the ideal candidate on the basis of getting somewhere with an infant technology an only a little bit of government money. $5M of SBIR attracted $80M of private investment which by its nature expects a high ROI which in turn requires really large sales volume. If the technology really works in the marketplace - no small trick - the return to the government in corporate income taxes alone will be among the largest ROI government ever gets from intruding in the marketplace. The stories that the federal agencies tell of sales volume by SBIR companies is small potatoes to ROIs like Jack Jewell's. But Jack will have to get his reward from the private market because the government is disinterested in adjusting its SBIR to bet on more Jack Jewells

Picolight (Boulder, CO) raised another $27M of venture capital to keep its 120 employees developing transceiver subsystems for short-reach (1-meter to 20-kilometer) optical-networking connections. That makes $80M raised since 1996. Picolight’s specialty is the Vertical Cavity Surface Emitting Laser (VCSEL) deriving from Jack Jewell's work first at Bell Labs, then at his co-founded Vixel before he founded Picolight. Both Vixel and Picolight got their funding starts from SDIO/BMDO's SBIR, back when BMDO cared about co-investment and entrepreneurs

Picolight (Boulder, CO) says it's part of a 14 company initiative for a next generation 10GB pluggable fiberoptic transceiver. And as soon as Nortel and Lucent and Corning pick themselves out of the overbuilding cellar, .... [fact from Laser Focus World, Jun01]

Picolight (Boulder, CO) took down $10.8M in VC funding in the fall of 1999, says Photonics Spectra Apr00. Picolight is the second child of Jack Jewell who first co-founded Vixel.. He got both started with SBIR from BMDO, Vixel in 1991 and Picolight in 1996. PS calls it a manufacturer of VCSEL devices. Vixel went public in 1999 but is presently languishing well below its first trading range.

Picolight $3.5M  Jack Jewell closed a $3.5M investment in two-year old Picolight (Boulder, CO) to develop the next generation of VCSELs. That funding on the top of three BMDO Phase 2 SBIRs brings his capital influx to about $8M. Jack tells how he got the first $250K to match the Fast Track $1M: One night a stranger knocked at his door up a long track from the road in the mountains above Boulder looking for Jack's wife who had published a scientific article on x-ray lithography. Her address was on the paper byline. He was interested in investing in it until Tanya said that it was really long term stuff but "by the way have you heard about Jack's new company?"

Picolight's VCSELs Light Up. Having won a BMDO Fast Track as a deserved reward for attracting private capital to a BMDO technology - next generation VCSELs - Picolight (Boulder, CO) also won two regular-way Phase 2 awards, also with rewards for new capital. Of course, from BMDO they are not just a handout of an R&D contract. They require an escalating match rate by private capital as both the technology and the company mature. BMDO did the same thing for the first company Jack Jewell founded - now Vixel Corp - which has raised tens of millions to go into full scale production. From the FT which had 4:1 (BMDO to private), the second has 2.5:1, and the third 0.7:1. BMDO also holds out the idea of expanding the amount if Picolight finds investors. BMDO's message: if you can't find investors </b>in your technology as it technically matures, you're kidding yourself about its potential in which case we will cut our losses.

Picolight Fast Track. A DOD Fast Track award is on its way to Picolight (Boulder, CO) for a shot at the next generation of vertical cavity surface emitting lasers, manufacturable oxide-defined VCSELs, that would dramatically upgrade instruments such as CD and DVD pickups, datacom transmitters, barcode scanners, printers, gas sensors and telecom 1.3 micron transmitters. Since Picolight just got started by Jack Jewell, one of the founders of Vixel (Broomfield, CO) and an alumnus of Bell Labs, it qualified for a 4:1 match of whatever third party cash it could recruit. Such recruiting is rarely easy for the kind of new technology that BMDO favors. (BMDO knows it cannot reach its technology dreams with safe incremental advances to present technology and thus bets on some risky stuff that VCs avoid.)

Vixel (and Jewell) got started with a BMDO (then SDIO) SBIR in 1991 and has since raised more than $30M to get a VCSEL industry rolling. Jewell said on a 1994 BMDO SBIR video that his dream was "to walk  into a consumer electronics store and see his products on every shelf";. Jewell now has a two-way play in VCSELs: he wins if Vixel sells a zillion of today's VCSELs and/or if Picolight sells a zillion of tomorrow's VCSELs. He's basically betting that his new venture will overtake his first venture. He has to decide which to hope for: Vixel's establishing a market whose next generation Picolight can exploit faster than Vixel can OR Picolight's leafrogging Vixel straight into a second generation technology before the first even recovers its investments.  BMDO and Jewell win either way. He's probably hoping more for the latter because the capital raising and the multiple founders of Vixel well  diluted his equity share. Still, even a small percent of a giant win makes him a winning entrepreneur. If he's economically rational and capitalistic, he'll root for the biggest pile of money

Jack's dreams can also be inferred from his November 1991 Scientific American article Microlasers in which Vixel is called by its first name, Photonics Research Inc. Jon Baron, DOD's Fast Track champion says that 75% of all Fast Track awards have gone to 4:1 matches that can only be had by first time Phase 2 winners under 10 employees.

Picometrix (Ann Arbor, MI)

Advanced Photonix up 10% [Oct 23, 07] after announcing that its subsidiary, Picometrix, has received a follow-on $750K AF Phase II SBIR for further non-destructive testing (NDT) application development involving the testing of radomes for defects such as delaminations and water intrusion utilizing the T-Ray 4000 terahertz system platform. [company press release]  Picometrix started life in 1992 with an SDIO SBIR when Steve Williamson got fed up with his university's handling of patenting his work.

Picometrix (Ann Arbor MI) got some national press [Business Week, Apr 11] for trying to develop a terahertz people scanner. Pico started life (as Picotronix) with 1992 SBIR from SDIO for Steve Williamson's launch from the cozy but bureaucratic university lab situation, and has had six Phase 2s to help along its commercial ventures in super-fast lasers. I didn't have to talk too hard to Steve to convince him that he was great SBIR material of the mettle I was looking for in the high-tech days of Star Wars.  It calls itself a leading supplier of high-speed optical receivers and ultrafast instrumentation since 1992.  Recently it said it was being bought for $12M by Advanced Photonix, another 1980s SDIO-SBIR winner.   Co-founder Rob Risser said the firm has been profitable every year of its existence except the IT crash years of 2002 and 2003. Half a million profit in 2004 on $7.5M revenue.  [facts from Scott Anderson, The Ann Arbor News, Mar 25, 05]

Piedmont Biofuels (Pittsboro, NC)

Thirteen NC companies will split $1 M from a new state fund intended to help businesses create environmentally friendly technologies. In the Triangle area: Ecocurrent of Raleigh received $100,000 to convert hog manure into electric power; Kyma Technologies of Raleigh received $60,000 to work with N.C. State University on a more efficient, cheaper electric switch.; 3F LLC of Raleigh received $100,000 to develop a natural fiber-reinforced concrete formula.; Piedmont Biofuels of Pittsboro received $75,000 to work on a reactor that more efficiently creates biodiesel.; Nextreme Thermal Solutions of Durham received $57,319 to manufacture a generator that converts waste heat into electricity.; Rain Water Solutions of Raleigh received $18,000 to develop a new rain barrel manufacturing process. [Raleigh News & Observer, Jul 1]

Pika Energy (Gorham, ME)

Maine Technology Institute today announced four new Development Awards — conditional loans — totaling $761,348 for four Maine technology companies. The awards by MTI, a publicly financed non-profit, were matched with combined contributions over $890,047 by the recipients: Wizbe Innovations (Manchester, ME)  $64,000 to develop parachute fabric for the U.S. Army with controllable and adjustable permeability. Wizbe initially began their work with a U.S. Army SBIR to develop a prototype fabric. ...  Pika Energy (Gorham, ME; no SBIR)   $274,291 to develop a wind turbine system that offers lower upfront costs to make it easier and less expensive for families and businesses to produce clean renewable electricity. Early stage development was supported with an MTI Seed Grant.   ...  Cerealus Holdings(Waterville, ME; no SBIR) $261,849 to commercialize their Cerecarb, which is designed to enable paper mills to reduce costs by substituting ash filler for expensive pulp fiber. ...  RainStorm(Orono, ME; no SBIR) $161,208 to expand access to affordable education opportunities nationally by providing local adult education programs with a simple, affordable course catalog and online registration website.   [Mass High Tech, Jun 27, 11 

Pilus Energy (Cincinnati, OH)

Tauriga Sciences (New York, NY; no SBIR, trading for a penny a share) micro-robot firm is acquiring startup Pilus Energy (Cincinnati, OH; no SBIR, a subsudiary of Bacterial Robotics (no SBIR) ) that uses tiny bacterial robots called BactoBots that metabolize wastewater and harvest direct current electricity to produce economically important gasses.  [Andy Brownfield, Cincinnati Business Courier, Nov 26, 13] 

Pinger

Ten Startups to WatchInstant Voicing by Pinger Founded 2005, Funding $11 million;  Sharing, Privately by Pownce  founded 2007 funding undisclosed; Cell-phone Streaming by Qik founded 2006 funding $4M;   Traffic Master by Dash Navigation founded 2003 $71M; Crisis Sourcing by Ushahidi founded 2008 funding undisclosed;  Partial Recall by QTech founded 2004 $5M; Are You ... Influential? by 33Across founded 2007, $1M;  Semantic Ads by Peer 39, 2006, $11M;  Mashups Made Easy by Mashery, 2006, $5M; Video Packet-Switching by Anagran, 2004, $40M. [MIT Tech Review, J/A08]

Pinnacle Technology

Kansas Grappling Also. Kansas bioscience leaders took steps toward stimulating collaboration between companies and university researchers pursuing new drug technology, biomaterials and plant genetics. The Kansas Bioscience Authority signed off on three planning grants totaling $580,000 for the potential creation of new bioscience centers of innovation. That initiative, investments in companies such as XenoTech (no SBIR) and Pinnacle Technology (Lawrence KS; $2M+ SBIR) and providing up to $7M toward the recruitment of two renowned scientists are the latest examples of how Kansas is attempting to bolster its bioscience economy, said Sandra Lawrence, chairwoman of the authority’s board. [Jason Gertzen, Kansas City Star, Jan 17]

Pioneer Surgical Technology (Marquette, MI)

The MichiganVCA honored Pioneer Surgical Technology, (Marquette, MI; no SBIR) with the Best Exit Award. Pioneer Surgical, a medical device company founded in 1992, was acquired by RTI Biologics earlier this year.[Sarah Schmid, xconomy.com, Nov 8, 13]    

Pixelligent (Baltimore, MD)

Pixelligent Technologies (Baltimore, MD; $4M SBIR) is looking to raise $3.5 million in debt funding, after closing a $10.4 million equity round late last year, according to a recent [SEC] filing.   ... uses manufactured nanomaterials to produce high-efficiency lighting, has raised over $36 million in equity funding to date and has been awarded more than $12 million in federal grants.  [Morgan Eichensehr, Baltimore Business Journal, Jul 3, 17]   ...  Awarded [Frost & Sullivan] Manufacturer of the Year for small/midsize companies with revenues under $1B, for its PixClearProcess™ that is revolutionizing chemical composite technology [company press release, Jun 19, 17]

Pixelligent Technologies (Baltimore. MD; $900K SBIR) raised $3.4 million [Series B round] in convertible debt to put toward expanding its nanocrystal manufacturing business. ...  has raised a total of $26 million in equity and received more than $12 million in federal government grants.    [Sarah Gantz, Baltimore Business Journal, Jun 16, 15]

nanocrystal company Pixelligent Technologies (Baltimore. MD; $900K SBIR, 40 employees) has raised $5.5 million in equity funding.  ... toward growth in Asia and Europe, as well as within the U.S. Pixelligent will also use the new funding to increase its staff size. The new funding brings Pixelligent's total to $23 million equity, plus more than $10 million in federal grants.  [Sarah Gantz, Baltimore Business Journal, Dec 12, 14]

nanocrystal-maker Pixelligent Technologies (Baltimore, MD; $900K SBIR) is working on a new type of lighting that would be more energy efficient and cast a higher quality light. The work, a partnership with OLEDWorks  (Rochester, NY; no SBIR), is backed by a $1.25 million grant from the DOEenrgy.   ...  OLED lights are sheets of glass that emit light when plugged in, ... so efficient they could last the lifetime of a building, but thousands of dollars per light  ...  expects this type of light to begin gaining traction in the commercial market by 2020.   [Sarah Gantz, Baltimore Business Journal, Sep 22, 14]

Pixelligent (Baltimore, MD; $1M SBIR, 32 employees) has raised $3.8 million.  ....   has now raised around $18 million and nearly $10 million in federal grants. ....   for a second production facility in Baltimore and to expand in global markets, mostly in Asia.  [Ryan McDonald, Baltimore Business Journal, Dec 16, 13]  won a $1M fed grant in November ..... manufacturing high-quality nanocrystal dispersions and polymer nanocomposites  [company website] 

Pixel Optics

Seeing Only the Forest. Almost everybody (93%) on the planet over the age of 45 suffer from presbyopia, says PixelOptics where people have trouble picking the bones out of the fish plate Pixel just got a DOD contract for goggles that would correct a warrior's vision "We're aiming for 20/8," says company R&D chief Dwight Duston. Eileen Zimmerman [Wired, Jun 06] stuck a knife in the claim by noting that Duston was also former head of research for Star Wars, so improved ability to actually hit anything is not guaranteed.  He was also the grand poobah of Star Wars SBIR which got a lot of interesting innovations their first serious money. He comes to Pixel by way of the VC operation The Egg Factory.  In his ten plus years at Star Wars, he ran the office that put the earliest money into anything new, although as the project matured from a pure exploration into a development, the ratio of pure science to SBIR kept shrinking.  For SBIR he provided the shield from internal politics that undercuts every other agency program and steers money into immediate tasks and away from disruptive innovation. I picked the winners and losers and he kept the hyenas from the food supply.

Pixim (Mountain View, CA)

In-Q-Tel's strategic investment funding will be used to accelerate Pixim (Mountain View, CA; no SBIR)'s new product development and for general working capital purposes to meet the strong growth arising from demand for Pixim chipsets. ... known for its award-winning, patented Digital Pixel System® (DPS) technology and for setting the industry standard for wide dynamic range image capture in the security camera market [In-Q-Tel press release]

Pixtronix (Andover, MA)

Pixtronix (Andover, MA; no SBIR) picked up $19 million in a new round of equity and warrants, and may have brought in a major cell phone maker as a new strategic investor ... founded in 2005 by CTO Nesbitt Hagood, and is developing improved electronic displays designed to consume less power. The company unveiled its first product, PerfectLight, in November of 2008 [Mass High Tech, Dec 29, 09]

Pixtronix (Andover, MA; no SBIR) emerged form secrecy to unveil its new MEMS display technology. ...  raised $31M in two rounds.  [Mass High Tech, Nov 7]

Planar Energy (Orlando, FL)

Planar Energy (Orlando, FL;no SBIR)—a company spun out of America’s National Renewable Energy Laboratory in 2007. The firm is about to complete a pilot production line that will print lithium-ion batteries onto sheets of metal or plastic, like printing a newspaper. [The Economist, Jan 29, 11]

Planar Systems

Planar Systems (Beaverton, OR: $2.3M SBIR) a subsidiary of Leyard Optoelectronic Co., Ltd  (China), a leading worldwide provider of display systems, announced that they have entered into a definitive merger agreement to acquire NaturalPoint  (Corvallis, OR; no SBIR), the global leader in optical tracking and motion capture solutions, for $125 million [cash]  [company press release, Nov 8, 16]

Planar Systems (Beaverton, OR; $1.3M SBIR)  up 32% [Aug 13, 15] was sold to Leyard Optoelectronic Co. Ltd.  (China), which makes LED display products and ancillary systems. Planar specializes in display and digital signage technology. ....   Leyard paid $156.8 million, a 51 percent premium  [Andy Giegerich, Portland Business Journal, Aug 13, 15]

Planar Systems up 18% [Aug 7, 15] on quarterly results

Planar Systems down 11% [May 11, 15]

Planar Systems down 23% [May 8, 15]

Planar Systems up 13% [Feb 26, 15]

Planar Systems up 10% [Feb 5, 15]

Planar Systems down 17% [Feb 4, 15]

Planar Systems  up 11% [Jan 26, 15]

Planar Systems up 16% [Dec 26, 14]

Planar Systems down 11% [Nov 11, 14]

Planar Systems up 20% [Nov 10, 14]

Planar Systems up 73% [Nov 6, 14] on strong revenue growth for the year

Planar Systems up 15% [Aug 4,14]

Planar down 18% [Apr 28, 10]

Planar  down 11% [Feb 3, 10]

Planar  up 11% [Feb 2, 10]

Planar  up 21% [Feb 1, 10]

Planar  down 13% [Jan 29, 10]

Planar Sys up 12% [Jan 4, 10]

Planar Systems up 10% [Jul 22, 08]

Planar Systems up 12% [Jul 16, 08]

Planar Systems down 14% [Apr 29, 08] on earnings disappointment.

Planar Systems up 10% [Feb 26, 08]

Planet Labs (San Francisco, CA)

Small eyes in the sky.  Planet Labs (San Francisco, CA; no SBIR, 40 employees) founded in 2010 by three scientists who worked at NASA. Mr. Boshuizen is Australian, while Mr. Marshall is British. The third, Robbie Schingler, is an American  ...  has already put dozens of small satellites in space. Once they are connected, they will be able to provide near-constant images of what is going on back on Earth.  .....   Several young companies with roots in Silicon Valley are trying to elbow their way into a business long dominated by national governments and aeronautics giants like Boeing.  ....  The company has so far booked contracts worth more than the $65 million in private equity it has raised, according to Will Marshall, the company’s co-founder and chief executive.  ....  but potential customers who have seen the products think the satellites are approximately 95 percent cheaper than most satellites, a figure Mr. Marshall would neither confirm nor dispute.   ...  Another start-up, Masten Space Systems (Mojave, CA; one SBIR) is developing rockets designed for unmanned research flights. Skybox Imaging  (Mountain View, CA; no SBIR) makes satellites similar to those of Planet Labs, though they are significantly larger.  [QUENTIN HARDY and NICK BILTON, New York Times, Mar 16, 14]

Plano Microwave (Plano, TX)

Air Force (USAF) selected Sierra Nevada (Sparks, NV; $1M SBIR, founded 1963, 2500 employees) and its partner Embraer (Brazil) Defense and Security for its Light Air Support (LAS) program.  ...   deemed the A-29 Super Tucano aircraft, and the overall solution offered by SNC, to be the superior choice for this critical mission. The initial $427.5 million delivery order is to supply the USAF with 20 A-29 Super Tucano aircraft.    ...  for. light air support, reconnaissance and training capabilities to the Afghanistan military. As such, it is a vital element of the United States’ Afghan withdrawal strategy   .. work will be in Jacksonville, FL  [company press release Feb 27, 13] over the years it has gathered up companies:  Space Dev (Poway, CA; $5M SBIR) ;MicroSat Systems (Littleton, CA; $11M SBIR) ; Straight Flight  (Denver, CO; no SBIR) ; Waveband (Torrance, CA; $17M SBIR); Aviation Resources Delaware (no SBIR); Inter-4 (San Francisco, CA; no SBIR); Turtle Mountain Communications (no SBIR) ;  Plano Microwave (Plano, TX; no SBIR) ; Spectral Systems (Beavercreek, OH; no SBIR) ;Advanced Countermeasure Systems (Sacramento, CA; no SBIR) . 

Plasan (Bennington, VT)

Plasan  (Bennington, VT; no SBIR) ) that manufactures products for the auto and defense industries has bought a Massachusetts design company.....  announced a deal to buy KaZaK (Woburn, MA; $40+M SBIR over 15 years). Plasan describes KaZaK as a leader in composite structures and low-cost, automated composite manufacturing. The Bennington Banner reports that Plasan CEO Dan Ziv says KaZaK will help Plasan boost its manufacturing capability. Plasan North America in Bennington produces armor for military vehicles. Plasan Carbon Composites makes auto parts. [AP, Jul 1, 11]

PlasmaTech Biopharmaceuticals (Dallas TX)

A biotechnology company seeking to bring to market a genetic therapy from Nationwide Children’s Hospital has proposed a Cleveland headquarters and research lab after merging with a Texas company.  ... Abeona Therapeutics (Cleveland, OH; no SBIR) said it would create 20 new jobs in three years in Cleveland – averaging $120,000 annual pay – under an incentive approved Monday by the Ohio Tax Credit Authority ... went public in May when it was acquired by Plasmatech Biopharmaceuticals (formerly Access Pharmaceuticals, Dallas, TX; no SBIR) with the combined company keeping Abeona’s name. It has raised a total of $40 million from investors and acquisition proceeds   [Carrie Ghose,Columbus Business First, Jul 27, 15]

PlasmaTech Biopharmaceuticals (Dallas TX; no SBIR) up 108% [May 5,15]  after George Soros's hedge fund grabbed a 5% passive stake.    Exploiting two distinct proprietary platforms, PlasmaTech Bio is active in the development and commercialization of cancer supportive care products and plasma-derived therapeutics. The company has a robust product pipeline that includes: a novel plasma fractionation process, a proven patented drug delivery platform, two commercial stage products and multiple follow-on products in development.   ...  reported $12M private placements in April [company website]

Platelet BioGenesis (Boston, MA)

Platelet BioGenesis (Boston, MA;  no SBIR) startup spun out of Harvard lab, developing a process to produce life-saving human platelets from stem cells, announced it has raised $10 million in Series A. [company press release, Jun 8, 17]

Platypus (Madison, WI)

Imbed Biosciences (Madison, WI; $500K SBIR) received a [NIH SBIR] grant of $1.5 million to continue developing biologic dressings [containing silver nanoparticles that allows closure of hard-to-heal wounds without infection or silver toxicity] that could be used to prevent wound infections and promote cell growth and healing. [Kathleen Gallagher, Milwaukee Journal Sentinel, Jul 28, 14] first product platform is antibacterial silver nanofilms ...  co-founder [one of five] Nicholas Abbott is Professor and Chairmain of the Chemical Engineering Department at the University of Wisconsin-Madison. Dr Abbott has 20 years of experience in colloid and surface science, and is an internationally recognized leader in the field. He is the cofounder of Platypus Technologies (Fitchburg, WI; $9M SBIR), a nanotechnology company.  [company website]

A $2.2 million contract with a U.S. Army research center could bring [Platypus Technologies, Madison, WI; $8.5M SBIR] one step closer to its goal of making a portable sensor that detects deadly gases and other toxins. ... U.S. Rep. Tammy Baldwin (D-Wis.) helped the company secure the funds in the DOD Appropriations bill for fiscal 2010, ... "Platypus is a company that goes out and meets people in the federal government. Like Orbitec and Oshkosh Truck, they're out there talking to people on a regular basis," said Jack Heinemann, director of the Wisconsin Security Research Consortium, which works to get more lucrative, classified defense contract work into Wisconsin.  [Kathleen Gallagher, Milwaukee Journal Sentinel, Jan 6, 10]  Will the Wisconsin Republican Congresscritters complain about homegrown corruption in government the same way in complains about Obama's irresponsible government finance? 

Jeff Williams will make his first-ever pitch to venture capitalists this month,  marketing a business with enormous potential that is operating at the intersection of biotech and nanotechnology. Platypus Technologies (Madison WI, nearly $7M SBIR) has exclusive rights to 13 patents that cover the use of liquid crystals for sensors and other detection devices. The Madison company employs 18 people. [Milwaukee Journal-Sentinel, Sep 18]  Nice technology, I suppose, but why did HHS SBIR put in $7M without noticeable private investment? Just what is SBIR's objective? Will HHS ever be called to account for its ROI on SBIR?

Two Wisconsin businesses will receive state funding for technology development:  NovaScan (Milwaukee) $50K for technology to measure the electrical properties of materials used to identify tissue types in the body, and Platypus Technologies (Madison) $50K for nanotechnologies for the life sciences. [Milwaukee Journal Sentinel, Oct 17]  Platypus has hauled in about $7M in SBIR.

Play-i (Mountain View, CA)

Backed by Google Ventures (which helped furnish $1 million in seed funding; who needs government money?), and run by former Google, Amazon and Apple workers, Play-i (Mountain View, CA; no SBIR) aims to help kids understand technology, not necessarily turn them into engineers before they reach high school. ....uses robots to teach kids the rudiments of coding ....  has so far generated more than $675,000 from a crowdfunding campaign   [Lauren Hepler, Silicon Valley Business Journal, Nov 19, 13]

PLC Medical Systems (Franklin, MA)

PLC Systems (Franklin, MA; no SBIR) has closed $6 million in secured convertible debt financing expected to help the Franklin medical device technology firm reinstitute clinical trials for its RenalGuard system. [Mass High Tech, Feb 23, 11]

Plenty of medical companies are sharing Muller's pain. PLC Medical Systems (Franklin, MA; no SBIR) canceled a scheduled clinical trial last fall of a new hydration and urine collection system to protect patients with impaired kidneys from the side effects of X-ray procedures. "We had the hospitals and patients ready to go," said Mark R. Tauscher, the company's president and chief executive.  [Barnaby Feder, NY Times, Apr 5, 09]

Plextronics (Pittsburgh, PA)

Plextronics (Pittsburgh, PA; $300K SBIR) sale to Solvay America Inc. for $32.6 million has received approval from a Delaware bankruptcy court. ...  Founded in 2002 as a spinoff from Carnegie Mellon University, Plextronics develops customized inks to enhance the performance of organic light emitting diodes. Solvay has been longtime investor in Plextronics.   [Justine Coyne, Pittsburgh Business Times, Mar 10, 14]

Plextronics (Pittsburgh, PA; $300K SBIR) said it has voluntarily filed for Chapter 11 bankruptcy and will conduct an auction for the sale of the company.  ..... develops customized inks to enhance the performance of organic light emitting diodes for a number of applications,   Justine Coyne, Pittsburgh Business Times, Jan 17, 14]

Innovation Works and the Pittsburgh Life Sciences Greenhouse have spent the past decade as a tag-team source for fledgling companies — ideas even — to find the financial support needed to grow into viable, productive and profitable companies.  .... Looking at the 2001-2005 period, firms funded by the two groups during this period includeAethon (no SBIR), Vivisimo ($700K SBIR), ALung Technologies (no SBIR), Plextronics ($300K SBIR), Inc., RedZone Robotics ($1.6M SBIR) and Thorley Industries (no SBIR) (4moms). Other than Vivisimo, which was bought by IBM in 2012, all of those companies are core firms in the portfolios of local venture capital firms [Ethan Lott, Pittsburgh Business Times, Jul 8, 13]

Plextronics (Pittsburgh, PA; $300K SBIR) said it will partner with a Dutch organization on organic light emitting diode technology.  ....said in a news release that it and Holst Centre would team up on research for what it called "game-changing technology that opens the door to many possible lighting applications in living and working environments."  [Paul Gough, Pittsburgh Business Times, Aug 28, 12]

Innovation Works, Hazelwood (PA) VC fund, in 2007 invested $6.1 M in technology companies, including its 100th investment.  The  specializes in giving a leg up to young technology companies cites three [no SBIR] success stories: Knopp Neurosciences, which is working on a drug therapy to slow the advance ALS ("Lou Gehrig's disease"). ... granted "orphan drug" status by the FDA ; Printed electronics manufacturer Plextronics, which attracted more than $20 M in new investment last year and set an efficiency record with its solar cells;  Thorley Industries signed a $215 M deal with Hasbro for that company to manufacture and sell a new line of Thorley products  [Elwin Greene, Pittsburgh Post-Gazette, May 2].

Plextronics, a Pittsburgh start-up developing organic photovoltaic technology for solar power, said it has raised $20.6M in a second round  [Matt MarshallVenture Beat, Sep 5]

Plexxikon (Berkeley, CA)

Immucell (Portland, ME; $2.4M SBIR) up 10% [Nov 13, 15]

A skin cancer drug developed in the Bay Area will work with another locally grown drug after federal regulators approved the combination. Cotellic — originally the work of  Exelixis (South San Francisco, CA; no SBIR) before being handed off to biotech giant Genentech Inc. — can be used in combination with Zelboraf, another Genentech drug developed by Plexxikon (Berkeley, CA; $300K SBIR) .  ....  The drugs, which reportedly will cost $17,600 a month, can now be used to treat advanced melanoma that has spread to other parts of the body or can't be removed by surgery.     [Ron Leuty, San Francisco Business Times, Nov 10, 15]

Afferent Pharmaceuticals (San Mateo, CA; no SBIR) raised a $55 million Series C round with an eye toward moving its chronic cough treatment into late-stage trials and going public ...  [CEO Kathy] Glaub, who was president of  Plexxikon (Berkeley, CA; $300K SBIR) and led it into a May 2013 acquisition by Daiichi Sankyo Group, said the funding gives Afferent "additional optionality" as it preps AF-219 for ptoential Phase III trials in pathologic cough, including in patients with IPF.  [Ron Leuty, San Francisco Business Times, Jul 9, 15]

Peter Hirth and Kathy Glaub, the executive duo who led Plexxikon (Berkeley, CA; $300K SBIR in 2003) on its quest to develop an important new treatment for melanoma, worked together for more than a decade, and they are heading out the door together.  Japan-based Daiichi Sankyo, that acquired Plexxikon for $805 million upfront a little more than two years ago, said today that Hirth, the CEO, and Glaub, the president, are leaving.  [Luke Timmerman, xconomy.com, May 31, 13]

Plexxikon (Berkeley, CA; $300K SBIR in the 1990s) hit the motherlode last week when it agreed to be acquired for $805 million upfront, plus $130 million in milestones, by Japan-based Daiichi Sankyo.  ...  after raising just $67 million. That’s the kind of return VCs live to see [Luke Timmerman, xconomy.com, Mar 7.11]

Pliant Therapeutics (Redwood City, CA)

Pliant Therapeutics (Redwood City, CA; no SBIR needed) launched  with $45 million committed to develop pills that stop fibrosis. The disease is a form of scarring, sometimes deadly, that can occur in several organs, including the lungs, liver, and the skin, where excessive scarring is called scleroderma. The first target for the company is in the lungs: idiopathic pulmonary fibrosis or IPF. There are drugs on the market to treat IPF, including one that Roche bought in 2014 for $8.3 billion, but Pliant CEO Bertrand Coulie told Forbes that there is plenty of room for improvement.  [Alex Lash, xconomy.com, Feb 19, 16]

Plug Power (Latham,NY)

span style="font-weight: bold;">Plug Power (Latham, NY) fuel cell maker is looking for new opportunities in China as the company inches closer to being profitable for the first time.  [Chelsea Diana, Albany Business Review, Nov 7, 16]

Plug Power’s first sale in France is setting the company up to make $10 million in revenue from Europe by next year. [Chelsea Diana, Albany Business Review, Sep 18, 15]

Plug Power has signed a hydrogen supply deal with Praxair, a hydrogen producer.  Praxair will supply and distribute liquid hydrogen to Plug Power's GenFuel customers. Gen Fuel is Plug's hydrogen fueling infrastructure that hit the market in January. Customers include Walmart and FedEx.... Plug has worked with Praxair since 2010  [Krystle S. Morey, Albany Business Review, Nov 5, 14]

Plug Power  down 17% [Nov 12, 14]

Plug Power has reached an agreement with M&T Bank to offer financing packages for the first time to customers looking to purchase fuel cells, refueling stations and service agreements.  ... manufactures hydrogen fuel cells that are used by manufacturers and retailers to power forklifts in large warehouses and distribution centers.  ...  A GenKey package with 250 units, a hydrogen refueling station and service over five years costs between $8 million and $12 million.   [Krystle S. Morey, Albany Business Review, Sep 23, 14]

Air Liquide (French) reduced its stake in fuel cell manufacturer Plug Power (Latham, NY; no SBIR, founded 1997, 169 employees ) to free-up money for future investments in innovative technologies. ...  Air Liquide has been involved in a joint venture targeting the European market for fuel cell-powered forklift trucks, HyPulsion, with Plug Power since 2012. Last year, Air Liquide invested $6.5 million in Plug after the fuel cell maker ran into financial problems.   [Krystle S. Morey, Albany Business Review, Aug 29, 14]

Five months after scoring its largest order in company history, Plug Power says Walmart is expanding the order.  .... reached an agreement on the largest deal in its history with Walmart in February. The contract commits Plug to build six refueling stations in the next two years.  [Krystle S. Morey, Albany Business Review, Jul 24, 14]

Plug Power (Latham, NY; no SBIR) announced that it raised a net $116.3 million by selling 22.6 million shares of common stock at $5.50 a share ...  makes hydrogen fuel-cell systems that are used to power forklifts.  ... expects to book $150 million in 2014. That would be four times the amount booked last year.  [Albany Business Review, May 2, 14]

Plug Power sold $124.3 million worth of stock in its biggest stock sale ever, capitalizing on its recent rebound from penny-stock territory.  .... priced at a deep discount to Plug's recent stock price, suggesting some pushback among buyers  .... Among other stocks in the fuel-cell sector, FuelCell Energy is up 73% this year. Canada's Ballard Power Systems is up 174%. But the industry participants' shares have given head fakes before.   [Matt Jarzemsky, Wall Street Journal, Apr 24, 14]  Meanwhile, workers at ClearEdge Power (headquartered in Oregon and founded in 2003; no SBIR) in South Windsor, CT  were sent home, uncertain about what the future holds. ... Town Manager Matthew B. Gallagan said the fuel cell manufacturer will seek some form of bankruptcy protection. [Brian Dowling, Hartford Courant, Apr 24, 14]

Plug Power has scored the single-largest order in its 17-year history. The customer: Walmart, the world's largest retailer. ....  Walmart wants 1,740 of Plug's fuel-cell units in the next two years. It also committed to a six-year service contract ....  Walmart currently owns 535 of Plug's fuel-cell units.  [Adam Sichko, Albany Business Review, Feb 26, 14]

The fuel cells being made at Plug Power could generate profit for the upstate New York company by mid-2014, investors learned on Nov. 14. ....   has never turned a profit in its 16-year history. ....   well-known for its stock's sudden surge, and then abrupt collapse, at the turn of the 21st century.  ....  went public at $15 a share in 1999, two years after it was founded. [Andy Sichko, Albany Business Review, Nov 15, 13]

Plug Power (Latham, NY; no SBIR) expects to raise about $10 million through the sale of its common stock.  .... makes fuel cells that large companies use to power the forklifts used in manufacturing facilities and distribution warehouses ....  received a $6.5 million infusion from French gas distribution company Air Liquide, entered into a contract with the U.S. Department of Energy to test fuel cells in refrigerated trucks, and announced a new, more powerful fuel cell. Marsh said the company is now on track to achieve profitability by mid-2014. [Barbara Pinckney, The Business Review (Albany), Sep 11, 13]  In August 2013 was awarded a $650,000 contract from the U.S. Department of Energy that could expand its target market beyond forklifts ....   to demonstrate how the hydrogen-based fuel cells it manufacturers can power the refrigeration units in semi-trailer trucks.  [Barbara Pinckney, The Business Review (Albany), Aug 23, 13]

Plug Power's stock sale will fund its operations for a few more months, but will not help it’s bid to maintain its Nasdaq listing.  .... makes fuel cells for forklifts   [Barbara Pinckney, The Business Review (Albany), Feb 22, 13]

Pork is a handout to someone else. Sen Schumer said Thursday that fuel-cell funding that would benefit Plug Power (Latham, NY) cleared a hurdle and was headed to the full Senate.  .... Plug CEO said the funding was also critical “to accelerate the use of fuel cells in early market applications.”   [The Business Review (Albany), May 8]  Where is the market failure that needs government intervention?

(Plug Power's two billionaire Russian shareholders are unwinding their partnership investment in the Latham [NY] fuel-cell company. ... The two men partnered in a company called Smart Hydrogen Inc. that invested $217M in Plug in 2006, a move that allowed the company to acquire two Canadian fuel-cell companies last year. [Larry Rulison, Albany Times-Union, Apr 26]

Pluromed (Woburn, MA)

Pluromed (Woburn, MA; $1.5M SBIR) said the (FDA) has approved its LeGoo surgical gel to temporarily stop blood flow, and that it plans to expand its staff and manufacturing space over the next year. ... already has been selling the gel for a couple years in Europe, where it has the CE Mark and where it has been used in more than 1,000 surgical procedures including beating heart surgery (coronary artery bypass without the use of a heart-lung machine), bypass of the leg (in patients treated for peripheral vascular disease), and microvascular reconstruction.  [Lori Valigra, Mass High Tech, Oct 7, 11]

Pluromed (Woburn, MA; $1.5M SBIR) medical device company, has raised $1.1 million of a planned $3.9 million funding round, according to federal documents. With a total of $7.25 million raised over three previous rounds, Pluromed has now taken in almost $8.5 million in funding, federal documents showed.  ...  Founded in 2003, Pluromed was one of the first seven recipients the Accelerator Program loans, directed by the Massachusetts Life Sciences Center [Mass High Tech, Apr 23]

(Pluromed (Woburn, MA; one SBIR) said it has entered into an alliance with Boston Scientific Corp., the large Natick-based medical device company, to distribute one of its products.  ... focused on the use of gel plugs in medical procedures; its products are used in cardiac, vascular, prostate, and liver surgery as well as to treat kidney stones. [Boston Globe, Oct 9, 09]

PLx Pharma (Houston, TX)

PLx Pharma (Houston, TX; $3.4M SBIR) down 19% [Apr 20, 17]   announced completion of merger with Dipexium Pharmaceuticals [company press release, Apr 20, 17]

PLx Pharma  (Houston, TX; no SBIR, founded 2002), which is commercializing a delayed-release aspirin based on its proprietary lipid coating, withdrew its plans for an initial public offering ... had filed to raise $68 million   [renaissancecapital.com, Mar 7, 16]  thanks to PrivCo for the alert

PLX Technology (Sunnyvale, CA)

Semiconductor company Avago Technologies Ltd. (Singapore) has agreed to buy PLX Technology (Sunnyvale, CA;  no SBIR) in an all-cash [$300M] deal, that boosts Avago's enterprise storage and networking services.  [Sarah Drake, Silicon Valley Business Journal, Jun 23, 14]

PMT (Chanhassen, MN)

Guess who's in court.   PMT (Chanhassen, MN; no SBIR) medical device and equipment manufacturer, violated federal civil rights laws by refusing to hire women and workers over 40, according to a lawsuit filed Wednesday in federal court by the U.S. Equal Employment Opportunity Commission. Despite hiring at least 70 people between Jan. 1, 2007, and late 2010, an EEOC investigation showed that PMT hired no female salespeople.  .... started in 1979 and “is dedicated to the research and development of specialty products, devices and instruments used in the medical field  [James Walsh, Minneapolis Star Tribune, Mar 5, 14]

PMV Pharmaceuticals (Cranbury,NJ)

With a $74 million Series B round, PMV Pharmaceuticals (Cranbury, NJ; no SBIR) became the latest startup to haul in cash to try to develop cancer drugs that interact with one of the most important yet difficult targets in cancer biology, the tumor suppressor protein p53. [Alex Lash, xconomy.com, Feb 24, 17]

PneumRx (Mountain View, CA)

PneumRx (Mountain View, CA; no SBIR) was acquired by British healthcare firm BTG for $230 million up front and up to $245 million in future milestones. PneumRx makes a device called the RePneu Coil to treat emphysema; it has been on the European market for six years but is not yet approved in the U.S.  [Alex Lash, xconomy.com, Dec 4, 14]

Point Source (Germantown,OH)

Point Source  (Germantown, OH; $900K SBIR, 12 employees) is seeking a new building in German Township.  ...  due its rapid growth. The new headquarters building would be larger and make parking, shipping and receiving easier   [Tristan Navera, Dayton Business Journal, Apr 1, 15]

Polarean (Durham,NC)

Polarean (Durham, NC;  no SBIR, founded 2012) health care technology company with General Electric roots has raised nearly $2 million of a planned $10.6 million funding round. ...  had already raised more than $500,000 in two separate debt offerings. ...   according to its website, designs and manufactures equipment for the production of hyper-polarized xenon or helium gas. ...  [secured] all of GE Healthcare’s assets in the field of hyper polarized gas MRI    .   [Lauren K. Ohnesorge,Triangle Business Journal, Sep 8, 15]

Polatis (Andover, MA)

Polatis (Andover, MA; no SBIR) said it has raised $8 million in venture capital. .... specializes in all-optical switch technology. [Boston Globe, Jun 2,09]

Polychromix (Wilmington MA)

Polychromix (Wilmington, MA; $600K SBIR) an innovative developer of material analysis and chemical sensing technologies, announced a strategic investment and development agreement with In-Q-Tel [company press release, Oct 1, 07] 

Polychromix (Wilmington MA; $600K SBIR) which employs 20 people, develops a handheld device designed to analyze various materials for the U.S. military and intelligence agencies, got an investment from In-Q-Tel (CIA's VC) which also plans to help Polychromix commercialize its technology for a range of government security agencies.  [Mass High Tech, Oct 1, 07]

Polyera (Skokie, IL)

NIST TIP winners  $22 million in funding for nine research projects targeting innovative manufacturing technologies in fields ranging from biopharmaceuticals and electronics to renewable energy sources and energy storage:  Isogenis (Aurora, CO; $4.8M SBIR);  ActaCell,  (Austin, TX; no SBIR);  Engineered BioPharmaceuticals (Manchester, CT; no SBIR); Arsenal Medical  (Watertown, MA; no SBIR); Kent Displays (Kent, OH; $2.6M SBIR); Precision BioSciences (Research Triangle Park, NC; $340K SBIR); Ginkgo BioWorks (Boston, MA; one SBIR); Sinmat (Gainesville, FL; $4.4M SBIR); Polyera (Skokie, IL; no SBIR).

PolyMedica (Wakefield, MA)

PolyMedica (Wakefield, MA; 2 Phase 1 SBIRs), provider of products for diabetics, has agreed to be acquired by a giant pharmacy benefits manager,  Medco Health Solutions for about $1.5 B cash.

PolyMedix (Radnor, PA)

PolyMedix (Radnor, PA; $5.7M SBIR, founded 2002) facing a $6.8 million loan payment, filed for Bankruptcy Court protection, according to [SEC] documents [John George, Philadelphia Business Jounral, Apr 2, 13]

Polymedix (Radnor, PA; $8.5M SBIR) CEO, sent a letter to shareholders stating, “PolyMedix continues to work with its financial advisers on a financing transaction or other strategic transaction to fund the continued clinical development of brilacidin and its technology platform.” Brilacidin, formerly known as PMX-30063, is an experimental antibiotic compound. [John George, Philadelphia Business Journal, Beb 7, 13]

PolyMedix (Radnor, PA; $8M SBIR) said it has stopped enrollment in two clinical trials for its new drug candidate PMX-60056 because of observations of reductions in blood pressure in some study patients.  [John George, Philadelphia Business Journal, May 10, 12]

PolyMedix (Radnor, PA; $4.2M SBIR) and the University of Massachusetts received a $750,000 [Army STTR] contract ... to conduct further testing on [multidrug resistant biofilm-embedded bacteria ]antimicrobial compounds [John George, Philadelphia Business Journal, Nov 16, 10] raised $20M in stock offering Nov 09

PolyMedix (Radnor, PA; $4.5m SBIR) received a $986,000 phase-II NIH grant to support the company’s development of antimicrobial compounds to treat a mouth infection. [John George, Philadelphia Business Journal, Sep 30 , 10]

PolyMedix (Radnor, PA; $3.6M SBIR) announced a public equity offering of up to $21 million. ... for development of an antibiotic and a heparin antagonist  [Philadelphia Business Journal, Nov 11, 09]

Polymer Technology Systems (Indianapolis, IN)

Polymer Technology Systems (Indianapolis, IN; no SBIR),  a diagnostic medical device maker, won Innovation of the Year for a line of products to rapidly determine cholesterol rates and other levels in blood.  The Mira Awards are sponsored by Techpoint. The private company founded in 1992 has sales representatives and/or distributors worldwide.[Indianapolis Star, May 19]

Polynoma (San Diego, CA)

Polynoma (San Diego, CA; no SBIR, fewer than ten employees) a tiny biotech has launched a Phase 3 trial of a vaccine against melanoma, the most dangerous form of skin cancer. ... different because it includes hundreds of antigens, molecules that provoke an immune response, taken from three lines of melanoma cells, [CEO] Hopper said.  ... largely bankrolled by Cheong Kong Group, Hong Kong-based conglomerate  [Bradley Fikes, utsandiego.com, Jan. 13, 2015]

PolyNova (Long Island, NY)

After a few years fine-tuning its investment strategy, Accelerate Long Island has seeded its first group of startups. The nonprofit organization and the Long Island Emerging Technologies Fund announced plans to put $500,000 into five Long Island, NY-based biotech and cleantech startups: Goddard Labs, Green Sulfcrete, PolyNova, SynchroPET, and Traverse Biosciences.  [Ben Fidler, xconomy.com, Jun 9, 14] None had SBIR.

PolyPlus (Berkeley, CA)

PolyPlus Battery (Berkeley, CA; one 1999 SBIR) has landed a nearly $9 million investment from the U.S. Department of Energy to scale up production of new kinds of batteries.....  will ramp up production of advanced lithium-air, lithium-water and lithium-sulfur batteries.... to produce the batteries at factory scale, ... to extend the driving range of electric vehicles.[George Avalos, Oakland Tribune, Jun 12, 12]  founded 1991 ... 27 employees including 7 PhDs [company website] Why government money for what should be an ROI investment?  faces one big technical problem: Its lithium-air battery can be recharged just 40 to 50 times, vs. thousands of times for traditional lithium-ion batteries [Alexandra Dean, Bloomberg Business Week, Apr 5, 12]  DOE is desparately pushing efficient batteries for the political dream of a nationwide adoption of electric autos in the windstorm of private market resistance.

ARPA-E Awards. The administration announced $106M in ARPA-E stimulus awards. Small biz winners:  Ginkgo BioWorks (Boston, MA; one SBIR) $6M primary;  OPX Biotech (no SBIR) $6M primary; Logos Tech (Arlington, VA; $2M SBIR) secondary;Sion Power (Tucson, AZ; $250K SBIR) $5M primary; ReVolt Tech (no SBIR) $5M primary; PolyPlus Battery (Berkeley, CA; one SBIR) $5M; Pellion Tech (no SBIR) $3.2M primary; A123 Systems  secondary, twice;  Planar Energy Devices (no SBIR) $4M; Maxpower (Harleysville, PA; $9M SBIR) secondary; NanoLab (Newton, MA; $5M SBIR) secondary; Codexis (no SBIR) $4.6M; Nexant (no SBIR) secondary.

PolyPlus  (Berkeley, CA; $100K SBIR a decade ago)  is developing lightweight, high-energy batteries that can use the surrounding air as a cathode.  is partnering with a manufacturing firm to develop single-use lithium metal-air batteries for the government, and it expects these batteries to be on the market within a few years. The company also has rechargeable lithium metal-air batteries in the early stages of development that could eventually power electric vehicles that can go for longer in between charges.  [Katherine Bourzac, MIT Tech Review, Jun 26, 09]

PolyRemedy

PolyRemedy (no SBIR) said that it closed a $20 million Series C financing. ... focused on integrated wound management systems.  [Boston Globe, Jun 7, 11]

Polysciences (Warrington, PA)

Polysciences (Warrington, PA; $200K SBIR long ago) raised $4 million in a debt offering completed Wednesday, according to [SEC] documents ... maker of laboratory products and specialty monomers/polymers for microscopy, histology, biotechnology, electronics and other industrial applications. ...  founded in 1961, last month opened an office in Taiwan to expand its global presence. [John George, Philadelphia Business Journal, Oct 20, 11]

Polystor

UltraCell  (Livermore, CA; $800K SBIR) will get $1 million from the state of Ohio to help move more of its manufacturing operations to the Dayton region. .. has production operations in the area, recently landed a $3 million contract [funded by stimulus dollars] with the USAF to develop portable fuel cells for use by soldiers in the field.  ...  raised $3.8 million in venture funding to help expand operations at its facility in Dayton. ... has raised $30 million total since it was started in 2002 [Dayton Business Journal, Dec 18, 09] launched with technology licensed from Lawrence Livermore National Laboratories ...  [In 2007] it planned to invest $74M in the Dayton operation. The state has promised $15.2M in loans, grants and tax credits.  [Dayton Business Journal, May 15, 07]  portfolio.com lists James Kaschmitter as Chairman & CEO. Kaschmitter had a battery firm Polystor ($500K SBIR in 1996)and founded PowerStor (no SBIR) in 1997 as a spin-off from PolyStor [allbusiness.com, Dec 99].

Wha'ppen Polystor? The story is simple and heart-warming for government R&D types. Polystor started life with a DARPA contract that allowed the founder to skip out of Livermore Labs (which was looking for ways to de-populate). A BMDO Phase 2 SBIR followed which induced a British company to toss in money which led to a mass production Army contract in 1999 plus $9.5M from the Advanced Battery Consortium and an ATP grant. PolyStor was the first Li-ion battery producer in the United States and the first to use a nickel cobalt oxide cathode that delivers the highest capacity and energy density in the industry, says Branscom et al. In winter 2001 the firm employed roughly 150 people, with a staff of 35 in research and development. In 2002, Polystor ceased operations. Sweet story ends. Which suggests several hard questions for the government advocates:  1) Why did all that government money not produce a sustainable economic winner? ; 2) Is the battery powered vehicle still a government pipe-dream?; 3) Did the government ever ask whether that technology at that price could survive in a competitive market place especially in a company nurtured by government handout?; 4) How much government money is too much?

Portola Pharmaceuticals (San Diego, CA)

Portola Pharma up 47% [Jun 23,17]

Portola Pharma up 13% [May 9,17]

Portola Pharma up 34% [Dec 23, 16] announced that [FDA] accepted Portola's New Drug Application (NDA) granting priority review for betrixaban, an oral, once-daily Factor Xa inhibitor anticoagulant, for extended-duration prophylaxis of venous thromboembolism (VTE) in acute medically ill patients with risk factors for VTE. [company press release, Dec 23, 16]

Portola Pharma down 13% [Nov 8, 16]

Portola Pharmaceuticals (South San Francisco, CA; $500K SBIR) said the FDA needs more information to make an approval decision about andexanet alfa (AndexXa), an emergency drug that reverses the effect of blood thinners. [Alex Lash, xconomy.com, Aug 19, 16]

Vertex Pharmaceuticals said one of the four Phase 3 trials testing the experimental cystic fibrosis drug VX-661 with ivacaftor (Kalydeco) failed and is being shut down. The combination is meant to improve upon Vertex’s approved pairing of CF drugs ivacaftor-lumacaftor (Orkambi), and Vertex is testing it in a variety of genetic subsets of CF patients. Data from the other three trials should come in late 2016 or early 2017.  [Alex Lash, xconomy.com, Aug 19, 16]

Portola Pharma down 15% [Aug 18, 16]

Portola Pharmaceuticals down 29% [Mar 24, 16] said late-stage data showed its oral anticoagulant was not superior to an injectable standard therapy in preventing blood clots in acutely ill patients. [Reuters, Mar 24, 16]

Portola Pharmaceuticals took an important step toward its first drug approval with its experimental antidote for blood-thinning drugs passing a key clinical study, according to early results.  ...  said it would file for [FDA] approval of the drug, known as andexanet alfa, by the end of this year. Portola last year won the FDA's "breakthrough therapy" designation for the drug, which could accelerate its trip through the regulatory agency's approval process. [Ron Leuty, San Francisco Business Times, Apr 8, 15]

Portola Pharma  up 10% [Feb 13, 15]

Portola Pharma (S San Francisco, CA; $500K SBIR) up 12% [Feb 6, 15]

Portola Pharma down 10% [Oct 2, 14]

Portola Pharma ($500K SBIR) up 16% [Oct 1, 14]

Portola Pharmaceuticals (South San Francisco, CA; $500K SBIR) made a deal with Daiichi Sankyo for late-stage clinical testing of a drug for people taking anticoagulants — the company's third such deal with new-generation blood-thinning drugs in the past two years.  ....  now has collaborations in Phase III clinical trials with all the major manufacturers of so-called Factor Xa inhibitors.  [Steven E.F. Brown, San Francisco Business Times, Jul 7, 14]

Portola Pharma (S San Francisco, CA; $500K SBIR) down 10% [Jul 7,14]

Portola Pharmaceuticals (South San Francisco, CA; $500K SBIR) started enrolling patients in a late-stage clinical trial of a treatment for major bleeding in patients taking common anticoagulants.  [Steven E.F. Brown, San Francisco Business Times, May 13, 14]

Portola Pharma up 12% [Oct 16, 13]

Portola Pharma down 13% [Oct 8, 13]

Portola Pharma up 13% [Sep 5, 13]

Portola Pharma (South San Francisco, CA; $500K SBIR)  up 10% [Jun 27, 13]

Portola Pharmaceuticals IPO expected to raise $100M. [Ron Leuty, San Francisco Business Times, May 14, 13]   

Portola Pharma (South San Francisco, CA; $500K SBIR) up 12% [May 28, 13]

Accumetrics (San Diego, CA; no SBIR) develops, manufactures, and markets the VerifyNow® System, a comprehensive suite of tests for the assessment of platelet response to antiplatelet therapies. ...  signed an agreement with Portola Pharmaceuticals, (South San Francisco, CA; $500K SBIR) to develop and supply the VerifyNow System and VerifyNow Tests for use in clinical trials. [Accumetrics company press release] has raised $24 million from investors since 2009 .. employs 70 people [signonsandiego.com, Mar 2, 11]

Possis Medical

Possis Medical (Minneapolis; $250K SBIR) up 35% [Feb 11, 08] as it sold itself to Bayer for $344M.

Pothole Pros (Waldorf, MD)

Fifteen university research teams from Maryland will receive a total of $4.1 million to work with local companies to turn their research into products that could one day be sold on the commercial market.  .... MIPS will contribute $1.8 million and private companies will contribute $2.8 million. The companies:  A&G Pharmaceutical (Columbia, MD; no SBIR),  Rehabtics LLC (Baltimore, MD; no SBIR)  High Impact Environmental (Church Hill, MD; no SBIR),  Birich Technologies (Towson, MD; no SBIR), Earth Networks (Germantown, MD; no SBIR), Fiberight (Halethorpe, MD; no SBIR), CoolCAD Electronics (College Park,MD $1.6M SBIR), XChanger Companies (Annapolis, MD; no SBIR), Remedium Technologies (College Park, MD; no SBIR), Pothole Pros LLC (Waldorf, MD; no SBIR), Hoopers Island Oyster Aquaculture (Fishers Creek, MD; no SBIR),  Metompkin Seafood (Crisfield, MD; no SBIR) GreatGrow Maryland LLC (Rock Hall, MD; no  SBIR), vCalc (Hagerstown, MD;  SBIR), Shore Thing Shellfish (Tall Timbers, MD; no SBIR). ($114,094)  [Sarah Gantz,  Baltimore Business Journal, Feb 26, 14] 

PowerGenix (San Diego, CA)

in hybrid vehicles like the Toyota Prius and the Ford Focus. When they're stopped, so are their engines. When the driver presses down on the accelerator, powerful batteries start the engine and move the car Dan Squiller, chief executive of Scripps Ranch-based battery maker PowerGenix (no SBIR), is betting that technology will spread to other cars too, as it has in Europe. ... a good match for the nickel-zinc rechargeable batteries PowerGenix has been developing over the last decade.  [Onell Soto, signonsandiego.com, May 25, 11]

Army's venture venture.  The Army's VC (OnPoint Tech) current investment portfolio : A123 Systems (Boston, MA; $750K SBIR, IPO 2009) advanced Lithium-Ion based cells for rechargeable battery packs;  Atraverda (UK) advanced bi-polar battery electrodes for rechargeable batteries;  Integrated Fuel Cell Technologies  (Burlingto MA; no SBIR) next generation fuel cell systems for portable devices;  Nanosolar (Palo Alto, CA; $1.7M SBIR) thin-film solar technology for roll-to-roll printing of solar cells on flexible substrates,   PowerGenix (San Diego, CA; no SBIR) next-generation rechargeable batteries; Power Precise (Herndon, VA; no SBIR) a fabless semiconductor company specializing in battery management devices; Ultra Cell (Livermore, CA; no SBIR) integrated fuel cell systems; Zinc Matrix Power (Santa Barbara, CA; no SBIR) high-performance rechargeable alkaline battery technology for commercial and military markets;  Akermin (St Louis, MO; no SBIR) portable fuel cells based on its proprietary “Stabilized Enzyme Biofuel Cell” SEBC™ technology; Superprotonic (Pasadena CA; $200K SBIR) solid acid fuel cell.  [defense-ventures.com]  No surprise that a VC, even one doing it for the government, sees tech opportunity much different than does Army SBIR. I note that the three outside trustees (of five trustees) of OnPoint are a DOD political appointee, and entrepreneur/attorney, and Paul Gompers from Harvard Business School who with Josh Lerner publish a lot of venture research. Lerner did a lot of SBIR study until, I presume, he gave up on SBIR's ever being anything but a political handout.

PowerGenix (San Diego, CA; no SBIR; founded Y2K) is still a pip-squeak, having raised only $61 million from venture capitalists and praying for revenue of $10 million this year. ...  In December it began selling its AA rechargeable nickel-zinc batteries in Ritz Camera stores. It now has agreements to deliver $70 million worth of its batteries over the next three years to makers of power tools, garden tools and electric scooters and bicycles; shipping starts this fall. The attraction: Zinc is plentiful, nontoxic, recyclable and enables production of batteries with a high rate of discharge. ...  Says Lux Research Senior Analyst Ying Wu, "PowerGenix is the cheaper option, for now, and it has strong performance." But if the price of lithium-ion cells drops, Wu says, PowerGenix will be challenged.   [Kerry Dolan, Forbes, May 11]

inc Power. PowerGenix (San Diego, CA) landed a $17M round of financing in November ... For the past few years, PowerGenix has been developing a battery that it says is as much as 75% lighter, 30% smaller and 10 times as powerful as existing nickel-cadmium or nickel-metal hydride batteries. [Wall Street Journal, Jan 29, 07] No SBIRs yet.

Powerlight (Berkeley CA)

Powerlight, of Berkeley, CA, a large venture-backed solar installer, ..just won a contract to help build the world's largest solar photovoltaic power project: a 11-megawatt solar power plant in Serpa, Portugal. [Apr 29, 06]

Power Precise Solutions

Army's venture venture.  The Army's VC (OnPoint Tech) current investment portfolio : A123 Systems (Boston, MA; $750K SBIR, IPO 2009) advanced Lithium-Ion based cells for rechargeable battery packs;  Atraverda (UK) advanced bi-polar battery electrodes for rechargeable batteries;  Integrated Fuel Cell Technologies  (Burlington MA; no SBIR) next generation fuel cell systems for portable devices;  Nanosolar (Palo Alto, CA; $1.7M SBIR) thin-film solar technology for roll-to-roll printing of solar cells on flexible substrates,   PowerGenix (San Diego, CA; no SBIR) next-generation rechargeable batteries; Power Precise (Herndon, VA; no SBIR) a fabless semiconductor company specializing in battery management devices; Ultra Cell (Livermore, CA; no SBIR) integrated fuel cell systems; Zinc Matrix Power (Santa Barbara, CA; no SBIR) high-performance rechargeable alkaline battery technology for commercial and military markets;  Akermin (St Louis, MO; no SBIR) portable fuel cells based on its proprietary “Stabilized Enzyme Biofuel Cell” SEBC™ technology; Superprotonic (Pasadena CA; $200K SBIR) solid acid fuel cell.  [defense-ventures.com] No surprise that a VC, even one doing it for the government, sees tech opportunity much different than does Army SBIR. I note that the three outside trustees (of five trustees) of OnPoint are a DOD political appointee, and entrepreneur/attorney, and Paul Gompers from Harvard Business School who with Josh Lerner publish a lot of venture research. Lerner did a lot of SBIR study until, I presume, he gave up on SBIR's ever being anything but a political handout.

The Army is about to start using technology that measures the remaining power in batteries, developed by Herndon, Va.-based PowerPrecise Solutions, which received an investment from [Army VC] OnPoint in March 2004. The Army expects to save $65 million a year with the new product. It has put $61.8 million into the fund since Congress mandated its creation in the fiscal 2002 Defense Appropriations Act. .. The other Army "VC" investments: higher power density fuel cell system based on generating hydrogen from highly concentrated methanol for use in portable electronics (UltraCell); advanced rechargeable batteries based on silver zinc (Zinc Matrix Power);thin-film solar technology (Nanosolar).  [Kimberly Palmer, GovExec, May 15]

PowerVision (Belmont, CA)

Medical device company PowerVision (Belmont, CA; no SBIR) raised $10 million to complete a $30 million Series D funding. ...  developed an implantable lens that restores vision at all distances for people with cataracts and presbyopia. The lens mimics a healthy eye’s natural process of changing shape and adjusting focus.  ....  to complete patient enrollment in its ongoing lens study, which is expect to close by the end of the year, and help launch a new study next year.  [Sarah Drake, Silicon Valley Business Journal, Jun 17, 14]

PowerVision (Belmont, CA; no SBIR) that is developing a new kind of lens for the eye closed on $24 million in financing by several backers, including Medtronic ... is developing an an intraocular lens, which is implanted in the eye. The idea is to restore the eye’s ability to adjust its focus. The company will use the funds to expand its research and development efforts and for a clinical trial in Europe. None of its products are as-yet approved for sale. [Janet Moore, Minneapolis Star Tribune, Jul 15, 11]

Pozen(Chapel Hill, NC)

A small Chapel Hill (NC) drug maker is teaming up with one of the world's largest pharmaceutical companies to create a painkiller that would neutralize a nagging side effect: stomach ulcers.  As part of the deal, Pozen would receive up to $375M in payments and bonuses from AstraZeneca, which is based in London. If the drug wins U.S. regulatory approval for patient use, Pozen also stands to earn even more in sales royalties through 2023. The company's stock jumped nearly 40% on Wednesday's news.  Pozen, a 10-year-old company with 35 employees, is demonstrating a talent coveted by many drug startups in the Triangle: attracting major corporate firepower to back experimental medicines. [Raleigh News and Observer, Aug 3]  No SBIR record.

Prairie Technologies (Middleton, WI)

scientific equipment maker Bruker  has acquired Prairie Technologies (Middleton, WI; $5.3M SBIR, 30-employees) that makes high-tech microscopes for an undisclosed amount. Bruker said that the acquisition will expand Bruker’s Nano Surfaces Division’s existing life science atomic force microscopy (Bio-AFM) systems [Don Seiffert, Boston Business Journal, Sep 13, 13]

Pranalytica (Santa Monica, CA)

Pranalytica (Santa Monica, CA; $500K SBIR) started as a developer of sensors for analyzing human breath for disease, but is now leading the quest to make small lasers that can knock down antiaircraft missiles. ... [Founder] At age 60, C. Kumar N. Patel had a resume of accomplishments few scientists could match. In a span of four decades, Patel invented the carbon dioxide laser, which revolutionized manufacturing and surgical procedures, obtained 38 patents and ran the physics and engineering departments at Bell Labs, a premier research operation historically attached to AT&T ...  left the relative comfort of academia, tapped his life savings and started a tiny technology company ....   Amid the rising concern about terrorists using chemical weapons, the Pentagon began looking for reliable, portable devices that could be used to detect chemical agents and explosives. Patel's technology looked promising. In 2004, the Defense Department awarded the company a $13-million grant. ...  Since that 2008 breakthrough with the anti-missile laser, Pranalytica has grown to 15 employees.  [Peter Pae, Los Angeles Times, Jan 26,09]

Precision Biopsy

Precision Biopsy  (Aurora, CO; no SBIR) biotech working on alternative prostate cancer biopsy procedures, said it's raised $33.6 million in new financing.  ... [to] "accelerate commercial expansion of (its) ClariCore biopsy system, designed to provide accurate real-time classification of prostate tissue during biopsy procedures, and its Focal Therapy program which seeks to provide targeted localized therapy to reduce complications and improve outcomes."    [Ben Miller, Denver Business Journal, Oct 5, 15]

Allied Minds, a Boston-based investment firm specializing in early-stage university ventures, has partnered with the University of Colorado to establish Precision Biopsy LLC, which is developing an optical biopsy needle to be used in diagnosis of prostate cancer.  [Denver Post, Jul 16, 08]

Precision BioSciences (Research Triangle Park, NC)

Fresh off a deal [with Baxalta] that could ultimately be worth $1.6 billion, Precision BioSciences will look to more than double its headcount this year. [Jason deBruyn,Triangle Business Journal, Apr 7, 16]

Baxalta, a global biopharmaceutical leader, and  Precision BioSciences (Durham, NC; $500K SBIR), the genome editing company, announced a global collaboration to develop a broad series of allogeneic chimeric antigen receptor (CAR) T cell therapies directed towards areas of major unmet need in multiple cancers. .... Precision BioSciences will receive an upfront payment of $105 million from Baxalta, with additional option fees, developmental, clinical, regulatory, and sales milestones, potentially totaling up to $1.6 billion, in addition to royalties on worldwide sales.    [joint companies press release, Feb 25, 16] Baxalta is a recent spin-off from Baxter International.

Precision BioSciences (Durham, NC; $500K  SBIR) a Duke University spinout announced Monday it raised $25.6 million [Series A financing] to continue its work. ... to very precisely change the human genome. ...  The possibility of altering human DNA carries so much upside that some scientists have begun to imagine a health care world so changed that it would hardly be recognizable by today’s standards. However, the scientific advances also cause some concern.    [Jason deBruyn, Triangle Business Journal, May 11, 15]

NIST TIP winners  $22 million in funding for nine research projects targeting innovative manufacturing technologies in fields ranging from biopharmaceuticals and electronics to renewable energy sources and energy storage:  Isogenis (Aurora, CO; $4.8M SBIR);  ActaCell, (Austin,TX; no SBIR);  Engineered BioPharmaceuticals (Manchester, CT; no SBIR); Arsenal Medical (Watertown, MA; no SBIR); Kent Displays (Kent, OH; $2.6M SBIR); Precision BioSciences (Research Triangle Park, NC; $340K SBIR); Ginkgo BioWorks (Boston, MA; one SBIR); Sinmat (Gainesville, FL; $4.4M SBIR); Polyera (Skokie, IL; no SBIR).   

Precision for Medicine (Chevy Chase, MD)

Biotech Precision for Medicine (Chevy Chase, MD, no SBIR) ranked #10 in VC funding for 2013 at $150 million , and the top collector for non-software/Internet firms.  [Bruce Bigelow, xconomy.com, Jan 17, 13]

Precision Genome Engineering (Seattle, WA)

Precision Genome Engineering (Seattle, WA; no SBIR) or Pregenen, has been purchased by Bluebird bio  ... Former Pregenen shareholders are also eligible to receive up to $135 million if certain clinical and commercial milestones are achieved.  ... Pregenen is a recognized leader in the development and reprogramming of novel Homing Endonuclease and MegaTAL based enzymes that provide a highly specific and efficient way to silence, edit, or insert genetic components,” said Pregenen co-founder Dr. Andrew Scharenberg, in a statement.   [Ben Miller, Puget Sound Business Journal, Jul 1, 14]

Precision Ocular Metrology (Albuquerque, NM)

Medical device startup Precision Ocular Metrology (Albuquerque, NM; no SBIR, founded 2012) [focused on mapping the topography of the eyes] is not only debuting a new product in the Albuquerque market, but is also keeping its headquarters here — a move that will create 10 new jobs in the coming months. ...  the company benefited from the New Mexico Angel Investment Tax Credit, which allows accredited investors that file a New Mexico tax return to take a tax credit up to $25,000 in exchange for investing in local companies whose focus is high-tech or manufacturing.  [Sal Christ, Albuquerque Business First, Oct 5, 15]

Precision Optics (Gardner,MA)

Precision Optics (Gardner, MA; $400K SBIR two decades ago) has formed a deal with Intuitive Surgical Operations Inc., a surgical robotics firm in California, bringing $2.5 million to Precision Optics. ...  said it plans to continue pursuing its technology outside of medical robotics, focusing on its Lenslock endoscopes, Microprecision optical elements and handheld stereoendoscopes.   [Michelle Lang, Mass High Tech, Aug 5, 11]

Precision Optics (Gardner, MA; $500K SBIR) sold its optical filter line to a New Jersey company for $250,000 and a three-year royalty agreement  [Mass High Tech, Jan 22, 08]

Precision Optics which had a sliver of HHS SBIR money in the late 80s is in danger of de-listing for lack of $1 stock price for 30 days. 

Precision Optics, a bit HHS SBIR played in the late 80s, raised another $5M in a rights offering to buy the $1.30 stock at $1

Precision Therapeutics (Pittsburgh,PA)

The recapitalization of Precision Therapeutics (Pittsburgh, PA; no SBIR, founded 1995) that transformed the life sciences company into Helomics caps a 20-year saga that illustrates just about every fundraising vehicle deployed in the region.  Starting with high-net-worth individuals, the company landed a who's who of Pittsburgh business funders ... That gave way to venture capital rounds, led at first by local firms and then some of the largest national institutional investors.  [Patty Tascarella,  Pittsburgh Business Times, Nov 21, 14]   dedicated to personalized cancer care. Precision offers a portfolio of products developed to help guide physicians and patients with difficult clinical decisions throughout the cancer care continuum. ... first commercial test, ChemoFx®, is a proprietary chemoresponse marker which helps improve patient outcomes by supporting physicians in the selection of effective treatments for women with gynecologic cancer. [company website]  

West Penn Allegheny Health System, found that a test developed by Precision Therapeutics (Pittsburgh, PA; no SBIR) can show who will mostly likely not respond to platinum-based chemotherapy for ovarian cancer, a standard approach in treating the disease. More important, test results can be available before treatment begins.  ..... began marketing the test in 2006, the company’s first and primary product, spokeswoman Pam Ranallo said. Krivak’s study is the first to demonstrate the product’s value before treatment begins. Platinum-based agents are the standard of care in treating ovarian cancer   [Kris Mamula, Pittsburgh Business Times, Jul 11, 13]

Precision Virologics (St. Louis, MO)

Precision Virologics (St. Louis, MO; no SBIR) announced a $500,000 investment from Oncolys BioPharma, a publicly traded Japanese company focusing on the development of novel viral-based biologics for the treatment of cancer and serious infectious diseases. This investment signals global interest in the [company], which is developing biologically targeted vaccines for emerging infectious diseases, including Zika and Chikungunya.  The half-million-dollar investment is the second major milestone in one week for Precision. Last Tuesday, the biotech company announced its entrance into a license agreement with the Office of Technology Management, the tech transfer arm of Washington University.  [Washington University press release, Mar 31, 17]

Predictive Biosciences (Lexington, MA)

Predictive Biosciences (Lexington, MA;  no SBIR) announced the completion of a $25 million Series C round of growth capital financing. ... describes itself as a commercial stage, fully-integrated developer of novel molecular diagnostic cancer assays and a provider of anatomic pathology laboratory products and services  [Boston Globe, Jun 16, 10]

Predictive Biosciences (Lexington, MA; no SBIR) closed on a $21.75 million Series B financing to fund clinical trials for its oncology testing assays. The -based firm stated it would use the capital to develop its urine-based test that can detect the presence of cancer. The firm plans to launch a multi-center clinical trial for patients with recurring bladder cancer in 2009. A portion of the money will also be used to establish a new independent laboratory. [Mass High Tech, Oct 16, 08]

Pregmama (Gaithersburg, MD)

 The Maryland Technology Development Corp. (Tedco) has invested $1.1 million in 14 state startups.The grants were made through the organization's Technology Commercialization Fund. ... toward advancing the each company's technology and product commercialization efforts. Common Curriculum LLC, Diagnostic Biochips Inc. and Firejack Inc. were each awarded $100,000.  • Authentik Solutions LLC; Brain Sentry LLC; Clear Guide Medical LLC; ConverGene LLC; Cordex Systems LLC; Pregmama LLC; SameGrain, Inc; TimberRock Energy Solutions, Inc. and Vasoptic Medical, Inc. each received $75,000. • Magpie Sensing LLC was awarded $74,990  • Weinberg Medical Physics LLC received $60,000  [Baltimore Business Journal, Jul 19, 13]

Presage Biosciences (Seattle, WA)

Presage Biosciences (Seattle, WA; no SBIR) has been named one of FierceBiotech ’s “Fierce 15” of 2013.  ... a spinoff company of the Fred Hutchinson Cancer Research Center  .... patented a novel method for simultaneously analyzing multiple cancer drug candidates and drug combinations within a single tumor while that tumor is still in a patient.  .... FierceBiotech evaluates hundreds of private companies from around the world each year before selecting the 15 it considers the most innovative, creative and promising.   The other Fierce 14 are:   Acetylon Pharmaceuticals;   AnaptysBioCytomX  (Santa Barbara, CA; $500K SBIR); FibroGen  (South San Francisco, CA; $1.3M SBIR);  Immunocore; Jounce TherapeuticsKala PharmaceuticalsMacroGenics  (Rockville, MD; $2.6M SBIR) ; Moderna Therapeutics; Nimbus Discovery; Scioderm; UltragenyxUniQure; and Visterra.  [Valerie Bauman,  Puget Sound Business Journal , Sep 24] 

Presage Biosciences (Seattle, WA; no SBIR) said in a regulatory filing that it has raised $1.6M of an equity financing that could be worth as much as $10.5 million over time. Presage, a spinoff from the Fred Hutchinson Cancer Research Center, has some cool technology for helping separate the winners from the losers in the early stages of drug development. It has previously raised at least $4 million  [Luke Timmerman, xconomy.com, Aug11, 11]

Presidio Pharmaceuticals (San Francisco, CA)

BioCryst Pharmaceuticals is buying Presidio Pharmaceuticals (San Francisco, CA; no SBIR) for $101 million in stock....  in a bid to achieve together what neither company has been able to do alone: produce new treatments for the debilitating hepatitis C infection that afflicts 170 million people worldwide.....  despite more than $200 million spent on research and development. [John Murawski, Raleigh News & Observer, Oct 19, 12]

Pressure BioSciences (South Easton, MA)

Pressure BioSciences  (South Easton, MA, one SBIR), a 2009 Larta NIH-CAP company focused on the development of novel instruments and solutions to the error prone nature of biological sample preparation, has recently entered in to a distribution agreement with Netherlands-based LA Biosystems BV to market and sell their instruments in Belgium, the Netherlands, and Luxembourg. This follows on the coattails of a collaboration with the Henry C. Lee Institute of Forensic Science and international co-marketing and distribution agreements with KeraFAST LLC (USA), Digilab Inc. (USA), OROBOROS (Austria) and IUL Instruments GmbH (Germany).  [LARTAVox,  Mar 21, 12]

Pressure BioSciences (South Easton, MA;  one SBIR) completed an $800,000 private placement  ...   to support commercialization of its Pressure Cycling Technology platform, which uses rapid cycles of hydrostatic pressure between ambient and ultra high levels to control biomolecular interactions.    [Michelle Lang, Mass High Tech, Feb 9, 12]

On the heels of receiving $112,000 in loans from three of its investors, Pressure BioSciences (South Easton, MA; one SBIR) was awarded [$650K DOD SBIR] ... help fund the development of an automated, high-throughput, high-pressure system, including instruments and consumables, for safe and accurate processing of pathogenic organisms such as viruses and bacteria. [Lori Valigra, Mass High Tech, Oct 14, 11]

Pressure BioSciences(South Easton, MA; one SBIR)  was awarded a $649,498 [SBIR] grant from the U.S. Department of Defense....  will help fund the development of an automated, high-throughput, high-pressure system, including instruments and consumables, for safe and accurate processing of pathogenic organisms such as viruses and bacteria. The system will be based on the company’s pressure cycling technology, which uses rapid cycles of hydrostatic pressure between ambient and ultra high levels to control biomolecular interactions. ... a substantial portion of the remaining development costs of a new system aimed at the sample preparation market. He estimated the size of that market at $6 billion, including approximately 80,000 laboratories and 500,000 researchers worldwide. [Lori Valigra, Mass High Tech, Oct 14, 11]  Sounds an awful lot like merely reducing business risk for a working technology which competes with private capital and enters the territory of corporate welofare.  Ah well, DOD likes certainty in its spending.

Pressure Biosciences (no SBIR) has pulled in $1.2 million through a combination of equity, warrants and securities.  [Mass High Tech, Dec 4, 09]

Pressure BioSciences (South Easton, MA; no SBIR) sold about $1.16 million in stock and warrants, as a first tranche of a $2.5 million private placement. [Mass High Tech, Nov 19, 09]

Pressure BioSciences (South Easton, MA; no SBIR, 27 employees) has announced restructuring steps, including a 40 percent reduction in workforce, closing of a research facility in Rockville, Md., and widespread cost reductions  ... will focus on Pressure Cycling Technology (PCT) for the mass spectrometry market, as well as the biological sample preparation market. Other company projects not related to the new strategy will be terminated.  [Mass High Tech, Dec 2, 08]

Prevencio (Kirkland; WA)

Prevencio (Kirkland; WA; no SBIR) announced the successful results of a new heart disease test, which will enable the company to continue raising its $20 million Series C funding ... “With the successful presentation of clinical data of the HART CAD test at the European Society of Cardiology scientific sessions.  [Casey Coombs, Puget Sound Business Journal, Sep 8, 16]

Preventice (Minneapolis, MN)

Regulators cleared [startup] Preventice ( Minneapolis, MN; no SBIR) remote heart-monitoring device for sale in Europe, the company announced  ....   pairs a smartphone with a device about the size of a pager in a single kit. Patients stick the device on their chests and the smartphone collects data, which physicians review after a set period of monitoring.  .....   partnered with Mayo Clinic to develop the product.   [Katherine Grayson, Minneapolis / St Paul Business Journal, Oct 9, 13]

Prevention Pharmaceuticals (New Haven, CT)

Prevention Pharmaceuticals (New Haven, CT; no SBIR) has sold $650,000 of a $2 million securities offering, through a combination of debt, options and warrants .... to introduce an OTC zinc-salts heartburn gel cap called Acid-Fix that is based on technology out of Yale University [Lori Valigra, Mass High Tech, Jan 13, 11]

Prieto Battery (Fort Collins, CO)

startup  Prieto Battery  (Fort Collins, CO; no SBIR), spun out of Colorado State University, has succeeded in producing what founder Amy Prieto calls “the first true 3-D battery that can be charged and discharged, and that will hold a charge”—in other words, that fills the basic requirements of a conventional battery. 3-D batteries could be cheaper to make, faster to charge, safer, smaller, and less environmentally toxic than conventional batteries. [Richard Martin, technologyreview.com, Oct 26, 15]

Primera Biosystems

Primera Biosystems (Mansfield, MA; no SBIR) reports it has closed on a $20 million Series C round of financing, ... a molecular diagnostics company developing a proprietary nucleic acid analysis system [Mass High Tech, Sep 21, 09]

Molecular diagnostics company Primera Biosystems(Mansfield, MA; no SBIR) closed on a $21M Series B financing led by a British investment firm ... has operated quietly since it closed an $11M Series A financing in 2005. [Mass High Tech, Jan 8, 08]/p>

Primordial (St Paul, MN)

Primordial (St Paul, MN; $1M SBIR) which makes software that helps vehicles navigate off-road terrain, has landed a $2.9 million military contract.  ....  has received more than $10 million in military funding to develop the product since launching in 2002. [Katharine  Grayson, Minneapolis / St Paul Business Journal, Nov 15, 12]  Sounds like the Army found a product it likes and is using SBIR money for the final engineering. Legal, but.

PrimorigenBiosciences

Primorigen Biosciences got a Phase I SBIR grant of $362,714 from NIH. The grant allows the Madison biotech company to compete for an additional $1.6 million grant in the future, company executives said. Primorigen is developing new antibodies and other products for cell therapy research. ... will accelerate Primorigen’s development of a new protein detection test to support cell research on Type I diabetes, the company said.  [Milwaukee Journal-Sentinel, Sep 4, 08]

Primus Power (Hayward, CA)

Primus Power (Hayward, CA; no SBIR) raised $20 million for a new round ....  from [South African] strategic investor Anglo American Platinum  [John Sailors, San Francisco Business Times, Feb 5, 14]

Princeton Satellite Systems (Plainsboro, NJ)

Reaching for the stars.   Princeton Satellite Systems (Plainsboro, NJ; $7M SBIR) was selected for two NASA STTRs on their new topic, T2.01-9960, Advanced Nuclear Propulsion! Our research institution partner is Princeton Plasma Physics Laboratory. Our proposals were featured in NASA’s official press release! Here is a quote:      High temperature superconducting coils for a future fusion reaction space engine. These coils are needed for the magnetic field that allows the engine to operate safely. Nuclear fusion reactions are what power our sun and other stars, and an engine based on this technology would revolutionize space flight. [company press release, Jun 6, 17]

Principia Biopharma (South San Francisco, CA)

Principia Biopharma (South San Francisco, CA; no SBIR)  raised $50 million in a Series B round aimed at pushing its experimental drugs against autoimmune diseases and cancer into clinical trials.   .... raised $40 million in 2011  .... noted three drugs in its portfolio:     An oral drug that inhibits BTK, or Bruton’s tyrosine kinase, an enzyme that is required for signaling B cell receptors that can lead to proliferation and survival of cancer cells in the blood. Principia said the drug could be used against cancer and autoimmune diseases;      An oral inhibitor of FGFR, or fibroblast growth factor receptors, that can slow the progression of solid tumors, and;      A drug tackling autoimmune and inflammatory diseases by blocking the path of IL-17, which is produced by cells that respond to a breach of the immune system. IL-17, which scientists believe plays a role in multiple sclerosis, rheumatoid arthritis and other conditions, activates cells that produce more of a certain type of small proteins, called cytokines, that promote inflammation.   [Ron Leuty, San Francisco Business Times, Apr 22, 14]

Prism Solar Technologies (Lake Katrine, NY)

solar-power startups in particular have seen a three-year surge, from a low of no venture investment in the third quarter of 2005 to a high of more than half a billion dollars in the second quarter of this year.  CaliSolar (Sunnyvale, CA; no SBIR) $13M; Wakonda Technologies (Fairport, NY; $200K SBIR) $9M; Prism Solar Technologies (Lake Katrine, NY; no SBIR) $9M. [Dean Takahashi, MIT Tech Review, S/O 08]

Procept BioRobotics (Redwood Shores, CA)

Medical-device startup Procept BioRobotics (Redwood Shores, CA; no SBIR, founded 2009) raised $42 million  to treat prostate issues. ... has raised $43.6 million to date. ...  to develop a surgical product for trans-urethral resection of prostate tissue ...  for a limited commercial launch of AquaBeam in targeted international markets   [Gina Hall, Silicon Valley Business Journal,  Jul 7, 15]

ProCertus BioPharm (Madison, WI)

Other [Wisconsin] companies the MoneyTree report showed raising venture funding in the second quarter were: Aquarius Technologies (Port Washington, WI; no SBIR) developer of wastewater treatment technologies, $4 million; NeuWave Medical (Madison, WI; no SBIR) medical device company, $2.63 million; ProCertus BioPharm (Madison, WI; $1.6M SBIR) drug developer, $1.7 million; and Zurex Pharma (Madison, WI; no SBIR) drug developer, $1 million.  [Kathleen Gallagher, Milwaukee Journal Sentinel, Jul 19, 11]

ProCertus BioPharm< (Madison, WI; $1.6M SBIR) has raised $1.7 million to fund clinical trials to determine whether its products can safely help cancer patients avoid side effects of radiation and chemotherapy. ... ProCertus' products are applied to skin or the inside of the mouth minutes before cancer therapy to protect cells that will be exposed to chemotherapy and radiation.  [Kathleen Gallagher, Milwaukee Journal Sentinel, Apr 5, 11]

ProCertus BioPharm  (Madison, WI; $1.6M SBIR), developing drugs to protect cancer patients from common chemotherapy and radiation side effects will announce Tuesday it has raised $2.1 million. ...  has also started enrolling patients in a clinical trial to determine whether its DermX product prevents burns caused by radiation therapy, said Paul Weiss, the company's acting chief executive officer. ....  ProCertus licenses its technology from the Wisconsin Alumni Research Foundation. The company raised $2.3 million in 2007. [Kathleen Gallagher, Milwaukee Journal Sentinel, Jun 30, 09]

Proclara Biosciences (formerly NeuroPhage Pharmaceuticals, Cambridge, MA)

Despite a litany of high profile failures among drugs to fight Alzheimer’s disease, biotechs and pharma companies continue to pour billions of dollars into the fight. The latest firm to get a financial boost is a startup from , that until today has been known as Neurophage Pharmaceuticals  (Cambridge, MA; no SBIR).  ....    has raised $47 million from current backer Merieux Development and a group of high net worth individuals, and changed its name to Proclara Biosciences.   [Ben Fidler, xconomy.com, Sep 7, 16]

Procyrion (Houston,TX)

Procyrion (Houston, TX; no SBIR) medical device company, raised $5.15 million of what is expected to be a $10 million raise, according to [SEC] filing  ...  manufactures a booster pump for the heart that is less stressful than surgery.  [Joe Martin, Houston Business Journal, Jul 14, 15]

Fannin Innovation Studio (Houston, TX) currently has 10 portfolio companies, which include Procyrion  (Houston, TX; no SBIR), a medtech device startup that makes Aortix, a thinner-than-a-pencil circulatory support pump implanted in the aorta through the femoral artery via a catheter.  [Angela Shah, xconomy.com, Feb 11, 15]

Profectus BioSciences (Baltimore,MD)

Profectus BioSciences (Baltimore, MD; $2.4M SBIR) received a $9.5 million DOD grant for a phase 1 clinical trial of its Ebola vaccine. ...  Profectus' fourth this year — all for work developing and manufacturing Ebola vaccines. The new grant brings the company's total funding up to at least $49.8 million. ... new grant will support a clinical trial of Profectus' VesiculoVax, a vaccine for Ebola Zaire, a common strain of the deadly virus   [Sarah Gantz,  Baltimore Business Journal, Oct 31, 14]

Profectus BioSciences (Baltimore, MD; $1M SBIR) was awarded a total of $6.25 million in funds from the [NIH]. ...includes three SBIR grants totaling $2.9 million. ... develops vaccines for chronic viral diseases  ... grants are in addition to $4.4 million the company recently secured. Those funds included an SBIR grant of $3.1 million ...   an HIV and cancer research company, is a spinout from the Institute of Human Virology formed to commercialize research spearheaded by Dr. Robert C. Gallo, the famed AIDS co-discoverer who oversees the institute. [Emily Mullen, Baltimore Business Journal, Oct 7, 10]

Progenics Pharmaceuticals

Progenics Pharma up 11% [Sep 18, 17]

Progenics Pharma up 12% [Aug 28, 17]

Progenics Pharma down 15% [Aug 9, 17]

Progenics Pharma down 13% [May 4, 17] reported wider loss [company press release, May 4, 17]

Progenetics Pharma up 10% [Feb 16,17]

Progenics Pharma up 10% [Nov 8, 16]

Progenics Pharm up 11% [Sep 30, 16]

Progenics Pharma up 24% [Jul 20, 16]

Progenics Pharma down 10% [Mar 15,16]

Progenics Pharmaup 18% [Feb 16, 16]

Progenics Pharma up 11% [Oct 23,15]

Progenics down 11% [Jul 29,15]

Progenics Pharma up 14% [Jun 30, 15]

Progenics Pharma down 11% [Jun 24, 15]

Progenics Pharma up 10% [May 6,15]

Progenics Pharma  up 17% [Nov 7, 14]

Salix Pharmaceuticals announced that federal regulators have signaled they will approve its drug Relistor for treatment of chronic pain in non-cancer patients. ... will not require Salix and its partner Progenics Pharmaceuticals to submit additional data as part of its new drug application.  [David Bracken, Raleigh News & Observer, Jul 14, 14]

Progenics Pharma up 16% [Jan 30, 14]

Progenics Pharma down 27% [Jan 29, 14]

Progenics Pharma up 10% [Nov 21, 13]

Progenics Pharma down 10% [Sep 16, 13]

Progenics Pharma up 12% [Jul 11, 13]

Progenics Pharma down 11% [Jun 20, 13]

Progenics Pharma up 31% [Jun 11, 12] said a [FDA] advisory committee will review Salix's opioid-induced constipation treatment in patients with chronic pain, after Salix formally appealed the FDA's response on the drug last year. [Wall Street Journal, Jun 11]

Progenics Pharma down 14% [May 1, 13]

Progenics Pharma up 29% [Mar 15, 13]

Progenics Pharma (Tarrytown, NY; $34M SBIR, until 2007)  up10% [Mar 7, 13]

Progenics Pharma down 50%  [Jul 30, 12]

Progenics Pharma  up 31% [Dec 20, 11] after [Progenics and Salix] said a late-stage study for an expanded use of the constipation treatment Relistor yielded positive results. [AP, Dec 20]

Progenics Pharma  up 21% [Nov 30, 11]

Progenics Pharmaup 15% [Oct 4, 11]

Progenics Pharma up 10% [Aug 29, 11]

Progenics Pharma  up 11% [Aug 15, 11]

Progenics Pharmaup 12% [Aug 11, 11]

Progenics Pharma up 16% [Aug 9, 11]

Progenics Pharma down 11% [Aug 4, 11]

Progenics Pharma  up 11% [Sep 22, 10]

Progenics Pharma  up 13% [Jul 21, 10]

Progenics Pharma  down 10% [Jul 16, 10]

Progenics Pharma up 11% [May 26, 10]

Progenics Pharma up 12% [May 12, 10]

Progenics Pharma up 11% [Nov 16, 09]

Progenics Pharma down 11% [Jun 22, 09]

Progenics Pharma  down 12% [Apr 20, 09]

Progenics Pharma  up 14% [Mar 26, 09]

Progenics Pharma  up 11% [Mar 23, 09]

Progenics Pharma up 14% [Mar 12, 09]

Progenics Pharma  down 21% [Dec 1, 08]  On a stock bloodbath day

Progenics Pharma down 11% [Nov 14, 08]

Progenix Pharma down 10% [Oct 22, 08]

Progenics Pharma up 11% [Oct 13, 08]

Progenics Pharmaceuticals which dropped more than 60% when its lead drug, Relistor, failed a phase 3 trial last month for postoperative ileus, a constipation-like condition that follows abdominal surgery.  Then the stock jumped more than 30% in the other direction yesterday after the drug was recommended for approval in the European Union for treating opioid-induced constipation (OIC), and is trading up another 26% today after the FDA approved it last night. In fact Progenics has roughly tripled since I said investors had overreacted to the failed drug study. [motleyfool.com, Apr 25, 08]

Progenics Pharmaceuticals up 22%, topped the list of Biggest Percentage Price Gainers on the Nasdaq. Wall Street Journal, Apr 22]

Progenics Pharmaceutical up 19% after the company said its Relistor constipation drug was approved for sale in Canada.  [AP, Apr 1, 08]

Progenics Pharmaceuticals down 63% after the company and its partner Wyeth said their constipation drug failed a late-stage clinical trial. [AP, Mar 12, 08]

Progenics Pharmaceuticals up 10% [Jan 8, 08]

Progenity (San Diego, CA

Venture Capital investments in San Diego 3Q2016.    Ostendo Technologies (Carlsbad, CA; one SBIR)  $42 million;  Tealium ( San Diego; no SBIR)  $35 million ; Singlera Genomics   (San Diego, CA; no SBIR) $20 million;  Avelas Biosciences     (San Diego, CA; no SBIR)  $20 million ;  Fortis Therapeutics     (San Diego, CA; no SBIR) $18 million ; Histogen   (San Diego, CA; no SBIR) $16 million ; Medsphere Systems  (Carlsbad, CA; no SBIR) $15 million;  CellSavers  (San Diego, CA; no SBIR) $15 million;  Progenity  (San Diego, CA; no SBIR) $12 million; AristaMD  (San Diego, CA; no SBIR)  $11 million.   [Bruce Bigelow, xconomy.com, Oct 11, 16] 

Prologic

Efficient Ears. On average, companies generated roughly $28 in earmark revenue for every dollar they spent lobbying. By any standard, that's a hefty ratio: The companies in the Standard & Poor's 500-stock index brought in just $17.52 in revenues for every dollar of capital expenditure in 2006. ... Says Keith Ashdown, chief investigator for the watchdog group Taxpayers for Common Sense: "The lion's share of these projects is about politics and jobs, rather than real needs." [Business Week, Sep 17]  The earmark efficiency champ is an SBIR company, Scientific Research (Atlanta GA and others; about $15M SBIR), that got $344 in earmarked funds per dollar of political "investment".Other SBIR investors: Isothermal Systems (KY and WA; $2M SBIR) at $221 per lobbying dollar; Prologic (Fairmont WV; $2M SBIR) at $133 per dollar; Trex Enterprises (San Diego CA; $7M SBIR) at $116 per dollar. From an efficiency viewpoint, politicians make a good investment. You just have to learn how to kiss frogs.

Promedior (Malvern, PA)

Promedior (Lexington, MA; no SBIR, founded 2012, 10 employees) says its drug to treat a rare bone marrow disease known as myelofibrosis can reverse the disease and allow patients to start producing blood normally again.   The company presented results of the first part of a Phase 2 trial of PRM-151 ....  most recent investment came in 2012, a $22 million round that brought the company's total to $65 million, according to federal filings.  [Don Seiffert, Boston Business Journal, Dec 9, 14]

Promedior (no SBIR), a biotechnology company relocating here from [Malvern, PA], has opened new office and lab space in Lexington, ...   looking to develop treatments for fibrosis, and it said it has raised a total of $65 million in funding to date.... In a statement, Bruhn said: “We were attracted to the unique resources of the Massachusetts life sciences industry, which includes the full complement of world class companies involved in drug development along with highly innovative government initiatives that support biotechnology companies. [Chris Reidy, Boston Globe, Dec 17, 12]  Live better where your industry thrives.

Promedior  (Malvern, PA. no SBIR) raised $21.5 million in a first closing of a series D round of venture capital financing  [John George, Philadelphia Business Journal, Mar 7, 12]

Promega (Madison, WI)

Promega (Madison, WI; $5M SBIR in 1990s)  said it plans to seek FDA approval for one of its products for the first time. The product—a test that doctors would use to make decisions around diagnosing and treating patients with colorectal cancer—has been in use since 2004, but has only been used as a lab-developed test (and therefore is not subject to the same FDA oversight as other diagnostics).  [Jeff Buchanan, xconomy.com, Jul 12, 17]

The U.S. Supreme Court ruled against Promega in a patent case the lab supplies maker had brought against Life Technologies, a business unit of Thermo Fisher Scientific  the [AP] reported. Promega filed suit claiming that Life Technologies infringed on a U.S. patent when the company supplied a plant in London with an enzyme meant to be combined with other components to make DNA analysis kits. [Jeff Buchanan, xconomy.com, Mar 7, 17]

The Supreme Court sided with Life Technologies in a patent infringement case that limits the international reach of U.S. patent laws.  The justices ruled unanimously on Wednesday that the company’s shipment of a single part of a patented invention for assembly in another country did not violate patent laws. Life Technologies supplied an enzyme used in DNA analysis kits to a plant in London and combined it with several other components to make kits sold worldwide.   Promega (Madison, WI; $5M SBIR) sued, arguing that the kits infringed a U.S. patent.  [AP, Feb 22, 17]

Representatives of a global investment banking firm are calling shareholders of Promega (Madison, WI; $5M SBIR, founded 1978) [maker of biotech research tools] to say an investor group's $625-a-share offer is lower than comparable transactions in the industry, a shareholder told the Journal Sentinel  ...  "Promega is one of the stars of the tech story in Wisconsin," said Don Layden, a Milwaukee lawyer who is not connected with the situation.    [Kathleen Gallagher, Milwaukee Journal Sentinel, Oct 13, 15]

Promentis Pharma (Milwaukee, WI)

Promentis Pharmaceuticals (Milwaukee, WI; $500K SBIR)  that is developing drugs to treat schizophrenia and other psychiatric disorders, has raised an additional $17.2 million from investors, bringing the total in its third round of financing to $26 million.  [Guy Boulton, Milwaukee Journal Sentinel, Mar 29, 17]

Promentis Pharmaceuticals (Milwaukee, WI; $500K SBIR, founded 2007) developing compounds for the treatment of schizophrenia and other central nervous system disorders, has raised $8.7 million in equity funding, according to [SEC] filing ... said it is developing compounds aimed at modifying brain chemistry by targeting the glutamate system, which is critical to transmitting signals in the brain. Promentis previously raised $2.9 million of venture capital in 2014.  [Kathleen Gallagher, Milwaukee Journal Sentinel, Oct 10, 16]

Promentis Pharmaceuticals (Bayside, WI; $500K SBIR) developing drugs that modify brain chemistry to treat central nervous system (CNS) disorders, inked an exclusive licensing deal this month with the University of Montana. The two have been research partners for about five years   [Jeff Engel, xconomy.com, Feb 12, 15]

Promentis Pharmaceuticals (Milwaukee, WI; $500K SBIR, founded 2007, three full-time employees) that is developing drugs to treat schizophrenia and other central nervous system disorders, has raised $2.9 million from investors, company executives said.   ....  developing compounds aimed at modifying brain chemistry by targeting the glutamate system, which is critical to transmitting signals in the brain. The company will use the money to bring two of the compounds into clinical trials for humans, said Chad E. Beyer, president and chief executive officer.  The funding provides the "financial bandwidth" to get the two compounds into clinical trials within the next two years, Beyer said.  ....  exclusively licensed its original technology from Marquette University and the University of Wisconsin-Milwaukee. ... In 2012, it received a $1.8 million [NIH] award  [Kathleen Gallagher, Milwaukee Journal Sentinel, Jan 16, 14]

Chad E. Beyer, the former head of neurochemistry at Wyeth Pharmaceuticals, has been named [CEO] at Promentis Pharmaceuticals (Milwaukee, WI; $500K SBIR) drug development start-up. [Milwaukee Journal Sentinel, Jul 25, 13]

Promentis Pharmaceuticals   (Milwaukee, WI; $500K SBIR) developing drugs to treat schizophrenia and other central nervous system disorders said Thursday it has raised $1.94 million from investors. [Kathleen Gallagher, Milwaukee Journal Sentinel, Feb 26, 10]

Promentis Pharmaceuticals (Milwaukee, WI; $500K SBIR; founded 2006) will receive a $250,000 Technology Venture Fund loan from the state Department of Commerce to continue development of pharmaceuticals that treat psychiatric, behavioral and neurological disorders. ... initially focused on the development of a new class of antipsychotic medications for the treatment of schizophrenia. [Business Journal of Milwaukee, Feb 11, 10]

start-ups in the drug field within the Milwaukee 7 economic development region suggests another strategic direction for the regional economy. Those new ventures come as Concordia University of Wisconsin mounts an impressive campaign to build a new pharmacy school in southeastern Wisconsin, possibly in downtown Milwaukee. ... New ventures  in the emerging drug-making concentration:  MPP Group  (no SBIR),a venture headed by serial entrepreneur Frank Langley that is building drugs aimed at alcoholism. James Cook, a University of Wisconsin-Milwaukee researcher, developed the compounds.  Neuro Amp (no SBIR),a spin-off from PhysioGenix (Wauwatosa, WI; $3M SBIR) that is aiming at diseases of the central nervous system and Alzheimer's.  Promentis (no SBIR), collaboration between Marquette University's David Baker and UWM researchers and former Schwarz Pharma managers who are targeting schizophrenia and central nervous system disorders.  Cytometix (no SBIR),a 2004 start-up headed by Lane Brostrom that is developing drugs for the treatment of pain and asthma. Endece  (no SBIR),a 2006 Mequon start-up headed by James Yarger that is developing compounds for treating cancer, sepsis, learning and memory. [John Torinus, Milwaukee Journal Sentinel, Jan 31, 09]

Pronutria formerly Essentient (Cambridge, MA)

Pronutria (Cambridge, MA; no SBIR) said it's raised $12.25 million in new funding and launched two clinical trials for its novel nutrient products that can treat diseases.  ...  formerly named Essentient, founded in 2011 ....  emerged from stealth mode in November, with details about its ProNutrein products and its $10.8 million in Series A funding [Kyle Alspach, Boston Business Journal, Feb 14, 14]

Pronutria, (formerly Essentient, Cambridge, MA; no SBIR) unveiled details about its funding from founder Flagship Ventures and its plans to offer novel nutrient products that can treat diseases. ....  disclosed that it raised $10.8 million in Series A funding during [past two years]  ....  company says its ProNutrein products are naturally occurring, orally consumed pure protein products that "trigger pharmacological effects through precise and reproducible delivery of specific amino acids."  [Kyle Alspach, Boston Business Journal, Oct 22, 13]

Propagenix (Rockville, MD)

Maryland Technology Development Corp approved awards of $8.5 million to 29 new stem cell research projects. The for-profit firms each receiving over $1M are:  TissueGene (Rockville, MD; $100K SBIR), Longeveron LLC (Miami, FL; no SBIR), MaxCyte (Gaithersburg, MD; $1M SBIR), Propagenix (Rockville, MD; no SBIR),  Seraxis (Germantown, MD; no SBIR), and 3Dnamics (Germantown, MD; no SBIR).   [Morgan Eichensehr, Baltimore Business Journal, May 16, 17]

Pro-Pharmaceuticals

Pro-Pharmaceuticals  has closed a $6 million private placement  [Mass High Tech, May 12, 10]

Propeller Health (Madison, WI)

Propeller Health (Madison, WI; no SBIR) announced that it received FDA clearance to market a sensor it has developed for use with Ellipta, a dry powder inhaler made by the U.K.-based pharmaceutical giant GlaxoSmithKline. ....  PH makes Internet-connected inhalers and sensors designed to help patients with asthma and chronic obstructive pulmonary disease.  [Jeff Buchanan, xconomy.com, Nov 8, 16]

Propeller Health (Madison, WI; no SBIR) said it’s partnered with the U.K.-based Vectura Group to develop a connected dry powder inhaler for patients with asthma and chronic obstructive pulmonary disease (COPD). The two groups will initially work to develop an add-on sensor for one of the inhalers that Vectura currently sells.  The announcement comes on the heels of partnerships Propeller has forged or expanded with Boehringer Ingelheim (Germany), Aptar Pharma (Crystal Lake, IL; no SBIR), and GlaxoSmithKline (U.K.) during the past six months. GSK’s Ellipta inhaler is also of the dry powder variety, as opposed to other types like soft mist and metered-dose.   [Jeff Buchanan, xconomy.com, May 31, 16]

Propulsive Wing (Syracuse, NY)

Most Innovative Technology ... at the 10th Annual SmartStart UNYTECH Venture Forum–– Propulsive Wing, (Syracuse, NY; no SBIR) developing an unmanned aerial vehicle (UAV) platform.  [Business Review (Albany), May 19, 10]

ProstaGene (Wynnewood, PA)

ProstaGene (Wynnewood, PA; no SBIR) raised $400,000 from private investors to support commercialization of a gene-based test to help guide prostate cancer treatment. [John George. Philadelphia Business Journal, May 3, 16]

Protagonist Therapeutics (Menlo Park,CA)

Protagonist Thera up 16% [Sep 27, 16]

Protagonist Therapeutics (Milpitas, CA; two SBIRs)  IPO raised $90 million.  .... is working on oral drugs to treat inflammatory bowel disease.    [Cromwell Schubarth, Silicon Valley Business Journal, Aug 11, 16]

Protagonist Therapeutics (Milpitas, CA; one prior SBIR) set targets for its upcoming IPO in which it hopes to raise up to $87.2 million. [Cromwell Schubarth, Silicon Valley Business Journal, Aug 1, 16]  [won Phase 1 SBIR] that supports preclinical research aimed at discovering and optimizing lead molecules as novel peptide mimetics of the natural hepcidin hormone. Protagonist aims to develop these mimetics as potential injectable treatments for iron overload disorders, such as beta-thalassemia and hereditary hemochromatosis.  [company press release, Jul 28, 16]  announced the closing of a $40 million Series C financing  [company press release, Jul 16, 15]

Protagonist Therapeutics (Milpitas, CA; no SBIR, founded 2001) filed plans to raise up to $75 million in  IPO.  ....  develops drugs that treat colon diseases.  .... has raised $67 million since it was founded    [Cromwell Schubarth, Silicon Valley Business Journal, Jul 11, 16]

 In its second round of venture funding, Protagonist Therapeutics (Menlo Park, CA; no SBIR) raised $14 million.
... to develop alternatives to biologic and small molecule drugs using new technology called disulfide-rich peptide, or DRP. Johnson & Johnson Development Corp. led the round  [Stephen EF Brown, San Francisco Business Times, Jun 4, 13]

Protein Foundry (Milwaukee, WI)

Protein Foundry LLC  (Milwaukee, WI; no prior SBIR), a Medical College of Wisconsin spin-off that makes specialty biochemical compounds for researchers, said it has received a $250,000 [NIH SBIR] grant.  ...  to develop a safe and efficient method for delivering therapeutic proteins into nerve cells  [Kathleen Gallagher, Milwaukee Journal Sentinel, Oct 14, 15]   manufactures recombinant proteins for biomedical research [company website]

Protein Sciences (Meriden,CT)

Flublok, a flu vaccine made from cells rather than egg protein, is now available at Target pharmacies as its developer, Protein Sciences (Meriden, CT;  $1.3M SBIR) seeks to broaden sales in the upcoming flu season. ...  the vaccine is now in 6,000 stores   [Mara Lee, Hartford Courant, Sep 23, 15]

Protein Sciences (Meriden, CT; $1.6M SBIR) says its Flublok vaccine has been granted 12 years of regulatory exclusivity by [FDA] ... company's flu vaccine uses recombinant DNA to produce the proteins that form its active ingredients. Other flu vaccines rely on active influenza strains, grown in chicken eggs or in cell-based cultures, to synthesize the necessary proteins.  [ZACH MELVIN, Hartford Courant, Jun 4, 15]

[FDA] licensed Protein Sciences (Meriden, CT; $1.5M SBIR) Pearl River, N.Y., manufacturing plant for production of its flagship influenza vaccine, Flublok.  [Brian Dowling, Hartford Courant, May 13, 15]

Protein Sciences (Meriden, CT;  $1.4M SBIR, 130 employees) is two months away from testing a vaccine for Ebola. ...  [CEO] Manon Cox said Protein Sciences plans to deliver samples to [NIH] for testing in December. She and U.S. Rep. Rosa DeLauro said the vaccine could be available for medical workers or members of the U.S. military early next year.  ...  gets most of its business from a new flu vaccine that entered the market two years ago ... Work on the vaccine is mostly self-funded at this point, the company said   [Brian Dowling, Hartford Courant, Oct 6, 14]   When urgent demand strikes, SBIR's structure makes it of little value. But regular government has the capacity and organization to do almost anything in an emergency, a point usually overlooked by the small government crowd that cries "liberty" as a screen for wanting lower taxes.

Protein Sciences (Meriden, CT;  $1.4M SBIR) announced a major distribution agreement that will ....  make Flublok available to people through its more than 230 clinics nationwide and to employers that arrange their vaccination clinics through the company.   ... vaccine is produced differently from traditional flu vaccines [as] the company makes a genetic copy of the virus, and from that makes large quantities of the influenza virus protein, the main ingredient of most inactivated flu vaccines.     [Brian Dowling, Hartford Courant, Aug 20, 14]

Protein Sciences (Meriden, CT; $1.4M SBIR) is negotiating an incentive deal that could bring 100 or more jobs to its Meriden [CT] complex, even as the maker of a breakthrough flu vaccine readies a manufacturing plant in New York's Rockland County.  [Dan Haar, Hartford Courant, Dec 17, 13]

Protein Sciences (Meridan, CT; $1.4M SBIR) skirted bankruptcy, fought off a hostile takeover bid, spent three years angling for a sorely-needed government contract, and survived a four-year dialogue with the FDA before winning approval this year for the first influenza vaccine made with genetic engineering and without eggs.  [Bernadette Tansey, xconomy.com, Mar 11, 13]

Protein Sciences (Meriden, CT; $1.4M SBIR) is investing millions of dollars in a new manufacturing facility for its flu vaccine — in Rockland County, N.Y. [Dan Haar, Hartford Courant, Dec 4, 12]

Protein Sciences facing possible bankruptcy and liquidation has been awarded a $35 million federal [HHS] contract to develop a faster way to make vaccines for pandemic influenza. ...  But only a day earlier, creditors filed a petition in federal bankruptcy court seeking to force Protein Sciences into bankruptcy and liquidation, saying they were owed $11.7 million. Almost all of that money is owed to Emergent BioSolutions, a vaccine company in Rockville, Md., that lent Protein Sciences $10 million last year in advance of the pending acquisition of virtually all the assets of Protein Sciences by Emergent. The acquisition deal fell apart, and Emergent sued Protein Sciences and its top executives, accusing them of fraud and breach of agreements. [Andrew Pollack, New York Times, Jun 23]

Protein Sciences claimed breach of contract in cancelling its sale to Emergent BioSolutions which counter-claimed thatProtein Sciences had no legal right to end the deal on its own, calling the claims "baseless." [Wash Post, Jul 30, 08]

Protein Sciences (Meriden, CT; $900K SBIR) came out slugging, saying a lawsuit by its merger partner was an attempt to cripple the maker of a next-generation flu vaccine, forcing it into bankruptcy so it could be bought more cheaply. Emergent BioSolutions is backing out on millions of dollars in loans that it agreed to make as part of a merger agreement in May, Protein Sciences said in a press release. The loans are critical to keeping the cash-strapped company afloat while it pursues licensing and further work on its FluBlok vaccine.  [Kenneth Gosselin, Hartford Courant, Jul 11, 08]

Emergent BioSolutions, in a push to diversify beyond its biodefense business, plans to announce today that it is buying Protein Sciences (Meriden, CT; $900K SBIR), a maker of a next-generation flu vaccine that federal regulators have put on a fast track to approval. for $75M [Kendra Marr, Washington Post, May 27]

ProteinSimple (formerly Cell Biosciences) (Santa Clara, CA )

Startup Unchained Labs (Pleasanton, CA; no SBIR) pulled in $25 million in a Series A financing. ...  started by Tim Harkness, who built Santa Clara protein analysis technology company ProteinSimple. That company sought to raise $86.3 million in an initial public offering last year, before its $300 million acquisition in August by Minneapolis-based Techne Corp ... Unchained Labs sees itself as a life sciences tools company. It plans to buy businesses and product lines, starting with the recent acquisition of Optim, an analytical instrument designed to help drug developers measure protein stability and, as a result, poor drug candidates early in the development process.   [Ron Leuty, San Francisco Business Times, Feb 12, 15]

Techne (which does business as Bio-Techne) has agreed to buy protein-analysis technology maker ProteinSimple (Santa Clara, CA; no SBIR) for $300 million in cash, the company announced ...  filed in May to raise up to $86.25 million in an IPO but has apparently decided that it was better off being acquired than going public. ...  changed its name from Cell Biosciences in 2011  [Katharine Grayson, Minneapolis / St. Paul Business Journal, Jun 18, 14] 

ProteinSimple  (Santa Clara, CA;  no SBIR) (formerly Cell Biosciences) bioscience company that has created protein analysis tools to help researchers understand the role of proteins in disease, has filed for an IPO with the intent to raise $86.25 million  .....  [said the money] may be used for actions including "the acquisition of other products, businesses or technologies, although we currently have no commitments or agreements relating to any of these types of transactions.”   [Silicon Valley Business Journal, May 2, 14]

Proteon Therapeutics (Waltham, MA)

Proteon Thera (Waltham. MA; $250K SBIR in Kansas) down 75% [Dec 13, 16] announced that its first Phase 3 clinical trial with investigational vonapanitase, PATENCY-1, did not meet its primary endpoint of improved primary unassisted patency compared to placebo (p=0.254). However, the top-line results for the trial's secondary endpoint suggested that vonapanitase may improve secondary patency compared to placebo (p=0.048).   [company press release, Dec 13, 16]

Proteon Thera down 12% [Nov 3, 16]

Proteon Thera  up 12% [Jun 27, 16]

Proteon Thera down 12% [May 6, 16]

Proteon Thera down 14% [Feb 22, 16]

Proteon Thera down 10% [Oct 23,15]

Proteon Thera down 13% [Aug 7, 15]

Proteon Thera down 10% [Jul 6, 15]

Proteon Thera down 10% [Jul 2, 15]

Proteon Thera up 17% [May 15, 15]

Proteon Thera (Kansas City, MO; $250K SBIR) down 12% [May 14, 15]

Proteon Thera ($200K SBIR)down 12% [Apr 20,15]

Proteon Thera ($250K SBIR) up 18% [Apr 8,15]

Proteon Thera (Kansas City, MO; two SBIRs)  up 15% [Dec 9, 14] 

Proteon Thera (Kansas City, MO; $250K SBIR) down 10% [Dec 3, 14]

Proteon Therapeutics  (Kansas City, MO; $250K SBIR), a developer of drugs for kidney and vascular disease, has brought in another $15.2 million in equity- and options-based funding says an SEC filing  [Erin Kutz, xconomy.com, Aug 12, 11]

Proteon Therapeutics  (Waltham, MA (research in KC); $200K SBIR) has received an additional $12 million in venture capital. ... developing a blood vessel-dilating drug candidate [Kansas City Business Journal, May 28, 09]

Biopharmaceutical startup Proteon Therapeutics (Waltham, MA; $250K SBIR) has completed a $38 million Series B equity financing deal and has signed a deal with Novartis worth a potential half billion dollars  [Mass High Tech, Mar 5]

Proteon Therapeutics (Waltham, MA and KC, MO; 2 SBIRs)  reports it has been awarded a patent by the European Patent Office covering the use of a class of proteins known as elastase, for dilating arteries and veins in humans.

Biopharmaceutical company Proteon Therapeutics (Waltham, MA; two Phase 1SBIRs) has locked up $12M financing following last year's $19M. ... to advance its first product candidate, PRT-201, into human clinical studies in both hemodialysis vascular access and peripheral arterial disease [Mass High Tech, Sep 6, 07]

Proteostasis Therapeutics

Proteostasis Therapeutics (Cambridge, MA; no SBIR) raised $50 million in an IPO despite a tough environment for biotech and even IPOs in general. The bad news: Proteostasis had to significantly discount its deal to raise that money. It sold 6.25 million shares at $8 apiece, well below its projections. [Ben Fidler, xconomy.com, Feb 11, 16]  developing novel therapeutics that regulate protein homeostasis to improve outcomes for patients with orphan and protein processing diseases, today announced that it has received Fast Track designation from the U.S. Food and Drug Administration (FDA) for PTI-428, an investigational oral treatment for cystic fibrosis (CF).  [company press release, Feb 1, 16]

Proteostasis Therapeutics (Cambridge, MA; no SBIR) has added to its three-year-old Series A funding, boosting it from a planned $5 million to taking $70.6 million of what is now a planned $81.8 million round ... developer of a drug discovery platform aimed at developing therapeutics based on small molecules for Parkinson’s disease, Huntington’s disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease.  [Rodney Brown, Mass High Tech, Jun 2, 11]

David Pendergast, the former CEO who led Transkaryotic Therapies through its sale to Shire Pharmaceutical Group, has helped new startup Proteostasis Therapeutics (no SBIR) raise $45 M in its first round, the company said.  Proteostasis was founded on the research of Jeffrey Kelley of the Scripps Research Institute in California and Susan Lindquist of the Whitehead Institute for Biomedical Research at MIT[Mass High Tech, Aug 25]

Proteotech

In Washington state’s biotech cluster, 83 local biotech companies were awarded grants worth a combined $34 million,   Adaptive TCR, AVI Biopharma, Omeros, Proteotech, and Trubion Pharmaceuticals and 78 others. [Luke Timmerman, Seattle Times, Nov 3] Most were $245K, a little money for almost everyone. Too little money to make a big swing in effect. Just politics.

Proteus Biomedical (Redwood City, CA)

It’s hard to find a better example of how technology is revolutionizing patient care than the tiny edible sensor Proteus Biomedical (Redwood City, CA; no SBIR) plans to begin selling this fall in the UK.  When the grain-of-sand-sized sensor is integrated into a drug tablet or capsule and activated by stomach fluid, it signals when the medicine was taken to a patch on the patient’s body. Then the patch relays the information along with the person’s heart rate and other medical details to a caregiver’s phone – all without a visit to the doctor.  [Steve Johnson, San Jose Mercury News, Mar 26, 12]

Proteus Biomedical  (Redwood, CA; no SBIR) a seven-year-old start-up, that is working on "smart pills" — internal sensors that monitor a person's health ... has lined up more than $60 million in funding and will concentrate for now on designing smart pills that monitor mechanical and electrical devices, as opposed to, say, blood chemistry.  [Josh Quittner, Time, Dec 15, 08]

A system that monitors pill taking and its effects is being engineered by a Silicon Valley startup. The technology consists of pills that report when they've been taken, and sensors that monitor the body's responses. The company behind the technology, Proteus Biomedical, (Redwood City, CA; no SBIR), calls its technology the Raisin system. George Savage, Proteus's cofounder and a former ER physician, says that the company was motivated by the fact that so many medical problems stem from drug compliance problems. According to Savage, 40 percent of hospital readmissions for heart failure happen because patients fail to take their medications properly. [Michael Chorost, MIT Tech Review, Mar 20]

Proteus Digital Health (Redwood City, CA)

data from mobile and wearable devices could chart the student’s vital signs and sleep and activity patterns and compare them to a “sociability index” so as to suggest whether he or she is entering a manic or depressed stage, thus enabling earlier intervention when needed.  That is the vision that Proteus Digital Health (Redwood City, CA; no SBIR, founded 2001) is refining, and for which it disclosed raising another $120 million from unidentified investors.    ....  Before the latest funding round, Proteus had raised about $200 million, Thomspon said.  [Patrick Hoge, San Francisco Business Times, Jun 2, 14]

Proteus Digital Health (Redwood City, CA; no SBIR) pioneering the use of ingested sensors in health care, has raised a $62.5 million Series F round of capital ... The total Proteus has raised since 2003 is now more than $150 million, the company said. [Patrick Hoge, San Francisco Business Times, May 2, 13]

Protez Pharmaceuticals (Malvern, PA)

Novartis AG< purchased Protez Pharmaceuticals(Malvern, PA; no SBIR) a developer of antibiotics, this week for $400 M cash. [Pittsburgh Business Times, Jun 6]

Prothena

Elan Corp. spinout Prothena (no SBIR) will take an experimental drug aimed at a rare protein-misfolding disease into a late-stage clinical trial, the company said ... Elan seeded Prothena with $125 million, but the company now has about $300 million in the bank, said Chief Scientific Officer Gene Kinney. Now Prothena is ready to take NEOD-001 into the late-stage trial.   [Ron Leuty, San Francisco Business Times, Dec 2, 14]

ProThera Biologics (Providence, RI)

ProThera Biologics (East Providence, RI; $3M SBIR) received a $500,000 financing commitment from the Slater Technology Fund, according to Slater. Slater reports that the $500,000 commitment follows its initial $100,000 grant to ProThera in 2001. [Mass High Tech, Jun 25]

Proto Labs (Maple Plain,MN)

Proto Labs (Maple Plain, MN; no SBIR), which moved into the Triangle last year by acquiring a Raleigh 3D printing company, is expanding in Wake County and adding 170 jobs over the next five years. [Raleigh News & Observer, Jun 19, 15]

FineLine Prototyping  (Raleigh, NC; no SBIR) that performs additive manufacturing, otherwise known as 3-D printing, has been acquired by Proto Labs (Maple Plain, MN; no SBIR, founded 1999) for $38 million.   ....  Proto Labs focuses on "quick-turn" manufacturing of custom parts using computer numerical control (CNC) machining and injection molding. [Jesse Burkhart, Triangle Business Journal, Apr 23, 14]

Medical devices start-ups powered Minnesota to the best quarterly VC performance in eight years just as a sagging economy curbed venture spending across the country. ... Seven medical device firms captured $130 million, led by CVRx (Brooklyn Park, MN; no SBIR) that makes a device that treats high blood pressure, raised $84 million on top of the $200 million investors have already poured into the company.  Cardiac Concepts  (no SBIR) first-round financing totaled a hefty $21 million. ... Other notable deals: Proto Labs (Maple Plain, MN; no SBIR) -based maker of injection molded products, attracted $67.2 million. Sage Electrochromics (Faribault, MN; $2M SBIR) raised $13.3 million, which makes glass that influences building temperatures, previously won $16 million in venture financing.  [[Minneapolis Star Tribune, Oct 26, 08]

Proton Energy Systems (Wallingford, CT)

New England energy stimulus money for small biz:  $2.2 million for an energy storage project at Beacon Power  .... $2.1M for Proton Energy (Wallingford, CT; $1.7M SBIR) and Penn State University aim to develop an advanced energy storage device that incorporates a regenerative fuel cell  ....  General Compression, (Newton , MA; no SBIR)  $750K for a novel compressed air energy storage process [Kyle Alspach, Mass High Tech, Jul 13, 10]

Fuel Your Senators.  Proton Energy Systems (Wallingford, CT; $1.3M SBIR), a renewable hydrogen technology developer, has received a $2.62 million Army contract fto develop a regenerative fuel cell system, company officials said.... The two US Senators helped secure funding for the project...  In August, Proton announced being bought from its parent company Distributed Energy Systems Corp. by F9 Investments LLC for $10.2 million. [Mass High Tech, Oct 16, 08]

Proton Energy Systems (Wallingford, CT)  got a $2.3 million contract for a hydrogen technology-oriented follow-on research project for the development of fuel cell technologies [Nov 06]

High Flying Hydrogen. MDA gave Proton Energy Systems (Wallingford CT) got a $1.25M SBIR Phase 3 for continued development of regenerative fuel cell technology for high altitude airships. Proton is a a subsidiary of Distributed Energy Systems.  [Mass High Tech, Oct 12]  Phase 3, which isn't SBIR money, lets the government hand out a contract to the Phase 2 winner without further competition. The company is also in the middle of a three-year, $3.8 M project with the Department of Energy to develop methods to reduce the cost of high-pressure hydrogen generation from proton exchange membrane electrolysis.

Protonex Technology  (Southborough, MA)

Protonex Technology said it has been selected by the defense contractor Lockheed Martin to develop power supply concepts that will enable its HULC robotic exoskeleton to support extended missions of 72 hours or more. [Boston Globe, Feb 11, 10]

Protonex Technology reports it has landed $1.5 million from the U.S. Army for supplying portable battery charger fuel cells. [Mass High Tech, Feb 4, 10]

Protonex Technology landed a [Army and stimulus] contract worth $1.85 million for the development and supply of advanced portable battery charger/auxiliary power units (APU) fuel cell systems. ... could increase to $6.4 million if three option phases are awarded.  [Mass High Tech, Jan 20, 10]

A small unmanned aerial vehicle powered by a Protonex fuel cell has set an unofficial endurance record after a flight of more than 23 hours, the company. said. [Boston Globe, Oct 15, 09]  The Navy sponsored the project.

Protonex Technology got a $2 million follow-on contract from the U.S. Army to make Protonex’ solid oxide fuel cell (SOFC) power systems more rugged and robust to meet the Army’s needs. [Mass High Tech, Sep 22, 09]

Protonex Technology (Southborough, MA; $1.8M SBIR) announced Thursday it received a $599,000 contract with the U.S. Naval Research Laboratory to develop fuel cell power systems for aerial drones.  [Mass High Tech, Sep 17, 09]

Protonex Technology (Southborough, MA; $2M SBIR) said its fuel-cell power system has been successfully tested in a Talon military robot from Foster-Miller. [Boston Globe, Apr 21]

Protonex Technology won a $400,000 contract from the Army's ARO for further development of the use of high-performance liquid fuels in its solid-oxide fuel cell power systems.  .... In April, Protonex received a $3.65 million contract from ARO to develop the next generation of the firm’s Pulse M250 military power system. [Mass High Tech, Sep 9, 08]

Protonex Technology landed its second military contract in two weeks, receiving a $3.65 million contract from the Army. [Mass High Tech, Apr 28]

Protonex Technology (Southborough, MA) got a $1.62 M contract with the NRL for advanced development of high power fuel cell systems for small UAVs.  ... makes fuel cells for commercial use. It began working with Cummins on applications in the trucking industry last September. ... shares debuted on the London Stock Exchange last July  [Mass High Tech, Apr 23, 08]

Protonex reports a new subcontract from Cummins to supply solid oxide fuel cell (SOFC) power systems for integration into a demonstration system for commercial mobile applications. [Mass High Tech, Sep 24, 07]

Protonex reports Raytheon has agreed to participate in the development of Protonex' portable fuel cell power system for the Army. ... Since going public last July on London's Alternative Investment Market (AIM), Protonex has doubled its head count from about 40 employees last year to 85 employees. [Mass High Tech, Sep 12]

Protonex was up 20%, back to the 90s after a drop and a day off from trading. [Jul 6, 07]

Protonex took an 18% swan dive despite announcing an $800K AF contract extension. [Jul 3, 07]

Protonex Technology (Southborough, MA; $1M SBIR) which makes high-performance proton exchange membrane (PEM) fuel cells will pay $12M for Mesoscopic Devices (Broomfield, CO; $5M+ SBIR) which makes a range of fuel cells.

They Still Speak English. Ross Kerber [Boston Globe, Jan 28] notes that four Boston area companies have gone public recently by listing on the London AIM exchange. Of the four, fuel cell developer Protonex Technology had about $1M in SBIR, and fish farmer Aqua Bounty had just one Phase 1. 

Prototype Productions (Ashburn, VA)

Prototype Productions (Ashburn, VA; $1.4M SBIR)  built or invented 176 gadgets over the years, spanning the defense, aerospace and medical industries. They’ve made stuff for the Patriot missile, grenade launchers and Chinook helicopters. ...  hoping to [gross] $30 million to $50 million by mid-decade. ...  90 employees ... During our tour, Joe took me to a room and pointed at a box the size of two refrigerators. He called it a 3D laser printer. It’s too technical to get into, but he said the printer is the next advance in manufacturing. “Many say America is losing its industrial base, which is true to some extent,” he said. “But in the future, we won’t worry about this because we will no longer manufacture things. We will print things. Laser centering is the next trillion-dollar industry.”    [Thomas Heath, Washington Post, Apr 25, 11]

Provagen

Two spinoff companies from N.C. State University and N.C. A&T State University are the first to receive loans and legal help from a new set of programs designed by the N.C. Biotechnology Center in Research Triangle Park. The programs offer companies $50,000 in startup loans as well as free legal help from area law firms. ... NCSU's company, Sirga Advanced Biopharma, uses the technology of biochemistry professor Paul F. Agris to identify therapies for drug-resistant diseases ... A&T's spinoff company, Provagen, was formed to commercialize protein technology developed by John Allen, a molecular biologist.  [Raleigh News & Observer, Jun 22]

Provenance Biopharmaceuticals (Waltham, MA)

Provenance Biopharmaceuticals (Waltham, MA; no SBIR) has raised $8 million from brand new stealthy health care products acquisition company Allopexx Enterprises LLC to fund development of an anti-cancer therapy.   [Rodney Brown, Mass High Tech, Dec 23, 11]

Proventys

A Durham medical research company co-founded by Ralph Snyderman, former CEO of the Duke University Health System, has attracted interest from several health-care heavy hitters and enough cash to introduce its first product this year. Proventys (no SBIR) is working on software that promises to help prevent complications from chemotherapy by identifying at-risk cancer patients. The company plans to use part of its $5.65 million in private financing to test the technology, and it might target other therapeutic areas.  [Raleigh News & Observer, May 15, 08]

Provista Diagnostics (Scottsdale, AZ)

Provista Diagnostics (Scottsdale, AZ; no SBIR, founded 2007)  has licensed some biomarker technologies developed by Joshua LaBaer and Karen Anderson at the Biodesign Institute at Arizona State University.  ...  will evaluate whether the technologies are effective in the early detection of breast and ovarian cancer as well as the human papillomavirus. [Angela Gonzalez, Phoenix Business Journal, Nov 4, 13]

Pryor Medical Devices (Arvada, CO and San Antonio, TX;)

Pryor Medical Devices (San Antonio, TX; no SBIR), announced it has received FDA 510(k) clearance for the sale and distribution of its ER-REBOATM catheter. REBOA (Resuscitative Endovascular Balloon Occlusion of the Aorta) is a minimally invasive technique used by the Trauma, Critical Care and Emergency Medicine community to temporarily occlude large vessels using a balloon. [W. Scott Bailey, San Antonio Business Journal, Nov 13, 15]  won a $14.3 million contract with the U.S. military that will support the advancement of the REBOA science.  [Bailey, Nov 10, 15] The technology was invented and patented by a team from the U.S. military and the University of Michigan  [fiercemedicaldevices.com, Apr 19, 15]

Pryor Medical Devices (Arvada, CO and San Antonio, TX; no SBIR, founded 2012, three employees) formed to provide minimally invasive solutions for noncompressible torso hemorrhage [company website] closed on $5 million in Series B funding to support the development of its flagship product — the ER-REBOA Catheter [designed to temporarily occlude large blood vessels through a less invasive procedure].  ... A pair of individuals from the U.S. military and University of Michigan invented and secured a patent for the device. They have licensed the technology exclusively to Pryor Medical, which has improved the technology and is now seeking to commercialize the device.   [W. Scott Bailey, San Antonio Business Journal, Sep 22, 15]

PsiKick (Santa Clara, CA)

PsiKick (Santa Clara, CA; no SBIR) raised $16.5 million in Series B funding to develop its battery-free systems. [Gina Hall, Silicon Valley Business Journal, Dec 23, 15]  Company website claims Our systems-on-chip operate at up to 1,000x lower power than existing state-of-the-art “low power” solutions. ...  Harvest energy from multiple ambient sources, including indoor and outdoor solar, thermal gradients, RF, vibration, and more. Store and manage energy for reliable operation across varying environmental conditions.

pSivida (Watertown, MA)

pSivida (Watertown, MA; no SBIR) has taken a $15 million payment from Alimera Sciences (Alpharetta, GA; no SBIR) to cover licensing of its lead product Iluvien to treat diabetic macular edema (DME).  ... pSivida was launched in Australia, and reincorporated as a U.S. company based in Watertown in April of 2008.     [Mass High Tech, Apr 29, 10]

PTC Therapeutics (S Plainfield, NJ)

PTC Therapeutics down 12% [May 8, 17] said that it would receive a net price of $35,000 annually per patient for Emflaza, the muscular dystrophy drug it acquired from Marathon Pharmaceuticals LLC last month. ...  Marathon had ignited a backlash from patient advocates and politicians in February when it announced a wholesale list price of $89,000 annually for Emflaza after it was approved for sale by [FDA]. The price was some 70 times more than some U.S. patients had been paying to import Emflaza from the U.K.  [Joseph Walker, Wall Strreet Journal, May 8, 17]

Akashi Therapeutics (Cambridge, MA; no SBIR, founded 2011 as Dart Therapeutics) has been cleared by the FDA to resume testing an experimental Duchenne muscular dystrophy drug roughly a year after a patient taking the treatment died in a clinical trial.  ...  Eteplirsen, from Sarepta Therapeutics, is meant to slow the progression of the disease, but for just a 13 percent genetic subset of Duchenne patients. The steroid deflazacort—which has been available for years in other countries—was approved in the U.S. in February for all Duchenne patients, but also only helps temporarily delay the disease’s grim march. (Deflazacort hasn’t launched yet; Marathon Pharmaceuticals sold the drug’s rights to PTC Therapeutics last week).  [Ben Fidler, xconomy.com, Mar 22, 17]

PTC Therapeutics down 19% [Mar 16, 17]  Marathon Pharmaceuticals LLC has struck a deal to sell its muscular-dystrophy treatment to PTC Therapeutics Inc., one month after Marathon’s $89,000 price tag for the drug spurred an outcry from patient advocates and federal lawmakers.  Marathon will receive $140 million up front from the sale—$75 million in cash and about $65 million in PTC stock. ... Some analysts questioned the wisdom of the deal for PTC, considering the scrutiny around the drug’s price and the existence of alternative treatments.  [Joseph Walker, Wall Street Journal, Mar 16, 17]

PTC Therapeutics is seeking FDA approval of its drug ataluren (Translarna) for Duchenne muscular dystrophy “over protest” of the agency. Ataluren has already failed three clinical trials and twice been denied an FDA review. RBC Capital Markets analyst Simos Simeonidis wrote that PTC has “very little chance” of success. The FDA will decide on ataluren by Oct. 24. [Ben Fidler, xconomy.com, Mar 10, 17]

PTC Thera down 20% [Mar 2, 17] said its cystic-fibrosis treatment failed to meet its primary or secondary endpoints in a late-stage study. [Dow Jones Newswire, Mar 2, 17]

PTC Thera up 10% [Jan 9, 17]

PTC Thera up 88% [Nov 11, 16] announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended the renewal of the conditional marketing authorization of Translarna(TM) (ataluren) for the treatment of nonsense mutation Duchenne muscular dystrophy (nmDMD) in ambulatory patients five years and older. [company press release]

PTC Thera up 13% [Nov 7, 16]

PTC Thera up 19% [Nov 4, 16]

PTC Thera down 33% [Nov 3, 16]

PTC Thera down 40% [Oct 17, 16] said [FDA] denied its first appeal of the regulator's refusal to review PTC's application for its experimental Duchenne muscular dystrophy drug. [Dow Jones Newswire]

PTC Thera up 21% [Sep 30, 16] 

PTC Thera up 21% [Sep 19, 16]

PTC Thera up 28% [Aug 5, 16] Translarna revenue of $15.4M in second quarter represents 150%  year-over-year growth. PTC continues to grow its global commercial footprint and expand access to Translarna.  [company press release, Aug 4, 16]

PTC Therapeutics (South Plainfield, NJ; $5M SBIR) said its Duchenne muscular dystrophy drug ataluren (Translarna) faces a regulatory delay in Europe. As TheStreet.com reports, the drug is no closer to approval in the U.S.  [Alex Lash, xconomy.com, Jul 29, 16]

PTC Thera down 13% [Jul 26, 16]

PTC Thera up 20% [May 20, 16]

PTC Thera up 43% [Apr 15, 16]

PTC Thera down 10% [Apr 8, 16]

PTC Thera up 15% [Mar 2,16]

PTC Thera down 30% [Mar 1,16]

PTC Thera down 29% [Feb 26, 16]

PTC Thera down 62% [Feb 23, 16]  announced that it received yesterday evening a Refuse to File letter from [FDA] regarding PTC's New Drug Application (NDA) for Translarna(TM) (ataluren), an oral, first-in-class, protein restoration therapy for the treatment of nonsense mutation Duchenne muscular dystrophy (nmDMD).  [company press release, Feb 23, 16]

PTC Thera up 11% [Jan 20, 16]

PTC Thera down 12% [Jan 11, 16]

PTC Thera up 19% [Dec 16, 15]

PTC Thera down 13% [Nov 19, 15]

PTC Thera up 11% [Nov 2, 15]

PTC Thera down 16% [Oct 19,15]

PTC Therapeutics's (South Plainfield, NJ; $5M SBIR) experimental muscle disorder drug failed to meet the main goal in a keenly watched late-stage study, but the company said data from all trials on the drug supported a U.S. marketing application  [Reuters, Oct 15, 15]

PTC Thera up 10% [Aug 26, 15]

PTC Thera up 10% [Aug 17, 15]

PTC Thera  up 14% [Jul 15,15]

PTC Thera down 13% [May 5,15]

PTC Thera up 10% [Feb 24, 15]

PTC Thera (S Plainfield, NJ; $4.8M SBIR)  up 18% [Feb 20, 15]

PTC Thera down 10% [Dec 15, 14]

PTC Thera up 13% [Dec 2, 14]

PTC Thera up 12% [Nov 24, 14]

PTC Thera down 10% [Oct 6, 14]

PTC Thera up 11% [Sep 15, 14]

PTC Thera up 10% [Sep 8, 14]

PTC Threa down 10% [Aug 7, 14]

PTC Thera up 10% [Jul 22, 14]

PTC Thera up 10% [Jun 5, 14]

PTC Thera up 15% [May 28, 14]

PTC Thera up 31% [May 23, 14]

PTC Thera down 12% [May 2, 14]

PTC Thera up 11% [Apr 29, 14]

PTC Thera up 12% [Apr 22, 14]

PTC Thera  down 13% [Apr 10, 14]

PTC Thera down 15% [Mar 24,14]

PTC Therapeutics up 10% [Feb 10, 14]

PTC Thera down 14% [Feb 3, 14]

PTC Therapeutics up 10% [Jan 17, 14]

PTC Therapeutics (S Plainfield, NJ; $5M SBIR)  up 13% [Jan 15, 14]

PTC Therapeutics  ($5M SBIR) up 14% [Dec 16, 13]

PTC Thera (S Plainfield, NJ; $5M SBIR) up 26% [Sep 23, 13]

PTC Therapeutics (South Plainfield, NJ; $5M SBIR)  up 10% [Jun 28, 13]

PTC Therapeutics (South Plainfield, NJ; $5M SBIR)  down 10% [Jun 27, 13]

PTC Therapeutics (S Plainfield, NJ; $5.4M SBIR) up 10% [Jun 20, 13]

Genzyme will pay PTC Therapeutics (Plainfield, NJ; $5M SBIR)  $100 million, as well as milestone and royalty payments, to commercialize its drug, PTC124, outside the U.S. and Canada, where PTC will commercialize the drug. [Mass High Tech, Jul 17, 08]

Pulmatrix (Lexington, MA)

Pulmatrix  (Lexington, MA; no SBIR), a clinical stage biotechnology company , said that it has secured $14 million in new funding in a Series B1 round ... to accelerate the development of its drug candidate pipeline. The company is focused on discovering and developing a new class of therapies for the prevention, treatment, and control of respiratory diseases.  [Chris Reidy, Boston Globe, Aug 15, 11]

Pulmatrix (Lexington, MA; no SBIR) said it has been awarded a $5.7 million grant from DARPA. ...  focused on new treatments for respiratory diseases, and the DARPA grant is for developing potential treatments for respiratory infections caused by weaponized, engineered, or naturally occurring pathogens  [Boston Globe, Dec 14, 10]

Pulmatrix (Lexington, MA; no SBIR)is starting a Phase 1b/2a clinical trial of its new inhaled influenza treatment PUR003, which possibly could be used against the current swine flu. .... said that its lead drug candidate PUR003 is a so-called Cationic Airway Lining Modulator drug. ... founded in 2003 by scientists from Harvard University and MIT with an eye to creating inhaled drugs and supporting technologies to treat and control disease. ... Earlier this year, Pulmatrix secured $3.5 million [VC]  [Mass High Tech, May 4, 09]

Pulmatrix (Lexington, MA; no SBIR) has closed on more than $3 million in a recent funding round.  Pulmatrix’s mission is to prevent the spread of airborne and respiratory infectious diseases in animals and humans with a mixed hardware-chemical combination. It was founded in 2003 by scientists from Harvard University and MIT with an eye to creating inhaled drugs and supporting technologies to treat and control disease.  [Mass High Tech, Mar 13, 09]

Pulmotect (Houston, TX)

Pulmotect, (Houston, TX;  no SBIR) which is developing an inhalant that stimulates the lungs’ immune system against inhaled pathogens, has closed on $1.75 million in Series A funding and a $1 million grant from [NIH]. [Angela Shah, xconomy.com, April 18, 16]

Pulmotect (Houston, TX; yes SBIR, founded 2007) received a $3 million [NIH] grant, which will be used to propel its immunotherapy drug into the next levels of clinical trials. ... developing products to boost the immune system and protect against lung infections.  ...has raised about $18 million in total funding since inception. It received $7.1 million from the Cancer Prevention Research Institute of Texas in 2012. [Joe Martin, Houston Business Journal, May 27, 15]  three-year NIH SBIR grant is the sixth award for Pulmotec ...  Backed by $15 million in grant and equity funding to date  [company website]

Pulse Electronics (Rockville, MD)

Pulse Electronics (Rockville, MD; one SBIR) down 34% [Sep 26, 14]

Pulse Therapeutics (St Louis, MO)

Pulse Therapeutics (St. Louis, MO; no  SBIR, founded 2008)  medical device startup, has raised about $10 million from a group of investors [Brian Feldt, St. Louis Business Journal, Jan 29, 16]   The Magnetically-Enhanced Diffusion (MED) system ™ is designed to improve the fluid dynamics in stagnant flow vessels by using patented magnet-based technology to convey intravenously administered, iron-oxide MED MicroBeads and physician-selected agents at a much faster rate than otherwise possible. This promises to improve care for stroke and other diseases.   [company website]

Pulse Therapeutics  (St Louis, MO; no SBIR, founded 2008) uses magnets to help clear the blood clots that can cause strokes.  ... Magnetically-Enhanced Diffusion (MED) system ™ is designed to improve the fluid dynamics in stagnant flow vessels by using patented magnet-based technology to convey intravenously administered, iron-oxide MED MicroBeads and physician-selected agents at a much faster rate than otherwise possible. .... continues to attract investors and garner media coverage.   [company website]

Cultivation Capital has invested just short of $11 million of the $20 million tech fund it created in 2012.   ...  started out as a tech fund, created its life sciences fund in 2013 with plans to invest some $30 million over five years.  ....  its portfolio: Immunophotonics (Columbia, MO; no SBIR) developed a cancer vaccineMolecular Sensing  (Nashville, TN; no SBIR) commercializing a label-free molecular interaction assay system based on Back-Scattering InterferometryAdarza BioSystems (WEST HENRIETTA, NY; $1.8M SBIR) early stage medical diagnosticsCardialen (Minneapolis, MN; no SBIR) developed a treatment to keep the heart in a normal rhythm for people suffering from atrial fibrillation (AF)Euclises Pharmaceuticals (St Louis, MO; no SBIR) developing pain and cancer medications; Mobius Therapeutics (St Louis, MO; no SBIR) commercial stage venture focused on ophthalmic surgery solutions; Pulse Therapeutics (St. Louis, MO; no SBIR) developed a new approach to accelerate the concentration and delivery of physician-selected agents within the vasculature; Galera Therapeutics (Malvern, PA; no SBIR) focused on the development of breakthrough drugs targeting the oxygen metabolic pathways.  [Brian Feldt, St. Louis Business Journal, Oct 27, 14]   

Pulse Therapeutics  (St Louis, MO; no SBIR, founded 2009) medical device company in the Downtown T-REx co-working space. ...  raised $1.3 million from three investors  ... founded in 2009 by Francis Creighton and Rogers Ritter, and is developing a magnet-based technology to dissolve blood clots.  [Brian Feldt,  St. Louis Business Journal, Mar 6, 2014]

Puma Biotechnology (Los Angeles, CA)

Puma Biotechnology  (Los Angeles, CA; no SBIR) announced that [FDA] approved NERLYNX™ (neratinib), formerly known as PB272, a once-daily oral tyrosine kinase inhibitor for the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer, following adjuvant trastuzumab-based therapy. Puma expects neratinib to become commercially available in September 2017.  [company press release, Jul 17, 17]

PUR Biologics

Histogen  (San Diego, CA; no SBIR, founded 2007, a regenerative medicine company, says it has partnered with a group of medical device investors to establish a joint venture, PUR Biologics, to adapt its expertise in fibroblasts, the cells that form connective tissue, for use in orthopedics. [Bruce Bigelow, xconomy.com, Mar 11, 13]

Pure Bioscience (El Cajon, CA)

Pure Bioscience (El Cajon, CA; no SBIR) says it can provide extra safety against food-borne illnesses with a new antimicrobial product that could be approved this year.  .... The company estimates the potential U.S. market for such a direct food disinfectant is $1 billion annually. Pure’s rinse uses the same nontoxic active ingredient as a product the company already has on the market, Pure Hard Surface, Lambert said. The ingredient, silver dihydrogen citrate, emits silver ions when ingested by microbes, killing them by disrupting their DNA. [Bradley Fikes, utsandiego.com, Jan 28, 14]

Purfresh (Fremont, CA)

Purfresh (Fremont, CA; no SBIR) has raised $2 million of a $2.5 million traunche of funding.  The Fremont-based company makes technology used to clean and purify food and water. It's raised $26 million since March of 2010, according to financial disclosures, on top of a $25 million round the company announced in 2008.[San Francisco Business Times, Jul 8, 11]

Purillume (Cary, NC)

An LED startup with Cree roots is raising cash, prepping to debut a table lamp its CEO hopes will be a game-changer in the competitive lighting industry. ....  started (Cary, NC; no SBIR in stealth mode, founded 2014]  [Lauren K. Ohnesorge, Triangle Business Journal, Aug 11, 16]

Pursuit Vascular (Maple Grove, MN)

Pursuit Vascular (Maple Grove, MN; no SBIR, founded 2009, eight employees) nabs $2 million for infection-fighting tech  [Minneapolis St Paul Business Journal, Aug 19, 16] has enjoyed at least one advantage in its quest to market its technology, which reduces catheter infections in kidney dialysis and other patients.  The product is a polymer rod coated witha dry, antimicrobial agent that kills bacteria inside a catheter, reducing infections by about 75 percent.  e ability to prove ClearGuard’s effectiveness in lab testing, rather than a clinical setting, helped Pursuit gain relatively rapid approval by the FDA.   .... has used the Minnesota Angel Tax Credit as a tool in raising $4 million on its  financing, which returned 25 percent to those investors  ...  According to the Centers for Disease Control, one of today’s top seven health care challenges is catheter related bloodstream infections.   [Dan Emerson, Minnesota Business, May 2015]

Pursuit Vascular (Maple Grove, MN; no SBIR) which makes an infection-fighting antimicrobial rod, has closed on about $1.6 million in funding [Series B round] .  ...  to complete product evaluations and boost manufacturing capacity ahead of a commercial launch, said CEO Doug Killion.   [Katharine Grayson, Minneapolis / St. Paul Business Journal, Feb 9, 15]

Pursuit Vascular (Maple Grove, MN; no SBIR) which makes an infection-fighting antimicrobial rod, has closed on about $1.6 million in funding [part of a Series B round].  ... to complete product evaluations and boost manufacturing capacity ahead of a commercial launch, said CEO Doug Killion. ... received [FDA] approval in late 2013. The company's product is inserted into hemodialysis catheters to kill infection-causing microorganisms.  [Katharine Grayson, Minneapolis / St. Paul Business Journal, Feb 9, 15]

Medical-device startup Pursuit Vascular (Maple Grove, MN; no SBIR) has closed on nearly $1.6 million in capital after receiving regulatory approval to sell its infection-fighting catheter technology. ....  company's product, called ClearGuard HD, is an antimicrobial rod that’s inserted into hemodialysis catheters to kill infection-causing microorganisms. Kidney-disease patients undergoing regular hemodialysis treatments often have a catheter left in their chests continuously, increasing the risk of developing a severe infection. [Katharine Grayson, Minneapoils / St Paul Business Journal, Feb 24, 14]

Pursuit Vascular (Maple Grove, MN; no SBIR) closed on about $1.3 million in capital, according to a regulatory filing. ....  trying to raise a total of $2 million. ...  developing a product that aims to reduce infection in hemodialysis patients, announced plans to kick off the round in April after closing on $750,000 in bridge financing. [Katherine Grayson, Minneapolis St Paul Business Journal, Aug 17, 12]

Pursuit Vascular (Maple Grove, MN; no SBIR) raised $750,000 in bridge financing during the first quarter and will soon kick off another round of fundraising, the company announced. ...  has developed a catheter technology that it says could reduce the risk of infection in hemodialysis patients. In addition to the bridge financing, the company now wants to raise $2 million, which it will put toward prepping for clinical trials and intellectual-property costs.  [Katherine Grayson, Minneapolis / St Paul Business Journal, Apr 30, 12]

PurThread (Durham, NC)

textile firm PurThread (Durham, NC; no SBIR) raised $7 million in an angel round led by its own board chair ....  to develop its antimicrobial fabric technology. ......  also has a line of anti-odor sportswear based on the same technology  [Lauren Ohnesorge, Triangle Business Journal, Nov 4, 13]

PvP Biologics (San Diego, CA)

Takeda Pharmaceutical and PvP Biologics (San Diego, CA; no SBIR) announced a global agreement for the development of KumaMax, a novel enzyme designed to break down the immune-reactive parts of gluten in the stomach, thereby avoiding the painful symptoms and damage done in the small intestine from accidental gluten ingestion.  ... PvP will conduct all [R&D] through phase 1 proof-of-principle studies per a pre-defined development plan. Takeda will fund $35 million for PvP’s expenses related to the plan in exchange for an exclusive option to acquire PvP following receipt of a pre-defined data package. Upon PvP’s successful completion of the development plan, Takeda may exercise its option to acquire PvP by paying an undisclosed fee as well as development and regulatory milestones. [joint companies press release, Jan 5, 17]

Takeda Pharmaceutical (Japan) and a subsidiary have decided to invest in two San Diego biotech companies ...  PvP Biologics (no SBIR) will get $35 million to develop celiac therapy, which breaks down gluten in the stomach before it reaches the intestine.  Avidity Biosciences (no SBIR) has raised $16 million in a venture-financing round led by the subsidiary, Takeda Ventures. Avidity has invented a technology that delivers a class of RNA medications more widely throughout the body. [Bradley Fikes, San Diego Union Tribune, Jan 9, 17]

PvP Biologics (San Diego, CA and Seattle, WA;  no SBIR yet) a University of Washington spin-out, is advancing a scientifically designed enzyme that could help people with celiac disease. The UW Institute for Protein Design created the enzyme, called KumaMax.  It targets parts of gluten that cause the autoimmune reaction leading to celiac disease.  The disease affects an estimated 2.4 million Americans.  ... was launched through CoMotion at the UW, the collaborative innovation hub dedicated to expanding the societal impact of the UW community.   [company press release, Dec 20, 16]